Short-term exposure to triclosan decreases thyroxine in vivo via upregulation of hepatic catabolism in young long-evans rats

Toxicological Sciences

Volumn 113, Issue 2, 2009, Pages 367-379

  Paul, Katie B ^a   Hedge, Joan M ^b   Devito, Michael J ^b   Crofton, Kevin M ^b  

^a UNIVERSITY OF NORTH CAROLINA   (United States)

^b U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

Author keywords

Glucuronyltransferase; Hepatic transport; Mode of action; Sulfotransferase; Thyroid disruption; Triclosan

Indexed keywords

CARRIER PROTEIN; CYTOCHROME P450; CYTOCHROME P450 1A1; CYTOCHROME P450 2B1; CYTOCHROME P450 2B2; CYTOCHROME P450 3A1; CYTOCHROME P450 3A23; ETHOXYRESORUFIN DEETHYLASE; GLUCURONOSYLTRANSFERASE; GLUCURONOSYLTRANSFERASE 1A1; GLUCURONOSYLTRANSFERASE 1A6; GLUCURONOSYLTRANSFERASE 2B5; LIOTHYRONINE; MESSENGER RNA; MULTIDRUG RESISTANCE PROTEIN; MULTIDRUG RESISTANCE PROTEIN 1B; MULTIDRUG RESISTANCE PROTEIN 2; ORGANIC ANION TRANSPORTER 1A1; ORGANIC ANION TRANSPORTER 1A4; PENTOXYRESORUFIN O DEETHYLASE; SULFOTRANSFERASE; SULFOTRANSFERASE 1B1; SULFOTRANSFERASE 1C1; THYROTROPIN; THYROXINE; TRICLOSAN; UNCLASSIFIED DRUG; UNCLASSIFIED ENZYME;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; EXPOSURE; FEMALE; GENE EXPRESSION; GLUCURONIDATION; HORMONE TRANSPORT; HYPOTHYROXINEMIA; IN VIVO STUDY; LIOTHYRONINE BLOOD LEVEL; LIVER METABOLISM; LIVER MICROSOME; LIVER PARENCHYMA; LONG EVANS RAT; NONHUMAN; RADIOIMMUNOASSAY; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; THYROID DISEASE; THYROID HORMONE METABOLISM; THYROTROPIN BLOOD LEVEL; THYROXINE BLOOD LEVEL;

ANIMALS; ANTI-INFECTIVE AGENTS, LOCAL; CYTOCHROME P-450 ENZYME SYSTEM; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; GENE EXPRESSION; GLUCURONOSYLTRANSFERASE; LIVER; MICROSOMES, LIVER; RATS; RATS, LONG-EVANS; RECEPTORS, STEROID; RNA, MESSENGER; SULFOTRANSFERASES; THYROXINE; TRICLOSAN; UP-REGULATION;

RATTUS;

EID: 75249098796     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfp271     Document Type: Article

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