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Volumn 141, Issue 11, 2015, Pages 1985-1994

Radiation-induced fibrosis: mechanisms and implications for therapy

Author keywords

Cancer; Fibroblast; Fibrosis; Inflammation; Radiation; TGF ; Therapy

Indexed keywords

CANCER GROWTH FACTOR; COLLAGEN; NITROGEN DERIVATIVE; REACTIVE OXYGEN METABOLITE; TRANSFORMING GROWTH FACTOR BETA;

EID: 84951569652     PISSN: 01715216     EISSN: 14321335     Source Type: Journal    
DOI: 10.1007/s00432-015-1974-6     Document Type: Review
Times cited : (433)

References (128)
  • 1
    • 1542362493 scopus 로고    scopus 로고
    • Pulmonary complications of radiation therapy
    • PID: 15062608
    • Abratt RP, Morgan GW, Silvestri G, Willcox P (2004) Pulmonary complications of radiation therapy. Clin Chest Med 25:167–177. doi:10.1016/s0272-5231(03)00126-6
    • (2004) Clin Chest Med , vol.25 , pp. 167-177
    • Abratt, R.P.1    Morgan, G.W.2    Silvestri, G.3    Willcox, P.4
  • 2
    • 17044385039 scopus 로고    scopus 로고
    • TLR signaling in the gut in health and disease
    • COI: 1:CAS:528:DC%2BD2MXivFKisbo%3D, PID: 15814663
    • Abreu MT, Fukata M, Arditi M (2005) TLR signaling in the gut in health and disease. J Immunol 174:4453–4460
    • (2005) J Immunol , vol.174 , pp. 4453-4460
    • Abreu, M.T.1    Fukata, M.2    Arditi, M.3
  • 3
    • 31844437458 scopus 로고    scopus 로고
    • ATM sequence variants and risk of radiation-induced subcutaneous fibrosis after postmastectomy radiotherapy
    • PID: 16338099
    • Andreassen CN et al (2006) ATM sequence variants and risk of radiation-induced subcutaneous fibrosis after postmastectomy radiotherapy. Int J Radiat Oncol Biol Phys 64:776–783. doi:10.1016/j.ijrobp.2005.09.014
    • (2006) Int J Radiat Oncol Biol Phys , vol.64 , pp. 776-783
    • Andreassen, C.N.1
  • 4
    • 69549118638 scopus 로고    scopus 로고
    • Radiation produces differential changes in cytokine profiles in radiation lung fibrosis sensitive and resistant mice
    • PID: 19187543
    • Ao X, Zhao L, Davis MA, Lubman DM, Lawrence TS, Kong FM (2009) Radiation produces differential changes in cytokine profiles in radiation lung fibrosis sensitive and resistant mice. J Hematol Oncol 2:6. doi:10.1186/1756-8722-2-6
    • (2009) J Hematol Oncol , vol.2 , pp. 6
    • Ao, X.1    Zhao, L.2    Davis, M.A.3    Lubman, D.M.4    Lawrence, T.S.5    Kong, F.M.6
  • 5
    • 6944249055 scopus 로고    scopus 로고
    • Concomitant use of tamoxifen with radiotherapy enhances subcutaneous breast fibrosis in hypersensitive patients
    • COI: 1:CAS:528:DC%2BD2cXnvFCgtbY%3D, PID: 15328527
    • Azria D et al (2004) Concomitant use of tamoxifen with radiotherapy enhances subcutaneous breast fibrosis in hypersensitive patients. Br J Cancer 91:1251–1260. doi:10.1038/sj.bjc.6602146
    • (2004) Br J Cancer , vol.91 , pp. 1251-1260
    • Azria, D.1
  • 6
    • 58149144774 scopus 로고    scopus 로고
    • Single nucleotide polymorphisms, apoptosis, and the development of severe late adverse effects after radiotherapy
    • COI: 1:CAS:528:DC%2BD1cXhtF2nurnP, PID: 18829510
    • Azria D et al (2008) Single nucleotide polymorphisms, apoptosis, and the development of severe late adverse effects after radiotherapy. Clin Cancer Res 14:6284–6288. doi:10.1158/1078-0432.CCR-08-0700
    • (2008) Clin Cancer Res , vol.14 , pp. 6284-6288
    • Azria, D.1
  • 7
    • 84858046332 scopus 로고    scopus 로고
    • Dynasplint for the management of trismus after treatment of upper aerodigestive tract cancer: a retrospective study
    • PID: 22180114
    • Baranano CF, Rosenthal EL, Morgan BA, McColloch NL, Magnuson JS (2011) Dynasplint for the management of trismus after treatment of upper aerodigestive tract cancer: a retrospective study. Ear Nose Throat J 90:584–590
    • (2011) Ear Nose Throat J , vol.90 , pp. 584-590
    • Baranano, C.F.1    Rosenthal, E.L.2    Morgan, B.A.3    McColloch, N.L.4    Magnuson, J.S.5
  • 8
    • 84855858666 scopus 로고    scopus 로고
    • Randomized controlled trial of forward-planned intensity modulated radiotherapy for early breast cancer: interim results at 2 years
    • PID: 21345620
    • Barnett GC et al (2012) Randomized controlled trial of forward-planned intensity modulated radiotherapy for early breast cancer: interim results at 2 years. Int J Radiat Oncol Biol Phys 82:715–723. doi:10.1016/j.ijrobp.2010.10.068
    • (2012) Int J Radiat Oncol Biol Phys , vol.82 , pp. 715-723
    • Barnett, G.C.1
  • 9
    • 0026065036 scopus 로고
    • Relationship between early and late normal-tissue injury after postmastectomy radiotherapy
    • COI: 1:STN:280:DyaK3MzgsFGrsg%3D%3D
    • Bentzen SM, Overgaard M (1991) Relationship between early and late normal-tissue injury after postmastectomy radiotherapy. Radiother Oncol J Eur Soc Ther Radiol Oncol 20:159–165
    • (1991) Radiother Oncol J Eur Soc Ther Radiol Oncol , vol.20 , pp. 159-165
    • Bentzen, S.M.1    Overgaard, M.2
  • 10
    • 0024310806 scopus 로고
    • Early and late normal-tissue injury after postmastectomy radiotherapy alone or combined with chemotherapy
    • COI: 1:STN:280:DyaK3c%2FmtlaqsA%3D%3D, PID: 2573667
    • Bentzen SM, Overgaard M, Thames HD, Christensen JJ, Overgaard J (1989) Early and late normal-tissue injury after postmastectomy radiotherapy alone or combined with chemotherapy. Int J Radiat Biol 56:711–715
    • (1989) Int J Radiat Biol , vol.56 , pp. 711-715
    • Bentzen, S.M.1    Overgaard, M.2    Thames, H.D.3    Christensen, J.J.4    Overgaard, J.5
  • 11
    • 0027267258 scopus 로고
    • Clinical correlations between late normal tissue endpoints after radiotherapy: implications for predictive assays of radiosensitivity
    • COI: 1:STN:280:DyaK2c%2FgtV2lug%3D%3D, PID: 8398261
    • Bentzen SM, Overgaard M, Overgaard J (1993) Clinical correlations between late normal tissue endpoints after radiotherapy: implications for predictive assays of radiosensitivity. Eur J Cancer 29A:1373–1376
    • (1993) Eur J Cancer , vol.29A , pp. 1373-1376
    • Bentzen, S.M.1    Overgaard, M.2    Overgaard, J.3
  • 12
    • 35848965217 scopus 로고    scopus 로고
    • Coronoidectomy for the treatment of trismus in head and neck cancer patients
    • PID: 17767087
    • Bhrany AD, Izzard M, Wood AJ, Futran ND (2007) Coronoidectomy for the treatment of trismus in head and neck cancer patients. Laryngoscope 117:1952–1956. doi:10.1097/MLG.0b013e31812eee13
    • (2007) Laryngoscope , vol.117 , pp. 1952-1956
    • Bhrany, A.D.1    Izzard, M.2    Wood, A.J.3    Futran, N.D.4
  • 13
    • 79955013110 scopus 로고    scopus 로고
    • Potential targets for intervention in radiation-induced heart disease
    • COI: 1:CAS:528:DC%2BC3cXhsVKksbrN, PID: 20583977
    • Boerma M, Hauer-Jensen M (2010) Potential targets for intervention in radiation-induced heart disease. Curr Drug Targets 11:1405–1412
    • (2010) Curr Drug Targets , vol.11 , pp. 1405-1412
    • Boerma, M.1    Hauer-Jensen, M.2
  • 15
    • 38349168155 scopus 로고    scopus 로고
    • A randomized, prospective study using the LPG technique in treating radiation-induced skin fibrosis: clinical and profilometric analysis
    • COI: 1:STN:280:DC%2BD1c%2FlslWhsw%3D%3D, PID: 18211604
    • Bourgeois JF, Gourgou S, Kramar A, Lagarde JM, Guillot B (2008) A randomized, prospective study using the LPG technique in treating radiation-induced skin fibrosis: clinical and profilometric analysis. Skin Res Technol 14:71–76. doi:10.1111/j.1600-0846.2007.00263.x
    • (2008) Skin Res Technol , vol.14 , pp. 71-76
