Biotechnological production of ethanol: Biochemistry, processes and technologies

Engineering in Life Sciences

Volumn 16, Issue 4, 2016, Pages 307-329

  Sarris, Dimitris ^a   Papanikolaou, Seraphim ^a  

^a AGRICULTURAL UNIVERSITY OF ATHENS   (Greece)

Author keywords

Biofuels; Renewable resources; Saccharomyces cerevisiae; Waste valorization; Zymomonas mobilis

Indexed keywords

ASEPTIC CONDITIONS; BIOCHEMISTRY; BIODIESEL; BIOFUELS; CARBON; ENERGY RESOURCES; ENZYME ACTIVITY; ETHANOL; FERMENTATION; GLYCEROL; RENEWABLE ENERGY RESOURCES; SACCHARIFICATION; YEAST;

CONSOLIDATED BIO-PROCESSING; CONVENTIONAL ENERGY SOURCES; RENEWABLE RESOURCE; SEPARATE HYDROLYSIS AND FERMENTATION; SIMULTANEOUS SACCHARIFICATION AND CO-FERMENTATION; SIMULTANEOUS SACCHARIFICATION AND FERMENTATION; WASTE VALORIZATIONS; ZYMOMONAS MOBILIS;

BIOETHANOL;

ALCOHOL; BIODIESEL; BIOETHANOL; BIOFUEL; GLYCEROL; HEXOSE; LIGNOCELLULOSE; PENTOSE; STARCH; XYLOSE;

BACTERIUM; BIOCHEMISTRY; BIOFUEL; BIOMASS; BIOTECHNOLOGY; CATABOLISM; CELLULOSE; ENERGY RESOURCE; ETHANOL; FERMENTATION; HYDROLYSIS; RENEWABLE RESOURCE; SUBSTRATE; SUGAR; TECHNOLOGICAL DEVELOPMENT; YEAST;

ALCOHOL PRODUCTION; BACTERIAL STRAIN; BIOCHEMISTRY; BIOENGINEERING; BIOMASS; BIOPROCESS; BIOTECHNOLOGICAL PRODUCTION; BIOTECHNOLOGY; BREATHING; CARBON SOURCE; CATABOLISM; ENERGY RESOURCE; FERMENTATION; HYDROLYSIS; LIQUID; NONHUMAN; REGULATORY MECHANISM; REVIEW; SACCHARIFICATION; SACCHAROMYCES CEREVISIAE; ZYMOMONAS MOBILIS;

SACCHAROMYCES CEREVISIAE; ZYMOMONAS MOBILIS;

EID: 84953268519     PISSN: 16180240     EISSN: 16182863     Source Type: Journal    
DOI: 10.1002/elsc.201400199     Document Type: Review

References (176)

