Simvastatin attenuates radiation-induced murine lung injury and dysregulated lung gene expression

American Journal of Respiratory Cell and Molecular Biology

Volumn 44, Issue 3, 2011, Pages 415-422

  Mathew, Biji ^a   Huang, Yong ^a   Jacobson, Jeffrey R ^a   Berdyshev, Evegeny ^a   Gerhold, Lynnette M ^b   Wang, Ting ^a   Moreno Vinasco, Liliana ^a   Lang, Gabriel ^a   Zhao, Yutong ^a   Chen, Chin Tu ^b   LaRiviere, Patrick J ^b   Mauceri, Helena ^c   Sammani, Saad ^a   Husain, Aliya N ^d   Dudek, Steven M ^a   Natarajan, Viswanathan ^a   Lussier, Yves A ^a   Weichselbaum, Ralph R ^c   Garcia, Joe G N ^a  

^a UNIVERSITY OF CHICAGO   (United States)

^b UNIVERSITY OF CHICAGO   (United States)

^c UNIVERSITY OF CHICAGO   (United States)

^d UNIVERSITY OF CHICAGO   (United States)

Author keywords

Gene dysregulation; Lung vascular permeability; Protein protein interaction; Radiation pneumonitis; Simvastatin

Indexed keywords

GELATINASE B; GENE PRODUCT; HERMES ANTIGEN; PROTEIN CCNA2A; PROTEIN CDC2; PROTEIN FCER1G; PROTEIN KINASE SYK; PROTEIN LTGAM; PROTEIN P53; PROTEIN VAV3; SIMVASTATIN; SPHINGOLIPID; TRANSCRIPTION FACTOR NRF2; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL INFILTRATION; CONTROLLED STUDY; DOSE TIME EFFECT RELATION; GENE EXPRESSION REGULATION; LEUKOCYTE; LIPID METABOLISM; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; OXIDATIVE STRESS; PROTEIN ANALYSIS; PROTEIN PROTEIN INTERACTION; RADIATION INJURY;

ANIMALS; ANTIGENS, CD44; BRONCHOALVEOLAR LAVAGE; GENE EXPRESSION REGULATION; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; LUNG; LUNG INJURY; MICE; MICE, INBRED C57BL; PROTEIN INTERACTION MAPPING; RADIATION INJURIES; RADIATION PNEUMONITIS; SIMVASTATIN; TRANSCRIPTION, GENETIC;

MURINAE; MUS;

EID: 79952204107     PISSN: 10441549     EISSN: None     Source Type: Journal    
DOI: 10.1165/rcmb.2010-0122OC     Document Type: Article

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