Short-term in vivo exposure to the water contaminant triclosan: Evidence for disruption of thyroxine

Environmental Toxicology and Pharmacology

Volumn 24, Issue 2, 2007, Pages 194-197

  Crofton, Kevin M ^a   Paul, Katie B ^b   DeVito, Michael J ^a   Hedge, Joan M ^a  

^a U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

^b UNIVERSITY OF NORTH CAROLINA   (United States)

Author keywords

Endocrine disruptor; Thyroid hormone (TH); Thyroxine (T4); Triclosan

Indexed keywords

PREGNANE X RECEPTOR; THYROXINE; TRICLOSAN;

ARTICLE; BODY WEIGHT; CONTROLLED STUDY; FEMALE; HOMEOSTASIS; IN VIVO STUDY; LIVER WEIGHT; NONHUMAN; PRIORITY JOURNAL; RAT; THYROXINE BLOOD LEVEL; WATER CONTAMINATION;

RATTUS;

EID: 34447620302     PISSN: 13826689     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.etap.2007.04.008     Document Type: Article

References (36)

1. Adolfsson-Erici M., Pettersson M., Parkkonen J., and Sturve J. Triclosan, a commonly used bactericide found in human milk and in the aquatic environment in Sweden. Chemosphere 46 (2002) 1485-1489
2. Bhargava H.N., and Leonard P.A. Triclosan: applications and safety. Am. J. Infect. Control 24 (1996) 209-218
3. Capen C.C. Mechanisms of chemical injury of thyroid gland. Prog. Clin. Biol. Res. 387 (1994) 173-191
4. Chen C., Staudinger J.L., and Klaassen C.D. Nuclear receptor, pregname X receptor, is required for induction of UDP-glucuronosyltranferases in mouse liver by pregnenolone-16 alpha-carbonitrile. Drug Metabol. Dispos. 31 (2003) 908-915
5. Craft E.S., DeVito M.J., and Crofton K.M. Comparative responsiveness of hypothyroxinemia and hepatic enzyme induction in Long-Evans rats versus C57BL/6J mice exposed to TCDD-like and phenobarbital-like polychlorinated biphenyl congeners. Toxicol. Sci. 68 (2002) 372-380
6. Crofton K.M. Developmental disruption of thyroid hormone: correlations with hearing dysfunction in rats. Risk Anal. 24 (2004) 1665-1671
7. Dayan A.D. Risk assessment of triclosan [Irgasan((R))] in human breast milk. Food Chem. Toxicol. 45 (2007) 125-129
8. DeVito M., Biegel L., Brouwer A., Brown S., Brucker-Davis F., Cheek A.O., Christensen R., Colborn T., Cooke P., Crissman J., Crofton K., Doerge D., Gray E., Hauser P., Hurley P., Kohn M., Lazar J., McMaster S., McClain M., McConnell E., Meier C., Miller R., Tietge J., and Tyl R. Screening methods for thyroid hormone disruptors. Environ. Health Perspect. 107 (1999) 407-415
9. Friesema E.C., Jansen J., Milici C., and Visser T.J. Thyroid hormone transporters. Vitam. Horm. 70 (2005) 137-167
10. Foran C.M., Bennett E.R., and Benson W.H. Developmental evaluation of a potential non-steroidal estrogen triclosan. Mar Environ Res. 50 (2000) 153-156
11. Hanioka N., Omae E., Nishimura T., Jinno H., Onodera S., Yoda R., and Ando M. Interaction of 2,4,4′-trichloro-2′-hydroxydiphenyl ether with microsomal cytochrome P450-dependent monooxygenases in rat liver. Chemosphere 33 (1996) 265-276
12. Heath R.J., and Rock C.O. A triclosan-resistant bacterial enzyme. Nature 406 (2000) 145-146
13. Hill R.N., Crisp T.M., Hurley P.M., Rosenthal S.L., and Singh D.V. Risk assessment of thyroid follicular cell tumors. Environ. Health Perspect. 106 (1998) 447-457
14. Ishibashi H., Matsumura N., Hirano M., Matsuoka M., Shiratsuchi H., Ishibashi Y., Takao Y., and Arizono K. Effects of triclosan on the early life stages and reproduction of medaka Oryzias latipes and induction of hepatic vitellogenin. Aquat. Toxicol. 67 (2004) 167-179
15. Jacobs M.N., Nolan G.T., and Hood S.R. Lignans, bacteriocides and organochlorine compounds activate the human pregnane X receptor (PXR). Toxicol. Appl. Pharmacol. 209 (2005) 123-133
16. Jinno H., Hanioka N., Onodera S., Nishimura T., and Ando M. Irgasan DP 300 (5-chloro-2-(2,4-dichlorophenoxy)-phenol) induces cytochrome P450s and inhibits haem biosynthesis in rat hepatocytes cultured on Matrigel. Xenobiotica 27 (1997) 681-692