    • Bourgeois, J.F.1    Gourgou, S.2    Kramar, A.3    Lagarde, J.M.4    Guillot, B.5
  • 16
    • 14544278377 scopus 로고    scopus 로고
    • Inhibition of Rho kinase modulates radiation induced fibrogenic phenotype in intestinal smooth muscle cells through alteration of the cytoskeleton and connective tissue growth factor expression
    • COI: 1:CAS:528:DC%2BD2MXisFCqtbg%3D, PID: 15710979
    • Bourgier C et al (2005) Inhibition of Rho kinase modulates radiation induced fibrogenic phenotype in intestinal smooth muscle cells through alteration of the cytoskeleton and connective tissue growth factor expression. Gut 54:336–343. doi:10.1136/gut.2004.051169
    • (2005) Gut , vol.54 , pp. 336-343
    • Bourgier, C.1
  • 17
    • 33745524904 scopus 로고    scopus 로고
    • Phase III randomized trial of very accelerated radiation therapy compared with conventional radiation therapy in squamous cell head and neck cancer: a GORTEC trial
    • Bourhis J et al (2006) Phase III randomized trial of very accelerated radiation therapy compared with conventional radiation therapy in squamous cell head and neck cancer: a GORTEC trial. Clin Oncol 24:2873–2878. doi:10.1200/JCO.2006.08.057
    • (2006) Clin Oncol , vol.24 , pp. 2873-2878
    • Bourhis, J.1
  • 18
    • 0036707711 scopus 로고    scopus 로고
    • Shoulder movement after breast cancer surgery: results of a randomised controlled study of postoperative physiotherapy
    • PID: 12500933
    • Box RC, Reul-Hirche HM, Bullock-Saxton JE, Furnival CM (2002) Shoulder movement after breast cancer surgery: results of a randomised controlled study of postoperative physiotherapy. Breast Cancer Res Treat 75:35–50
    • (2002) Breast Cancer Res Treat , vol.75 , pp. 35-50
    • Box, R.C.1    Reul-Hirche, H.M.2    Bullock-Saxton, J.E.3    Furnival, C.M.4
  • 19
    • 0031897649 scopus 로고    scopus 로고
    • Molecular and cellular basis of radiation fibrosis
    • COI: 1:CAS:528:DyaK1cXivF2htrs%3D, PID: 9587078
    • Burger A, Loffler H, Bamberg M, Rodemann HP (1998) Molecular and cellular basis of radiation fibrosis. Int J Radiat Biol 73:401–408
    • (1998) Int J Radiat Biol , vol.73 , pp. 401-408
    • Burger, A.1    Loffler, H.2    Bamberg, M.3    Rodemann, H.P.4
  • 20
    • 33644839430 scopus 로고    scopus 로고
    • Partial volume rat lung irradiation: temporal fluctuations of in-field and out-of-field DNA damage and inflammatory cytokines following irradiation
    • COI: 1:CAS:528:DC%2BD28XitVOgt7c%3D, PID: 16524844
    • Calveley VL, Khan MA, Yeung IW, Vandyk J, Hill RP (2005) Partial volume rat lung irradiation: temporal fluctuations of in-field and out-of-field DNA damage and inflammatory cytokines following irradiation. Int J Radiat Biol 81:887–899. doi:10.1080/09553000600568002
    • (2005) Int J Radiat Biol , vol.81 , pp. 887-899
    • Calveley, V.L.1    Khan, M.A.2    Yeung, I.W.3    Vandyk, J.4    Hill, R.P.5
  • 21
    • 3142686722 scopus 로고    scopus 로고
    • Topical superoxide dismutase reduces post-irradiation breast cancer fibrosis
    • COI: 1:CAS:528:DC%2BD2MXlt1Kquro%3D, PID: 15090266
    • Campana F et al (2004) Topical superoxide dismutase reduces post-irradiation breast cancer fibrosis. J Cell Mol Med 8:109–116
    • (2004) J Cell Mol Med , vol.8 , pp. 109-116
    • Campana, F.1
  • 22
    • 84951570938 scopus 로고    scopus 로고
    • Camphausen K (2013) Pirfenidone in treating patients with fibrosis caused by radiation therapy for cancer. Accessed 23 Oct 2014
    • Camphausen K (2013) Pirfenidone in treating patients with fibrosis caused by radiation therapy for cancer. https://clinicaltrials.gov/ct2/show/NCT00020631. Accessed 23 Oct 2014
  • 23
    • 0043197852 scopus 로고    scopus 로고
    • Intracellular antioxidants: from chemical to biochemical mechanisms
    • COI: 1:CAS:528:DyaK1MXnsFSku7k%3D, PID: 10541450
    • Chaudiere J, Ferrari-Iliou R (1999) Intracellular antioxidants: from chemical to biochemical mechanisms. Food Chem Toxicol 37:949–962
    • (1999) Food Chem Toxicol , vol.37 , pp. 949-962
    • Chaudiere, J.1    Ferrari-Iliou, R.2
  • 24
    • 84924503572 scopus 로고    scopus 로고
    • Association of and gene haplotypes with the development of radiation-induced fibrosis in patients with nasopharyngeal carcinoma
    • COI: 1:CAS:528:DC%2BC2cXhsVajsrnE, PID: 24940494
    • Cheuk IW, Yip SP, Kwong DL, Wu VW (2014) Association of and gene haplotypes with the development of radiation-induced fibrosis in patients with nasopharyngeal carcinoma. Mol Clin Oncol 2:553–558. doi:10.3892/mco.2014.276
    • (2014) Mol Clin Oncol , vol.2 , pp. 553-558
    • Cheuk, I.W.1    Yip, S.P.2    Kwong, D.L.3    Wu, V.W.4
  • 25
    • 0031975533 scopus 로고    scopus 로고
    • Influence of Aloe vera on the glycosaminoglycans in the matrix of healing dermal wounds in rats
    • COI: 1:STN:280:DyaK1c7mslehsg%3D%3D, PID: 9507902
    • Chithra P, Sajithlal GB, Chandrakasan G (1998) Influence of Aloe vera on the glycosaminoglycans in the matrix of healing dermal wounds in rats. J Ethnopharmacol 59:179–186
    • (1998) J Ethnopharmacol , vol.59 , pp. 179-186
    • Chithra, P.1    Sajithlal, G.B.2    Chandrakasan, G.3
  • 26
    • 0034906761 scopus 로고    scopus 로고
    • A pilot study of pentoxifylline in the treatment of radiation-induced trismus
    • COI: 1:STN:280:DC%2BD3MvislSjtA%3D%3D, PID: 11474263
    • Chua DT, Lo C, Yuen J, Foo YC (2001) A pilot study of pentoxifylline in the treatment of radiation-induced trismus. Am J Clin Oncol 24:366–369
    • (2001) Am J Clin Oncol , vol.24 , pp. 366-369
    • Chua, D.T.1    Lo, C.2    Yuen, J.3    Foo, Y.C.4
  • 27
    • 4444278103 scopus 로고    scopus 로고
    • Antitumor histone deacetylase inhibitors suppress cutaneous radiation syndrome: implications for increasing therapeutic gain in cancer radiotherapy
    • COI: 1:CAS:528:DC%2BD2cXitFCns7g%3D, PID: 15026552
    • Chung YL, Wang AJ, Yao LF (2004) Antitumor histone deacetylase inhibitors suppress cutaneous radiation syndrome: implications for increasing therapeutic gain in cancer radiotherapy. Mol Cancer Ther 3:317–325
    • (2004) Mol Cancer Ther , vol.3 , pp. 317-325
    • Chung, Y.L.1    Wang, A.J.2    Yao, L.F.3
  • 28
    • 0028917283 scopus 로고
    • Late effects of radiation therapy on the gastrointestinal tract
    • COI: 1:STN:280:DyaK2M3ivFCktg%3D%3D, PID: 7713784
    • Coia LR, Myerson RJ, Tepper JE (1995) Late effects of radiation therapy on the gastrointestinal tract. Int J Radiat Oncol Biol Phys 31:1213–1236. doi:10.1016/0360-3016(94)00419-l
    • (1995) Int J Radiat Oncol Biol Phys , vol.31 , pp. 1213-1236
    • Coia, L.R.1    Myerson, R.J.2    Tepper, J.E.3
  • 29
    • 33846573898 scopus 로고    scopus 로고
    • Fibroblast differentiation in wound healing and fibrosis
    • COI: 1:CAS:528:DC%2BD2sXmt1Glu70%3D, PID: 17280897
    • Darby IA, Hewitson TD (2007) Fibroblast differentiation in wound healing and fibrosis. Int Rev Cytol 257:143–179. doi:10.1016/S0074-7696(07)57004-X
    • (2007) Int Rev Cytol , vol.257 , pp. 143-179
    • Darby, I.A.1    Hewitson, T.D.2
  • 30
    • 0030133352 scopus 로고    scopus 로고
    • Blood radicals: reactive nitrogen species, reactive oxygen species, transition metal ions, and the vascular system
    • COI: 1:CAS:528:DyaK28XivFaquro%3D, PID: 8860419
    • Darley-Usmar V, Halliwell B (1996) Blood radicals: reactive nitrogen species, reactive oxygen species, transition metal ions, and the vascular system. Pharm Res 13:649–662
    • (1996) Pharm Res , vol.13 , pp. 649-662
