The determination and application of fixed-dose analgesic combinations for treating multimodal pain

Journal of Pain

Volumn 11, Issue 8, 2010, Pages 701-709

  Raffa, Robert B ^a   Pergolizzi Jr , Joseph V ^b   Tallarida, Ronald J ^c  

^a TEMPLE UNIVERSITY SCHOOL OF PHARMACY   (United States)

^b JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c TEMPLE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Analgesic; drug combination; isobole; multimodal; synergy

Indexed keywords

ACETYLSALICYLIC ACID; ALPHA 2 ADRENERGIC RECEPTOR STIMULATING AGENT; ANALGESIC AGENT; ANTICONVULSIVE AGENT; ANTIDEPRESSANT AGENT; BUTORPHANOL; CANNABINOID; CORTICOSTEROID; CYCLOOXYGENASE 2 INHIBITOR; DULOXETINE; GABAPENTIN; GLUCOSAMINE; IBUPROFEN; LOCAL ANESTHETIC AGENT; MILNACIPRAN; MORPHINE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; NARCOTIC ANALGESIC AGENT; NONSTEROID ANTIINFLAMMATORY AGENT; NORADRENALIN UPTAKE INHIBITOR; OPIATE; PARACETAMOL; PENTAZOCINE; PREGABALIN; SEROTONIN UPTAKE INHIBITOR; TAPENTADOL; TRAMADOL; TRIPTAN DERIVATIVE; UNINDEXED DRUG; VENLAFAXINE;

ANALGESIA; BALANCE DISORDER; BLEEDING; CANCER PAIN; CARDIOTOXICITY; CENTRAL NERVOUS SYSTEM; CHRONIC PAIN; CLINICAL PRACTICE; COGNITIVE DEFECT; DISEASE SEVERITY; DIZZINESS; DOSE RESPONSE; DRUG EFFICACY; DRUG INDICATION; DRUG MECHANISM; DRUG POTENTIATION; DRUG SAFETY; DRUG TARGETING; DRUG USE; FIBROMYALGIA; GAIT DISORDER; HUMAN; LIVER TOXICITY; LONG TERM CARE; LOW BACK PAIN; NAUSEA; NEPHROTOXICITY; NEUROTRANSMISSION; NOCICEPTION; PAIN; PATHOPHYSIOLOGY; PERIPHERAL EDEMA; PRACTICE GUIDELINE; REVIEW; RISK BENEFIT ANALYSIS; SOMNOLENCE; VOMITING; WORLD HEALTH ORGANIZATION; DRUG COMBINATION;

ANALGESICS; DRUG THERAPY, COMBINATION; HUMANS; PAIN;

EID: 77955710170     PISSN: 15265900     EISSN: 15288447     Source Type: Journal    
DOI: 10.1016/j.jpain.2009.12.010     Document Type: Review

References (66)