1. Balat, M., Balat, H., Recent trends in global production and utilization of bio-ethanol fuel. Appl. Energy 2009, 86, 2273-2282.
2. Quéré, C. L., Andres, R. J., Boden, T., Conway, T. et al., The global carbon budget 1959-2011. Earth Sys. Sci. Data 2013, 5, 165-185.
3. Tyson, K. S., Bozell, J., Wallace, R., Petersen, E. et al., Biomass oil analysis: research needs and recommendations, Technical Report No. NREL/TP-510-34796, National Renewable Energy Laboratory, Golden, CO 2004.
4. Bozell, J. J., Petersen, G. R., Technology development for the production of biobased products from biorefinery carbohydrates-the US Department of Energy's "top 10" revisited. Green Chem. 2010, 12, 539-554.
5. Sarkar, N., Ghosh, S. K., Bannerjee, S., Aikat, K., Bioethanol production from agricultural wastes: An overview. Renew. Energy 2012, 37, 19-27.
6. Ginkel, S. V., Sung, S., Lay, J.-J., Biohydrogen production as a function of pH and substrate concentration. Env. Sci. Pollut. Res. 2001, 35, 4726-4730.
7. Kapdan, I. K., Kargi, F., Bio-hydrogen production from waste materials. Enzyme Microb. Technol. 2006, 38, 569-582.
8. Martins das Neves, L. C., Converti, A, Vessoni Penna, T. C., Biogas production: new trends for alternative energy sources in rural and urban zones. Chem. Eng. Technol. 2009, 32, 1147-1153.
9. Kotay, S. M., Das, D., Biohydrogen as a renewable energy resource-prospects and potentials. Int. J. Hydrogen Energ. 2008, 33, 258-263.
10. Reith, J., Wijffels, R. H., Barten, H., Bio-methane and bio-hydrogen: Status and perspectives of biological methane and hydrogen production, Dutch Biological Hydrogen Foundation, Petten, the Netherlands 2003.
11. Papanikolaou, S., Aggelis, G., Lipids of oleaginous yeasts. Part II: Technology and potential applications. Eur. J. Lipid Sci. Technol. 2011, 113, 1052-1073.
12. Lois, E., Definition of biodiesel. Fuel 2007, 7-8, 1212-1213.
13. Ratledge, C., Cohen, Z., Microbial and algal oils: do they have a future for biodiesel or as commodity oils? Lipid Technol. 2008, 20, 155-160.
14. Papanikolaou, S., Oleaginous yeasts: biochemical events related with lipid synthesis and potential biotechnological applications. Fermentat. Technol. 2012, 1, e103.
15. Chisti, Y., Biodiesel from microalgae. Biotechnol. Adv. 2007, 25, 294-306.
16. Koutinas, A. A., Chatzifragkou, A., Kopsahelis, N., Papanikolaou, S. et al., Design and techno-economic evaluation of microbial oil production as a renewable resource for biodiesel and oleochemical production. Fuel 2014, 116, 566-577.
17. Philippoussis, A. N., Production of mushrooms using agro-industrial residues as substrates, in: Nigam, P. S., Pandey, A. (Eds.), Biotechnology for Agro-Industrial Residues Utilisation, Springer, 2009, pp. 163-196.
18. Hervé, G., Forslund, A., Dronne, Y., Biofuels and world agricultural markets: Outlook for 2020 and 2050, in: Dos Santos Bernardes, M. A. (Ed.), Economic Effects of Biofuel Production, InTech 2011, pp. 129-163. DOI: 10.5772/20581. Available from: http://www.intechopen.com/books/economic-effects-of-biofuel-production/biofuels-and-world-agricultural-markets-outlook-for-2020-and-2050.
19. Philbrook, A., Alissandratos, A., Easton, C. J., Biochemical processes for generating fuels and commodity chemicals from lignocellulosic biomass, in: Petre, M. (Ed.), Environmental Biotechnology - New Approaches and Prospective Applications, InTech 2013, pp. 39-64, ISBN: 978-953-51-0972-3, DOI: 10.5772/55309. Available from: http:/:/www.intechopen.com.sci:-hub.io:/books/environmental-biotechnology-new-approaches-and-prospective-applications:/biochemical-processes-for-generating-fuels-and-commodity-chemicals-from-lignocellulosic-biomass.
20. Datta, R., Maher, M. A., Jones, C., Brinker, R. W. et al., Ethanol-the primary renewable liquid fuel. J. Chem. Technol. Biotechnol. 2011, 86, 473-480.
21. Niven, R. K., Ethanol in gasoline: Environmental impacts and sustainability review article. Renew. Sustain. Energy Rev. 2005, 9, 535-555.
22. Poulopoulos, S., Samaras, D., Philippopoulos, C., Regulated and unregulated emissions from an internal combustion engine operating on ethanol-containing fuels. Atmos. Environ. 2001, 35, 4399-4406.
23. Wang, M., Han, J., Dunn, J. B., Cai, H. et al., Well-to-wheels energy use and greenhouse gas emissions of ethanol from corn, sugarcane and cellulosic biomass for US use. Environ. Res. Lett. 2012, 7, 045905.
24. Kopsahelis, N., Nisiotou, A., Kourkoutas, Y., Panas, P. et al., Molecular characterization and molasses fermentation performance of a wild yeast strain operating in an extremely wide temperature range. Bioresour. Technol. 2009, 10, 4854-4862.
25. Lin, Y., Tanaka, S., Ethanol fermentation from biomass resources: current state and prospects. Appl. Microbiol. Biotechnol. 2006, 69, 627-642.