    • Darley-Usmar, V.1    Halliwell, B.2
  • 31
    • 20944438542 scopus 로고    scopus 로고
    • Late radiation morbidity following randomization to preoperative versus postoperative radiotherapy in extremity soft tissue sarcoma
    • Davis AM et al (2005) Late radiation morbidity following randomization to preoperative versus postoperative radiotherapy in extremity soft tissue sarcoma. Radiother Oncol J Eur Soc Ther Radiol Oncol 75:48–53
    • (2005) Radiother Oncol J Eur Soc Ther Radiol Oncol , vol.75 , pp. 48-53
    • Davis, A.M.1
  • 32
    • 0036079356 scopus 로고    scopus 로고
    • Complete healing of severe osteoradionecrosis with treatment combining pentoxifylline, tocopherol and clodronate
    • COI: 1:CAS:528:DC%2BD38Xlt1Ort7g%3D, PID: 12036843
    • Delanian S, Lefaix JL (2002) Complete healing of severe osteoradionecrosis with treatment combining pentoxifylline, tocopherol and clodronate. Br J Radiol 75:467–469
    • (2002) Br J Radiol , vol.75 , pp. 467-469
    • Delanian, S.1    Lefaix, J.L.2
  • 34
    • 0032886276 scopus 로고    scopus 로고
    • Striking regression of chronic radiotherapy damage in a clinical trial of combined pentoxifylline and tocopherol
    • COI: 1:CAS:528:DyaK1MXmslGmtbw%3D, PID: 10506631
    • Delanian S, Balla-Mekias S, Lefaix JL (1999) Striking regression of chronic radiotherapy damage in a clinical trial of combined pentoxifylline and tocopherol. J Clin Oncol 17:3283–3290
    • (1999) J Clin Oncol , vol.17 , pp. 3283-3290
    • Delanian, S.1    Balla-Mekias, S.2    Lefaix, J.L.3
  • 35
    • 0035282768 scopus 로고    scopus 로고
    • Cu/Zn superoxide dismutase modulates phenotypic changes in cultured fibroblasts from human skin with chronic radiotherapy damage
    • COI: 1:CAS:528:DC%2BD3MXhsFSisL8%3D
    • Delanian S, Martin M, Bravard A, Luccioni C, Lefaix JL (2001) Cu/Zn superoxide dismutase modulates phenotypic changes in cultured fibroblasts from human skin with chronic radiotherapy damage. Radiother Oncol J Eur Soc Ther Radiol Oncol 58:325–331
    • (2001) Radiother Oncol J Eur Soc Ther Radiol Oncol , vol.58 , pp. 325-331
    • Delanian, S.1    Martin, M.2    Bravard, A.3    Luccioni, C.4    Lefaix, J.L.5
  • 36
    • 13244267161 scopus 로고    scopus 로고
    • Major healing of refractory mandible osteoradionecrosis after treatment combining pentoxifylline and tocopherol: a phase II trial
    • PID: 15641107
    • Delanian S, Depondt J, Lefaix JL (2005) Major healing of refractory mandible osteoradionecrosis after treatment combining pentoxifylline and tocopherol: a phase II trial. Head Neck 27:114–123. doi:10.1002/hed.20121
    • (2005) Head Neck , vol.27 , pp. 114-123
    • Delanian, S.1    Depondt, J.2    Lefaix, J.L.3
  • 37
    • 84922935276 scopus 로고    scopus 로고
    • Development and preliminary testing of head and neck cancer related external lymphedema and fibrosis assessment criteria
    • PID: 25190635
    • Deng J, Ridner SH, Wells N, Dietrich MS, Murphy BA (2014) Development and preliminary testing of head and neck cancer related external lymphedema and fibrosis assessment criteria. Eur J Oncol Nurs. doi:10.1016/j.ejon.2014.07.006
    • (2014) Eur J Oncol Nurs
    • Deng, J.1    Ridner, S.H.2    Wells, N.3    Dietrich, M.S.4    Murphy, B.A.5
  • 39
    • 5644257145 scopus 로고    scopus 로고
    • Trismus in head and neck oncology: a systematic review
    • COI: 1:STN:280:DC%2BD2cvntFWhug%3D%3D, PID: 15380165
    • Dijkstra PU, Kalk WW, Roodenburg JL (2004) Trismus in head and neck oncology: a systematic review. Oral Oncol 40:879–889. doi:10.1016/j.oraloncology.2004.04.003
    • (2004) Oral Oncol , vol.40 , pp. 879-889
    • Dijkstra, P.U.1    Kalk, W.W.2    Roodenburg, J.L.3
  • 40
    • 33847388792 scopus 로고    scopus 로고
    • Randomised trial of standard 2D radiotherapy (RT) versus intensity modulated radiotherapy (IMRT) in patients prescribed breast radiotherapy
    • Donovan E et al (2007) Randomised trial of standard 2D radiotherapy (RT) versus intensity modulated radiotherapy (IMRT) in patients prescribed breast radiotherapy. Radiother Oncol J Eur Soc Ther Radiol Oncol 82:254–264. doi:10.1016/j.radonc.2006.12.008
    • (2007) Radiother Oncol J Eur Soc Ther Radiol Oncol , vol.82 , pp. 254-264
    • Donovan, E.1
  • 41
  • 42
    • 34548588792 scopus 로고    scopus 로고
    • Linkage disequilibrium pattern of the ATM gene in breast cancer patients and controls; association of SNPs and haplotypes to radio-sensitivity and post-lumpectomy local recurrence
    • PID: 17623063
    • Edvardsen H et al (2007) Linkage disequilibrium pattern of the ATM gene in breast cancer patients and controls; association of SNPs and haplotypes to radio-sensitivity and post-lumpectomy local recurrence. Radiat Oncol 2:25. doi:10.1186/1748-717X-2-25
    • (2007) Radiat Oncol , vol.2 , pp. 25
    • Edvardsen, H.1
  • 43
    • 84879215288 scopus 로고    scopus 로고
    • SNP in TXNRD2 associated with radiation-induced fibrosis: a study of genetic variation in reactive oxygen species metabolism and signaling
    • COI: 1:CAS:528:DC%2BC3sXmtV2msLw%3D, PID: 23597419
    • Edvardsen H et al (2013) SNP in TXNRD2 associated with radiation-induced fibrosis: a study of genetic variation in reactive oxygen species metabolism and signaling. Int J Radiat Oncol Biol Phys 86:791–799. doi:10.1016/j.ijrobp.2013.02.025
    • (2013) Int J Radiat Oncol Biol Phys , vol.86 , pp. 791-799
    • Edvardsen, H.1
  • 44
    • 0042931224 scopus 로고    scopus 로고
    • Salivary gland sparing and improved target irradiation by conformal and intensity modulated irradiation of head and neck cancer
    • PID: 14509515
    • Eisbruch A et al (2003) Salivary gland sparing and improved target irradiation by conformal and intensity modulated irradiation of head and neck cancer. World J Surg 27:832–837
    • (2003) World J Surg , vol.27 , pp. 832-837
    • Eisbruch, A.1
  • 45
    • 0032764049 scopus 로고    scopus 로고
    • Free radicals and hearing. Cause, consequence, and criteria
    • COI: 1:CAS:528:DC%2BD3cXhsV2itA%3D%3D, PID: 10842581
    • Evans P, Halliwell B (1999) Free radicals and hearing. Cause, consequence, and criteria. Ann N Y Acad Sci 884:19–40
    • (1999) Ann N Y Acad Sci , vol.884 , pp. 19-40
    • Evans, P.1    Halliwell, B.2
  • 46
    • 0023213304 scopus 로고
    • Use of steroids to suppress vascular response to radiation
    • COI: 1:CAS:528:DyaL2sXhvFWqsLg%3D, PID: 3558047
    • Evans ML, Graham MM, Mahler PA, Rasey JS (1987) Use of steroids to suppress vascular response to radiation. Int J Radiat Oncol Biol Phys 13:563–567
    • (1987) Int J Radiat Oncol Biol Phys , vol.13 , pp. 563-567
    • Evans, M.L.1    Graham, M.M.2    Mahler, P.A.3    Rasey, J.S.4
  • 47
    • 0031216478 scopus 로고    scopus 로고
    • Particulate-cell interactions and pulmonary cytokine expression
    • COI: 1:CAS:528:DyaK2sXns1Onuro%3D, PID: 9400720
    • Finkelstein JN, Johnston C, Barrett T, Oberdorster G (1997) Particulate-cell interactions and pulmonary cytokine expression. Environ Health Perspect 105(Suppl 5):1179–1182
    • (1997) Environ Health Perspect , vol.105 , pp. 1179-1182
    • Finkelstein, J.N.1    Johnston, C.2    Barrett, T.3    Oberdorster, G.4
  • 48
    • 0034623147 scopus 로고    scopus 로고
    • Transforming growth factor-beta 1-induced activation of the ERK pathway/activator protein-1 in human lung fibroblasts requires the autocrine induction of basic fibroblast growth factor
    • COI: 1:CAS:528:DC%2BD3cXmsVKlur0%3D, PID: 10862759
