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Di Marzo V, Petrocellis LD. Plant, synthetic, and endogenous cannabinoids in medicine. Annu Rev Med 2006; 57:553-574. This is a review of recent clinical trials looking at the role of the cannabinoid (and endocannabinoid) system in medicine including pain management.
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Hohmann AG, Suplita RL 2nd. Endocannabinoid mechanisms of pain modulation. AAPS J 2006; 8:E693-E708. This is an excellent review on how the endocannabinoid system, mainly anandamide and 2-arachidonoylglycerol, mediates stress-induced analgesia and nociceptive processing at supraspinal level.
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Preliminary assessment of the efficacy, tolerability and safety of a cannabis-based medicine (Sativex) in the treatment of pain caused by rheumatoid arthritis
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The authors present further evidence of the efficacy of an oromucosal cannabis extract for pain, this time in rheumatoid arthritis
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Blake DR, Robson P, Ho M, et al. Preliminary assessment of the efficacy, tolerability and safety of a cannabis-based medicine (Sativex) in the treatment of pain caused by rheumatoid arthritis. Rheumatology 2006; 45:50-52. The authors present further evidence of the efficacy of an oromucosal cannabis extract for pain, this time in rheumatoid arthritis.
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Abrams DI, Jay CA, Shade SB, et al. Cannabis in painful HIV-associated sensory neuropathy: a randomized placebo-controlled trial. Neurology 2007; 68:515-521. This was the first trial to report the analgesic efficacy of smoked cannabis for neuropathic pain associated with HIV/AIDS.
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