New approaches to treating pain

Bioorganic and Medicinal Chemistry Letters

Volumn 26, Issue 4, 2016, Pages 1103-1119

  Wolkerstorfer, Andrea ^a   Handler, Norbert ^a   Buschmann, Helmut ^b  

^a M2N Consulting and Development GmBH   (Austria)

^b Development and Consulting GmbH   (Germany)

Author keywords

Analgesics; Non opioids; NSAIDs; Opioids; Pain

Indexed keywords

ANALGESIC AGENT; ANTIDEPRESSANT AGENT; CALCIUM CHANNEL BLOCKING AGENT; CANNABINOID; NONSTEROID ANTIINFLAMMATORY AGENT; SODIUM CHANNEL BLOCKING AGENT; TRANSIENT RECEPTOR POTENTIAL CHANNEL;

CHEMISTRY; HUMAN; METABOLISM; PAIN; PAIN MEASUREMENT;

ANALGESICS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ANTIDEPRESSIVE AGENTS; CALCIUM CHANNEL BLOCKERS; CANNABINOIDS; HUMANS; PAIN; PAIN MEASUREMENT; SODIUM CHANNEL BLOCKERS; TRANSIENT RECEPTOR POTENTIAL CHANNELS;

EID: 84953455400     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2015.12.103     Document Type: Review

References (141)