    • Finlay GA, Thannickal VJ, Fanburg BL, Paulson KE (2000) Transforming growth factor-beta 1-induced activation of the ERK pathway/activator protein-1 in human lung fibroblasts requires the autocrine induction of basic fibroblast growth factor. J Biol Chem 275:27650–27656. doi:10.1074/jbc.M000893200
    • (2000) J Biol Chem , vol.275 , pp. 27650-27656
    • Finlay, G.A.1    Thannickal, V.J.2    Fanburg, B.L.3    Paulson, K.E.4
  • 49
    • 84863325122 scopus 로고    scopus 로고
    • LY2109761 attenuates radiation-induced pulmonary murine fibrosis via reversal of TGF-beta and BMP-associated proinflammatory and proangiogenic signals
    • COI: 1:CAS:528:DC%2BC38XpvVOjtLg%3D, PID: 22547771
    • Flechsig P et al (2012) LY2109761 attenuates radiation-induced pulmonary murine fibrosis via reversal of TGF-beta and BMP-associated proinflammatory and proangiogenic signals. Clin Cancer Res 18:3616–3627. doi:10.1158/1078-0432.CCR-11-2855
    • (2012) Clin Cancer Res , vol.18 , pp. 3616-3627
    • Flechsig, P.1
  • 50
    • 84856330228 scopus 로고    scopus 로고
    • Adoptive transfer of IL-4Ralpha + macrophages is sufficient to enhance eosinophilic inflammation in a mouse model of allergic lung inflammation
    • COI: 1:CAS:528:DC%2BC38Xkslagt7k%3D, PID: 22292924
    • Ford AQ, Dasgupta P, Mikhailenko I, Smith EM, Noben-Trauth N, Keegan AD (2012) Adoptive transfer of IL-4Ralpha + macrophages is sufficient to enhance eosinophilic inflammation in a mouse model of allergic lung inflammation. BMC Immunol 13:6. doi:10.1186/1471-2172-13-6
    • (2012) BMC Immunol , vol.13 , pp. 6
    • Ford, A.Q.1    Dasgupta, P.2    Mikhailenko, I.3    Smith, E.M.4    Noben-Trauth, N.5    Keegan, A.D.6
  • 51
    • 84888141459 scopus 로고    scopus 로고
    • Enalapril mitigates radiation-induced pneumonitis and pulmonary fibrosis if started 35 days after whole-thorax irradiation
    • COI: 1:CAS:528:DC%2BC3sXhvFCisLrI, PID: 24131041
    • Gao F, Fish BL, Moulder JE, Jacobs ER, Medhora M (2013) Enalapril mitigates radiation-induced pneumonitis and pulmonary fibrosis if started 35 days after whole-thorax irradiation. Radiat Res 180:546–552. doi:10.1667/RR13350.1
    • (2013) Radiat Res , vol.180 , pp. 546-552
    • Gao, F.1    Fish, B.L.2    Moulder, J.E.3    Jacobs, E.R.4    Medhora, M.5
  • 52
    • 0032076253 scopus 로고    scopus 로고
    • Factors influencing the development of lung fibrosis after chemoradiation for small cell carcinoma of the lung: evidence for inherent interindividual variation
    • COI: 1:STN:280:DyaK1c3mvVemug%3D%3D, PID: 9607342
    • Geara FB, Komaki R, Tucker SL, Travis EL, Cox JD (1998) Factors influencing the development of lung fibrosis after chemoradiation for small cell carcinoma of the lung: evidence for inherent interindividual variation. Int J Radiat Oncol Biol Phys 41:279–286
    • (1998) Int J Radiat Oncol Biol Phys , vol.41 , pp. 279-286
    • Geara, F.B.1    Komaki, R.2    Tucker, S.L.3    Travis, E.L.4    Cox, J.D.5
  • 53
    • 33846219922 scopus 로고    scopus 로고
    • Radiotherapy for malignancy in patients with scleroderma: the Mayo Clinic experience
    • PID: 17236971
    • Gold DG, Miller RC, Petersen IA, Osborn TG (2007) Radiotherapy for malignancy in patients with scleroderma: the Mayo Clinic experience. Int J Radiat Oncol Biol Phys 67:559–567. doi:10.1016/j.ijrobp.2006.09.003
    • (2007) Int J Radiat Oncol Biol Phys , vol.67 , pp. 559-567
    • Gold, D.G.1    Miller, R.C.2    Petersen, I.A.3    Osborn, T.G.4
  • 54
    • 77953268611 scopus 로고    scopus 로고
    • Alternative activation of macrophages: mechanism and functions
    • COI: 1:CAS:528:DC%2BC3cXnt1Kls78%3D, PID: 20510870
    • Gordon S, Martinez FO (2010) Alternative activation of macrophages: mechanism and functions. Immunity 32:593–604. doi:10.1016/j.immuni.2010.05.007
    • (2010) Immunity , vol.32 , pp. 593-604
    • Gordon, S.1    Martinez, F.O.2
  • 55
    • 84863790153 scopus 로고    scopus 로고
    • Inhibition of serine palmitoyltransferase delays the onset of radiation-induced pulmonary fibrosis through the negative regulation of sphingosine kinase-1 expression
    • COI: 1:CAS:528:DC%2BC38XhtFSqtLrL, PID: 22615416
    • Gorshkova I et al (2012) Inhibition of serine palmitoyltransferase delays the onset of radiation-induced pulmonary fibrosis through the negative regulation of sphingosine kinase-1 expression. J Lipid Res 53:1553–1568. doi:10.1194/jlr.M026039
    • (2012) J Lipid Res , vol.53 , pp. 1553-1568
    • Gorshkova, I.1
  • 56
    • 84883463962 scopus 로고    scopus 로고
    • Inhibition of sphingosine-1-phosphate lyase rescues sphingosine kinase-1-knockout phenotype following murine cardiac arrest
    • COI: 1:CAS:528:DC%2BC3sXht12isbrJ, PID: 23892195
    • Gorshkova IA et al (2013) Inhibition of sphingosine-1-phosphate lyase rescues sphingosine kinase-1-knockout phenotype following murine cardiac arrest. Life Sci 93:359–366. doi:10.1016/j.lfs.2013.07.017
    • (2013) Life Sci , vol.93 , pp. 359-366
    • Gorshkova, I.A.1
  • 57
    • 0032840324 scopus 로고    scopus 로고
    • Clinical dose-volume histogram analysis for pneumonitis after 3D treatment for non-small cell lung cancer (NSCLC)
    • COI: 1:STN:280:DyaK1MvhsFCqsQ%3D%3D, PID: 10487552
    • Graham MV, Purdy JA, Emami B, Harms W, Bosch W, Lockett MA, Perez CA (1999) Clinical dose-volume histogram analysis for pneumonitis after 3D treatment for non-small cell lung cancer (NSCLC). Int J Radiat Oncol Biol Phys 45:323–329
    • (1999) Int J Radiat Oncol Biol Phys , vol.45 , pp. 323-329
    • Graham, M.V.1    Purdy, J.A.2    Emami, B.3    Harms, W.4    Bosch, W.5    Lockett, M.A.6    Perez, C.A.7
  • 58
    • 33847775630 scopus 로고    scopus 로고
    • A mobilization regimen to prevent mandibular hypomobility in irradiated patients: an analysis and comparison of two techniques
    • PID: 17322796
    • Grandi G, Silva ML, Streit C, Wagner JC (2007) A mobilization regimen to prevent mandibular hypomobility in irradiated patients: an analysis and comparison of two techniques. Med Oral Patol Oral Cir Bucal 12:E105–E109
    • (2007) Med Oral Patol Oral Cir Bucal , vol.12 , pp. E105-E109
    • Grandi, G.1    Silva, M.L.2    Streit, C.3    Wagner, J.C.4
  • 60
    • 0017351372 scopus 로고
    • Pulmonary effects of radiation therapy
    • COI: 1:STN:280:DyaE2s7htVSqtA%3D%3D, PID: 319723
    • Gross NJ (1977) Pulmonary effects of radiation therapy. Ann Intern Med 86:81–92
    • (1977) Ann Intern Med , vol.86 , pp. 81-92
    • Gross, N.J.1
  • 61
    • 84867076119 scopus 로고    scopus 로고
    • Three-dimensional conformal radiotherapy (3D-CRT) versus intensity modulated radiation therapy (IMRT) in squamous cell carcinoma of the head and neck: a randomized controlled trial
    • COI: 1:CAS:528:DC%2BC38XhsVSqtrzK
    • Gupta T et al (2012) Three-dimensional conformal radiotherapy (3D-CRT) versus intensity modulated radiation therapy (IMRT) in squamous cell carcinoma of the head and neck: a randomized controlled trial. Radiother Oncol J Eur Soc Ther Radiol Oncol 104:343–348. doi:10.1016/j.radonc.2012.07.001
    • (2012) Radiother Oncol J Eur Soc Ther Radiol Oncol , vol.104 , pp. 343-348
    • Gupta, T.1
  • 62
    • 0037094284 scopus 로고    scopus 로고
    • Effects of intercellular adhesion molecule 1 (ICAM-1) null mutation on radiation-induced pulmonary fibrosis and respiratory insufficiency in mice
    • COI: 1:CAS:528:DC%2BD38XksVSmtrg%3D, PID: 12011223
