Antioxidative activities of histidine containing caffeic acid-dipeptides

Bioorganic and Medicinal Chemistry Letters

Volumn 20, Issue 14, 2010, Pages 4266-4272

  Seo, Hyo Suk ^a   Kwak, Seon Yeong ^a   Lee, Yoon Sik ^a  

^a Seoul National University   (South Korea)

Author keywords

Antioxidant; Antioxidative activity; Caffeic acid; Caffeic acid histidine dipeptides

Indexed keywords

1,1 DIPHENYL 2 PICRYLHYDRAZYL; ANTIOXIDANT; CAFFEIC ACID; CAFFEIC ACID ALANINE HISTIDINE AMIDE; CAFFEIC ACID ASPARTATE HISTIDINE AMIDE; CAFFEIC ACID BETA ALANINE HISTIDINE AMIDE; CAFFEIC ACID CYSTEINE HISTIDINE AMIDE; CAFFEIC ACID HISTIDINE ALANINE AMIDE; CAFFEIC ACID HISTIDINE AMIDE; CAFFEIC ACID HISTIDINE ASPARTATE AMIDE; CAFFEIC ACID HISTIDINE BETA ALANINE AMIDE; CAFFEIC ACID HISTIDINE CYSTEINE AMIDE; CAFFEIC ACID HISTIDINE DIPEPTIDE CONJUGATE; CAFFEIC ACID HISTIDINE HISTIDINE AMIDE; CAFFEIC ACID HISTIDINE LYSINE AMIDE; CAFFEIC ACID HISTIDINE PHENYLALANINE AMIDE; CAFFEIC ACID HISTIDINE PROLINE AMIDE; CAFFEIC ACID HISTIDINE SERINE AMIDE; CAFFEIC ACID LYSINE HISTIDINE AMIDE; CAFFEIC ACID PHENYLALANINE AMIDE; CAFFEIC ACID PHENYLALANINE HISTIDINE AMIDE; CAFFEIC ACID PROLINE HISTIDINE AMIDE; CAFFEIC ACID SERINE HISTIDINE AMIDE; DIPEPTIDE; IRON THIOCYANATE; SCAVENGER; THIOCYANATE; UNCLASSIFIED DRUG;

ANTIOXIDANT ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG CONJUGATION; LIPID PEROXIDATION;

ANTIOXIDANTS; CAFFEIC ACIDS; DIPEPTIDES; HISTIDINE; LIPID PEROXIDATION; REACTIVE OXYGEN SPECIES;

EID: 77953871983     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2010.04.135     Document Type: Article

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51. 48 Sodium phosphate buffer (0.1 M, pH 7.5, 580 μL), 20 μL of xanthine oxidase from cow's milk obtained from Aldrich, and 200 μL of the 0.7 mM test samples were mixed in an Eppendorf tube at 25 °C for 15 min. Then, 400 μL of 0.15 mM xanthine solution was treated for 30 min at 25 °C, and was quenched by 100 μL of 1 N HCl. The absorbance of the reaction mixture was measured at 290 nm. Three independent measurements were performed, and each experiment was run in triplicate. The percentage of xanthine oxidase inhibitory activity was calculated when the absorbance at 290 nm of the control (without antioxidant) reached approximately 2.5 (2.547-2.558).