1. American Geriatrics Society http://www.americangeriatrics.org/education/ pharm-management.shtml (last accessed September 24, 2009)
2. L.M. Arnold Duloxetine and other antidepressants in the treatment of patients with fibromyalgia Pain Med 2 8(Suppl 2 2007 S63 S74
3. M. Backonja, and R.L. Glanzman Gabapentin dosing for neuropathic pain: Evidence from randomized, placebo-controlled clinical trials Clin Ther 25 2003 81 104
4. A. Berger, E. Dukes, B. McCarberg, M. Liss, and G. Oster Change in opioid use after the initiation of gabapentin therapy in patients with postherpetic neuralgia Clin Ther 25 2003 2809 2821
5. R. Bennett (for the CAPSS-112 Study Group), Kamin M, Rosenthal N, Karim R: Efficacy and safety of a tramadol/acetaminophen combination (ULTRACET™) in the management of fibromyalgia related pain: A multicenter, outpatient, randomized, double-blind, placebo-controlled study Arthritis Rheum 44 suppl 9 2001 S67
6. D. Bian, M.H. Ossipov, M. Ibrahim, R.B. Raffa, R.J. Tallarida, T.P. Malan, J. Lai, and F. Porreca Loss of antiallodynic and antinociceptive spinal-supraspinal morphine synergy in nerve-injured rats: Restoration by MK-801 or dynorphin antiserum Brain Res 831 1999 55 63
7. E.A. Bolan, R.J. Tallarida, and G. Pasternak Synergy between mu receptor subtypes: Evidence for functional interaction among mu receptor subtypes J Pharmacol Exp Ther 303 2002 557 562
8. D.G. Borenstein (for the CAPSS-112 Study Group), Kamin M, Rosenthal N, Karim R: Combination tramadol and acetaminophen (ULTRACET™) for the treatment of chronic lower back pain: A multicenter, outpatient, randomized, double-blind, placebo-controlled study Arthritis Rheum 44 suppl 9 2001 S67
9. M. Briley, and C. Moret Treatment of comorbid pain with serotonin norepinephrine reuptake inhibitors CNS Spectrums 13 2008 22 26
10. G. Casella, and R.L. Berger Statistical Inference 2002 Duxbury Press Grove, CA pp 243
11. E.E. Codd, R.P. Martinez, L. Molino, K.E. Rogers, D.J. Stone, and R.J. Tallarida Tramadol and several anticonvulsants synergize in attenuating nerve injury-induced allodynia Pain 134 2008 254 262
12. R.H. Dworkin, M. Backonja, M.C. Rowbotham, R.R. Allen, C.R. Argoff, G.J. Bennett, M.C. Bushnell, J.T. Farrar, B.S. Galer, J.A. Haythornthwaite, D.J. Hewitt, J.D. Loeser, M.B. Max, M. Saltarelli, K.E. Schmader, C. Stein, D. Thompson, D.C. Turk, M.S. Wallace, L.R. Watkins, and S.M. Weinstein Advances in neuropathic pain: Diagnosis, mechanisms, and treatment recommendations Arch Neurol 60 2003 1524 1534
13. 2C-adrenergic receptors mediate spinal analgesia and adrenergic-opioid synergy J Pharmacol Exp Ther 300 2002 282 290
14. FDA: Joint meeting of the Drug Safety and Risk Management Advisory Committee Nonprescription Drugs Advisory Committee and Anesthetic and Life Support Drugs Committee, Notice of Meeting Federal Register 74:28 April 24, 2009. Available at: http://www.fda.gov/OHRMS/DOCKETS/98fr/E9-9380.pdf (last accessed September 24, 2009)
15. M.K. Field, M.I. Gonzalez, R.J. Tallarida, and L. Singh Gabapentin and the NK1 antagonist CI-1021 act synergistically in two rat models of neuropathic pain J Pharmacol Exp Ther 303 2002 730 735
16. M.J. Field, P.J. Cox, E. Stott, H. Melrose, J. Offord, T.-Z. Su, S. Bramwell, L. Corradini, S. England, J. Winks, R.A. Kinloch, J. Hendrich, A.C. Dolphin, T. Webb, and D. Williams Identification of the α2-δ-1 subunit of voltage-dependent calcium channels as a molecular target for pain mediating the analgesic actions of pregabalin Proc Natl Acad Sci USA 103 2006 17537 17542
17. N.M. Gajraj Pregabalin for pain management Pain Practice 5 2005 95 102
18. B.S. Galer, R.H. Dworkin, A Clinical Guide to Neuropathic Pain 2000 McGraw-Hill Minneapolis, MN 22 32
19. B.S. Galer, M.P. Jensen, T. Ma, P.S. Davies, and M.C. Rowbotham The lidocaine patch 5% effectively treats all neuropathic pain qualities: Results of a randomized, double-blind, vehicle-controlled, 3-week efficacy study with use of the neuropathic pain scale Clin J Pain 18 2002 297 301