26. Matsakas, L., Christakopoulos, P., Fermentation of liquefacted hydrothermally pretreated sweet sorghum bagasse to ethanol at high-solids content. Bioresour. Technol. 2013, 127, 202-208.
27. Matsakas, L., Christakopoulos, P., Optimization of ethanol production from high dry matter liquefied dry sweet sorghum stalks. Biomass Bioenerg. 2013, 51, 91-98.
28. McMillan, J. D., Bioethanol production: Status and prospects. Renew. Energy 1997, 10, 295-302.
29. Sanchez, S., Demain, A. L., Metabolic regulation and overproduction of primary metabolites. Microb. Biotechnol. 2008, 1, 283-319.
30. Sarris, D., Kotseridis, Y., Linga, M., Galiotou-Panayotou, M. et al., Enhanced ethanol production, volatile compound biosynthesis and fungicide removal during growth of a newly isolated Saccharomyces cerevisiae strain on enriched pasteurized grape musts. Eng. Life Sci. 2009, 9, 29-37.
31. Sarris, D., Giannakis, M., Philippoussis, A., Komaitis, M. et al., Conversions of olive mill wastewater-based media by Saccharomyces cerevisiae through sterile and non-sterile bioprocesses. J. Chem. Technol. Biotechnol. 2013, 88, 958-969.
32. Sarris, D., Matsakas, L., Aggelis, G., Koutinas, A. A. et al., Aerated vs non-aerated conversions of molasses and olive mill wastewaters blends into bioethanol by Saccharomyces cerevisiae under non-aseptic conditions. Ind. Crops. Prod. 2014, 56, 83-93.
33. Kopsahelis, N., Agouridis, N., Bekatorou, A., Kanellaki, M. et al., Comparative study of spent grains and delignified spent grains as yeast supports for alcohol production from molasses. Bioresour. Technol. 2007, 98, 1440-1447.
34. Pickett, J., Anderson, D., Bowles, D., Bridgwater, T. et al., Sustainable biofuels: Prospects and challenges. Royal Society, London, UK 2008.
35. Zhang, M., Eddy, C., Deanda, K., Finkelstein, M. et al., Metabolic engineering of a pentose metabolism pathway in ethanologenic Zymomonas mobilis. Science 1995, 26, 240-243.
36. Hahn-Hägerdal, B., Galbe, M., Gorwa-Grauslund, M.-F., Lidén, G. et al., Bio-ethanol-the fuel of tomorrow from the residues of today. Trends Biotechnol. 2006, 24, 549-556.
37. Yang, S., Pappas, K. M., Hauser, L. J., Land, M. L. et al., Improved genome annotation for Zymomonas mobilis. Nat. Biotechnol. 2009, 27, 893-894.
38. Alzate, C. A. C., Toro, O. J. S., Energy consumption analysis of integrated flowsheets for production of fuel ethanol from lignocellulosic biomass. Energy 2006, 31, 2111-2123.
39. Dogaris, I., Gkounta, O., Mamma, D., Kekos, D. et al., Bioconversion of dilute-acid pretreated sorghum bagasse to ethanol by Neurospora crassa. Appl. Microbiol. Biotechnol. 2012, 95, 541-550.
40. Palmqvist, E., Hahn-Hägerdal, B., Fermentation of lignocellulosic hydrolysates. I: Inhibition and detoxification. Bioresour. Technol. 2000, 74, 25-33.
41. Rehm, H. J., Reed, G., Products of primary metabolism, in: Kosaric N. (Ed.), Biotechnology, VHC, Weinheim 1996, pp. 121-205.
42. Roukas, T., Continuous ethanol production from nonsterilized carob pod extract by immobilized Saccharomyces cerevisiae on mineral kissiris using a two-reactor system. Appl. Biochem. Biotechnol. 1996, 59, 299-307.
43. Najafpour, G., Biochemical Engineering and Biotechnology, First Edition, Elsevier Science, Amsterdam 2006.
44. Tampier, M., Smith, D., Bibeau, E., Beauchemin, P. et al., Identifying Environmentally Preferable Uses for Biomass Resources, Environmental Services Inc., Vancouver, Canada 2004, 132pp.
45. Demirbas, A., Biofuels securing the planet's future energy needs. Energy Convers. Mgmt. 2009, 50, 2239-2249.
46. Balat, M., Balat, H., Öz, C., Progress in bioethanol processing. Prog. Energy Combust. Sci. 2008, 34, 551-573.
47. Kim, S., Dale, B., Ethanol fuels: E10 or E85-life cycle perspectives (5 pp). Int. J. Life Cycle Assess. 2006, 11, 117-121.
48. Prasad, S., Singh, A., Joshi, H., Ethanol as an alternative fuel from agricultural, industrial and urban residues. Resour. Conserv. Recycl. 2007, 50, 1-39.
49. Marchetti, J., Miguel, V., Errazu, A., Possible methods for biodiesel production. Renew. Sust. Energy Rev. 2007, 11, 1300-1311.
50. Roukas, T., Ethanol production from carob pod extract by immobilized Saccharomyces cerevisiae cells on the mineral kissiris. Food Biotechnol. 1995, 9, 175-188.
51. Kopsahelis, N., Bosnea, L., Bekatorou, A., Tzia, C. et al., Alcohol production from sterilized and non-sterilized molasses by Saccharomyces cerevisiae immobilized on brewer's spent grains in two types of continuous bioreactor systems. Biomass Bioenerg. 2012, 45, 87-94.
52. Festel, G. W., Biofuels-economic aspects. Chem. Eng. Technol. 2008, 31, 715-720.
53. Ratledge, C., Yeast physiology-a micro-synopsis. Bioproc. Eng. 1991, 6, 195-203.
54. Aggelis, G., Microbiology and Microbial Technology, A, Stamoulis Publishers, Athens, Greece 2007.
