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Volumn 38, Issue 8, 2015, Pages 677-684

Epigenetic regulation of chondrocyte catabolism and anabolism in osteoarthritis

Author keywords

Cartilage; Chondrocytes; Epigenetics; Metabolism; Osteoarthritis

Indexed keywords

ADIPONECTIN; CATALASE; COLLAGENASE 3; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN BINDING PROTEIN; DNA METHYLTRANSFERASE 1; DNA METHYLTRANSFERASE 3A; GLUTATHIONE PEROXIDASE; HISTONE DEACETYLASE 1; HISTONE DEACETYLASE 2; HYPOXIA INDUCIBLE FACTOR 1ALPHA; INTERLEUKIN 1BETA; LEPTIN; NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE; REACTIVE OXYGEN METABOLITE; S ADENOSYLMETHIONINE; SIRTUIN 1; SUPEROXIDE DISMUTASE; TRANSCRIPTION FACTOR SOX9;

EID: 84949934623     PISSN: 10168478     EISSN: 02191032     Source Type: Journal    
DOI: 10.14348/molcells.2015.0200     Document Type: Article
Times cited : (56)

References (108)
  • 1
    • 3943054839 scopus 로고    scopus 로고
    • The Sir2 family of protein deacetylases
    • Blander, G, and Guarente, L. (2004). The Sir2 family of protein deacetylases. Ann. Rev. Biochem. 73, 417-435.
    • (2004) Ann. Rev. Biochem , vol.73 , pp. 417-435
    • Blander, G.1    Guarente, L.2
  • 3
    • 2942746517 scopus 로고    scopus 로고
    • Joint injury, repair, and remodeling: Roles in post-traumatic osteoarthritis
    • Buckwalter, J.A., and Brown, T.D. (2004). Joint injury, repair, and remodeling: roles in post-traumatic osteoarthritis. Clin. Orthop. Relat. Res. 2004, 7-16.
    • (2004) Clin. Orthop. Relat. Res , vol.2004 , pp. 7-16
    • Buckwalter, J.A.1    Brown, T.D.2
  • 4
    • 84863189550 scopus 로고    scopus 로고
    • CAMP response element-binding (CREB) recruitment following a specific CpG demethylation leads to the elevated expression of the matrix metalloproteinase 13 in human articular chondrocytes and osteoarthritis
    • Bui, C., Barter, M.J., Scott, J.L., Xu, Y., Galler, M., Reynard, L.N., Rowan, A.D., and Young, D.A. (2012). cAMP response element-binding (CREB) recruitment following a specific CpG demethylation leads to the elevated expression of the matrix metalloproteinase 13 in human articular chondrocytes and osteoarthritis. FASEB J. 26, 3000-3011.
    • (2012) FASEB J , vol.26 , pp. 3000-3011
    • Bui, C.1    Barter, M.J.2    Scott, J.L.3    Xu, Y.4    Galler, M.5    Reynard, L.N.6    Rowan, A.D.7    Young, D.A.8
  • 5
    • 84867420625 scopus 로고    scopus 로고
    • On acetyl-CoA as a gauge of cellular metabolic state. Cold Spring Harb
    • Cai, L., and Tu, B.P. (2011). On acetyl-CoA as a gauge of cellular metabolic state. Cold Spring Harb. Symp. Quant. Biol. 76, 195-202.
    • (2011) Symp. Quant. Biol , vol.76 , pp. 195-202
    • Cai, L.1    Tu, B.P.2
  • 6
    • 77956180402 scopus 로고    scopus 로고
    • SIRT1 is a redox-sensitive deacetylase that is post-translationally modified by oxidants and carbonyl stress
    • Caito, S., Rajendrasozhan, S., Cook, S., Chung, S., Yao, H., Friedman, A.E., Brookes, P.S., and Rahman, I. (2010). SIRT1 is a redox-sensitive deacetylase that is post-translationally modified by oxidants and carbonyl stress. FASEB J. 24, 3145-3159.
    • (2010) FASEB J , vol.24 , pp. 3145-3159
    • Caito, S.1    Rajendrasozhan, S.2    Cook, S.3    Chung, S.4    Yao, H.5    Friedman, A.E.6    Brookes, P.S.7    Rahman, I.8
  • 7
    • 67651152853 scopus 로고    scopus 로고
    • Individuality and epigenetics in obesity
    • Campion, J., Milagro, F.I., and Martinez, J.A. (2009). Individuality and epigenetics in obesity. Obesity Rev. 10, 383-392.
    • (2009) Obesity Rev , vol.10 , pp. 383-392
    • Campion, J.1    Milagro, F.I.2    Martinez, J.A.3
  • 8
    • 0347481187 scopus 로고    scopus 로고
    • Increased oxidative stress with aging reduces chondrocyte survival: Correlation with intracellular glutathione levels
    • Carlo, M.D., Jr., and Loeser, R.F. (2003). Increased oxidative stress with aging reduces chondrocyte survival: correlation with intracellular glutathione levels. Arthritis. Rheum. 48, 3419-3430.
