메뉴 건너뛰기




Volumn 37, Issue 2, 2012, Pages 210-214

Modulating pain in the periphery: Gene-based therapies to enhance peripheral opioid analgesia: Bonica lecture, ASRA 2010

Author keywords

[No Author keywords available]

Indexed keywords

OPIATE;

EID: 84859774496     PISSN: 10987339     EISSN: 15328651     Source Type: Journal    
DOI: 10.1097/AAP.0b013e31823b145f     Document Type: Article
Times cited : (9)

References (56)
  • 1
    • 37049180561 scopus 로고
    • Myelinated nociceptive afferents account for the hyperalgesia that follows a burn to the hand
    • Meyer RA, Campbell JN. Myelinated nociceptive afferents account for the hyperalgesia that follows a burn to the hand. Science. 1981;4515:1527Y1529. (Pubitemid 11031242)
    • (1981) Science , vol.213 , Issue.4515 , pp. 1527-1529
    • Meyer, R.A.1    Campbell, J.N.2
  • 3
    • 0023924048 scopus 로고
    • Myelinated afferents signal the hyperalgesia associated with nerve injury
    • Campbell JN, Raja SN, Meyer RA, Mackinnon SE. Myelinated afferents signal the hyperalgesia associated with nerve injury. Pain. 1988;1:89Y94.
    • (1988) Pain , vol.1 , pp. 89-94
    • Campbell, J.N.1    Raja, S.N.2    Meyer, R.A.3    MacKinnon, S.E.4
  • 4
    • 0025787684 scopus 로고
    • Topical application of clonidine relieves hyperalgesia in patients with sympathetically maintained pain
    • Davis KD, Treede RD, Raja SN, Meyer RA, Campbell JN. Topical application of clonidine relieves hyperalgesia in patients with sympathetically maintained pain. Pain. 1991;3:309Y317.
    • (1991) Pain , vol.3 , pp. 309-317
    • Davis, K.D.1    Treede, R.D.2    Raja, S.N.3    Meyer, R.A.4    Campbell, J.N.5
  • 5
    • 0021740987 scopus 로고
    • Evidence for different mechanisms of primary and secondary hyperalgesia following heat injury to the glabrous skin
    • Raja SN, Campbell JN, Meyer RA. Evidence for different mechanisms of primary and secondary hyperalgesia following heat injury to the glabrous skin. Brain. 1984;107:1179Y1188. (Pubitemid 15182103)
    • (1984) Brain , vol.107 , Issue.4 , pp. 1179-1188
    • Raja, S.N.1    Campbell, J.N.2    Meyer, R.A.3
  • 6
    • 0026323110 scopus 로고
    • Pain and hyperalgesia after intradermal injection of bradykinin in humans
    • Manning DC, Raja SN, Meyer RA, Campbell JN. Pain and hyperalgesia after intradermal injection of bradykinin in humans. Clin Pharmacol Ther. 1991;6:721Y729.
    • (1991) Clin Pharmacol Ther , vol.6 , pp. 721-729
    • Manning, D.C.1    Raja, S.N.2    Meyer, R.A.3    Campbell, J.N.4
  • 7
    • 0026693848 scopus 로고
    • Role of kinins in pain and hyperalgesia: Psychophysical studies in a patient with kininogen deficiency
    • Raja SN, Campbell JN, Meyer RA, Colman RW. Role of kinins in pain and hyperalgesia: psychophysical studies in a patient with kininogen deficiency. Clin Sci (Lond). 1992;3:337Y341.
    • (1992) Clin Sci (Lond) , vol.3 , pp. 337-341
    • Raja, S.N.1    Campbell, J.N.2    Meyer, R.A.3    Colman, R.W.4
  • 9
    • 0030247053 scopus 로고    scopus 로고
    • Progressive tactile hypersensitivity: An inflammation-induced incremental increase in the excitability of the spinal cord
    • DOI 10.1016/0304-3959(96)03105-3
    • Ma QP, Woolf CJ. Progressive tactile hypersensitivity: an inflammation-induced incremental increase in the excitability of the spinal cord. Pain. 1996;1:97Y106. (Pubitemid 26319641)
    • (1996) Pain , vol.67 , Issue.1 , pp. 97-106
    • Ma, Q.-P.1    Woolf, C.J.2
  • 10
    • 0021014399 scopus 로고
    • Evidence for a central component of post-injury pain hypersensitivity
    • Woolf CJ. Evidence for a central component of post-injury pain hypersensitivity. Nature. 1983;5944:686Y688. (Pubitemid 14201852)
    • (1983) Nature , vol.306 , Issue.5944 , pp. 686-688
    • Woolf, C.J.1
  • 11
    • 79951579664 scopus 로고    scopus 로고
    • Central sensitization: Implications for the diagnosis and treatment of pain
    • Woolf CJ. Central sensitization: implications for the diagnosis and treatment of pain. Pain. 2011;3(suppl):S2YS15.