55. Bellou, S., Baeshen, M. N., Elazzazy, A. M., Aggeli, D. et al., Microalgal lipids biochemistry and biotechnological perspectives. Biotechnol. Adv. 2014, 32, 1476-1493.
56. Ribéreau-Gayon, P., Dubourdieu, D., Donèche, B., Lonvaud, A. et al., (Ed.), Biochemistry of alcoholic fermentation and metabolic pathways of wine yeasts, Handbook of Enology: The Microbiology of Wine and Vinifications, John Wiley & Sons, New York 2006, pp. 53-77.
57. Hahn-Hagerdal, B., Lidén, G., Senac, T., Skoog, K. et al., Ethanolic fermentation of pentoses in ugnocellulose hydrolysates. Appl. Biochem. Biotechnol. 1991, 28-29, 131-144.
58. Hahn-Hagerdal, B., Wahlbom, C., Gárdonyi, M., van Zyl, W. et al., Metabolic engineering of Saccharomyces cerevisiae for xylose utilization. Adv. Biochem. Eng. Biotechnol. 2001, 73, 53-84.
59. Jeffries, T., Jin, Y.-S., Metabolic engineering for improved fermentation of pentoses by yeasts. Appl. Microbiol. Biotechnol. 2004, 63, 495-509.
60. Ito, T., Nakashimada, Y., Senba, K., Matsui, T. et al., Hydrogen and ethanol production from glycerol-containing wastes discharged after biodiesel manufacturing process. J. Biosci. Bioeng. 2005, 100, 260-265.
61. Choi, W. J., Hartono, M. R., Chan, W. H., Yeo, S. S. et al., Ethanol production from biodiesel-derived crude glycerol by newly isolated Kluyvera cryocrescens. Appl. Microbiol. Biotechnol. 2011, 89, 1255-1264.
62. Metsoviti, M., Paramithiotis, S., Drosinos, E. H., Galiotou-Panayotou, M. et al., Screening of bacterial strains capable of converting biodiesel-derived raw glycerol into 1, 3-propanediol, 2, 3-butanediol and ethanol. Eng. Life Sci. 2012, 12, 57-68.
63. Metsoviti, M., Paraskevaidi, K., Koutinas, A., Zeng, A.-P. et al., Production of 1, 3-propanediol, 2, 3-butanediol and ethanol by a newly isolated Klebsiella oxytoca strain growing on biodiesel-derived glycerol based media. Proc. Biochem. 2012, 47, 1872-1882.
64. Nwachukwu, R., Shahbazi, A., Wang, L., Ibrahim, S. et al., Bioconversion of glycerol to ethanol by a mutant Enterobacter aerogenes. AMB Εxpress 2012, 2, 1-6.
65. Cha, H., Kim, Y., Choi, W., Kang, D. et al., Ethanol production from glycerol using immobilized Pachysolen tannophilus during microaerated repeated-batch fermentor culture. J. Microbiol. Biotechnol. 2015, 25, 366-374.
66. Pronk, J. T., Steensma, H. Y., van Dijken, J. P., Pyruvate metabolism in Saccharomyces cerevisiae. Yeast 1996, 12, 1607-1633.
67. Fukuhara, H., The Kluyver effect revisited. FEMS Yeast Res. 2003, 3, 327-331.
68. Zamora, F., (Ed.), Biochemistry of alcoholic fermentation, Wine Chemistry and Biochemistry, Springer, New York 2009, pp. 3-26.
69. Weusthuis, R. A., Pronk, J. T., Van den Broek, P., Van Dijken, J., Chemostat cultivation as a tool for studies on sugar transport in yeasts. Microbiol. Rev. 1994, 58, 616-630.
70. Maier, A., Völker, B., Boles, E., Fuhrmann, G. F., Characterisation of glucose transport in Saccharomyces cerevisiae with plasma membrane vesicles (countertransport) and intact cells (initial uptake) with single Hxt1, Hxt2, Hxt3, Hxt4, Hxt6, Hxt7 or Gal2 transporters. FEMS Yeast Res. 2002, 2, 539-550.
71. Galiotou-Panayotou, M., Kalantzi, O., Aggelis, G., Modelling of simultaneous production of polygalacturonase and exopolysaccharide by Aureobasidium pullulans ATHUM 2915. Antonie Van Leeuwenhoek 1998, 73, 155-162.
72. Papanikolaou, S., Aggelis, G., Lipids of oleaginous yeasts. Part I: Biochemistry of single cell oil production. Eur. J. Lipid Sci. Technol. 2011, 113, 1031-1051.
73. Fakas, S., Papanikolaou, S., Galiotou-Panayotou, M., Komaitis, M. et al., Biochemistry and biotechnology of single cell oil, in: Pandey, A., et al., (Eds.), New Horizons in Biotechnology, AsiaTech Publishers Inc., New Delhi 2009, pp. 52-75.
74. Papanikolaou, S., Microbial conversion of glycerol into 1, 3-propanediol: Glycerol assimilation, biochemical events related with 1, 3-propanediol biosynthesis and biochemical engineering of the process, Microbial Conversions of Raw Glycerol, Nova Science Publishers, Inc., New York 2009, pp. 137-168.
75. Bideaux, C., Alfenore, S., Cameleyre, X., Molina-Jouve, C. et al., Minimization of glycerol production during the high-performance fed-batch ethanolic fermentation process in Saccharomyces cerevisiae, using a metabolic model as a prediction tool. Appl. Environ. Microbiol. 2006, 72, 2134-2140.
76. +). FEBS Lett. 1991, 286, 13-17.
77. Alfenore, S., Molina-Jouve, C., Guillouet, S., Uribelarrea, J.-L. et al., Improving ethanol production and viability of Saccharomyces cerevisiae by a vitamin feeding strategy during fed-batch process. Appl. Microbiol. Biotechnol. 2002, 60, 67-72.
78. Alfenore, S., Cameleyre, X., Benbadis, L., Bideaux, C. et al., Aeration strategy: A need for very high ethanol performance in Saccharomyces cerevisiae fed-batch process. Appl. Microbiol. Biotechnol. 2004, 63, 537-542.