    • Hallahan DE, Geng L, Shyr Y (2002) Effects of intercellular adhesion molecule 1 (ICAM-1) null mutation on radiation-induced pulmonary fibrosis and respiratory insufficiency in mice. J Natl Cancer Inst 94:733–741
    • (2002) J Natl Cancer Inst , vol.94 , pp. 733-741
    • Hallahan, D.E.1    Geng, L.2    Shyr, Y.3
  • 63
    • 0030468443 scopus 로고    scopus 로고
    • The assessment of doses and effects from intakes of radioactive particles
    • COI: 1:CAS:528:DyaK2sXlvVOrtQ%3D%3D, PID: 8982826
    • Harrison JD, Stather JW (1996) The assessment of doses and effects from intakes of radioactive particles. J Anat 189(Pt 3):521–530
    • (1996) J Anat , vol.189 , pp. 521-530
    • Harrison, J.D.1    Stather, J.W.2
  • 65
    • 0030724619 scopus 로고    scopus 로고
    • Murine susceptibility to radiation-induced pulmonary fibrosis is influenced by a genetic factor implicated in susceptibility to bleomycin-induced pulmonary fibrosis
    • COI: 1:CAS:528:DyaK2sXnslGru7s%3D, PID: 9393751
    • Haston CK, Travis EL (1997) Murine susceptibility to radiation-induced pulmonary fibrosis is influenced by a genetic factor implicated in susceptibility to bleomycin-induced pulmonary fibrosis. Cancer Res 57:5286–5291
    • (1997) Cancer Res , vol.57 , pp. 5286-5291
    • Haston, C.K.1    Travis, E.L.2
  • 66
    • 0036645068 scopus 로고    scopus 로고
    • Universal and radiation-specific loci influence murine susceptibility to radiation-induced pulmonary fibrosis
    • COI: 1:CAS:528:DC%2BD38XltF2jurw%3D, PID: 12097289
    • Haston CK et al (2002) Universal and radiation-specific loci influence murine susceptibility to radiation-induced pulmonary fibrosis. Cancer Res 62:3782–3788
    • (2002) Cancer Res , vol.62 , pp. 3782-3788
    • Haston, C.K.1
  • 67
    • 36348969634 scopus 로고    scopus 로고
    • Distinct loci influence radiation-induced alveolitis from fibrosing alveolitis in the mouse
    • COI: 1:CAS:528:DC%2BD2sXhtlSls7fO, PID: 18006824
    • Haston CK, Begin M, Dorion G, Cory SM (2007) Distinct loci influence radiation-induced alveolitis from fibrosing alveolitis in the mouse. Cancer Res 67:10796–10803. doi:10.1158/0008-5472.CAN-07-2733
    • (2007) Cancer Res , vol.67 , pp. 10796-10803
    • Haston, C.K.1    Begin, M.2    Dorion, G.3    Cory, S.M.4
  • 68
    • 33644781743 scopus 로고    scopus 로고
    • Influence of connective tissue diseases on the expression of radiation side effects: a systematic review
    • Holscher T, Bentzen SM, Baumann M (2006) Influence of connective tissue diseases on the expression of radiation side effects: a systematic review. Radiother Oncol J Eur Soc Ther Radiol Oncol 78:123–130. doi:10.1016/j.radonc.2005.12.013
    • (2006) Radiother Oncol J Eur Soc Ther Radiol Oncol , vol.78 , pp. 123-130
    • Holscher, T.1    Bentzen, S.M.2    Baumann, M.3
  • 69
    • 84874614101 scopus 로고    scopus 로고
    • Inhibition of radiation-induced skin fibrosis with imatinib
    • COI: 1:CAS:528:DC%2BC3sXjtlGguro%3D, PID: 23083077
    • Horton JA et al (2013a) Inhibition of radiation-induced skin fibrosis with imatinib. Int J Radiat Biol 89:162–170. doi:10.3109/09553002.2013.741281
    • (2013) Int J Radiat Biol , vol.89 , pp. 162-170
    • Horton, J.A.1
  • 70
    • 84887897144 scopus 로고    scopus 로고
    • Mesenchymal stem cells inhibit cutaneous radiation-induced fibrosis by suppressing chronic inflammation
    • COI: 1:CAS:528:DC%2BC3sXhvVCjsL7F, PID: 23897677
    • Horton JA, Hudak KE, Chung EJ, White AO, Scroggins BT, Burkeen JF, Citrin DE (2013b) Mesenchymal stem cells inhibit cutaneous radiation-induced fibrosis by suppressing chronic inflammation. Stem Cells 31:2231–2241. doi:10.1002/stem.1483
    • (2013) Stem Cells , vol.31 , pp. 2231-2241
    • Horton, J.A.1    Hudak, K.E.2    Chung, E.J.3    White, A.O.4    Scroggins, B.T.5    Burkeen, J.F.6    Citrin, D.E.7
  • 71
    • 84882280634 scopus 로고    scopus 로고
    • Quercetin inhibits radiation-induced skin fibrosis
    • COI: 1:CAS:528:DC%2BC3sXhsVSgt7fM, PID: 23819596
    • Horton JA et al (2013c) Quercetin inhibits radiation-induced skin fibrosis. Radiat Res 180:205–215. doi:10.1667/RR3237.1
    • (2013) Radiat Res , vol.180 , pp. 205-215
    • Horton, J.A.1
  • 72
    • 13844256107 scopus 로고    scopus 로고
    • Strain dependent differences in a histological study of CD44 and collagen fibers with an expression analysis of inflammatory response-related genes in irradiated murine lung
    • COI: 1:CAS:528:DC%2BD2MXisVOqsb4%3D, PID: 15613788
    • Iwakawa M et al (2004) Strain dependent differences in a histological study of CD44 and collagen fibers with an expression analysis of inflammatory response-related genes in irradiated murine lung. J Radiat Res 45:423–433
    • (2004) J Radiat Res , vol.45 , pp. 423-433
    • Iwakawa, M.1
  • 73
    • 84873320445 scopus 로고    scopus 로고
    • Randomized trial of pentoxifylline and vitamin E vs standard follow-up after breast irradiation to prevent breast fibrosis, evaluated by tissue compliance meter
    • COI: 1:CAS:528:DC%2BC38XhtFahsb3M, PID: 22846413
    • Jacobson G, Bhatia S, Smith BJ, Button AM, Bodeker K, Buatti J (2013) Randomized trial of pentoxifylline and vitamin E vs standard follow-up after breast irradiation to prevent breast fibrosis, evaluated by tissue compliance meter. Int J Radiat Oncol Biol Phys 85:604–608. doi:10.1016/j.ijrobp.2012.06.042
    • (2013) Int J Radiat Oncol Biol Phys , vol.85 , pp. 604-608
    • Jacobson, G.1    Bhatia, S.2    Smith, B.J.3    Button, A.M.4    Bodeker, K.5    Buatti, J.6
  • 74
    • 84951570939 scopus 로고    scopus 로고
    • Ji Y (2013) Efficiency study for acute radiation-induced and chemotherapy-induced pulmonary fibrosis with bevasizumab. Accessed 23 Oct 2014
    • Ji Y (2013) Efficiency study for acute radiation-induced and chemotherapy-induced pulmonary fibrosis with bevasizumab. https://clinicaltrials.gov/ct2/show/NCT01917877. Accessed 23 Oct 2014
  • 75
    • 84859832006 scopus 로고    scopus 로고
    • Long-term clinical outcome of intensity-modulated radiotherapy for inoperable non-small cell lung cancer: the MD Anderson experience
    • PID: 22079735
    • Jiang ZQ et al (2012) Long-term clinical outcome of intensity-modulated radiotherapy for inoperable non-small cell lung cancer: the MD Anderson experience. Int J Radiat Oncol Biol Phys 83:332–339. doi:10.1016/j.ijrobp.2011.06.1963
    • (2012) Int J Radiat Oncol Biol Phys , vol.83 , pp. 332-339
    • Jiang, Z.Q.1
  • 76
    • 0036535558 scopus 로고    scopus 로고
    • Dose response and latency for radiation-induced fibrosis, edema, and neuropathy in breast cancer patients
    • PID: 11955731
    • Johansson S, Svensson H, Denekamp J (2002) Dose response and latency for radiation-induced fibrosis, edema, and neuropathy in breast cancer patients. Int J Radiat Oncol Biol Phys 52:1207–1219
    • (2002) Int J Radiat Oncol Biol Phys , vol.52 , pp. 1207-1219
    • Johansson, S.1    Svensson, H.2    Denekamp, J.3
  • 77
    • 33645762347 scopus 로고    scopus 로고
    • Preliminary investigation of symptom distress in the head and neck patient population: validation of a measurement instrument
    • PID: 16601435
    • Jones HA et al (2006) Preliminary investigation of symptom distress in the head and neck patient population: validation of a measurement instrument. Am J Clin Oncol 29:158–162. doi:10.1097/01.coc.0000207424.62275.9d
    • (2006) Am J Clin Oncol , vol.29 , pp. 158-162
    • Jones, H.A.1
  • 79
    • 12244289275 scopus 로고    scopus 로고
    • Partial volume rat lung irradiation; assessment of early DNA damage in different lung regions and effect of radical scavengers