    • (2011) Pain , vol.3 , Issue.SUPPL.
    • Woolf, C.J.1
  • 12
    • 0034333009 scopus 로고    scopus 로고
    • Intradermal injection of norepinephrine evokes pain in patients with sympathetically maintained pain
    • Ali Z, Raja SN, Wesselmann U, Fuchs PN, Meyer RA, Campbell JN. Intradermal injection of norepinephrine evokes pain in patients with sympathetically maintained pain. Pain. 2000;2:161Y168.
    • (2000) Pain , vol.2 , pp. 161-168
    • Ali, Z.1    Raja, S.N.2    Wesselmann, U.3    Fuchs, P.N.4    Meyer, R.A.5    Campbell, J.N.6
  • 13
    • 33748461625 scopus 로고    scopus 로고
    • Local administration of norepinephrine in the stump evokes dose-dependent pain in amputees
    • DOI 10.1097/01.ajp.0000202980.51786.ae, PII 0000250820060600000011
    • Lin EE, Horasek S, Agarwal S, Wu CL, Raja SN. Local administration of norepinephrine in the stump evokes dose-dependent pain in amputees. Clin J Pain. 2006;5:482Y486. (Pubitemid 44350458)
    • (2006) Clinical Journal of Pain , vol.22 , Issue.5 , pp. 482-486
    • Lin, E.E.1    Horasek, S.2    Agarwal, S.3    Wu, C.L.4    Raja, S.N.5
  • 14
    • 0037044286 scopus 로고    scopus 로고
    • Opioids versus antidepressants in postherpetic neuralgia: A randomized, placebo-controlled trial
    • Raja SN, Haythornthwaite JA, Pappagallo M, et al. Opioids versus antidepressants in postherpetic neuralgia: a randomized, placebo-controlled trial. Neurology. 2002;7:1015Y1021.
    • (2002) Neurology , vol.7 , pp. 1015-1021
    • Raja, S.N.1    Haythornthwaite, J.A.2    Pappagallo, M.3
  • 15
    • 48849102067 scopus 로고    scopus 로고
    • Morphine versus mexiletine for treatment of postamputation pain: A randomized, placebo-controlled, crossover trial
    • Wu CL, Agarwal S, Tella PK, et al. Morphine versus mexiletine for treatment of postamputation pain: a randomized, placebo-controlled, crossover trial. Anesthesiology. 2008;2:289Y296.
    • (2008) Anesthesiology , vol.2 , pp. 289-296
    • Wu, C.L.1    Agarwal, S.2    Tella, P.K.3
  • 17
    • 0031780851 scopus 로고    scopus 로고
    • Efficacy of oxycodone in neuropathic pain: A randomized trial in postherpetic neuralgia
    • Watson CP, Babul N. Efficacy of oxycodone in neuropathic pain: a randomized trial in postherpetic neuralgia. Neurology. 1998;6:1837Y1841. (Pubitemid 28283261)
    • (1998) Neurology , vol.50 , Issue.6 , pp. 1837-1841
    • Watson, C.P.N.1    Babul, N.2
  • 18
    • 34848895455 scopus 로고    scopus 로고
    • Transdermal fentanyl reduces pain and improves functional activity in neuropathic pain states
    • DOI 10.1111/j.1526-4637.2006.00246.x
    • Agarwal S, Polydefkis M, Block B, Haythornthwaite J, Raja SN. Transdermal fentanyl reduces pain and improves functional activity in neuropathic pain states. Pain Med. 2007;7:554Y562. (Pubitemid 47490211)
    • (2007) Pain Medicine , vol.8 , Issue.7 , pp. 554-562
    • Agarwal, S.1    Polydefkis, M.2    Block, B.3    Haythornthwaite, J.4    Raja, S.N.5
  • 19
    • 77955932803 scopus 로고    scopus 로고
    • Prescription drug abuse: An epidemic dilemma
    • DuPont RL. Prescription drug abuse: an epidemic dilemma. J Psychoactive Drugs. 2010;2:127Y132.
