Late radiation morbidity following randomization to preoperative versus postoperative radiotherapy in extremity soft tissue sarcoma

Radiotherapy and Oncology

Volumn 75, Issue 1, 2005, Pages 48-53

  Davis, Aileen M ^a,j   O'Sullivan, Brian ^b,j   Turcotte, Robert ^c   Bell, Robert ^b,d,j   Catton, Charles ^b,j   Chabot, Pierre ^e   Wunder, Jay ^b,d,j   Hammond, Alex ^f   Benk, Veronique ^g   Kandel, Rita ^d,j   Goddard, Karen ^h   Freeman, Carolyn ^c   Sadura, Anna ⁱ   Zee, Benny ⁱ   Day, Andrew ⁱ   Tu, Dongsheng ⁱ   Pater, Joseph ⁱ  

^a TORONTO REHABILITATION INSTITUTE   (Canada)

^b PRINCESS MARGARET HOSPITAL   (Canada)

^c MCGILL UNIVERSITY HEALTH CENTRE   (Canada)

^d MOUNT SINAI HOSPITAL   (Canada)

^e MAISONNEUVE ROSEMONT HOSPITAL   (Canada)

^f LONDON REGIONAL CANCER PROGRAM   (Canada)

^g DEPARTMENT OF RADIATION ONCOLOGY   (Canada)

^h BRITISH COLUMBIA CANCER AGENCY   (Canada)

ⁱ Clinical Trials Group   (Canada)

^j UNIVERSITY OF TORONTO   (Canada)

more..

Author keywords

Extremity soft tissue sarcoma; Radiotherapy; Randomized trial; Toxicity

Indexed keywords

ADOLESCENT; ADULT; AGED; ARTICLE; CANCER RADIOTHERAPY; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; EDEMA; FEMALE; FIBROSIS; FISHER EXACT TEST; FOLLOW UP; HUMAN; JOINT STIFFNESS; LIMB TUMOR; MAJOR CLINICAL STUDY; MALE; MORBIDITY; MULTICENTER STUDY; MULTIVARIATE LOGISTIC REGRESSION ANALYSIS; PHYSICAL DISABILITY; POSTOPERATIVE CARE; PREOPERATIVE RADIOTHERAPY; PRIORITY JOURNAL; RANDOMIZATION; RANDOMIZED CONTROLLED TRIAL; RANK SUM TEST; SOFT TISSUE SARCOMA; SUBCUTANEOUS TISSUE FIBROSIS; TREATMENT OUTCOME;

ADOLESCENT; ADULT; AGED; DOSE FRACTIONATION; EDEMA; FEMALE; HUMANS; MALE; MIDDLE AGED; MORBIDITY; NEOADJUVANT THERAPY; RADIATION PNEUMONITIS; SARCOMA; TIME FACTORS;

EID: 20944438542     PISSN: 01678140     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.radonc.2004.12.020     Document Type: Article

References (34)

