Recent progress in sodium channel modulators for pain

Bioorganic and Medicinal Chemistry Letters

Volumn 24, Issue 16, 2014, Pages 3690-3699

  Bagal, Sharan K ^a   Chapman, Mark L ^b   Marron, Brian E ^b   Prime, Rebecca ^a   Storer, R Ian ^a   Swain, Nigel A ^a  

^a PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United Kingdom)

^b PFIZER INC   (United States)

Author keywords

Electrophysiology screening; Sodium channel drugs; Sodium channel structure; Sodium channel toxins; Voltage gated sodium channels

Indexed keywords

AZD 3161; CNV 1014802; DSP 2230; NKTR 171; PF 04531083; PF 05089771; SODIUM CHANNEL; SODIUM CHANNEL AFFECTING AGENT; UNCLASSIFIED DRUG; VOLTAGE GATED SODIUM CHANNEL; XEN 402; XEN 403; SODIUM CHANNEL BLOCKING AGENT;

ARTICLE; CRYSTAL STRUCTURE; DRUG SCREENING; ERYTHROMELALGIA; GENE MUTATION; HUMAN; INFLAMMATORY PAIN; NEUROPATHIC PAIN; PAIN; PROTEIN FAMILY; TRIGEMINUS NEURALGIA; ANIMAL; CHEMISTRY; DRUG DEVELOPMENT; METABOLISM;

ANIMALS; DRUG DISCOVERY; HUMANS; PAIN; SODIUM CHANNEL BLOCKERS; VOLTAGE-GATED SODIUM CHANNELS;

EID: 84905916440     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2014.06.038     Document Type: Review

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