20. Y. Grabovsky, and R.J. Tallarida Isobolographic analysis for combinations of a full and partial agonist: Curved isoboles J Pharmacol Exp Ther 310 2004 981 986
21. M. Hanna, C. O'Brien, and M.C. Wilson Prolonged-release oxycodone enhances the effects of existing gabapentin therapy in painful diabetic neuropathy patients Eur J Pain 12 2008 804 813
22. C.T. Hartrick Multimodal postoperative pain management Am J Health Syst Pharm 61 Suppl 1 2004 S4 S10
23. P. Horan, R.J. Tallarida, R.C. Haaseth, T.O. Matsunaga, V.J. Hruby, and F. Porreca Antinociceptive interactions of opioid delta receptor agonists with morphine in mice: Supra- and sub-additivity Life Sci 50 1992 1535 1541
24. G.A. Irving, M.S. Wallace, Pain Management for the Practicing Physician 1997 Churchill Livingstone New York, NY 9 16
25. E. Kalso, J.E. Edwards, R.A. Moore, and H.J. McQuay Opioids in chronic non-cancer pain: Systematic review of efficacy and safety Pain 112 2004 372 380
26. E. Kalso, K.H. Simpson, R. Slappendel, J. Dejonckheere, and U. Richarz Predicting long-term response to strong opioids in patients with low back pain: Findings from a randomised controlled trial of transdermal fentanyl and morphine BMC Med 5 2007 39
27. H. Kehlet, and J.B. Dahl The value of "multimodal" or "balanced analgesia" in postoperative pain treatment Anesth Analg 77 1993 1048 1056
28. M. Komhoff, H.J. Grone, T. Klein, H.W. Seyberth, and R.M. Nusing Localization of cyclooxygenase-1 and -2 in adult and fetal human kidney: Implication for renal function Amer J Physiol 272 1997 F460 F468
29. A. Lanas, M.A. Perez-Asia, F. Feu, J. Ponce, E. Saperas, S. Santolaria, L. Rodrigo, J. Balanzo, E. Bajador, P. Almela, J.M. Navarro, F. Carballo, M. Castro, E. Quintero and investigators of the Asociación Española de Gastroenterología (AEG) A nationwide study of mortality associated with hospital admission due to severe gastrointestinal events and those associated with nonsteroidal antiinflammatory use Amer J Gastroenterol 100 2005 1685 1693
30. J. Lashbrook, M.H. Ossipov, J.C. Hunter, R.B. Raffa, R.J. Tallarida, and F. Porreca Synergistic antiallodynic effects of spinal morphine with ketorolac and selective COX1 and COX2-inhibitors in nerve-injured rats Pain 82 1999 65 72
31. S. Loewe Die Mischiarnei Klin Wochenschr 6 1927 1077 1085
32. S. Loewe Die quantitativen Probleme der Pharmakologie Ergebn Physiol 27 1928 47 187
33. S. Loewe The problem of synergism and antagonism of combined drugs Arzneimittelforschung 3 1953 285 290
34. T. Meier, G. Wasner, M. Faust, T. Kuntzer, F. Ochsner, M. Hueppe, J. Bogousslavsky, and R. Baron Efficacy of lidocaine patch 5% in the treatment of focal peripheral neuropathic pain syndromes: A randomized, double-blind, placebo-controlled study Pain 106 2003 151 158
35. H.F. Miranda, F. Sierraita, and G. Pinardi Neostigmine interactions with nonsteroidal anti-inflammatory drugs Brit J Pharmacol 135 2002 1591 1597 (Pubitemid 36132692)
36. D. Mukherjee, S.E. Nissen, and E.J. Topol Risk of cardiovascular events associated with selective COX-2 inhibitors JAMA 286 2001 954 959 (Pubitemid 33010342)
37. ®) in treatment of chronic low back pain: A multicenter, outpatient, randomized, double-blind, placebo controlled trial J Rheumatol 31 2004 2454 2463
38. J. Pergolizzi, and L.M. Wills Multimodal analgesic therapy G. Shorten, D.B. Carr, D. Harmon, M.M. Puig, J. Browne, Postoperative Pain, an Evidence-based Guide to Practitioners, 1st ed 2006 Saunders Elsevier Philadelphia, PA 182 196
39. C.B. Pert, and S.H. Snyder Opiate receptor: Demonstration in nervous system Science 179 1973 1011 1014
40. R.B. Raffa Pharmacology of oral combination analgesics: Rational therapy for pain J Clin Pharm Ther 26 2001 257 264