1. C.N. Andreassen, J. Alsner, M. Overgaard, and J. Overgaard Prediction of normal tissue radiosensitivity from polymorphisms in candidate genes Radiother Oncol 69 2003 127 135
2. R.S. Bell, B. O'Sullivan, A. Davis, F. Langer, B. Cummings, and V.L. Fornasier Functional outcome in patients treated with surgery and irradiation for soft tissue tumours J Surg Oncol 48 1991 224 231
3. K. Bujko, H.D. Suit, D.S. Springfield, and K. Convery Wound healing after preoperative radiation for sarcoma of soft tissues Surg Gynecol Obstet 176 1993 124 134
4. M.J. Chmell, and H.S. Schwartz Analysis of variables affecting wound healing after musculoskeletal sarcoma resections J Surg Oncol 61 1996 185 189
5. J.D. Cox, J. Stetz, and T.F. Pajak Toxicity criteria of the Radiation Therapy Oncology Group (RTOG) and the European Organization for Research and Treatment of Cancer (EORTC) Int J Radiat Oncol Biol Phys 31 1995 1341 1346
6. A.M. Davis, R.S. Bell, E.M. Badley, K. Yoshida, and J.I. Williams Evaluating functional outcome in patients with lower extremity sarcoma Clin Orthop 1999 90 100
7. A.M. Davis, B. O'Sullivan, and R.S. Bell Function and health status outcomes in a randomized trial comparing pre-operative and post-operative radiotherapy in extremity soft tissue sarcoma J Clin Oncol 20 2002 4472 4477
8. A.M. Davis, S. Sennik, and A.M. Griffin Predictors of functional outcomes following limb salvage surgery for lower-extremity soft tissue sarcoma J Surg Oncol 73 2000 206 211
9. A.M. Davis, J.G. Wright, J.I. Williams, C. Bombardier, A. Griffin, and R.S. Bell Development of a measure of physical function for patients with bone and soft tissue sarcoma Qual Life Res 5 1996 508 516
10. W. Enneking Modification of the system for functional evaluation in the surgical management of musculoskeletal tumors In: Limb salvage in musculoskeletal oncology 1987 Churchill-Livingston New York p. 626-39
11. ICRU. Dose specification for reporting external beam therapy with photons and electrons (Report 29). International Commission on Radiation Units and Measurement, Bethesda; 1984.
12. H. Jung, H.P. Beck-Bornholdt, V. Svoboda, W. Alberti, and T. Herrmann Quantification of late complications after radiation therapy Radiother Oncol 61 2001 233 246
13. C.P. Karakousis, L.J. Emrich, U. Rao, and R.M. Krishnamsetty Feasibility of limb salvage and survival in soft tissue sarcomas Cancer 57 1986 484 491
14. K. Karasek, L.S. Constine, and R. Rosier Sarcoma therapy: functional outcome and relationship to treatment parameters Int J Radiat Oncol Biol Phys 24 1992 651 656
15. B. O'Sullivan, A.M. Davis, and R. Turcotte Preoperative versus postoperative radiotherapy in soft-tissue sarcoma of the limbs: a randomised trial Lancet 359 2002 2235 2241
16. B. O'Sullivan, J. Wylie, and C. Catton The local management of soft tissue sarcoma Semin Radiat Oncol 9 1999 328 348
17. J.J. Pavy, J. Denekamp, and J. Letschert EORTC Late Effects Working Group late effects toxicity scoring: the SOMA scale Radiother Oncol 35 1995 11 15
18. B.G. Peat, R.S. Bell, and A. Davis Wound-healing complications after soft-tissue sarcoma surgery Plast Reconstr Surg 93 1994 980 987
19. P.W. Pisters, L.B. Harrison, D.H. Leung, J.M. Woodruff, E.S. Casper, and M.F. Brennan Long-term results of a prospective randomized trial of adjuvant brachytherapy in soft tissue sarcoma J Clin Oncol 14 1996 859 868
20. L.R. Prosnitz, P. Maguire, and J.M. Anderson The treatment of high-grade soft tissue sarcomas with preoperative thermoradiotherapy Int J Radiat Oncol Biol Phys 45 1999 941 949
21. M.H. Robinson, L. Spruce, and R. Eeles Limb function following conservation treatment of adult soft tissue sarcoma Eur J Cancer 27 1991 1567 1574
22. S.A. Rosenberg, J. Tepper, and E. Glatstein The treatment of soft-tissue sarcomas of the extremities: prospective randomized evaluations of (1) limb-sparing surgery plus radiation therapy compared with amputation and (2) the role of adjuvant chemotherapy Ann Surg 196 1982 305 315
23. C. Sadoski, H.D. Suit, A. Rosenberg, H. Mankin, and J. Efird Preoperative radiation, surgical margins, and local control of extremity sarcomas of soft tissues J Surg Oncol 52 1993 223 230
24. T.N. Stern Clinical examination: a textbook for physical diagnosis 1964 Year Book Medical Publishers Chicago
25. S.F. Stinson, T.F. DeLaney, and J. Greenberg Acute and long-term effects on limb function of combined modality limb sparing therapy for extremity soft tissue sarcoma Int J Radiat Oncol Biol Phys 21 1991 1493 1499
26. H.D. Suit, H.J. Mankin, W.C. Wood, and K.H. Proppe Preoperative, intraoperative, and postoperative radiation in the treatment of primary soft tissue sarcoma Cancer 55 1985 2659 2667
27. A. Trotti Toxicity in head and neck cancer: a review of trends and issues Int J Radiat Oncol Biol Phys 47 2000 1 12
28. M. van Kampen, M.J. Eble, and T. Lehnert Correlation of intraoperatively irradiated volume and fibrosis in patients with soft-tissue sarcoma of the extremities Int J Radiat Oncol Biol Phys 51 2001 94 99
29. WHO. International classification of impairments, disabilities, and handicaps. Geneva: World Health Organization; 1980.
30. WHO. International classification of functioning, disability and health. Geneva: World Health Organization; 2001.
31. F. Wilcoxon Individual comparisons by ranking methods Biometrics 1 1945 80 83
32. A.N. Wilson, A. Davis, and R.S. Bell Local control of soft tissue sarcoma of the extremity: the experience of a multidisciplinary sarcoma group with definitive surgery and radiotherapy Eur J Cancer 6 1994 746 751
33. J.C. Yang, A.E. Chang, and A.R. Baker Randomized prospective study of the benefit of adjuvant radiation therapy in the treatment of soft tissue sarcomas of the extremity J Clin Oncol 16 1998 197 203
34. G.K. Zagars, M.T. Ballo, P.W. Pisters, R.E. Pollock, S.R. Patel, and R.S. Benjamin Preoperative vs. postoperative radiation therapy for soft tissue sarcoma: a retrospective comparative evaluation of disease outcome Int J Radiat Oncol Biol Phys 56 2003 482 488