Quercetin inhibits radiation-induced skin fibrosis

Radiation Research

Volumn 180, Issue 2, 2013, Pages 205-215

  Horton, Jason A ^a   Li, Fei ^a   Chung, Eun Joo ^a   Hudak, Kathryn ^a   White, Ayla ^a   Krausz, Kristopher ^a   Gonzalez, Frank ^a   Citrin, Deborah ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COFILIN; COLLAGEN; CYTOKINE; QUERCETIN; TRANSFORMING GROWTH FACTOR BETA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CLONOGENIC ASSAY; CONTRACTURE; FEMALE; FIBROBLAST; HINDLIMB; HUMAN; HUMAN CELL; MOUSE; MUSCLE CONTRACTILITY; NONHUMAN; PRIORITY JOURNAL; RADIATION DOSE; RADIATION IDUCED SKIN FIBROSIS; RADIATION RESPONSE; SKIN FIBROSIS; WESTERN BLOTTING; X RAY;

ADMINISTRATION, ORAL; ANIMALS; ANTIOXIDANTS; BIOTRANSFORMATION; CARCINOMA, SQUAMOUS CELL; CELL SHAPE; COLLAGEN; COLONY-FORMING UNITS ASSAY; DRUG EVALUATION, PRECLINICAL; FEMALE; FIBROBLASTS; FIBROSIS; GENES, REPORTER; HINDLIMB; HUMANS; MICE; MICE, INBRED C3H; NIH 3T3 CELLS; PHYTOTHERAPY; QUERCETIN; RADIATION-PROTECTIVE AGENTS; RADIODERMATITIS; RADIOTHERAPY; RANDOM ALLOCATION; SKIN; SKIN NEOPLASMS; TRANSCRIPTION, GENETIC; TRANSFORMING GROWTH FACTOR BETA;

EID: 84882280634     PISSN: 00337587     EISSN: 19385404     Source Type: Journal    
DOI: 10.1667/RR3237.1     Document Type: Article

References (33)