    • Khan MA, Van Dyk J, Yeung IW, Hill RP (2003) Partial volume rat lung irradiation; assessment of early DNA damage in different lung regions and effect of radical scavengers. Radiother Oncol J Eur Soc Ther Radiol Oncol 66:95–102
    • (2003) Radiother Oncol J Eur Soc Ther Radiol Oncol , vol.66 , pp. 95-102
    • Khan, M.A.1    Van Dyk, J.2    Yeung, I.W.3    Hill, R.P.4
  • 81
    • 77955007012 scopus 로고    scopus 로고
    • Inhibition of Smad3 expression in radiation-induced fibrosis using a novel method for topical transcutaneous gene therapy
    • PID: 20644068
    • Lee JW et al (2010) Inhibition of Smad3 expression in radiation-induced fibrosis using a novel method for topical transcutaneous gene therapy. Arch Otolaryngol Head Neck Surg 136:714–719. doi:10.1001/archoto.2010.107
    • (2010) Arch Otolaryngol Head Neck Surg , vol.136 , pp. 714-719
    • Lee, J.W.1
  • 82
    • 0031705636 scopus 로고    scopus 로고
    • Diagnosis of acute localized irradiation lesions: review of the French experimental experience
    • COI: 1:CAS:528:DyaK1cXmtF2itrY%3D, PID: 9753360
    • Lefaix JL, Daburon F (1998) Diagnosis of acute localized irradiation lesions: review of the French experimental experience. Health Phys 75:375–384
    • (1998) Health Phys , vol.75 , pp. 375-384
    • Lefaix, J.L.1    Daburon, F.2
  • 83
    • 77957229718 scopus 로고    scopus 로고
    • Angiogenesis and experimental hepatic fibrosis
    • COI: 1:CAS:528:DC%2BC3cXhsFWhurfK, PID: 20835605
    • Lemos QT, Andrade ZA (2010) Angiogenesis and experimental hepatic fibrosis. Mem Inst Oswaldo Cruz 105:611–614
    • (2010) Mem Inst Oswaldo Cruz , vol.105 , pp. 611-614
    • Lemos, Q.T.1    Andrade, Z.A.2
  • 84
    • 0036682445 scopus 로고    scopus 로고
    • Quantitative measurement of post-irradiation neck fibrosis based on the young modulus: description of a new method and clinical results
    • PID: 12209759
    • Leung SF, Zheng Y, Choi CY, Mak SS, Chiu SK, Zee B, Mak AF (2002) Quantitative measurement of post-irradiation neck fibrosis based on the young modulus: description of a new method and clinical results. Cancer 95:656–662. doi:10.1002/cncr.10700
    • (2002) Cancer , vol.95 , pp. 656-662
    • Leung, S.F.1    Zheng, Y.2    Choi, C.Y.3    Mak, S.S.4    Chiu, S.K.5    Zee, B.6    Mak, A.F.7
  • 85
    • 33646164362 scopus 로고    scopus 로고
    • Transforming growth factor-beta regulation of immune responses
    • COI: 1:CAS:528:DC%2BD28XkvFSqt7w%3D, PID: 16551245
    • Li MO, Wan YY, Sanjabi S, Robertson AK, Flavell RA (2006) Transforming growth factor-beta regulation of immune responses. Annu Rev Immunol 24:99–146. doi:10.1146/annurev.immunol.24.021605.090737
    • (2006) Annu Rev Immunol , vol.24 , pp. 99-146
    • Li, M.O.1    Wan, Y.Y.2    Sanjabi, S.3    Robertson, A.K.4    Flavell, R.A.5
  • 86
    • 34247848503 scopus 로고    scopus 로고
    • The role of PDGF in radiation oncology
    • COI: 1:CAS:528:DC%2BD2sXhtlertLzI, PID: 17217530
    • Li M, Jendrossek V, Belka C (2007) The role of PDGF in radiation oncology. Radiat Oncol 2:5. doi:10.1186/1748-717X-2-5
    • (2007) Radiat Oncol , vol.2 , pp. 5
    • Li, M.1    Jendrossek, V.2    Belka, C.3
  • 87
    • 49049115379 scopus 로고    scopus 로고
    • Factors associated with severe late toxicity after concurrent chemoradiation for locally advanced head and neck cancer: an RTOG analysis
    • COI: 1:CAS:528:DC%2BD1cXpvVWmtLc%3D, PID: 18559875
    • Machtay M et al (2008) Factors associated with severe late toxicity after concurrent chemoradiation for locally advanced head and neck cancer: an RTOG analysis. J Clin Oncol 26:3582–3589. doi:10.1200/JCO.2007.14.8841
    • (2008) J Clin Oncol , vol.26 , pp. 3582-3589
    • Machtay, M.1
  • 89
    • 0028908241 scopus 로고
    • The response of the urinary bladder, urethra, and ureter to radiation and chemotherapy
    • COI: 1:STN:280:DyaK2M3ivFCktQ%3D%3D, PID: 7713787
    • Marks LB, Carroll PR, Dugan TC, Anscher MS (1995) The response of the urinary bladder, urethra, and ureter to radiation and chemotherapy. Int J Radiat Oncol Biol Phys 31:1257–1280. doi:10.1016/0360-3016(94)00431-j
    • (1995) Int J Radiat Oncol Biol Phys , vol.31 , pp. 1257-1280
    • Marks, L.B.1    Carroll, P.R.2    Dugan, T.C.3    Anscher, M.S.4
  • 90
    • 0034178260 scopus 로고    scopus 로고
    • TGF-beta1 and radiation fibrosis: a master switch and a specific therapeutic target?
    • COI: 1:CAS:528:DC%2BD3cXjtVCitb4%3D, PID: 10802350
    • Martin M, Lefaix J, Delanian S (2000) TGF-beta1 and radiation fibrosis: a master switch and a specific therapeutic target? Int J Radiat Oncol Biol Phys 47:277–290
    • (2000) Int J Radiat Oncol Biol Phys , vol.47 , pp. 277-290
    • Martin, M.1    Lefaix, J.2    Delanian, S.3
  • 91
    • 84875710947 scopus 로고    scopus 로고
    • The cellular microenvironment of head and neck squamous cell carcinoma
    • InTech
    • Mathew M, Thomas SM (2012) The cellular microenvironment of head and neck squamous cell carcinoma. In: Li X (ed) Squamous cell carcinoma. InTech, pp 163–174. doi:10.5772/25652
    • (2012) Li X , pp. 163-174
    • Mathew, M.1    Thomas, S.M.2    carcinoma, S.C.3
  • 92
    • 79952204107 scopus 로고    scopus 로고
    • Simvastatin attenuates radiation-induced murine lung injury and dysregulated lung gene expression
    • COI: 1:CAS:528:DC%2BC3MXot1Kjsro%3D, PID: 20508068
    • Mathew B et al (2011) Simvastatin attenuates radiation-induced murine lung injury and dysregulated lung gene expression. Am J Respir Cell Mol Biol 44:415–422. doi:10.1165/rcmb.2010-0122OC
    • (2011) Am J Respir Cell Mol Biol , vol.44 , pp. 415-422
    • Mathew, B.1
  • 93
    • 69749090225 scopus 로고    scopus 로고
    • Exercise adherence in patients with trismus due to head and neck oncology: a qualitative study into the use of the Therabite
    • COI: 1:STN:280:DC%2BD1Mnhs1OqsQ%3D%3D, PID: 19414238
    • Melchers LJ, Van Weert E, Beurskens CH, Reintsema H, Slagter AP, Roodenburg JL, Dijkstra PU (2009) Exercise adherence in patients with trismus due to head and neck oncology: a qualitative study into the use of the Therabite. Int J Oral Maxillofac Surg 38:947–954. doi:10.1016/j.ijom.2009.04.003
    • (2009) Int J Oral Maxillofac Surg , vol.38 , pp. 947-954
    • Melchers, L.J.1    Van Weert, E.2    Beurskens, C.H.3    Reintsema, H.4    Slagter, A.P.5    Roodenburg, J.L.6    Dijkstra, P.U.7
  • 94
    • 0036127923 scopus 로고    scopus 로고
    • Microarray analysis indicates that pulmonary edema fluid from patients with acute lung injury mediates inflammation, mitogen gene expression, and fibroblast proliferation through bioactive interleukin-1
    • PID: 11893691
    • Olman MA, White KE, Ware LB, Cross MT, Zhu S, Matthay MA (2002) Microarray analysis indicates that pulmonary edema fluid from patients with acute lung injury mediates inflammation, mitogen gene expression, and fibroblast proliferation through bioactive interleukin-1. Chest 121:69S–70S
    • (2002) Chest , vol.121 , pp. 69S-70S
    • Olman, M.A.1    White, K.E.2    Ware, L.B.3    Cross, M.T.4    Zhu, S.5    Matthay, M.A.6
  • 95
    • 84951570940 scopus 로고    scopus 로고
    • Otón C (2013) Treatment of Radiation-induced Fibrosis in the Upper Aerodigestive Tract Cancer by a Combination of Pentoxifylline-tocopherol and Hyperbaric Oxygen (ORT-OXI-2009). Accessed 23 Oct 2014
    • Otón C (2013) Treatment of Radiation-induced Fibrosis in the Upper Aerodigestive Tract Cancer by a Combination of Pentoxifylline-tocopherol and Hyperbaric Oxygen (ORT-OXI-2009). https://clinicaltrials.gov/ct2/show/NCT01822405. Accessed 23 Oct 2014
