Cloxyquin (5-chloroquinolin-8-ol) is an activator of the two-pore domain potassium channel TRESK

Biochemical and Biophysical Research Communications

Volumn 441, Issue 2, 2013, Pages 463-468

  Wright, Paul D ^a   Weir, Gregory ^b   Cartland, Jamie ^a   Tickle, David ^a   Kettleborough, Catherine ^a   Cader, M Zameel ^b   Jerman, Jeff ^a  

^a Centre for Therapeutics Discovery   (United Kingdom)

^b UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

Assay; Cloxyquin; Ion channel; Migraine; Screening; TRESK

Indexed keywords

CLOXIQUINE; ION CHANNEL; PHORBOL 13 ACETATE 12 MYRISTATE; POTASSIUM CHANNEL; POTASSIUM CHANNEL STIMULATING AGENT; POTASSIUM CHANNEL TRESK; PROTEIN KINASE C; THALLIUM; UNCLASSIFIED DRUG;

ARTICLE; BACULOVIRUS; CELL CULTURE; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENZYME ACTIVATION; HUMAN; HUMAN CELL; MEMBRANE ELECTROPHYSIOLOGY; MIGRAINE; MIGRAINE WITH AURA; PRIORITY JOURNAL;

ANIMALS; CELL LINE; CHLOROQUINOLINOLS; HUMANS; PATCH-CLAMP TECHNIQUES; POTASSIUM CHANNELS; SMALL MOLECULE LIBRARIES;

EID: 84888010191     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2013.10.090     Document Type: Article

References (16)

1. R.B. Lipton, W.F. Stewart, S. Diamond, M.L. Diamond, and M. Reed Prevalence and burden of migraine in the United States: data from the American Migraine Study II Headache 41 2001 646 657
2. X. Zhang, D. Levy, R. Noseda, V. Kainz, M. Jakubowski, and R. Burstein Activation of meningeal nociceptors by cortical spreading depression: implications for migraine with aura The Journal of Neuroscience 30 2010 8807 8814
3. X. Zhang, D. Levy, V. Kainz, R. Noseda, M. Jakubowski, and R. Burstein Activation of central trigeminovascular neurons by cortical spreading depression Annals of Neurology 69 2011 855 865
4. B. de Vries, R.R. Frants, M.D. Ferrari, and A.M.J.M. van den Maagdenberg Molecular genetics of migraine Human Genetics 126 2009 115 132
5. R.G. Lafrenière, M.Z. Cader, J.-F. Poulin, I. Andres-Enguix, M. Simoneau, and N. Gupta A dominant-negative mutation in the TRESK potassium channel is linked to familial migraine with aura Nature Medicine 16 2010 1157 1160
6. + currents: two-pore domain potassium channels Physiological Reviews 90 2010 559 605
7. R.G. Lafrenière, and G.A. Rouleau Migraine: role of the TRESK two-pore potassium channel The International Journal of Biochemistry & Cell Biology 43 2011 1533 1536
8. + channels constitute a significant component of background potassium currents in murine dorsal root ganglion neurones The Journal of Physiology 585 2007 867 879
9. A. Tulleuda, B. Cokic, G. Callejo, B. Saiani, J. Serra, and X. Gasull TRESK channel contribution to nociceptive sensory neurons excitability: modulation by nerve injury Molecular Pain 7 2011 30
10. M.J. Steiger, T. Farrah, K. Rolles, P. Harvey, and A.K. Burroughs Cyclosporin associated headache Journal of Neurology, Neurosurgery, and Psychiatry 57 1994 1258 1259
11. C. Liu, J.D. Au, H.L. Zou, J.F. Cotten, and C.S. Yost Potent activation of the human tandem pore domain K channel TRESK with clinical concentrations of volatile anesthetics Anesthesia and Analgesia 99 2004 1715 1722
12. A.-K. Rahm, J. Gierten, J. Kisselbach, I. Staudacher, K. Staudacher, and P.A. Schweizer PKC-dependent activation of human K(2P) 18.1 K(+) channels British Journal of Pharmacology 166 2012 764 773
13. J. Zhang, T. Chung, and K. Oldenburg A simple statistical parameter for use in evaluation and validation of high throughput screening assays Journal of Biomolecular Screening 4 1999 67 73
14. + channel, TRESK, is activated by the cytoplasmic calcium signal through calcineurin The Journal of Biological Chemistry 279 2004 18550 18558
15. + channel by membrane stretch PLoS One 8 2013 e64471
16. W. Rohde, B. Cordell, R. Webster, and W. Levinson Inhibition of amino acyl tRNA synthetase activity by copper complexes of two metal binding ligands. N-Methyl isatin beta-thiosemicarbazone and 8-hydroxyquinoline Biochimica Et Biophysica Acta 477 1977 102 111