1. Ryan JL. Ionizing radiation: The good, the bad, and the ugly. J Invest Dermatol 132:985-93.
2. Hall EJ, Giaccia AJ. Radiobiology for the radiologist. 6th. Philadelphia: Lippincott Williams & Wilkins; 2006.
3. Rotelli AE, Guardia T, Juarez AO, de la Rocha NE, Pelzer LE. Comparative study of flavonoids in experimental models of inflammation. Pharmacol Res 2003; 48:601-6.
4. Phan TT, See P, Tran E, Nguyen TT, Chan SY, Lee ST, et al. Suppression of insulin-like growth factor signalling pathway and collagen expression in keloid-derived fibroblasts by quercetin: Its therapeutic potential use in the treatment and/or prevention of keloids. Br J Dermatol 2003; 148:544-52.
5. Wadsworth TL, Koop DR. Effects of the wine polyphenolics quercetin and resveratrol on pro-inflammatory cytokine expression in raw 264.7 macrophages. Biochem Pharmacol 1999; 57:941-9.
6. Phan TT, Lim IJ, Chan SY, Tan EK, Lee ST, Longaker MT. Suppression of transforming growth factor beta/smad signaling in keloid-derived fibroblasts by quercetin: Implications for the treatment of excessive scars. J Trauma 2004; 57:1032-7.
7. Randall K, Coggle JE. Expression of transforming growth factorbeta 1 in mouse skin during the acute phase of radiation damage. Int J Radiat Biol 1995; 68:301-9.
8. Li F, Patterson AD, Krausz KW, Dick B, Frey FJ, Gonzalez FJ, et al. Metabolomics reveals the metabolic map of procainamide in humans and mice. Biochem Pharmacol 2012; 83:1435-44.
9. Li F, Patterson AD, Hofer CC, Krausz KW, Gonzalez FJ, Idle JR. A comprehensive understanding of thiotepa metabolism in the mouse using uplc-esi-qtofms-based metabolomics. Biochem Pharmacol 2011; 81:1043-53.
10. Li F, Patterson AD, Hofer CC, Krausz KW, Gonzalez FJ, Idle JR. Comparative metabolism of cyclophosphamide and ifosfamide in the mouse using uplc-esi-qtofms-based metabolomics. Biochem Pharmacol 2010; 80:1063-74.
11. Lareu RR, Zeugolis DI, Abu-Rub M, Pandit A, Raghunath M. Essential modification of the sircol collagen assay for the accurate quantification of collagen content in complex protein solutions. Acta Biomater 2011; 6:3146-51.
12. Ngo P, Ramalingam P, Phillips JA, Furuta GT. Collagen gel contraction assay. Methods Mol Biol 2006; 341:103-9.
13. Suit HD, Walker AM. Assessment of the response of tumours to radiation:. Br J Cancer Suppl 1980; 4:1-10.
14. Suit H, Schlachter L, Andrews JR. "Oxygen effect" and tumor size as related to response of c3h/ba adenocarcinoma to local x irradiation. J Natl Cancer Inst 1960; 24:1271-81.
15. Oser M, Condeelis J. The cofilin activity cycle in lamellipodia and invadopodia. J Cell Biochem 2009; 108:1252-62.
16. Lin C, Yu Y, Zhao HG, Yang A, Yan H, Cui Y. Combination of quercetin with radiotherapy enhances tumor radiosensitivity in vitro and in vivo. Radiother Oncol 2012; 104:395-400.
17. Molin J, Sogaard PE. Overgaard J. Experimental studies on the radiation-modifying effect of bleomycin in malignant and normal mouse tissue in vivo. Cancer Treat Rep 1981; 65:583-9.
18. Stone HB. Leg contracture in mice: An assay of normal tissue response. Int J Radiat Oncol Biol Phys 1984; 10:1053-61.
19. Xavier S, Piek E, Fujii M, Javelaud D, Mauviel A, Flanders KC, et al. Amelioration of radiation-induced fibrosis: Inhibition of transforming growth factor-beta signaling by halofuginone. J Biol Chem 2004; 279:15167-76.
20. Londhe JS, Devasagayam TP, Foo LY, Ghaskadbi SS. Radioprotective properties of polyphenols from phyllanthus amarus linn. J Radiat Res 2009; 50:303-9.
21. Musonda CA, Chipman JK. Quercetin inhibits hydrogen peroxide (h2o2)-induced nf-kappab DNA binding activity and DNA damage in hepg2 cells. Carcinogenesis 1998; 19:1583-9.
22. Benkovic V, Knezevic AH, Dikic D, Lisicic D, Orsolic N, Basic I, et al. Radioprotective effects of quercetin and ethanolic extract of propolis in gamma-irradiated mice. Arh Hig Rada Toksikol 2009; 60:129-38.
23. Ferrer P, Asensi M, Segarra R, Ortega A, Benlloch M, Obrador E, et al. Association between pterostilbene and quercetin inhibits metastatic activity of b16 melanoma. Neoplasia 2005; 7:37-47.
24. Rupasinghe HP, Ronalds CM, Rathgeber B, Robinson RA. Absorption and tissue distribution of dietary quercetin and quercetin glycosides of apple skin in broiler chickens. J Sci Food Agric 90:1172-8.
25. Mullen W, Edwards CA, Crozier A. Absorption, excretion and metabolite profiling of methyl-, glucuronyl-, glucosyl-and sulphoconjugates of quercetin in human plasma and urine after ingestion of onions. Br J Nutr 2006; 96:107-16.
26. Williamson G, Barron D, Shimoi K, Terao J. In vitro biological properties of flavonoid conjugates found in vivo. Free Radic Res 2005; 39:457-69.
27. Kawai Y, Nishikawa T, Shiba Y, Saito S, Murota K, Shibata N, et al. Macrophage as a target of quercetin glucuronides in human atherosclerotic arteries: Implication in the anti-atherosclerotic mechanism of dietary flavonoids. J Biol Chem 2008; 283:9424-34.
28. Yang JH, Hsia TC, Kuo HM, Chao PD, Chou CC, Wei YH, et al. Inhibition of lung cancer cell growth by quercetin glucuronides via g2/m arrest and induction of apoptosis. Drug Metab Dispos 2006; 34:296-304.
29. Moulin V, Auger FA, Garrel D, Germain L. Role of wound healing myofibroblasts on re-epithelialization of human skin. Burns 2000; 26:3-12.
30. Sarrazy V, Billet F, Micallef L, Coulomb B, Desmouliere A. Mechanisms of pathological scarring: Role of myofibroblasts and current developments. Wound Repair Regen 19 Suppl 1:s10-5.
31. Reisdorf P, Lawrence DA, Sivan V, Klising E, Martin MT. Alteration of transforming growth factor-beta1 response involves down-regulation of smad3 signaling in myofibroblasts from skin fibrosis. Am J Pathol 2001; 159:263-72.
32. Jun JB, Na YI, Kim TH, Yoo DH. Dietary flavonoid apigenin inhibits endothelin-1-induced contraction of collagen gel. Rheumatol Int 30:1695-7.
33. Bohl M, Tietze S, Sokoll A, Madathil S, Pfennig F, Apostolakis J, et al. Flavonoids affect actin functions in cytoplasm and nucleus. Biophys J 2007; 93:2767-80.