  • 96
    • 33744938426 scopus 로고    scopus 로고
    • Matrix metalloproteases in aberrant fibrotic tissue remodeling
    • COI: 1:CAS:528:DC%2BD28XmtVOktrs%3D, PID: 16738205
    • Pardo A, Selman M (2006) Matrix metalloproteases in aberrant fibrotic tissue remodeling. Proceedings of the American Thoracic Society 3:383–388. doi:10.1513/pats.200601-012TK
    • (2006) Proceedings of the American Thoracic Society , vol.3 , pp. 383-388
    • Pardo, A.1    Selman, M.2
  • 97
    • 18344388096 scopus 로고    scopus 로고
    • Time course of pulmonary response of rats to inhalation of crystalline silica: NF-kappa B activation, inflammation, cytokine production, and damage
    • COI: 1:CAS:528:DC%2BD38Xjt1Gqs7k%3D
    • Porter DW et al (2002) Time course of pulmonary response of rats to inhalation of crystalline silica: NF-kappa B activation, inflammation, cytokine production, and damage. Inhalation Toxicol 14:349–367. doi:10.1080/08958370252870998
    • (2002) Inhalation Toxicol , vol.14 , pp. 349-367
    • Porter, D.W.1
  • 98
    • 0034162573 scopus 로고    scopus 로고
    • Definitive radiotherapy based on HDR brachytherapy with iridium 192 in uterine cervix carcinoma: report on the Vienna University Hospital findings (1993-1997) compared to the preceding period in the context of ICRU 38 recommendations
    • COI: 1:STN:280:DC%2BD3c3nt1ansA%3D%3D, PID: 10812362
    • Potter R, Knocke TH, Fellner C, Baldass M, Reinthaller A, Kucera H (2000) Definitive radiotherapy based on HDR brachytherapy with iridium 192 in uterine cervix carcinoma: report on the Vienna University Hospital findings (1993-1997) compared to the preceding period in the context of ICRU 38 recommendations. Cancer Radiother 4:159–172. doi:10.1016/s1278-3218(00)88900-3
    • (2000) Cancer Radiother , vol.4 , pp. 159-172
    • Potter, R.1    Knocke, T.H.2    Fellner, C.3    Baldass, M.4    Reinthaller, A.5    Kucera, H.6
  • 99
    • 37849008770 scopus 로고    scopus 로고
    • Inhibition of integrin alpha(v)beta6, an activator of latent transforming growth factor-beta, prevents radiation-induced lung fibrosis
    • COI: 1:CAS:528:DC%2BD1cXht12mt7g%3D, PID: 17916808
    • Puthawala K et al (2008) Inhibition of integrin alpha(v)beta6, an activator of latent transforming growth factor-beta, prevents radiation-induced lung fibrosis. Am J Respir Crit Care Med 177:82–90. doi:10.1164/rccm.200706-806OC
    • (2008) Am J Respir Crit Care Med , vol.177 , pp. 82-90
    • Puthawala, K.1
  • 101
    • 84951570941 scopus 로고    scopus 로고
    • Radiation Therapy Oncology Group (2014) Cooperative group common toxicity criteria. Accessed 23 Oct 2014
    • Radiation Therapy Oncology Group (2014) Cooperative group common toxicity criteria. http://www.rtog.org/ResearchAssociates/AdverseEventReporting/CooperativeGroupCommonToxicityCriteria.aspx. Accessed 23 Oct 2014
  • 103
    • 33748163045 scopus 로고    scopus 로고
    • Prevention and treatment of dysphagia and aspiration after chemoradiation for head and neck cancer
    • PID: 16763277
    • Rosenthal DI, Lewin JS, Eisbruch A (2006) Prevention and treatment of dysphagia and aspiration after chemoradiation for head and neck cancer. J Clin Oncol 24:2636–2643. doi:10.1200/JCO.2006.06.0079
    • (2006) J Clin Oncol , vol.24 , pp. 2636-2643
    • Rosenthal, D.I.1    Lewin, J.S.2    Eisbruch, A.3
  • 105
    • 31544436908 scopus 로고    scopus 로고
    • Oral complications of radiotherapy
    • PID: 16455482
    • Sciubba JJ, Goldenberg D (2006) Oral complications of radiotherapy. Lancet Oncol 7:175–183. doi:10.1016/S1470-2045(06)70580-0
    • (2006) Lancet Oncol , vol.7 , pp. 175-183
    • Sciubba, J.J.1    Goldenberg, D.2
  • 106
    • 0036857540 scopus 로고    scopus 로고
    • Effects of inflammatory cytokines on the permeability of human lung microvascular endothelial cell monolayers and differential eosinophil transmigration
    • COI: 1:CAS:528:DC%2BD38XpsFKmtbY%3D, PID: 12417884
    • Sedgwick JB, Menon I, Gern JE, Busse WW (2002) Effects of inflammatory cytokines on the permeability of human lung microvascular endothelial cell monolayers and differential eosinophil transmigration. J Allergy Clin Immunol 110:752–756
    • (2002) J Allergy Clin Immunol , vol.110 , pp. 752-756
    • Sedgwick, J.B.1    Menon, I.2    Gern, J.E.3    Busse, W.W.4
  • 107
    • 0024409891 scopus 로고
    • A quantitative histological study of strain-dependent differences in the effects of irradiation on mouse lung during the early phase
    • COI: 1:STN:280:DyaL1MzjtFyntg%3D%3D, PID: 2756101
    • Sharplin J, Franko AJ (1989) A quantitative histological study of strain-dependent differences in the effects of irradiation on mouse lung during the early phase. Radiat Res 119:1–14
    • (1989) Radiat Res , vol.119 , pp. 1-14
    • Sharplin, J.1    Franko, A.J.2
  • 108
    • 84892420931 scopus 로고    scopus 로고
    • Inhibition of the CXCL12/CXCR4-axis as preventive therapy for radiation-induced pulmonary fibrosis
    • COI: 1:CAS:528:DC%2BC3sXhslOjurjP, PID: 24244561
    • Shu HK et al (2013) Inhibition of the CXCL12/CXCR4-axis as preventive therapy for radiation-induced pulmonary fibrosis. PLoS ONE 8:e79768. doi:10.1371/journal.pone.0079768
    • (2013) PLoS ONE , vol.8 , pp. e79768
    • Shu, H.K.1
  • 109
    • 58749114205 scopus 로고    scopus 로고
    • Treating trismus with dynamic splinting: a cohort, case series
    • PID: 18227979
    • Shulman DH, Shipman B, Willis FB (2008) Treating trismus with dynamic splinting: a cohort, case series. Adv Ther 25:9–16. doi:10.1007/s12325-008-0007-0
    • (2008) Adv Ther , vol.25 , pp. 9-16
    • Shulman, D.H.1    Shipman, B.2    Willis, F.B.3
  • 110
    • 84857883847 scopus 로고    scopus 로고
    • Macrophage plasticity and polarization: in vivo veritas
    • COI: 1:CAS:528:DC%2BC38XjsV2ms7g%3D, PID: 22378047
    • Sica A, Mantovani A (2012) Macrophage plasticity and polarization: in vivo veritas. J Clin Investig 122:787–795. doi:10.1172/JCI59643
    • (2012) J Clin Investig , vol.122 , pp. 787-795
    • Sica, A.1    Mantovani, A.2
  • 111
    • 0036562520 scopus 로고    scopus 로고
    • Oral complications of cancer therapy Oncology (Williston Park, NY)
    • Sonis ST, Fey EG (2002) Oral complications of cancer therapy Oncology (Williston Park, NY) 16:680–686; discussion 686, 691–682, 695
    • (2002) 16:680–686; discussion , vol.691-682 , Issue.695 , pp. 686
    • Sonis, S.T.1    Fey, E.G.2
  • 112
    • 84951570943 scopus 로고    scopus 로고
    • Spanos W (2013) Study of topical superoxide dismutase to treat radiation induced fibrosis (Sodermix). Accessed 23 Oct 2014
    • Spanos W (2013) Study of topical superoxide dismutase to treat radiation induced fibrosis (Sodermix). https://clinicaltrials.gov/show/NCT01771991. Accessed 23 Oct 2014
  • 113
    • 77955627652 scopus 로고    scopus 로고
    • A preliminary report on the efficacy of a dynamic jaw opening device (dynasplint trismus system) as part of the multimodal treatment of trismus in patients with head and neck cancer
    • PID: 20684911
    • Stubblefield MD, Manfield L, Riedel ER (2010) A preliminary report on the efficacy of a dynamic jaw opening device (dynasplint trismus system) as part of the multimodal treatment of trismus in patients with head and neck cancer. Arch Phys Med Rehabil 91:1278–1282. doi:10.1016/j.apmr.2010.05.010
    • (2010) Arch Phys Med Rehabil , vol.91 , pp. 1278-1282
    • Stubblefield, M.D.1    Manfield, L.2    Riedel, E.R.3