1. Merskey, H., Bogduk, N., (eds.) Classification of Chronic Pain, 2nd ed., 2004, IASP Press, Seattle, WA, 207 Part III.
2. Waldmann, S.D., Saunders Elsevier, 2007.
3. Hunt, S.P., Mantyh, P.W., Nat. Rev. Neurosci., 2, 2001, 83.
4. Knaul, F.M., Farmer, P.E., Bhadelia, A., Berman, P., Horton, R., Lancet, 386, 2015, 722.
5. Kuner, R., Nat. Med., 16, 2010, 1258.
6. Babos, M.B., Grady, B., Wisnoff, W., McGhee, C., Dis. Mon., 59, 2013, 330.
7. Treat Guidel. Med. Lett. 2007, Vol. 5, p 23.
8. Barkin, R.L., Barkin, D., South. Med. J., 94, 2001, 756.
9. Wu, C.L., Raja, S.N., Lancet, 377, 2011, 2215.
10. Turk, D.C., Wilson, H.D., Cahana, A., Lancet, 377, 2011, 2226.
11. Ashburn, M.A., Staats, P.S., Lancet, 357, 2001, 24.
12. Maizels, M., McCarberg, B., Am. Fam. Physician, 71, 2005, 483.
13. Smith, P.A., Drug News Perspect., 17, 2004, 5.
14. Vanderah, T.W., Med. Clin. N. Am., 91, 2007, 1.
15. Paice, J.A., Ferrell, B., Cancer J. Clin., 61, 2011, 157.
16. Apolone, G., Corli1, O., Caraceni, A., Negri1, E., Deandrea, S., Montanari, M., Greco, M.T., Br. J. Cancer, 100, 2009, 1566.
17. Lema, M.J., Foley, K.M., Hausheer, F.H., Oncologist, 15, 2010, 3.
18. Portenoy, R.K., Lancet, 377, 2011, 2236.
19. American Academy of Pain Medicine. Facts and Figures on Pain. < http://www.painmed.org/patientcenter/facts_on_pain.aspx> [accessed Aug 15, 2015].
20. Global Burden of Disease Study 2013 Collaborators. Lancet, 386, 2015, 743.
21. Phillips, C.J., Harper, C., Curr. Opin. Support. Palliat. Care, 5, 2011, 127.
22. Langley, P., Müller-Schwefe, G., Nicolaou, A., Liedgens, H., Pergolizzi, J., Varrassi, G., J. Med. Econ., 13, 2010, 571.
23. Institute of Medicine, Relieving Pain in America: A Blueprint for Transforming Prevention, Care, Education, and Research. 2011, National Academies Press, Washington, DC.
24. Melnikova, I., Nat. Rev. Drug Disc., 9, 2010, 589.
25. Nightingale, S., Nat. Rev. Drug Disc., 11, 2012, 101.
26. Friderichs, E., Christoph, T., Buschmann, H.H., Ullmann's Encyclopedia of Industrial Chemistry. 2007, Wiley-VCH, Weinheim p 1.
27. Martin, T.J., Eisenach, J.C., J. Pharmacol. Exp. Ther., 299, 2001, 811.
28. Besson, J.M., Lancet, 357, 2001, 5.
29. MacPherson, R.D., Pharmacol. Ther., 88, 2000, 163.
30. Raffa, B.R., Pergolizzi, J.V., Tallarida, R.J. Jr., J. Pain, 11, 2010, 701.
31. Raja, S.N., Reg. Anesth. Pain Med., 37, 2012, 210.
32. Handy, C.R., Krudy, C., Boulis, N., Pain Res. Treat., 2011, 987597.
33. Gidal, B.E., Am. J. Manag. Care, 12, 2006, 269.
34. Williams, M., Kowaluk, E.A., Arneric, S.P., J. Med. Chem., 42, 1999, 1481.
35. Scascighini, L., Sprott, H., Nat. Clin. Pract. Rheumatol., 4, 2008, 74.
36. Woolf, C., J. Nat. Med., 16, 2010, 1241.
37. Datamonitor: Pipeline Insight: Neuropathic Pain, 2007.
38. Hennan, J.K., Huang, J., Barrett, T.D., Driscoll, E.M., Willens, D.E., Park, A.M., Crofford, L.J., Lucchesi, B.R., Circulation, 104, 2001, 820.
39. Segev, G., Katz, R., J. Hosp. Physician, 40, 2004, 39.
40. Kinch, S.K., Drug Discovery Today, 20, 2015, 3.
41. Dietis, N., Guerrini, R., Calo, G., Salvadori, S., Rowbotham, D.J., Lambert, D.G., Br. J. Anaesth., 103, 2009, 38.
42. Vallejo, R., Barkin, R.L., Wang, V.C., Pain Physician, 14, 2011, E343.
43. Bie, B., Pan, Z.Z., Mol. Pain, 3, 2007, 37.
44. Shukla, A.K., Westfield, G.H., Xiao, K., Reis, R.I., Huang, L.Y., Tripathi-Shukla, P., Qian, J., Li, S., Blanc, A., Oleskie, A.N., Dosey, A.M., Su, M., Liang, C.R., Gu, L.L., Shan, J.M., Chen, X., Hanna, R., Choi, M., Yao, X.J., Klink, B.U., Kahsai, A.W., Sidhu, S.S., Koide, S., Penczek, P.A., Kossiakoff, A.A., Woods, V.L. Jr, Kobilka, B.K., Skiniotis, G., Lefkowitz, R.J., Nature, 512, 2014, 218.