79. Michnick, S., Roustan, J. L., Remize, F., Barre, P., et al., Modulation of glycerol and ethanol yields during alcoholic fermentation in Saccharomyces cerevisiae strains overexpressed or disrupted for GPD1 encoding glycerol 3-phosphate dehydrogenase. Yeast 1997, 13, 783-793.
80. Nissen, T. L., Hamann, C. W., Kielland-Brandt, M. C., Nielsen, J. et al., Anaerobic and aerobic batch cultivations of Saccharomyces cerevisiae mutants impaired in glycerol synthesis Yeast 2000, 16, 463-474.
81. Diaz-Ruiz, R., Rigoulet, M., Devin, A., The Warburg and Crabtree effects: On the origin of cancer cell energy metabolism and of yeast glucose repression. Biochim. Βiophys. Acta 2011, 1807, 568-576.
82. Boulton, R., Singleton, V., Bisson, L., Kunkee, R. et al., Principles and Practices of Winemaking, Chapman Hall, New York 1996.
83. Diaz-Ruiz, R., Uribe-Carvajal, S., Devin, A., Rigoulet, M. et al., Tumor cell energy metabolism and its common features with yeast metabolism. Biochim. Βiophys. Acta 2009, 1796, 252-265.
84. Piškur, J., Rozpedowska, E., Polakova, S., Merico, A. et al., How did Saccharomyces evolve to become a good brewer? Trends Genet. 2006, 22, 183-186.
85. Pyun, Y. R., Modak, J. M., Chang, Y. K., Lim, H. C. et al., Optimization of biphasic growth of Saccharomyces carlsbergensis in fed-batch culture. Biotechnol. Bioeng. 1989, 33, 1-10.
86. Zhang, X.-C., Visala, A., Halme, A., Linko, P. et al., Functional state modelling approach for bioprocesses: Local models for aerobic yeast growth processes. J. Proc. Control 1994, 4, 127-134.
87. Carrascosa, J., Viguera, M. D., de Castro, I. N., Scheffers, W. et al., Metabolism of acetaldehyde and custers effect in the yeast. Antonie Van Leeuwenhoek 1981, 47, 209-215.
88. Wijsman, M. R., van Dijken, J. P., van Kleeff, B. H., Scheffers, W. A. et al., Inhibition of fermentation and growth in batch cultures of the yeast Brettanomyces intermedius upon a shift from aerobic to anaerobic conditions (Custers effect). Antonie Van Leeuwenhoek 1984, 50, 183-192.
89. van Dijken, J. P., Scheffers, W. A., Redox balances in the metabolism of sugars by yeasts. FEMS Microbiol. Rev. 1986, 1, 199-224.
90. Rodrigues, F., Ludovico, P., Leão, C., (Eds.), Sugar metabolism in yeasts: an overview of aerobic and anaerobic glucose catabolism, Biodiversity and Εcophysiology of Υeasts, Springer, 2006, pp. 101-121.
91. Koutinas, A. A., Vlysidis, A., Pleissner, D., Kopsahelis, N. et al., Valorization of industrial waste and by-product streams via fermentation for the production of chemicals and biopolymers. Chem. Soc. Rev. 2014, 43, 2587-2627.
92. Sun, Y., Cheng, J., Hydrolysis of lignocellulosic materials for ethanol production: a review. Bioresour. Technol. 2002, 83, 1-11.
93. Papanikolaou, S., Aggelis, G., Yarrowia lipolytica: a model microorganism used for the production of tailor-made lipids. Eur. J. Lipid Sci. Technol. 2010, 112, 639-654.
94. Ratledge, C., (Ed.), Yeasts, moulds, algae and bacteria as sources of lipids, Technological Advances in Improved and Alternative Sources Of Lipids, Springer, London 1994, pp. 235-291.
95. Brynjarsdottir, H., Wawiernia, B., Orlygsson, J., Ethanol production from sugars and complex biomass by Thermoanaerobacter AK5: The effect of electron-scavenging systems on end-product formation. Energy Fuel 2012, 26, 4568-4574.
96. McMillan, J., Xylose Fermentation to Ethanol: A review, National Renewable Energy Lab., Golden, CO 1993. Available from: http://www.nrel.gov/docs/legosti/old/4944.pdf.
97. Christakopoulos, P., Macris, B., Kekos, D., Direct fermentation of cellulose to ethanol by Fusarium oxysporum. Enzyme Microb. Technol. 1989, 11, 236-239.
98. Christakopoulos, P., Macris, B. J., Kekos, D., On the mechanism of direct conversion of cellulose to ethanol by Fusarium oxysporum: Effect of cellulase and β-glucosidase. Appl. Microbiol. Biotechnol. 1990, 33, 18-20.
99. Taherzadeh, M. J., Karimi, K., Enzymatic-based hydrolysis processes for ethanol. BioResources 2007, 2, 707-738.
100. Xiros, C., Christakopoulos, P., Enhanced ethanol production from brewer's spent grain by a Fusarium oxysporum consolidated system. Biotechnol. Biofuel. 2009, 2, 1-12.
101. Sonderegger, M., Jeppsson, M., Hahn-Hägerdal, B., Sauer, U. et al., Molecular basis for anaerobic growth of Saccharomyces cerevisiae on xylose, investigated by global gene expression and metabolic flux analysis. Appl. Environ. Microbiol. 2004, 70, 2307-2317.
102. Sonderegger, M., Schümperli, M., Sauer, U., Metabolic engineering of a phosphoketolase pathway for pentose catabolism in Saccharomyces cerevisiae. Appl. Environ. Microbiol. 2004, 70, 2892-2897.
