Universal and radiation-specific loci influence murine susceptibility to radiation-induced pulmonary fibrosis

Cancer Research

Volumn 62, Issue 13, 2002, Pages 3782-3788

  Haston, Christina K ^a   Zhou, Xinhui ^a   Gumbiner Russo, Laura ^a   Irani, Roxanna ^a   Dejournett, Robert ^a   Gu, Xiangjun ^a   Weil, Michael ^a   Amos, Christopher I ^a   Travis, Elizabeth L ^a  

^a UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BLEOMYCIN; OZONE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; ASTHMA; CHROMOSOME 1; CHROMOSOME 17; CHROMOSOME 18; CHROMOSOME 6; DISEASE PREDISPOSITION; FEMALE; GENE LOCUS; LUNG FIBROSIS; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; QUANTITATIVE TRAIT LOCUS; RADIATION EXPOSURE; RADIATION INJURY; RADIOSENSITIVITY; STRAIN DIFFERENCE;

ANIMALS; CHROMOSOME MAPPING; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GENOME; LINKAGE (GENETICS); MALE; MICE; MICE, INBRED C3H; MICE, INBRED C57BL; PULMONARY FIBROSIS; QUANTITATIVE TRAIT, HERITABLE; RADIATION INJURIES, EXPERIMENTAL;

EID: 0036645068     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (43)

1. The pathogenesis of pulmonary fibrosis: Is there a fibrosis gene?
2. Pulmonary morbidity 10-18 years after irradiation for Hodgkin's disease
3. Radiation pneumonitis in patients treated for breast cancer
4. How much could the radiotherapy dose be altered for individual patients based on a predictive assay of normal-tissue radiosensitivity?
5. Murine susceptibility to radiation-induced pulmonary fibrosis is influenced by a genetic factor implicated in susceptibility to bleomycin-induced pulmonary fibrosis
6. The genetic basis of strain-dependent differences in the early phase of radiation injury in mouse lung
7. Evidence for two patterns of inheritance of sensitivity to induction of lung fibrosis in mice by radiation, one of which involves two genes
8. A quantitative histological study of strain-dependent differences in the effects of irradiation on mouse lung during the intermediate and late phases
9. Quantitative histological study of strain-dependent differences in the effects of irradiation on mouse lung during the early phase
10. Inheritance of susceptibility to bleomycin-induced pulmonary fibrosis in the mouse
11. A genetic map of the mouse with 4,006 simple sequence length polymorphisms
12. MapManager, a Macintosh program for storage and analysis of experimental genetic mapping data
13. Genetic dissection of complex traits: Guidelines for interpreting and reporting linkage results
14. Maximum likelihood mapping of quantitative trait loci using full-sib families
15. Theoretical basis for separation of multiple linked gene effects in mapping quantitative trait loci
16. Mapping mendelian factors underlying quantitative traits using RFLP linkage maps
17. Empirical threshold values for quantitative trait mapping
18. Quantitative trait locus mapping of airway responsiveness to chromosomes 6 and 7 in inbred mice
19. Susceptibility to experimental interstitial lung disease is modified by immune- and non-immune-related genes
20. Different sensitivity to bleomycin-induced pulmonary fibrosis among various strains of mice
21. Susceptibility to ozone-induced inflammation, II. Separate loci control responses to acute and subacute exposures
22. Susceptibility to ozone-induced inflammation. I. Genetic control of the response to subacute exposure
23. Linkage analysis of susceptibility to ozone-induced lung inflammation in inbred mice
24. Genetic linkage analysis of susceptibility to particle exposure in mice
25. The genetics of asthma
26. Is there a fibrotic gene?
27. A genome-wide screen for asthma-associated quantitative trait loci in a mouse model of allergic asthma
28. Quantitative locus analysis of airway hyperresponsiveness in A/J and C57BI/6J mice
29. Alveolitis and collapse in the pathogenesis of pulmonary fibrosis
30. Early alterations in extracellular matrix and transforming growth factor β gene expression in mouse lung indicative of late radiation fibrosis
31. Expression of a tumor necrosis factor-α transgene in murine lung causes lymphocytic and fibrosing alveolitis. A mouse model of progressive pulmonary fibrosis
32. Resistance of TNF/LT α double deficient mice to bleomycin-induced fibrosis
33. Intratracheal injection of adenovirus containing the human MnSOD transgene protects athymic nude mice from irradiation-induced organizing alveolitis
34. Prevention of late effects of irradiation lung damage by manganese superoxide dismutase gene therapy
35. Intrapulmonary expression of a MnSOD transgene protects the lung from ionizing irradiation damage
36. Manganese superoxide dismutase (MnSOD) plasmid/liposome pulmonary radioprotective gene therapy: Modulation of irradiation-induced mRNA for IL-1. TNF-α and TGF-β correlates with delay of organizing alveolitis/fibrosis
37. Intratracheal administration of MnSOD plasmid/liposome (PL) complex improves the decreased pulmonary radiation resistance of SOD2 deficient mice
38. Decreased pulmonary radiation resistance of manganese superoxide dismutase (MnSOD)-deficient mice is corrected by human manganese superoxide dismutase-plasmid/liposome (SOD2-PL) intratracheal gene therapy
39. Pulmonary fibrosis: Pathways are slowly coming into light
40. Cellular events in alveolitis and the evolution of pulmonary fibrosis
41. Pathobiology of pulmonary fibrosis