45. Violin, J.D., Crombie, A.L., Soergel, D.G., Lark, M.G., Trends Pharmacol. Sci., 35, 2014, 308.
46. Soergel, D.G., Sulbach, R.A., Burnham, N., Lark, M.W., James, I.E., Sadler, B.M., Skobieranda, F., Violin, J.D., Webster, L.R., Pain, 2014, 1829, 155.
47. Vanderah, T.W., Clin. J. Pain, 26, 2010, S10.
48. Pradhan, A.A., Befort, K., Nozaki, C., Gavériaux-Ruff, C., Kieffer, B.L., Trends Pharmacol. Sci., 32, 2011, 581.
49. Mika, J., Popiolek-Barczyk, K., Rojewska, W., Starowicz, K., Przewlocka, B., PLoS One, 9, 2014, e104420.
50. Peppin, J.F., Raffa, R.B., J. Clin. Pharm. Ther., 40, 2015, 155.
51. Singh, N., Nolan, T.L., McCurdy, C.R., J. Mol. Graph. Model., 27, 2008, 131.
52. Huge, V., Rammes, G., Beyer, A., Zieglgänsberger, W., Azad, S.C., Eur. J. Pain, 13, 2009, 124.
53. Kivell, B., Prisinzano, T.E., Psychopharmacology (Berlin), 210, 2010, 109.
54. Aldrich, J.V., McLaughlin, J.P., AAPS J., 11, 2009, 312.
55. White, K.L., Scopton, A.P., Rives, M.L., Bikbulatov, R.V., Polepally, P.R., Brown, P.J., Kenakin, T., Javitch, J.A., Zjawiony, J.K., Roth, B.L., Mol. Pharmacol., 85, 2014, 83.
56. Zhou, L., Lovell, K.M., Frankowski, K.J., Slauson, S.R., Phillips, A.M., Streicher, J.M., Stahl, E., Schmid, C.L., Hodder, P., Madoux, F., Cameron, M.D., Prisinzano, T.E., Aubé, J., Bohn, L.M., J. Biol. Chem., 288, 2013, 36703.
57. Chiou, L.C., Liao, Y.Y., Fan, P.C., Kuo, P.H., Wang, C.H., Riemer, C., Prinssen, E.P., Curr. Drug Targets, 8, 2007, 117.
58. Lambert, D.G., Nat. Rev. Drug Disc., 7, 2008, 694.
59. Wolfe, G.I., Trivedi, J.R., Muscle Nerve, 30, 2004, 3.
60. Reimann, W., Schneider, F., Eur. J. Pharmacol., 349, 1998, 199.
61. Wade, W.E., Spruill, W.J., Clin. Ther., 31, 2009, 2804.
62. Grond, S., Sablotzki, A., Clin. Pharmacokinet., 43, 2004, 879.
63. Valle, M., Garrido, M.J., Pavo, J.M., Calvo, R., Troconiz, I.A., J. Pharmacol. Exp. Ther., 293, 2000, 646.
64. Raffa, R.B., Friderichs, E., Reimann, W., Shank, R.P., Codd, E.E., Vaught, J.L., J. Pharmacol. Exp Ther., 260, 1992, 275.
65. Raffa, R.B., Friderichs, E., Reimann, W., Shank, R.P., Codd, E.E., Vaught, J.L., Jacoby, H.I., Selve, N., J. Pharmacol. Exp. Ther., 267, 1993, 331.
66. Tzschentke, T.M., De Vry, J., Terlinden, R., Hennie, H.H., Lange, C., Strassburger, W., Haurand, M., Kolb, J., Schneider, J., Buschmann, H., Finkam, M., Jahnel, U., Friderichs, E., Drugs Future, 31, 2006, 1053.
67. Raffa, R.B., Buschmann, H., Christoph, T., Eichenbaum, G., Englberger, W., Flores, C.W., Hertrampf, T., Kögel, B., Schiene, K., Straßburger, W., Terlinden, R., Tzschentke, T.M., Expert Opin. Pharmacother., 13, 2012, 1437.
68. Zamanillo, D., Romero, L., Merlos, M., Vela, J.M., Eur. J. Pharmacol., 716, 2013, 78.
69. Almansa, C., Vela, J.M., Future Med. Chem., 6, 2014, 1179.
70. Vela, J.M., Merlos, M., Almansa, C., Expert. Opin. Invest. Drugs, 24, 2015, 883.
71. Dìaz, J.L., Cuberes, R., Berrocal, J., Contijoch, M., Christmann, U., Fernández, A., Port, A., Holenz, J., Buschmann, H., Laggner, C., Serafini, M.T., Burgueño, J., Zamanillo, D., Merlos, M., Vela, J.M., Almansa, C., J. Med. Chem., 55, 2012, 8211.
72. Peters, C.H., Ruben, P.C., Handb. Exp. Pharmacol., 221, 2014, 1.
73. Nardi, A., Damann, N., Hertrampf, T., Kless, A., ChemMedChem, 7, 2012, 1712.