103. Becker, J., Boles, E., A modified Saccharomyces cerevisiae strain that consumes L-arabinose and produces ethanol. Appl. Environ. Microbiol. 2003, 69, 4144-4150.
104. Mohagheghi, A., Linger, J., Smith, H., Yang, S. et al., Improving xylose utilization by recombinant Zymomonas mobilis strain 8b through adaptation using 2-deoxyglucose. Biotechnol. Biofuel. 2014, 7, 1-9.
105. Koutinas, A. A., Wang, R. H., Webb, C., The biochemurgist-bioconversion of agricultural raw materials for chemical production. Biofuel. Bioprod. Bioref. 2007, 1, 24-38.
106. Xiu, Z.-L., Zeng, A.-P., Present state and perspective of downstream processing of biologically produced 1, 3-propanediol and 2, 3-butanediol. Appl. Microbiol. Biotechnol. 2008, 78, 917-926.
107. Zeng, A.-P., Sabra, W., Microbial production of diols as platform chemicals: Recent progresses. Curr. Opin. Biotechnol. 2011, 22, 749-757.
108. André, A., Chatzifragkou, A., Diamantopoulou, P., Sarris, D. et al., Biotechnological conversions of bio-diesel-derived crude glycerol by Yarrowia lipolytica strains. Eng. Life Sci. 2009, 9, 468-478.
109. Liu, X., Jensen, P. R., Workman, M., Bioconversion of crude glycerol feedstocks into ethanol by Pachysolen tannophilus. Bioresour. Technol. 2012, 104, 579-586.
110. Liu, X., Mortensen, U. H., Workman, M., Expression and functional studies of genes involved in transport and metabolism of glycerol in Pachysolen tannophilus. Microb. Cell Fact. 2013, 12, 27.
111. Fakas, S., Makri, A., Bellou, S., Aggelis, G. et al., Pathways to aerobic glycerol fermentation and their regulation, in Aggelis, G. (Ed.), Microbial Conversions of Raw Glycerol, Nova Science Publishers Inc., New York 2009, pp. 9-18.
112. Makri, A., Fakas, S., Aggelis, G., Metabolic activities of biotechnological interest in Yarrowia lipolytica grown on glycerol in repeated batch cultures. Bioresour. Technol. 2010, 101, 2351-2358.
113. Oh, B.-R., Seo, J.-W., Heo, S.-Y., Hong, W.-K. et al., Efficient production of ethanol from crude glycerol by a Klebsiella pneumoniae mutant strain. Bioresour. Technol. 2011, 102, 3918-3922.
114. Biebl, H., Menzel, K., Zeng, A.-P., Deckwer, W.-D., Microbial production of 1, 3-propanediol. Appl. Microbiol. Biotechnol. 1999, 52, 289-297.
115. Zeng, A.-P., Biebl, H., Bulk chemicals from biotechnology: the case of 1, 3-propanediol production and the new trends. Adv. Biochem. Eng. Biotechnol. 2002, 74, 239-259.
116. Forage, R., Lin, E., DHA system mediating aerobic and anaerobic dissimilation of glycerol in Klebsiella pneumoniae NCIB 418. J. Bacteriol. 1982, 151, 591-599.
117. Ruch, F., Lin, E., Independent constitutive expression of the aerobic and anaerobic pathways of glycerol catabolism in Klebsiella aerogenes. J. Bacteriol. 1975, 124, 348-352.
118. Papanikolaou, S., Aggelis, G., Biotechnological valorization of biodiesel derived glycerol waste through production of single cell oil and citric acid by Yarrowia lipolytica. Lipid Technol. 2009, 21, 83-87.
119. Yu, Z., Zhang, H., Ethanol fermentation of acid-hydrolyzed cellulosic pyrolysate with Saccharomyces cerevisiae. Bioresour. Technol. 2004, 93, 199-204.
120. Del Campo, I., Alegría, I., Zazpe, M., Echeverría, M. et al., Diluted acid hydrolysis pretreatment of agri-food wastes for bioethanol production. Ind. Crops Prod. 2006, 24, 214-221.
121. Roukas, T., Liakopoulou-Kyriakides, M., Production of pullulan from beet molasses by Aureobasidium pullulans in a stirred tank fermentor. J. Food Eng. 1999, 40, 89-94.
122. El-Enshasy, H. A., Mohamed, N. A., Farid, M. A., El-Diwany, A. I. et al., Improvement of erythromycin production by Saccharopolyspora erythraea in molasses based medium through cultivation medium optimization. Bioresour. Technology 2008, 99, 4263-4268.
123. Liu, Y.-P., Zheng, P., Sun, Z.-H., Ni, Y., et al., Economical succinic acid production from cane molasses by Actinobacillus succinogenes. Bioresour. Technol. 2008, 99, 1736-1742.
124. Sharma, A., Vivekanand, V., Singh, R. P., Solid-state fermentation for gluconic acid production from sugarcane molasses by Aspergillus niger ARNU-4 employing tea waste as the novel solid support. Bioresour. Technol. 2008, 99, 3444-3450.
125. Chatzifragkou, A., Fakas, S., Galiotou-Panayotou, M., Komaitis, M. et al., Commercial sugars as substrates for lipid accumulation in Cunninghamella echinulata and Mortierella isabellina fungi. Eur. J. Lipid Sci. Technol. 2010, 11, 1048-1057.
126. Baptista, C. M. S. G., Cóias, J. M. A., Oliveira, A. C. M., Oliveira, N. M. C. et al., Natural immobilisation of microorganisms for continuous ethanol production. Enzyme Microb. Technol. 2006, 40, 127-131.
127. Nahvi, I., Emtiazi, G., Alkabi, L., Isolation of a flocculating Saccharomyces cerevisiae and investigation of its performance in the fermentation of beet molasses to ethanol. Biomass Bioenerg. 2002, 23, 481-486.