    • (2010) J Psychoactive Drugs , vol.2 , pp. 127-132
    • Dupont, R.L.1
  • 20
    • 41149091705 scopus 로고    scopus 로고
    • Non-medical use and abuse of commonly prescribed medications
    • DOI 10.1185/030079908X273435
    • Riggs P. Non-medical use and abuse of commonly prescribed medications. Curr Med Res Opin. 2008;3:869Y877. (Pubitemid 351428998)
    • (2008) Current Medical Research and Opinion , vol.24 , Issue.3 , pp. 869-877
    • Riggs, P.1
  • 21
    • 29244437860 scopus 로고    scopus 로고
    • Reversal of morphine, methadone and heroin induced effects in mice by naloxone methiodide
    • DOI 10.1016/j.lfs.2005.05.062, PII S0024320505007095
    • Lewanowitsch T, Miller JH, Irvine RJ. Reversal of morphine, methadone and heroin induced effects in mice by naloxone methiodide. Life Sci. 2006;7:682Y688. (Pubitemid 41821124)
    • (2006) Life Sciences , vol.78 , Issue.7 , pp. 682-688
    • Lewanowitsch, T.1    Miller, J.H.2    Irvine, R.J.3
  • 22
    • 1842663254 scopus 로고    scopus 로고
    • Local peripheral effects of μ-opioid receptor agonists in neuropathic pain in rats
    • DOI 10.1016/j.neulet.2004.01.056, PII S0304394004001338
    • Obara I, Przewlocki R, Przewlocka B. Local peripheral effects of mu-opioid receptor agonists in neuropathic pain in rats. Neurosci Lett. 2004;1-2:85Y89. (Pubitemid 38471994)
    • (2004) Neuroscience Letters , vol.360 , Issue.1-2 , pp. 85-89
    • Obara, I.1    Przewlocki, R.2    Przewlocka, B.3
  • 23
    • 0041965945 scopus 로고    scopus 로고
    • Attacking pain at its source: New perspectives on opioids
    • DOI 10.1038/nm908
    • Stein C, Schafer M, Machelska H. Attacking pain at its source: new perspectives on opioids. Nat Med. 2003;8:1003Y1008. (Pubitemid 37021779)
    • (2003) Nature Medicine , vol.9 , Issue.8 , pp. 1003-1008
    • Stein, C.1    Schafer, M.2    Machelska, H.3
  • 24
    • 0030821574 scopus 로고    scopus 로고
    • Opioid receptors on peripheral sensory axons
    • DOI 10.1016/S0006-8993(97)00446-0, PII S0006899397004460
    • Coggeshall RE, Zhou S, Carlton SM. Opioid receptors on peripheral sensory axons. Brain Res. 1997;1-2:126Y132. (Pubitemid 27380647)
    • (1997) Brain Research , vol.764 , Issue.1-2 , pp. 126-132
    • Coggeshall, R.E.1    Zhou, S.2    Carlton, S.M.3
  • 25
    • 0037371427 scopus 로고    scopus 로고
    • μ Opioid receptors and analgesia at the site of a peripheral nerve injury
    • DOI 10.1002/ana.10465
    • Truong W, Cheng C, Xu QG, Li XQ, Zochodne DW. mu opioid receptors and analgesia at the site of a peripheral nerve injury. Ann Neurol. 2003;3:366Y375. (Pubitemid 36258640)
    • (2003) Annals of Neurology , vol.53 , Issue.3 , pp. 366-375
    • Truong, W.1    Cheng, C.2    Xu, Q.-G.3    Li, X.-Q.4    Zochodne, D.W.5
  • 26
    • 77957875318 scopus 로고    scopus 로고
    • Mu and delta opioid receptors on nociceptors attenuate mechanical hyperalgesia in rat
    • Joseph EK, Levine JD. mu and delta opioid receptors on nociceptors attenuate mechanical hyperalgesia in rat. Neuroscience. 2010;1:344Y350.
    • (2010) Neuroscience , vol.1 , pp. 344-350
    • Joseph, E.K.1    Levine, J.D.2
  • 27
    • 58149200910 scopus 로고    scopus 로고
    • Transient receptor potential channels: Targeting pain at the source
    • Patapoutian A, Tate S, Woolf CJ. Transient receptor potential channels: targeting pain at the source. Nat Rev Drug Discov. 2009;1:55Y68.