74. De Lera Ruiz, M., Kraus, R.L., J. Med. Chem., 2015, 10.1021/jm501981g.
75. Lee, M.S., Prog. Med. Chem., 53, 2014, 147.
76. Williams, J.A., Day, M., Heavner, J.E., Expert Opin. Pharmacother., 9, 2008, 1575.
77. Mitchell, A.A., Sapienza-Crawford, A.J., Hanley, K.L., Lokey, K.J., Wells, L., McDowell, G.C., Stanton-Hicks, M., Expert. Opin. Pain Manag. Nurs., 14, 2013, e84.
78. Todorovic, S.M., Jevtovic-Todorovic, V., CNS Neurol. Disord.: Drug Targets, 5, 2006, 639.
79. Krafte, D.S., Bannon, A.W., Curr. Opin. Pharmacol., 8, 2008, 50.
80. Wood, J.N., Boorman, J.P., Okuse, K., Baker, M.D., J. Neurobiol., 61, 2004, 55.
81. Cummins, T.R., Sheets, P.L., Waxman, S.G., Pain, 131, 2007, 243.
82. Bagal, S.K., Chapman, M.L., Marron, B.E., Prime, R., Storer, R.I., Swain, N.A., BMCL Digest, 24, 2014, 3690.
83. Gutman, G.A., Chandy, K.G., Grissmer, S., Lazdunski, M., McKinnon, D., Pardo, L.A., Robertson, G.A., Rudy, B., Sanguinetti, M.C., Stuhmer, W., Wang, X., Pharmacol. Rev., 57, 2005, 473.
84. Wickenden, A.D., Krajewski, J.L., London, B., Wagoner, P.K., Wilson, W.A., Clark, S., Roeloffs, R., McNaughton-Smith, G., Rigdon, G.C., Mol. Pharmacol., 73, 2008, 977.
85. Tsantoulas, C., McMahon, S.B., Trends Neurosci., 37, 2014, 146.
86. Passmore, G.M., Selyanko, A.A., Mistry, M., Al-Qatari, M., Marsh, S.J., Matthews, E.A., Dickenson, A.H., Brown, T.A., Burbidge, S.A., Main, M., Brown, D.A., J. Neurosci., 23, 2003, 7227.
87. Zhou, J., Yang, C.X., Zhong, J.Y., Wang, H.B., NeuroReport, 24, 2013, 131.
88. Kang, D., Kim, D., Am. J. Physiol., 291, 2006, 138.
89. Bruner, J.K., Zou, B., Zhang, H., Zhang, Y., Schmidt, K., Li, M., Eur. J. Pharmacol., 740, 2014, 603.
90. Wright, P.D., Weir, G., Cartland, J., Tickle, D., Kettleborough, C., Cader, Z., Jerman, J., Biochem. Biophys. Res. Commun., 441, 2013, 463.
91. Alloui, A., Zimmermann, K., Mamet, J., Duprat, F., Noël, J., Chemin, J., Guy, N., Blondeau, N., Voilley, N., Rubat-Coudert, C., Borsotto, M., Romey, G., Heurteaux, C., Reeh, P., Eschalier, A., Lazdunski, M., EMBO J., 25, 2006, 2368.
92. Wrobel-Goldberg, S., Silberstein, S.D., CNS Drugs, 29, 2015, 443.
93. Romero-Reyes, M., Pardi, V., Akerman, S., Exp. Neurol., 27, 2015, 95.
94. Crowley, B.M., Stump, C.A., Nguyen, D.N., Potteiger, C.M., McWherter, M.A., Paone, D.V., Quigley, A.G., Bruno, J.G., Cui, D., Culberson, J.C., Danziger, A., Fandozzi, C., Gauvreau, D., Kemmerer, A.L., Menzel, K., Moore, E.L., Mosser, S.D., Reddy, V., White, R.B., Salvatore, C.A., Kane, S.A., Bell, I.M., Selnick, H.G., Fraley, M.E., Burgey, C.S., Bioorg. Med. Chem. Lett., 25, 2015, 4777.
95. < https://www.clinicaltrials.gov/show/NCT00797667>.
96. Wang, T., Yu, D., Lamb, M.L., Expert Opin. Ther. Pat., 19, 2009, 305.
97. Stachel, S.J., Sanders, J.M., Henze, D.A., Rudd, M.T., Su, H.P., Li, Y., Nanda, K.K., Egbertson, M.S., Manley, P.J., Jones, K.L., Brnardic, E.J., Green, A., Grobler, J.A., Hanney, B., Leitl, M., Lai, M.T., Munshi, V., Murphy, D., Rickert, K., Riley, D., Krasowska-Zoladek, A., Daley, C., Zuck, P., Kane, S.A., Bilodeau, M.T., J. Med. Chem., 57, 2014, 5800.
98. Lane, N.E., Schnitzer, T.J., Birbara, C.A., Mokhtarani, M., Shelton, D.L., Smith, M.D., Brown, M.T., N. Engl. J. Med., 363, 2010, 1521.
99. Wang, T., Yu, D., Lamb, M.L., Expert Opin. Ther. Pat., 19, 2009, 305.
100. Anand, P., Whiteside, G., Fowler, C.J., Hohmann, A.G., Brain Res. Rev., 60, 2009, 255.
101. Starowicz, K., Di Marzo, V., Eur. J. Pharmacol., 716, 2013, 41.
