Inhibition of radiation-induced skin fibrosis with imatinib

International Journal of Radiation Biology

Volumn 89, Issue 3, 2013, Pages 162-170

  Horton, Jason A ^a   Chung, Eun Joo ^a   Hudak, Kathryn E ^a   Sowers, Anastasia ^a   Thetford, Angela ^a   White, Ayla O ^a   Mitchell, James B ^a   Citrin, Deborah E ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

Author keywords

Dermal; Fibrosis; Imatinib; Platelet derived growth factor receptor; Radiation

Indexed keywords

COLLAGEN; IMATINIB; PLATELET DERIVED GROWTH FACTOR BETA RECEPTOR; TRANSFORMING GROWTH FACTOR BETA;

ACUTE TOXICITY; ALOPECIA; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTRACTURE; CONTROLLED STUDY; DESQUAMATION; ERYTHEMA; FEMALE; FOOD INTAKE; IMMUNOHISTOCHEMISTRY; MOLECULAR INTERACTION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RADIATION DERMATITIS; RADIATION DOSE; RADIATION INDUCED SKIN FIBROSIS; SKINFOLD THICKNESS;

ANIMALS; FEMALE; FIBROSIS; MICE; MICE, INBRED C3H; PHOSPHORYLATION; PIPERAZINES; PROTO-ONCOGENE PROTEINS C-ABL; PROTO-ONCOGENE PROTEINS C-KIT; PYRIMIDINES; RADIATION INJURIES, EXPERIMENTAL; RADIATION-PROTECTIVE AGENTS; RECEPTOR, PLATELET-DERIVED GROWTH FACTOR BETA; SIGNAL TRANSDUCTION; SKIN; TRANSFORMING GROWTH FACTOR BETA1;

EID: 84874614101     PISSN: 09553002     EISSN: 13623095     Source Type: Journal    
DOI: 10.3109/09553002.2013.741281     Document Type: Article

References (22)