    • (2009) Nat Rev Drug Discov , vol.1 , pp. 55-68
    • Patapoutian, A.1    Tate, S.2    Woolf, C.J.3
  • 28
    • 33645067653 scopus 로고    scopus 로고
    • Topical agents for the treatment of chronic pain
    • Argoff CE. Topical agents for the treatment of chronic pain. Curr Pain Headache Rep. 2006;1:11Y19.
    • (2006) Curr Pain Headache Rep , vol.1 , pp. 11-19
    • Argoff, C.E.1
  • 29
    • 43649101960 scopus 로고    scopus 로고
    • Peripherally-acting opioids
    • Opioids
    • Smith HS. Peripherally-acting opioids. Pain Physician. 2008;2(suppl):S121YS132. (Pubitemid 351682082)
    • (2008) Pain Physician , vol.11 , Issue.SPEC. ISS. 2
    • Smith, H.S.1
  • 31
    • 33749061243 scopus 로고    scopus 로고
    • Mechanisms of neuropathic pain
    • DOI 10.1016/j.neuron.2006.09.021, PII S0896627306007288
    • Campbell JN, Meyer RA. Mechanisms of neuropathic pain. Neuron. 2006;1:77Y92. (Pubitemid 44466361)
    • (2006) Neuron , vol.52 , Issue.1 , pp. 77-92
    • Campbell, J.N.1    Meyer, R.A.2
  • 32
    • 67650569183 scopus 로고    scopus 로고
    • Neuropathic pain: Models and mechanisms
    • Jarvis MF, Boyce-Rustay JM. Neuropathic pain: models and mechanisms. Curr Pharm Des. 2009;15:1711Y1716.
    • (2009) Curr Pharm des , vol.15 , pp. 1711-1716
    • Jarvis, M.F.1    Boyce-Rustay, J.M.2
  • 33
    • 49049121242 scopus 로고    scopus 로고
    • Peripherally acting mu-opioid receptor agonist attenuates neuropathic pain in rats after L5 spinal nerve injury
    • Guan Y, Johanek LM, Hartke TV, et al. Peripherally acting mu-opioid receptor agonist attenuates neuropathic pain in rats after L5 spinal nerve injury. Pain. 2008;2:318Y329.
    • (2008) Pain , vol.2 , pp. 318-329
    • Guan, Y.1    Johanek, L.M.2    Hartke, T.V.3
  • 34
    • 79960912227 scopus 로고    scopus 로고
    • Dynamic temporal and spatial regulation of mu opioid receptor expression in primary afferent neurons following spinal nerve injury
    • Lee CY, Perez FM, Wang W, et al. Dynamic temporal and spatial regulation of mu opioid receptor expression in primary afferent neurons following spinal nerve injury. Eur J Pain. 2011;7:669Y675.
    • (2011) Eur J Pain , vol.7 , pp. 669-675
    • Lee, C.Y.1    Perez, F.M.2    Wang, W.3
  • 35
    • 0037868094 scopus 로고    scopus 로고
    • Viral vectors for gene delivery to the nervous system
    • DOI 10.1038/nrn1104
    • Davidson BL, Breakefield XO. Viral vectors for gene delivery to the nervous system. Nat Rev Neurosci. 2003;5:353Y364. (Pubitemid 37280174)
    • (2003) Nature Reviews Neuroscience , vol.4 , Issue.5 , pp. 353-364
    • Davidson, B.L.1    Breakefield, X.O.2
  • 36
    • 80051551575 scopus 로고    scopus 로고
    • Gene therapy for pain: Results of a phase i clinical trial
    • Fink DJ, Wechuck J, Mata M, et al. Gene therapy for pain: results of a phase I clinical trial. Ann Neurol. 2011;2:207Y212.
    • (2011) Ann Neurol , vol.2 , pp. 207-212
    • Fink, D.J.1    Wechuck, J.2    Mata, M.3
  • 37
    • 34248363245 scopus 로고    scopus 로고
    • Gene therapy applications for the treatment of neuropathic pain
    • DOI 10.1586/14737175.7.5.487
    • Goss JR, Goins WF, Glorioso JC. Gene therapy applications for the treatment of neuropathic pain. Expert Rev Neurother. 2007;5:487Y506. (Pubitemid 46743442)
    • (2007) Expert Review of Neurotherapeutics , vol.7 , Issue.5 , pp. 487-506
    • Goss, J.R.1    Goins, W.F.2    Glorioso, J.C.3
  • 38
    • 0033647681 scopus 로고    scopus 로고
    • Genetic therapy for pain management
    • Wilson SP, Yeomans DC. Genetic therapy for pain management. Curr Rev Pain. 2000;6:445Y450.