128. Cáceres-Farfán, M., Lappe, P., Larqué-Saavedra, A., Magdub-Méndez, A. et al., Ethanol production from henequen (Agave fourcroydes Lem.) juice and molasses by a mixture of two yeasts. Bioresour. Technol. 2008, 99, 9036-9039.
129. Ergun, M., Mutlu, S., Application of a statistical technique to the production of ethanol from sugar beet molasses by Saccharomyces cerevisiae. Bioresour. Technol. 2000, 73, 251-255.
130. Joannis-Cassan, C., Riess, J., Jolibert, F., Taillandier, P. et al., Optimization of very high gravity fermentation process for ethanol production from industrial sugar beet syrup. Biomass Bioenerg. 2014, 70, 165-173.
131. Bambalov, G., Israilides, C., Tanchev, S., Alcohol fermentation in olive oil extraction effluents. Biolog. Waste 1989, 27, 71-75.
132. Zanichelli, D., Carloni, F., Hasanaj, E., D'Andrea, N. et al., Production of ethanol by an integrated valorization of olive oil byproducts. The role of phenolic inhibition. Env. Sci. Pollut. Res. 2007, 14, 5-6.
133. Massadeh, M. I., Modallal, N., Ethanol production from olive mill wastewater (OMW) pretreated with Pleurotus sajor-caju. Energy Fuel 2008, 22, 150-154.
134. Pinal, L., Cedeno, M., Gutierrez, H., Alvarez-Jacobs, J. et al., Fermentation parameters influencing higher alcohol production in the tequila process. Biotechnol. Lett. 1997, 19, 45-47.
135. Çaylak, B., Sukan, F. V., Comparison of different production processes for bioethanol. Turk. J. Chem. 1998, 22, 351-360.
136. Galbe, M., Sassner, P., Wingren, A., Zacchi, G. et al., Process engineering economics of bioethanol production. Adv. Biochem. Engin. Biotechnol. 2007, 108, 303-327.
137. Moukamnerd, C., Kawahara, H., Katakura, Y., Feasibility study of ethanol production from food wastes by consolidated continuous solid-state fermentation. JSBS 2013, 3, 143-148.
138. Pietrzak, W., Kawa-Rygielska, J., Ethanol fermentation of waste bread using granular starch hydrolyzing enzyme: Effect of raw material pretreatment. Fuel 2014, 134, 250-256.
139. Wang, R., Ji, Y., Melikoglu, M., Koutinas, A., Webb, C. et al., Optimization of innovative ethanol production from wheat by response surface methodology. Proc. Safety Environ. Prot. 2007, 85, 404-412.
140. Hahn-Hägerdal, B., Jeppsson, H., Skoog, K., Prior, B. et al., Biochemistry and physiology of xylose fermentation by yeasts. Enzyme Microb. Technol. 1994, 16, 933-943.
141. Palmqvist, E., Hahn-Hägerdal, B., Fermentation of lignocellulosic hydrolysates. I: Inhibition and detoxification. Bioresour. Technol. 2000, 74, 17-24.
142. Margeot, A., Hahn-Hagerdal, B., Edlund, M., Slade, R. et al., New improvements for lignocellulosic ethanol. Curr. Opin. Biotechnol. 2009, 20, 372-380.
143. Philippoussis, A., Zervakis, G., Diamantopoulou, P., Bioconversion of agricultural lignocellulosic wastes through the cultivation of the edible mushrooms Agrocybe aegerita, Volvariella volvacea and Pleurotus spp. World J. Microbiol. Biotechnol. 2001, 17, 191-200.
144. Aggelis, G., Ehaliotis, C., Nerud, F., Stoychev, I. et al., Evaluation of white-rot fungi for detoxification and decolorization of effluents from the green olive debittering process. Appl. Microbiol. Biotechnol. 2002, 59, 353-360.
145. Ayed, L., Assas, N., Sayadi, S., Hamdi, M. et al., Involvement of lignin peroxidase in the decolourization of black olive mill wastewaters by Geotrichum candidum. Lett. Appl. Microbiol. 2005, 40, 7-11.
146. Sayadi, S., Ellouz, R., Decolourization of olive mill waste-waters by the white-rot fungus Phanerochaete chrysosporium: involvement of the lignin-degrading system. Appl. Microbiol. Biotechnol. 1992, 37, 813-817.
147. Sayadi, S., Ellouz, R., Roles of lignin peroxidase and manganese peroxidase from phanerochaete chrysosporium in the decolorization of olive mill wastewaters. Appl. Environ. Microbiol. 1995, 61, 1098-1103.
148. Tsioulpas, A., Dimou, D., Iconomou, D., Aggelis, G. et al., Phenolic removal in olive oil mill wastewater by strains of Pleurotus spp. in respect to their phenol oxidase (laccase) activity. Bioresour. Technol. 2002, 84, 251-257.
149. Wesenberg, D., Kyriakides, I., Agathos, S. N., White-rot fungi and their enzymes for the treatment of industrial dye effluents. Biotechnol. Adv. 2003, 22, 161-187.
150. Lakhtar, H., Ismaili-Alaoui, M., Philippoussis, A., Perraud-Gaime, I. et al., Screening of strains of Lentinula edodes grown on model olive mill wastewater in solid and liquid state culture for polyphenol biodegradation. Int. Biodeter. Biodegr. 2010, 64, 167-172.
151. Nasidi, M., Agu, R., Deeni, Y., Walker, G., Improved production of ethanol using bagasse from different sorghum cultivars. Biomass Bioenerg. 2015, 72, 288-299.
152. Chatzifragkou, A., Papanikolaou, S., Effect of impurities in biodiesel-derived waste glycerol on the performance and feasibility of biotechnological processes. Appl. Microbiol. Biotechnol. 2012, 95, 13-27.
