Improvement of erythromycin production by Saccharopolyspora erythraea in molasses based medium through cultivation medium optimization

Bioresource Technology

Volumn 99, Issue 10, 2008, Pages 4263-4268

  El Enshasy, H A ^a   Mohamed, N A ^b   Farid, M A ^b   El Diwany, A I ^b  

^a Universities and Research centers District   (Egypt)

^b NATIONAL RESEARCH CENTRE   (Egypt)

Author keywords

Agricultural wastes; Cultivation conditions; Erythromycin; Saccharopolyspora erythraea

Indexed keywords

CARBON; MOLASSES; NITROGEN; OPTIMIZATION; SUGAR CANE;

CULTIVATION CONDITIONS; ERYTHROMYCIN; SACCHAROPOLYSPORA ERYTHRAEA;

DRUG PRODUCTS;

AMMONIUM SULFATE; ERYTHROMYCIN; MOLASSES; NITROGEN;

CARBON; DRUG PRODUCTS; MOLASSES; NITROGEN; OPTIMIZATION; SUGAR CANE;

ANTIMICROBIAL ACTIVITY; BACTERIUM; CARBON; CULTIVATION; MOLASSE; NITROGEN; OPTIMIZATION; SUGAR CANE; WASTE;

ARTICLE; CARBON SOURCE; CULTURE MEDIUM; CULTURE OPTIMIZATION; DRUG MANUFACTURE; DRUG SYNTHESIS; FUNGUS CULTURE; NONHUMAN; PRIORITY JOURNAL; SACCHAROPOLYSPORA; STREPTOMYCES ERYTHRAEUS; SUGARCANE;

1-PROPANOL; AGRICULTURE; AMMONIUM SULFATE; BIOTECHNOLOGY; CARBOHYDRATES; CARBON; CHEMISTRY, ORGANIC; CULTURE MEDIA; ERYTHROMYCIN; FERMENTATION; GLUCOSE; INDUSTRIAL MICROBIOLOGY; MOLASSES; NITROGEN; SACCHAROPOLYSPORA;

AFRICA; EGYPT; NORTH AFRICA;

SACCHAROPOLYSPORA ERYTHRAEA; SACCHARUM; ZEA MAYS;

EID: 40849142590     PISSN: 09608524     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biortech.2007.08.050     Document Type: Article

References (34)