41. R.B. Raffa Mechanism of action of analgesics used to treat osteoarthritis pain Rheum Dis Clin N Amer 29 2003 733 745
42. R.B. Raffa Pharmacological aspects of successful long-term analgesia Clin Rheumatol 25 Suppl 1 2006 S9 S15
43. R.B. Raffa, E. Friderichs, W. Reimann, R.P. Shank, E.E. Codd, J.L. Vaught, H.I. Jacoby, and N. Selve Complementary and synergistic antinociceptive interaction between the enantiomers of tramadol J Pharmacol Exp Ther 267 1993 331 340
44. R.B. Raffa, D.J. Stone Jr., and R.J. Tallarida Discovery of "self-synergistic" spinal/supraspinal antinociception produced by acetaminophen (paracetamol) J Pharmacol Exp Ther 295 2000 291 294
45. R.B. Raffa, D.J. Stone Jr., and R.J. Tallarida Unexpected and pronounced antinociceptive synergy between spinal acetaminophen (paracetamol) and phentolamine Eur J Pharmacol 412 2001 R1 R2
46. R.B. Raffa, R. Clark-Vetri, R.J. Tallarida, and A.I. Wertheimer Combination strategies for pain management Expert Opin Pharmacother 4 2003 1697 1708
47. M.C. Rowbotham, P.S. Davies, C. Verkempinck, and B.S. Galer Lidocaine patch: Double-blind controlled study of a new treatment method for post-herpetic neuralgia Pain 65 1996 39 44
48. M.A. Schumacher, A.I. Basbaum, and W.L. Way Opioid analgesics & antagonists B.G. Katzung, Basic and Clinical Pharmacology 2007 McGraw Hill New York, NY 489 510
49. 3H-etorphine to rat brain homogenate Proc Natl Acad Sci USA 70 1973 1947 1949
50. W.E. Smalley, W.A. Ray, J.R. Daugherty, and M.R. Griffin Nonsteroidal anti-inflammatory drugs and the incidence of hospitalizations for peptic ulcer disease in elderly persons Amer J Epidemiol 141 1995 539 545
51. H.S. Smith Combination opioid analgesics Pain Physician 11 2008 201 214
52. H.S. Smith Potential analgesic mechanisms of acetaminophen Pain Physician 12 2009 269 280
53. J.B. Smith, and A.L. Willis Aspirin selectively inhibits prostaglandin production in human platelets Nature 231 1971 235 237
54. D.H. Solomon, S. Schneeweiss, R. Levin, and J. Avorn Relationship between COX-2 specific inhibitors and hypertension Hypertension 44 2004 140 145
55. R.J. Tallarida The Interaction Index: A measure of drug synergism Pain 98 2002 163 168
56. R.J. Tallarida Perspectives in Pharmacology: An overview of drug combination analysis with isobolograms J Pharmacol Exp Ther 319 2006 1 7
57. R.J. Tallarida Interactions between drugs and occupied receptors Pharmacol Ther 113 2007 197 209
58. R.J. Tallarida, and R.B. Raffa Testing for synergism over a range of fixed ratio drug combinations: Replacing the isobologram Life Sci 58 1996 PL23 PL28
59. R.J. Tallarida, D.J. Stone, J.D. McCary, and R.B. Raffa A response surface analysis of synergism between morphine and clonidine J Pharmacol Exp Ther 289 1999 8 13
60. R.J. Tallarida, A. Cowan, and R.B. Raffa Antinociceptive synergy additivity and subadditivity with combinations of oral glucosamine plus nonopioid analgesics in mice J Pharmacol Exp Ther 307 2003 699 704
61. L. Terenius Stereospecific interaction between narcotic analgesics and a synaptic plasma membrane Acta Pharmacol Toxicol 32 1973 317 320
62. J.E. Tetzlaff The pharmacology of local anesthetics Anesthesiol Clin N Amer 18 2000 217 233
63. T.M. Tzschentke, T. Christoph, B. Kögel, K. Schiene, H.H. Hennies, W. Englberger, M. Haurand, U. Jahnel, T.I. Cremers, E. Friderichs, and J. De Vry (-)-(1R2R)-3-(3-dimethylamino-1-ethyl-2-methyl-propyl)-phenol hydrochloride (tapentadol HCl): A novel mu-opioid receptor agonist/norepinephrine reuptake inhibitor with broad-spectrum analgesic properties J Pharmacol Exp Ther 323 2007 265 276
64. J.R. Vane Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs Nature 231 1971 232 235
65. C.J. Woolf Pain: Moving from symptom control toward mechanism-specific pharmacologic management Ann Intern Med 140 2004 441 451
66. World Health Organization http://www.who.int/cancer/palliative/ painladder/en (last accessed September 24, 2009)