    • (2000) Curr Rev Pain , vol.6 , pp. 445-450
    • Wilson, S.P.1    Yeomans, D.C.2
  • 40
    • 0037333714 scopus 로고    scopus 로고
    • Transgene-mediated enkephalin release enhances the effect of morphine and evades tolerance to produce a sustained antiallodynic effect in neuropathic pain
    • DOI 10.1016/s0304-3959(02)00346-9
    • Hao S, Mata M, Goins W, Glorioso JC, Fink DJ. Transgene-mediated enkephalin release enhances the effect of morphine and evades tolerance to produce a sustained antiallodynic effect in neuropathic pain. Pain. 2003;1-2:135Y142. (Pubitemid 36298869)
    • (2003) Pain , vol.102 , Issue.1-2 , pp. 135-142
    • Hao, S.1    Mata, M.2    Goins, W.3    Glorioso, J.C.4    Fink, D.J.5
  • 41
    • 57649203290 scopus 로고    scopus 로고
    • Transgene-mediated enkephalin expression attenuates signs of naloxone-precipitated morphine withdrawal in rats with neuropathic pain
    • Hao S, Hu J, Fink DJ. Transgene-mediated enkephalin expression attenuates signs of naloxone-precipitated morphine withdrawal in rats with neuropathic pain. Behav Brain Res. 2009;1:84Y89.
    • (2009) Behav Brain Res , vol.1 , pp. 84-89
    • Hao, S.1    Hu, J.2    Fink, D.J.3
  • 42
    • 14844339192 scopus 로고    scopus 로고
    • Attenuation of pain-related behavior in a rat model of trigeminal neuropathic pain by viral-driven enkephalin overproduction in trigeminal ganglion neurons
    • DOI 10.1016/j.ymthe.2004.12.011, PII S1525001604015886
    • Meunier A, Latremoliere A, Mauborgne A, et al. Attenuation of pain-related behavior in a rat model of trigeminal neuropathic pain by viral-driven enkephalin overproduction in trigeminal ganglion neurons. Mol Ther. 2005;4:608Y616. (Pubitemid 40353118)
    • (2005) Molecular Therapy , vol.11 , Issue.4 , pp. 608-616
    • Meunier, A.1    Latremoliere, A.2    Mauborgne, A.3    Bourgoin, S.4    Kayser, V.5    Cesselin, F.6    Hamon, M.7    Pohl, M.8
  • 44
    • 42249099473 scopus 로고    scopus 로고
    • Enkephalin-encoding herpes simplex virus-1 decreases inflammation and hotplate sensitivity in a chronic pancreatitis model
    • Yang H, McNearney TA, Chu R, et al. Enkephalin-encoding herpes simplex virus-1 decreases inflammation and hotplate sensitivity in a chronic pancreatitis model. Mol Pain. 2008;4:8.
    • (2008) Mol Pain , vol.4 , pp. 8
    • Yang, H.1    McNearney, T.A.2    Chu, R.3
  • 46
    • 58849087513 scopus 로고    scopus 로고
    • Gene therapy for bladder overactivity and nociception with herpes simplex virus vectors expressing preproenkephalin
    • Yokoyama H, Sasaki K, Franks ME, et al. Gene therapy for bladder overactivity and nociception with herpes simplex virus vectors expressing preproenkephalin. Hum Gene Ther. 2009;1:63Y71.
    • (2009) Hum Gene Ther , vol.1 , pp. 63-71
    • Yokoyama, H.1    Sasaki, K.2    Franks, M.E.3
  • 47
    • 0035382666 scopus 로고    scopus 로고
    • Gene therapy of bladder pain with herpes simplex virus (HSV) vectors expressing preproenkephalin (PPE)
    • Yoshimura N, Franks ME, Sasaki K, et al. Gene therapy of bladder pain with herpes simplex virus (HSV) vectors expressing preproenkephalin (PPE). Urology. 2001;6(suppl 1):116.