17. Kanda R., Griffin P., James H.A., and Fothergill J. Pharmaceutical and personal care products in sewage treatment works. J. Environ. Monit. 5 (2003) 823-830
18. Klaassen C.D., and Slitt A.L. Regulation of hepatic transporters by xenobiotic receptors. Curr. Drug Metabol. 6 (2005) 309-328
19. Koibuchi N., and Iwasaki T. Regulation of brain development by thyroid hormone and its modulation by environmental chemicals. Endocr. J. 53 (2006) 295-303
20. Kretschmer X.C., and Baldwin W.S. CAR and PXR: xenosensors of endocrine disrupters?. Chemico-Biol. Interact. 155 (2005) 111-128
21. Levy C.W., Roujeinikova A., Sedelnikova S., Baker P.J., Stuitje A.R., Slabas A.R., Rice D.W., and Rafferty J.B. Molecular basis of triclosan activity. Nature 398 (1999) 383-384
22. Loraine G.A., and Pettigrove M.E. Seasonal variations in concentrations of pharmaceuticals and personal care products in drinking water and reclaimed wastewater in southern California. Environ. Sci. Technol. 40 (2006) 687-695
23. Mackenzie P.I., Walter Bock K., Burchell B., Guillemette C., Ikushiro S., Iyanagi T., Miners J.O., Owens I.S., and Nebert D.W. Nomenclature update for the mammalian UDP glycosyltransferase (UGT) gene superfamily. Pharmacogen. Genom. 15 (2005) 677-685
24. McMurry L.M., Oethinger M., and Levy S.B. Triclosan targets lipid synthesis. Nature 394 (1998) 531-532
25. Mitchell M.L., and Klein R.Z. The sequelae of untreated maternal hypothyroidism. Eur. J. Endocrinol. 151 Suppl. 3 (2004) U45-U48
26. Morreale de Escobar G., Obregon M.J., and Escobar del Rey F. Role of thyroid hormone during early brain development. Eur. J. Endocrinol. 151 Suppl. 3 (2004) U25-U37
27. Nakada N., Tanishima T., Shinohara H., Kiri K., and Takada H. Pharmaceutical chemicals and endocrine disrupters in municipal wastewater in Tokyo and their removal during activated sludge treatment. Water Res. 40 (2006) 3297-3303
28. Schuur A.G., Legger F.F., van Meeteren M.E., Moonen M.J., van Leeuwen-Bol I., Bergman A., Visser T.J., and Brouwer A. In vitro inhibition of thyroid hormone sulfation by hydroxylated metabolites of halogenated aromatic hydrocarbons. Chem. Res. Toxicol. 11 (1998) 1075-1081
29. Veldhoen N., Skirrow R.C., Osachoff H., Wigmore H., Clapson D.J., Gunderson M.P., Van Aggelen G., and Helbing C.C. The bactericidal agent triclosan modulates thyroid hormone-associated gene expression and disrupts postembryonic anuran development. Aquat. Toxicol. 80 (2006) 217-227
30. Visser T.J. Pathways of thyroid hormone metabolism. Acta Medica Austriaca 23 (1996) 10-16
31. Wang L.Q., Falany C.N., and James M.O. Triclosan as a substrate and inhibitor of 3′-phosphoadenosine 5′-phosphosulfate-sulfotransferase and UDP-glucuronosyl transferase in human liver fractions. Drug Metabol. Dispos. 32 (2004) 1162-1169
32. Wolff M.S., Teitelbaum S.L., Windham G., Pinney S.M., Britton J.A., Chelimo C., Godbold J., Biro F., Kushi L.H., Pfeiffer C.M., and Calafta A.M. Pilot study of urinary biomarkers of phytoestrogens, phthalates, and phenols in girls. Environ. Health Perspect. 115 (2007) 116-117
33. You L. Steroid hormone biotransformation and xenobiotic induction of hepatic steroid metabolizing enzymes. Chemico-Biol. Interact. 147 (2004) 233-246
34. Zhou J., Zhang J., and Xie W. Xenobiotic nuclear receptor-mediated regulation of UDP-glucuronosyl-transferases. Curr. Drug Metabol. 6 (2005) 289-298
35. Zhou T., Ross D.G., DeVito M.J., and Crofton K.M. Effects of short-term in vivo exposure to polybrominated diphenyl ethers on thyroid hormones and hepatic enzyme activities in weanling rats. Toxicol. Sci. 61 (2001) 76-82
36. Zoeller R.T., and Crofton K.M. Thyroid hormone action in fetal brain development and potential for disruption by environmental chemicals. Neurotoxicology 21 (2000) 935-945