102. Guindon, J., Hohmann, A.G., Br. J. Pharmacol., 153, 2008, 319.
103. Beaulieu, P., Ware, M., Curr. Opin. Anaesthesiol., 20, 2007, 473.
104. McCarberg, B.H., J. Pain Palliat. Care Pharmacother., 21, 2007, 19.
105. Russo, E.B., Ther. Clin. Risk Manag., 4, 2008, 245.
106. Schlosburg, J.E., Kinsey, S.G., Lichtman, A.H., AAPS J., 11, 2009, 39.
107. Pillarisetti, S., Alexander, C.W., Khanna, I., Drug Discovery Today, 14, 2009, 1098.
108. Min, J.W., Liu, W.H., He, X.H., Peng, B.W., Toxicon, 71, 2013, 66.
109. Gunthorpe, M.J., Chizh, B.A., Drug Discovery Today, 14, 2008, 56.
110. Brederson, J.D., Kym, P.R., Szallasi, A., Eur. J. Pharmacol., 716, 2013, 61.
111. Tominaga, M., Tominaga, T., Pflügers Arch., 451, 2005, 143.
112. Jia, Y., McLeod, R.L., Hey, J.A., Drug News Perspect., 18, 2005, 165.
113. Szallasi, A., Cortright, D.N., Blum, C.A., Eid, S.R., Nat. Rev. Drug Disc., 6, 2007, 357.
114. Anand, P., Bley, K., Br. J. Anaesth., 107, 2011, 490.
115. Baron, R., Lancet, 356, 2000, 785.
116. Knotkova, H., Pappagallo, M., Szallasi, A., Clin. J. Pain, 24, 2008, 142.
117. Jann, M.W., Slade, J.H., Pharmacotherapy, 27, 2007, 1571.
118. McCleane, G., CNS Drugs, 22, 2008, 139.
119. Baron, R., Binder, A., Wasner, G., Lancet Neurol., 9, 2010, 807.
120. Lee, Y.C., Chen, P.P., Expert Opin. Pharmacother., 11, 2010, 2813.
121. Dickenson, A.H., Ghandehari, J., Handb. Exp. Pharmacol., 177, 2007, 145.
122. Zaremba, P.D., Bialek, M., Blaszczyk, B., Cioczek, P., Czuczwar, S., J. Pharmacol. Rep., 58, 2006, 1.
123. Zhuo, M., Wu, G., Wu, L.J., Mol. Brain, 4, 2011, 31.
124. Fisher, K., Coderre, T.J., Hagen, N.A., J. Pain Symptom Manage., 20, 2000, 358.
125. Collins, S., Sigtermans, M.J., Dahan, A., Zuurmond, W.W., Perez, R.S., Pain Med. (Malden), 11, 2010, 1726.
126. Yalcin, I., Tessier, L.H., Petit-Demoulière, N., Waltisperger, E., Hein, L., Freund-Mercier, M.J., Barrot, M., Exp. Neurol., 221, 2010, 115.
127. Burnstock, G., Eur. J. Pharmacol., 716, 2013, 24.
128. Burnstock, G., Mol. Pain, 5, 2009, 69.
129. Ruan, H.-Z., Burnstock, G., Histochem. Cell Biol., 120, 2003, 415.
130. Fukuhara, N., Imai, Y., Sakakibara, A., Morita, K., Kitayama, S., Tanne, K., Dohi, T., Neurosci. Lett., 292, 2000, 25.
131. McGaraughty, S., Jarvis, M.F., Drug Dev. Res., 7, 2006, 376.
132. Burnstock, G., Handb. Exp. Pharmacol., 194, 2009, 333.
133. Barclay, J., Patel, S., Dorn, G., Wotherspoon, G., Moffatt, S., Eunson, L., Abdel′al, S., Natt, F., Hall, J., Winter, J., Bevan, S., Wishart, W., Fox, A., Ganju, P., J. Neurosci., 22, 2002, 8139.
134. Chessell, I.P., Dudley, A., Billinton, A., Drug Discovery Today, 17, 2012, 875.
135. Schnitzer, T.J., Marks, J.A., Osteoarthritis Cartilage, 23, 2015, 8.
136. Bigal, M.E., Dodick, D.W., Rapoport, A.M., Silberstein, S.D., Ma, Y., Yang, R., Loupe, P.S., Burstein, R., Newman, L.C., Lipton, R.B., Lancet Neurol., 14, 2015, 1081.
137. Bigal, M.E., Edvinsson, L., Rapoport, A.M., Lipton, R.B., Spierings, E.L., Diener, H.C., Burstein, R., Loupe, P.S., Ma, Y., Yang, R., Silberstein, S.D., Lancet Neurol., 14, 2015, 1091.
138. Dodick, D.W., Goadsby, P.J., Silberstein, S.D., Lipton, R.B., Olesen, J., Ashina, M., Wilks, K., Kudrow, D., Kroll, R., Kohrman, B., Bargar, R., Hirman, J., Smith, J., Lancet Neurol., 13, 2014, 1100.
139. Lin, X., Wang, M., Zhang, J., Xu, R., Curr. Med. Chem., 23, 2014, 4405.
140. Cao, F.L., Xu, M., Wang, Y., Gong, K.R., Zhang, J.T., Pharmacol. Biochem. Behav., 128, 2015, 1.
141. Butera, J.A., J. Med. Chem., 50, 2007, 2543.