    • (2001) Urology , vol.6 , Issue.SUPPL. 1 , pp. 116
    • Yoshimura, N.1    Franks, M.E.2    Sasaki, K.3
  • 48
    • 9244259139 scopus 로고    scopus 로고
    • Herpes vector-mediated gene transfer in treatment of diseases of the nervous system
    • DOI 10.1146/annurev.micro.58.030603.123709
    • Glorioso JC, Fink DJ. Herpes vectorYmediated gene transfer in treatment of diseases of the nervous system. Annu Rev Microbiol. 2004;253Y271. (Pubitemid 39551987)
    • (2004) Annual Review of Microbiology , vol.58 , pp. 253-271
    • Glorioso, J.C.1    Fink, D.J.2
  • 50
    • 0037024624 scopus 로고    scopus 로고
    • Virally mediated delivery of enkephalin and other neuropeptide transgenes in experimental pain models
    • Wilson SP, Yeomans DC. Virally mediated delivery of enkephalin and other neuropeptide transgenes in experimental pain models. Ann N Y Acad Sci. 2002;971:515Y521. (Pubitemid 35305346)
    • (2002) Annals of the New York Academy of Sciences , vol.971 , pp. 515-521
    • Wilson, S.P.1    Yeomans, D.C.2
  • 52
    • 41149144815 scopus 로고    scopus 로고
    • Joint capsule treatment with enkephalin-encoding HSV-1 recombinant vector reduces inflammatory damage and behavioural sequelae in rat CFA monoarthritis
    • DOI 10.1111/j.1460-9568.2008.06076.x
    • Lu Y, McNearney TA, Wilson SP, Yeomans DC, Westlund KN. Joint capsule treatment with enkephalin-encoding HSV-1 recombinant vector reduces inflammatory damage and behavioural sequelae in rat CFA monoarthritis. Eur J Neurosci. 2008;5:1153Y1165. (Pubitemid 351432328)
    • (2008) European Journal of Neuroscience , vol.27 , Issue.5 , pp. 1153-1165
    • Lu, Y.1    McNearney, T.A.2    Wilson, S.P.3    Yeomans, D.C.4    Westlund, K.N.5
  • 53
    • 58149260263 scopus 로고    scopus 로고
    • The pro-nociceptive effects of remifentanil or surgical injury in mice are associated with a decrease in delta-opioid receptor mRNA levels: Prevention of the nociceptive response by on-site delivery of enkephalins
    • Cabanero D, Celerier E, Garcia-Nogales P, et al. The pro-nociceptive effects of remifentanil or surgical injury in mice are associated with a decrease in delta-opioid receptor mRNA levels: Prevention of the nociceptive response by on-site delivery of enkephalins. Pain. 2009;1-2:88Y96.
    • (2009) Pain , vol.1-2 , pp. 88-96
    • Cabanero, D.1    Celerier, E.2    Garcia-Nogales, P.3
  • 54
    • 34548791722 scopus 로고    scopus 로고
    • Treatment of inflamed pancreas with enkephalin encoding HSV-1 recombinant vector reduces inflammatory damage and behavioral sequelae
    • DOI 10.1038/sj.mt.6300228, PII 6300228
    • Lu Y, McNearney TA, Lin W, Wilson SP, Yeomans DC, Westlund KN. Treatment of inflamed pancreas with enkephalin encoding HSV-1 recombinant vector reduces inflammatory damage and behavioral sequelae. Mol Ther. 2007;10:1812Y1819. (Pubitemid 47434188)
    • (2007) Molecular Therapy , vol.15 , Issue.10 , pp. 1812-1819
    • Lu, Y.1    McNearney, T.A.2    Lin, W.3    Wilson, S.P.4    Yeomans, D.C.5    Westlund, K.N.6
  • 55
    • 38549133380 scopus 로고    scopus 로고
    • Enhanced peripheral analgesia using virally mediated gene transfer of the μ-opioid receptor in mice
    • DOI 10.1097/01.anes.0000299836.61785.79, PII 0000054220080200000019
    • Zhang G, Mohammad H, Peper BD, Raja S, Wilson SP, Sweitzer SM. Enhanced peripheral analgesia using virally mediated gene transfer of the mu-opioid receptor in mice. Anesthesiology. 2008;2:305Y313. (Pubitemid 351156741)
    • (2008) Anesthesiology , vol.108 , Issue.2 , pp. 305-313
    • Zhang, G.1    Mohammad, H.2    Peper, B.D.3    Raja, S.4    Wilson, S.P.5    Sweitzer, S.M.6
  • 56
    • 79952923984 scopus 로고    scopus 로고
    • Peripheral opioid receptor agonists for analgesia: A comprehensive review
    • Vadivelu N, Mitra S, Hines RL. Peripheral opioid receptor agonists for analgesia: a comprehensive review. J Opioid Manag. 2011;1:55Y68.
    • (2011) J Opioid Manag , vol.1 , pp. 55-68
    • Vadivelu, N.1    Mitra, S.2    Hines, R.L.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.