153. Pagliaro, M., Rossi, M., The Future of Glycerol, Volume 8, Royal Society of Chemistry, Cambridge 2010.
154. Yazdani, S. S., Gonzalez, R., Anaerobic fermentation of glycerol: A path to economic viability for the biofuels industry. Curr. Opin. Biotechnol. 2007, 18, 213-219.
155. Clomburg, J. M., Gonzalez, R., Anaerobic fermentation of glycerol: A platform for renewable fuels and chemicals. Trends Biotechnol. 2013, 31, 20-28.
156. Tchakouteu, S., Kalantzi, O., Gardeli, C., Koutinas, A. et al., Lipid production by yeasts growing on biodiesel-derived crude glycerol: Strain selection and impact of substrate concentration on the fermentation efficiency. J. Appl. Microbiol. 2015, 118, 911-927.
157. Mu, Y., Teng, H., Zhang, D.-J., Wang, W. et al., Microbial production of 1, 3-propanediol by Klebsiella pneumoniae using crude glycerol from biodiesel preparations. Biotechnol. Lett. 2006, 28, 1755-1759.
158. Rossi, D. M., da Costa, J. B., de Souza, E. A., Peralba, M. et al., Bioconversion of residual glycerol from biodiesel synthesis into 1, 3-propanediol and ethanol by isolated bacteria from environmental consortia. Renew. Energy 2012, 39, 223-227.
159. Lezinou, V., Christakopoulos, P., Kekos, D., Macris, B. et al., Simultaneous saccharification and fermentation of sweet sorghum carbohydrates to ethanol in a fed-batch process. Biotechnol. Lett. 1994, 16, 983-988.
160. Tropea, A., Wilson, D., La Torre, L. G., Curto, R. B. L. et al., Bioethanol production from pineapple wastes. J. Food Res. 2014, 3, 60.
161. Roukas, T., Ethanol production from non-sterilized beet molasses by free and immobilized Saccharomyces cerevisiae cells using fed-batch culture. J. Food. Eng. 1996, 27, 87-96.
162. Tao, F., Miao, J. Y., Shi, G. Y., Zhang, K. C. et al., Ethanol fermentation by an acid-tolerant Zymomonas mobilis under non-sterilized condition. Proc. Biochem. 2005, 40, 183-187.
163. Weuster-Botz, D., Aivasidis, A., Wandrey, C., Continuous ethanol production by Zymomonas mobilis in a fluidized bed reactor. Part II: Process development for the fermentation of hydrolysed B-starch without sterilization. Appl. Microbiol. Biotechnol. 1993, 39, 685-690.
164. Roukas, T., Ethanol production from nonsterilized carob pod extract by free and immobilized Saccharomyces cerevisiae cells using fed-batch culture. Biotechnol. Bioeng. 1994, 43, 189-194.
165. Vallet, C., Said, R., Rabiller, C., Martin, M. et al., Natural abundance isotopic fractionation in the fermentation reaction: Influence of the nature of the yeast. Bioorg. Chem. 1996, 24, 319-330.
166. Navarro, A., Sepulveda, M., Rubio, M., Bio-concentration of vinasse from the alcoholic fermentation of sugar cane molasses. Waste Management 2000, 20, 581-585.
167. Cruz, S. H., Batistote, M., Ernandes, J. R., Effect of sugar catabolite repression in correlation with the structural complexity of the nitrogen source on yeast growth and fermentation. J. Inst. Brew. 2003, 109, 349-355.
168. Kiran, S., Sikander, A., Lkram-ul- Haq, Time course study for yeast invertase production by submerged fermentation. J. Biol. Sci. 2003, 3, 984-988.
169. Najafpour, G., Younesi, H., Syahidah Ku Ismail, K., Ethanol fermentation in an immobilized cell reactor using Saccharomyces cerevisiae. Bioresour. Technol. 2004, 92, 251-260.
170. Baptista, C. M. S. G., Cóias, J. M. A., Oliveira, A. C. M., Oliveira, N. M. C. et al., Natural immobilisation of microorganisms for continuous ethanol production. Enzyme Microb. Technol. 2006, 40, 127-131.
171. Betiku, E., Alade, O., Media evaluation of bioethanol production from cassava starch hydrolysate using Saccharomyces cerevisiae. Energ. Sourc. A 2014, 36, 1990-1998.
172. Sreekumar, O., Basappa, S. C., Characterization of a superior thermotolerant mutant of Zymomonas mobilis ZM4 for ethanol production in glucose medium. Biotechnol. Lett. 1991, 13, 365-370.
173. Davis, L., Rogers, P., Pearce, J., Peiris, P. et al., Evaluation of Zymomonas-based ethanol production from a hydrolysed waste starch stream. Biomass Bioenerg. 2006, 30, 809-814.
174. Ruanglek, V., Maneewatthana, D., Tripetchkul, S., Evaluation of Thai agro-industrial wastes for bio-ethanol production by Zymomonas mobilis. Proc. Biochem. 2006, 41, 1432-1437.
175. Cazetta, M. L., Celligoi, M. A. P. C., Buzato, J. B., Scarmino, I. S. et al., Fermentation of molasses by Zymomonas mobilis: Effects of temperature and sugar concentration on ethanol production. Bioresour. Technol. 2007, 98, 2824-2828.
176. Todhanakasem, T., Sangsutthiseree, A., Areerat, K., Young, G. M. et al., Biofilm production by Zymomonas mobilis enhances ethanol production and tolerance to toxic inhibitors from rice bran hydrolysate. New Biotechnol. 2014, 31, 451-459.