  • 114
    • 84923331302 scopus 로고    scopus 로고
    • Significant fibrosis after radiation therapy in a patient with Marfan syndrome
    • PID: 25324993
    • Suarez EM, Knackstedt RJ, Jenrette JM (2014) Significant fibrosis after radiation therapy in a patient with Marfan syndrome. Radiat Oncol J 32:208–212. doi:10.3857/roj.2014.32.3.208
    • (2014) Radiat Oncol J , vol.32 , pp. 208-212
    • Suarez, E.M.1    Knackstedt, R.J.2    Jenrette, J.M.3
  • 115
    • 63049126565 scopus 로고    scopus 로고
    • The use of ebselen for radioprotection in cultured cells and mice
    • COI: 1:CAS:528:DC%2BD1MXkt1Shtbo%3D, PID: 19439217
    • Tak JK, Park JW (2009) The use of ebselen for radioprotection in cultured cells and mice. Free Radic Biol Med 46:1177–1185. doi:10.1016/j.freeradbiomed.2009.01.023
    • (2009) Free Radic Biol Med , vol.46 , pp. 1177-1185
    • Tak, J.K.1    Park, J.W.2
  • 116
    • 80053348598 scopus 로고    scopus 로고
    • Hydrogen therapy attenuates irradiation-induced lung damage by reducing oxidative stress
    • COI: 1:CAS:528:DC%2BC3MXhtlersbjE, PID: 21764987
    • Terasaki Y et al (2011) Hydrogen therapy attenuates irradiation-induced lung damage by reducing oxidative stress. Am J Physiol Lung Cell Mol Physiol 301:L415–L426. doi:10.1152/ajplung.00008.2011
    • (2011) Am J Physiol Lung Cell Mol Physiol , vol.301 , pp. L415-L426
    • Terasaki, Y.1
  • 117
    • 33646251828 scopus 로고    scopus 로고
    • Concurrent administration of adjuvant chemotherapy and radiotherapy after breast-conserving surgery enhances late toxicities: long-term results of the ARCOSEIN multicenter randomized study
    • COI: 1:CAS:528:DC%2BD28XksVCktLk%3D, PID: 16542788
    • Toledano A et al (2006) Concurrent administration of adjuvant chemotherapy and radiotherapy after breast-conserving surgery enhances late toxicities: long-term results of the ARCOSEIN multicenter randomized study. Int J Radiat Oncol Biol Phys 65:324–332. doi:10.1016/j.ijrobp.2005.12.020
    • (2006) Int J Radiat Oncol Biol Phys , vol.65 , pp. 324-332
    • Toledano, A.1
  • 118
    • 0036277026 scopus 로고    scopus 로고
    • Myofibroblasts and mechano-regulation of connective tissue remodelling
    • COI: 1:CAS:528:DC%2BD38XjsFOgsbw%3D, PID: 11988769
    • Tomasek JJ, Gabbiani G, Hinz B, Chaponnier C, Brown RA (2002) Myofibroblasts and mechano-regulation of connective tissue remodelling. Nat Rev Mol Cell Biol 3:349–363. doi:10.1038/nrm809
    • (2002) Nat Rev Mol Cell Biol , vol.3 , pp. 349-363
    • Tomasek, J.J.1    Gabbiani, G.2    Hinz, B.3    Chaponnier, C.4    Brown, R.A.5
  • 119
    • 0037198039 scopus 로고    scopus 로고
    • Approach of evolutionary theories of ageing, stress, senescence-like phenotypes, calorie restriction and hormesis from the view point of far-from-equilibrium thermodynamics
    • COI: 1:CAS:528:DC%2BD38XktFOlsr4%3D, PID: 12044942
    • Toussaint O, Remacle J, Dierick JF, Pascal T, Frippiat C, Royer V, Chainiaux F (2002) Approach of evolutionary theories of ageing, stress, senescence-like phenotypes, calorie restriction and hormesis from the view point of far-from-equilibrium thermodynamics. Mech Ageing Dev 123:937–946
    • (2002) Mech Ageing Dev , vol.123 , pp. 937-946
    • Toussaint, O.1    Remacle, J.2    Dierick, J.F.3    Pascal, T.4    Frippiat, C.5    Royer, V.6    Chainiaux, F.7
  • 120
    • 0034946073 scopus 로고    scopus 로고
    • Organizational response of normal tissues to irradiation
    • COI: 1:STN:280:DC%2BD3MzptlSgsw%3D%3D, PID: 11447575
    • Travis EL (2001) Organizational response of normal tissues to irradiation. Seminars in radiation oncology 11:184–196
    • (2001) Seminars in radiation oncology , vol.11 , pp. 184-196
    • Travis, E.L.1
  • 121
    • 84904207662 scopus 로고    scopus 로고
    • Patient-reported voice and speech outcomes after whole-neck intensity modulated radiation therapy and chemotherapy for oropharyngeal cancer: prospective longitudinal study
    • PID: 24803039
    • Vainshtein JM, Griffith KA, Feng FY, Vineberg KA, Chepeha DB, Eisbruch A (2014) Patient-reported voice and speech outcomes after whole-neck intensity modulated radiation therapy and chemotherapy for oropharyngeal cancer: prospective longitudinal study. Int J Radiat Oncol Biol Phys 89:973–980. doi:10.1016/j.ijrobp.2014.03.013
    • (2014) Int J Radiat Oncol Biol Phys , vol.89 , pp. 973-980
    • Vainshtein, J.M.1    Griffith, K.A.2    Feng, F.Y.3    Vineberg, K.A.4    Chepeha, D.B.5    Eisbruch, A.6
  • 122
    • 68649111832 scopus 로고    scopus 로고
    • Alternative activation of macrophages: immune function and cellular biology
    • COI: 1:CAS:528:DC%2BD1MXotFKis70%3D, PID: 19264378
    • Varin A, Gordon S (2009) Alternative activation of macrophages: immune function and cellular biology. Immunobiology 214:630–641. doi:10.1016/j.imbio.2008.11.009
    • (2009) Immunobiology , vol.214 , pp. 630-641
    • Varin, A.1    Gordon, S.2
  • 124
    • 79954997865 scopus 로고    scopus 로고
    • Treatment for radiation-induced pulmonary late effects: spoiled for choice or looking in the wrong direction?
    • COI: 1:CAS:528:DC%2BC3cXhsVKksb3F, PID: 20583979
    • Williams JP, Johnston CJ, Finkelstein JN (2010) Treatment for radiation-induced pulmonary late effects: spoiled for choice or looking in the wrong direction? Curr Drug Targets 11:1386–1394
    • (2010) Curr Drug Targets , vol.11 , pp. 1386-1394
    • Williams, J.P.1    Johnston, C.J.2    Finkelstein, J.N.3
  • 125
    • 2442481893 scopus 로고    scopus 로고
    • Amelioration of radiation-induced fibrosis: inhibition of transforming growth factor-beta signaling by halofuginone
    • COI: 1:CAS:528:DC%2BD2cXivVKgs70%3D, PID: 14732719
    • Xavier S et al (2004) Amelioration of radiation-induced fibrosis: inhibition of transforming growth factor-beta signaling by halofuginone. J Biol Chem 279:15167–15176. doi:10.1074/jbc.M309798200
    • (2004) J Biol Chem , vol.279 , pp. 15167-15176
    • Xavier, S.1
  • 126
    • 77957884094 scopus 로고    scopus 로고
    • Pathogenetic mechanisms in radiation fibrosis
    • COI: 1:CAS:528:DC%2BC3cXht1Kqsb%2FJ
    • Yarnold J, Brotons MC (2010) Pathogenetic mechanisms in radiation fibrosis. Radiother Oncol J Eur Soc Ther Radiol Oncol 97:149–161. doi:10.1016/j.radonc.2010.09.002
    • (2010) Radiother Oncol J Eur Soc Ther Radiol Oncol , vol.97 , pp. 149-161
    • Yarnold, J.1    Brotons, M.C.2
  • 127
    • 82055180507 scopus 로고    scopus 로고
    • The development of classically and alternatively activated macrophages has different effects on the varied stages of radiation-induced pulmonary injury in mice
    • COI: 1:CAS:528:DC%2BC38Xjs1yhsg%3D%3D, PID: 22104268
    • Zhang H et al (2011) The development of classically and alternatively activated macrophages has different effects on the varied stages of radiation-induced pulmonary injury in mice. J Radiat Res 52:717–726
    • (2011) J Radiat Res , vol.52 , pp. 717-726
    • Zhang, H.1
  • 128
    • 62349118232 scopus 로고    scopus 로고
    • Inflammation and chronic oxidative stress in radiation-induced late normal tissue injury: therapeutic implications
    • COI: 1:CAS:528:DC%2BD1MXjsFGqsrw%3D, PID: 19149566
    • Zhao W, Robbins ME (2009) Inflammation and chronic oxidative stress in radiation-induced late normal tissue injury: therapeutic implications. Curr Med Chem 16:130–143
    • (2009) Curr Med Chem , vol.16 , pp. 130-143
    • Zhao, W.1    Robbins, M.E.2


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