1. Banik R.M., Santhiagu A., and Upadhyay S.N. Optimization of nutrients for gellan gum production by Sphingomonas paucimobilis ATCC-31461 in molasses based medium using response surface methodology. Bioresour. Technol. 98 (2007) 792-797
2. Bershtein E.M., Vasilyeva N.G., and Polyak M.S. Unification of nutrient medium for determination of biological activity of some antibiotics with agar diffusion method. Antibiotiki. 28 (1983) 250-254
3. Bezborodov A.M., and Galynkin V.A. Regulation of the synthesis of acetyl-coA-derived metabolites in the culture Actinomyces erythreus. Mikrobiologia. 2 (1970) 246-252
4. Bushell M.E., Dunstan G.L., and Wilson G.C. Effect of small scale culture vessel type on hyphal fragment size and erythromycin production in Saccharopolyspora erythraea. Biotechnol. Lett. 19 (1997) 849-852
5. Campa-Córdova A.I., Luna-González A., Ascenci F., Cortés-Jacinto E., and Cáceres-Martínez C.J. Effects of chloramphenicol, erythromycin, and furazolidone on growth of Isochrysis galbana and Chaetoceros gracilis. Aquaculture 260 (2006) 145-150
6. Cazetta M.L., Celligoi M.A.P.C., Buzato J.B., Scarmino I.S., and da Silva R.S.F. Optimization study for sorbitol production by Zymomonas mobilis in sugar cane molasses. Process Biochem. 40 (2005) 747-751
7. Cha S.H., Lim J.S., Yoon C.S., Koh J.H., Chang H.I., and Kim S.W. Production of mycelia and exo-biopolymer from molasses by Cordyceps sinensis 16 in submerged culture. Bioresour. Technol. 98 (2007) 165-168
8. El-Enshasy, H., Beshay, U., 2000. Production of erythromycin by immobilized cells of Saccharopolyspora erythraea. The world Congress in Biotechnology. In: The 11th International Biotechnology Symposium and Exhibition, Biotechnology 2000, Berlin (3-8 Sept. 2000), vol. 4, pp. 308-311.
9. Escalante L., Lopez H., Mateos R., Lara F., and Sanchez S. Transient repressiono f erythromycin formation in Streptomyces erythreus. J. Gen. Microbiol. 128 (1982) 2011-2015
10. Flores M.E., and Sánchez S. Nitrogen regulation of erythromycin formation in Streptomyces erythreus. FEMS Microbiol. Lett. 26 (1985) 191-194
11. Flores M.E., and Sánchez S. Ammonium assimilating enzymes and erythromycin formation in Saccharopolyspora erythraea. J. Gen. Microbiol. 35 (1989) 203-211
12. Flores M.E. Nitrogen regulation of urease synthesis in Saccharopolyspora erythraea ATCC 11365. FEMS Microbiol. Lett. 139 (1996) 57-62
13. Hamedi J., Khodagholi F., and Hassani-Nasab A. Increased erythromycin production by alginate as a medium ingredient or immobilization support in cultures of Saccharopolyspora erythraea. Biotechnol. Lett. 27 (2005) 661-664
14. Heydarian S.M., Mirjalili N., and Ison A.P. Effect of shear on morphology and erythromycin production in Saccharopolyspora erythraea fermentations. Bioprocess Eng. 21 (1999) 31-40
15. Hoyt J.C., and Robbins R.A. Macrolide antibiotics and pulmonary inflammation. FEMS Microbiol. Lett. 205 (2001) 1-7
16. Ikram-ul H., Ali S., Qadeer M.A., and Iqbal J. Citric acid production by selected mutants of Aspergillus niger from cane molasses. Bioresour. Technol. 93 (2004) 125-130
17. Khosla C., Gokhale R.S., Jacobsen J.R., and Cane D.E. Tolerance and specificity of polyketide synthases. Ann. Rev. Biochem. 68 (1999) 219-253
18. Kim Y.-K., and Cerniglia C.E. Influence of erythromycin A on the microbial population in aquaculture sediment microcosms. Aquatic Toxicol. 73 (2005) 230-241
19. Lesmana M., Lebron C.I., Taslim D., Tjaniadim P., Subekti D., Wasfy M.O., Campbell J.R., and Oyofo B.A. In vitro antibiotic susceptibility of Neisseria gonorrhoeae in Jakarta, Indonesia. Antimicrob. Agents Chemother. 45 (2001) 359-362
20. Marini F., and Teatini L. Erythromycin production kinetics. Biotechnol. Bioeng. Symp. 4 (1973) 209-215
21. Martin J.F., and Demain A.L. Control of antibiotic biosynthesis. Microbiol. Rev. 44 (1980) 230-251
22. Martin S.M., and Bushell M.E. Effect of hyphal micromorphology on bioreactor performance of antibiotic producing Saccharopolyspora erythraea cultures. Microbiology 142 (1996) 1783-1788
23. Moffitt C.M. Field trials of investigational new animal drugs. Vet. Hum. Toxicol. 40 (1998) 48-52
24. Moragues M.D., Estevez J.J., Rementería A., and Sevilla M.J. Effect of n-alkanols on acidification curves of Aureobasidium pullulans suspensions. Exp. Mycol. 18 (1994) 1-6
25. Najafpour G.D., and Shan C.P. Enzymatic hydrolysis of molasses. Bioresour. Technol. 86 (2003) 91-94
26. Nakornchai S., and Konthiang P. Activity of azithromycin or erythromycin in combination with antimalarial drugs against multidrug-resistant Plasmodium falciparum in vitro. Acta Trop. 100 (2006) 185-191
27. Nuntnarumit P., Kiatchoosakun P., Tantiprapa W., and Boonkasidech S. Efficacy of oral erythromycin for treatment of feeding intolerance in preterm infants. J. Pediatr. 148 (2006) 600-605
28. Potvin J., and Péringer P. Influence of n-propanol on growth and antibiotic production by an industrial strain of Streptomyces erythreus under different nutritional conditions. Biotechnol. Lett. 15 (1993) 455-460
29. Potvin J., and Péringer P. Ammonium regulation in Saccharopolyspora erythraea. Biotechnol. Lett. 16 (1994) 63-68
30. Prescott J.F. Antibiotics: miracle drugs or pig food?. Can Vet. J. 38 (1997) 763-766
31. Reeve L.M., and Baumberg S. Physiological controls of erythromycin production by Saccharopolyspora erythraea are exerted at least in part at the level of transcription. Biotechnol. Lett. 20 (1998) 585-589
32. Singh M.P., Mandal S.K., and Roy D.K. Studies on erythromycin fermentation: nutritional requirements of Streptomyces erythreus for erythromycin production. Ind. J. Pharm. Sci. 43 (1981) 137-141
33. Stocks S.M., and Thomas C.R. Strength of mild-logarithmic and stationary phase of Saccharopolyspora erythraea hyphae during a batch fermentation in defined nitrate-limited medium. Biotechnol. Bioeng. 73 (2001) 370-378
34. Stocks S.M., and Thomas C.R. Viability, strength, and fragmentation of Saccharopolyspora erythraea in submerged fermentation. Biotechnol. Bioeng. 75 (2001) 702-709