1. Abdollahi A , Li M , Ping G , Plathow C , Domhan S , Kiessling F , Lee LB , McMahon G , Grone HJ , Lipson KE. 2005. Inhibition of plateletderived growth factor signaling attenuates pulmonary fi brosis. The Journal of Experimental Medicine 201: 925-935. (Pubitemid 40524462)
2. Akhmetshina A , Venalis P , Dees C , Busch N , Zwerina J , Schett G , Distler O , Distler JH. 2009. Treatment with imatinib prevents fi brosis in different preclinical models of systemic sclerosis and induces regression of established fi brosis. Arthritis and Rheumatism 60: 219-224.
3. Anscher MS , Th rasher B , Zgonjanin L , Rabbani ZN , Corbley MJ , Fu K , Sun L , Lee WC , Ling LE , Vujaskovic Z. 2008. Small molecular inhibitor of transforming growth factor-beta protects against development of radiation-induced lung injury. International Journal of Radiation Oncology Biology Physics 71: 829-837.
4. Bhattacharyya S , Ishida W, Wu M, Wilkes M, Mori Y , Hinchcliff M , Leof E , Varga J. 2009. A non-Smad mechanism of fi broblast activation by transforming growth factor-beta via c-Abl and Egr-1: Selective modulation by imatinib mesylate. Oncogene 28: 1285-1297
5. Bibi Y , Gottlieb AB. 2008. A potential role for imatinib and other small molecule tyrosine kinase inhibitors in the treatment of systemic and localized sclerosis. Journal of the American Academy of Dermatology 59: 654-658.
6. Bonner JC. 2004. Regulation of PDGF and its receptors in fi brotic diseases. Cytokine & Growth Factor Reviews 15: 255-273. (Pubitemid 38781050)
7. Bruna A , Darken RS , Rojo F , Ocana A , Penuelas S , Arias A , Paris R, Tortosa A , Mora J , Baselga J. 2007. High TGFbeta-Smad activity confers poor prognosis in glioma patients and promotes cell proliferation depending on the methylation of the PDGF-B gene. Cancer Cell 11: 147-160. (Pubitemid 46209848)
8. Brush J , Lipnick SL , Phillips T , Sitko J , McDonald JT , McBride WH. 2007. Molecular mechanisms of late normal tissue injury. Seminars in Radiation Oncology 17: 121-130. (Pubitemid 46467382)
9. Choudhury A , Zhao H, Jalali F , Al Rashid S , Ran J , Supiot S , Kiltie AE, Bristow RG. 2009. Targeting homologous recombination using imatinib results in enhanced tumor cell chemosensitivity and radiosensitivity. Molecular Cancer Therapeutics 8: 203-213.
10. Chung L , Fiorentino DF , Benbarak MJ , Adler AS , Mariano MM, Paniagua RT , Milano A , Connolly MK , Ratiner BD , Wiskocil RL. 2009. Molecular framework for response to imatinib mesylate in systemic sclerosis. Arthritis and Rheumatism 60: 584-591.
11. Classen JF , Henrohn D , Rorsman F , Lennartsson J , Lauwerys BR , Wikstrom G , Rorsman C , Lenglez S , Franck-Larsson K , Tomasi JP. 2009. Lack of evidence of stimulatory autoantibodies to plateletderived growth factor receptor in patients with systemic sclerosis. Arthritis and Rheumatism 60: 1137-1144
12. Czuwara-Ladykowska J , Gore EA , Shegogue DA , SmiTheA , Trojanowska M. 2001. differential regulation of transforming growth factor-beta receptors type I and II by platelet-derived growth factor in human dermal fi broblasts. The British Journal of Dermatology 145: 569-575.
13. Distler JH, Jungel A , Huber LC , Schulze-Horsel U , Zwerina J , Gay RE, Michel BA , Hauser T , Schett G , Gay S. 2007. Imatinib mesylate reduces production of extracellular matrix and prevents development of experimental dermal fi brosis. Arthritis and Rheumatism 56: 311-322. (Pubitemid 46106205)
14. Flanders KC , Sullivan CD , Fujii M, Sowers A , Anzano MA , Arabshahi A , Major C , Deng C , Russo A , Mitchell JB. 2002. Mice lacking Smad3 are protected against cutaneous injury induced by ionizing radiation. The American Journal of Pathology 160: 1057-1068 (Pubitemid 34224592)
15. Flanders KC , Major CD , Arabshahi A , Aburime EE , Okada MH , Fujii M , Blalock TD , Schultz GS , Sowers A , Anzano MA. 2003. Interference with transforming growth factor-beta/Smad3 signaling results in accelerated healing of wounds in previously irradiated skin. The American Journal of Pathology 163: 2247-2257 (Pubitemid 37466469)
16. Gabrielli A , Svegliati S , Moroncini G , Luchetti M , Tonnini C , Avvedimento EV. 2007. Stimulatory autoantibodies to the PDGF receptor: A link to fi brosis in scleroderma and a pathway for novel therapeutic targets. Autoimmunity Reviews 7: 121-126. (Pubitemid 350116724)
17. Garber K. 2009. Companies waver in eff orts to target transforming growth factor beta in cancer. Journal of the National Cancer Institute 101: 1664-1667
18. Herskind C , Bamberg M, Rodemann HP. 1998. The role of cytokines in the development of normal-tissue reactions after radiotherapy. Strahlentherapie und Onkologie 174(Suppl. 3): 12-15. (Pubitemid 28506585)
19. Kay J , High WA. 2008. Imatinib mesylate treatment of nephrogenic systemic fi brosis. Arthritis and Rheumatism 58: 2543-2548
20. Kerkela R, Grazette L , Yacobi R, Iliescu C , Patten R, Beahm C , Walters B , Shevtsov S , Pesant S , Clubb FJ. 2006. Cardiotoxicity of the cancer therapeutic agent imatinib mesylate. Nature Medicine 12: 908-916. (Pubitemid 44175142)
21. Li M , Abdollahi A , Grone HJ , Lipson KE , Belka C , Huber PE. 2009. Late treatment with imatinib mesylate ameliorates radiation-induced lung fi brosis in a mouse model. Radiation Oncology 4: 66.
22. Li M , Ping G , Plathow C , Trinh T , Lipson KE , Hauser K , Krempien R , Debus J , Abdollahi A , Huber PE. 2006. Small molecule receptor tyrosine kinase inhibitor of platelet-derived growth factor signaling (SU9518) modifi es radiation response in fi broblasts and endothelial cells. BMC Cancer 6: 79 .