    • (2003) Arthritis. Rheum , vol.48 , pp. 3419-3430
    • Carlo, M.D.1    Loeser, R.F.2
  • 9
    • 0028097874 scopus 로고
    • Obesity as a risk factor for osteoarthritis of the hand and wrist: A prospective study
    • Carman, W.J., Sowers, M., Hawthorne, V.M., and Weissfeld, L.A. (1994). Obesity as a risk factor for osteoarthritis of the hand and wrist: a prospective study. Am. J. Epidemiol. 139, 119-129.
    • (1994) Am. J. Epidemiol , vol.139 , pp. 119-129
    • Carman, W.J.1    Sowers, M.2    Hawthorne, V.M.3    Weissfeld, L.A.4
  • 13
    • 79954609893 scopus 로고    scopus 로고
    • Hypoxia increases sirtuin 1 expression in a hypoxia- inducible factor-dependent manner
    • Chen, R., Dioum, E.M., Hogg, R.T., Gerard, R.D., and Garcia, J.A. (2011). Hypoxia increases sirtuin 1 expression in a hypoxia- inducible factor-dependent manner. J. Biol. Chem. 286, 13869-13878.
    • (2011) J. Biol. Chem , vol.286 , pp. 13869-13878
    • Chen, R.1    Dioum, E.M.2    Hogg, R.T.3    Gerard, R.D.4    Garcia, J.A.5
  • 14
    • 27444436307 scopus 로고    scopus 로고
    • Is progressive osteoarthritis an atheromatous vascular disease
    • Conaghan, P.G., Vanharanta, H., and Dieppe, P.A. (2005). Is progressive osteoarthritis an atheromatous vascular disease? Ann. Rheum. Dis. 64, 1539-1541.
    • (2005) Ann. Rheum. Dis , vol.64 , pp. 1539-1541
    • Conaghan, P.G.1    Vanharanta, H.2    Dieppe, P.A.3
  • 17
    • 33751005849 scopus 로고    scopus 로고
    • Prevalence of knee osteoarthritis in the United States: Arthritis data from the Third National Health and Nutrition Examination Survey 1991-94
    • Dillon, C.F., Rasch, E.K., Gu, Q., and Hirsch, R. (2006). Prevalence of knee osteoarthritis in the United States: arthritis data from the Third National Health and Nutrition Examination Survey 1991-94. J. Rheumatol. 33, 2271-2279.
    • (2006) J. Rheumatol , vol.33 , pp. 2271-2279
    • Dillon, C.F.1    Rasch, E.K.2    Gu, Q.3    Hirsch, R.4
  • 18
    • 84863519104 scopus 로고    scopus 로고
    • Increased synovial fluid visfatin is positively linked to cartilage degradation biomarkers in osteoarthritis
    • Duan, Y., Hao, D., Li, M., Wu, Z., Li, D., Yang, X., and Qiu, G. (2012). Increased synovial fluid visfatin is positively linked to cartilage degradation biomarkers in osteoarthritis. Rheumatol. Int. 32, 985-990.
    • (2012) Rheumatol. Int , vol.32 , pp. 985-990
    • Duan, Y.1    Hao, D.2    Li, M.3    Wu, Z.4    Li, D.5    Yang, X.6    Qiu, G.7
  • 20
    • 61349159991 scopus 로고    scopus 로고
    • Regulation of cartilage-specific gene expression in human chondrocytes by SirT1 and nicotinamide phosphoribosyltran-sferase
    • Dvir-Ginzberg, M., Gagarina, V., Lee, E.J., and Hall, D.J. (2008). Regulation of cartilage-specific gene expression in human chondrocytes by SirT1 and nicotinamide phosphoribosyltran-sferase. J. Biol. Chem. 283, 36300-36310.
    • (2008) J. Biol. Chem , vol.283 , pp. 36300-36310
    • Dvir-Ginzberg, M.1    Gagarina, V.2    Lee, E.J.3    Hall, D.J.4
  • 21
    • 79961125549 scopus 로고    scopus 로고
    • Tumor necrosis factor alpha-mediated cleavage and inactivation of SirT1 in human osteoarthritic chondrocytes
    • Dvir-Ginzberg, M., Gagarina, V., Lee, E.J., Booth, R., Gabay, O., and Hall, D.J. (2011). Tumor necrosis factor alpha-mediated cleavage and inactivation of SirT1 in human osteoarthritic chondrocytes. Arthritis Rheum. 63, 2363-2373.
    • (2011) Arthritis Rheum , vol.63 , pp. 2363-2373
    • Dvir-Ginzberg, M.1    Gagarina, V.2    Lee, E.J.3    Booth, R.4    Gabay, O.5    Hall, D.J.6
  • 23
    • 36448997363 scopus 로고    scopus 로고
    • Vascular pathology and osteoarthritis
    • Findlay, D.M. (2007). Vascular pathology and osteoarthritis. Rheumatology 46, 1763-1768.
    • (2007) Rheumatology , vol.46 , pp. 1763-1768
    • Findlay, D.M.1
  • 24
    • 78650978303 scopus 로고    scopus 로고
    • Potential involvement of SIRT1 in the pathogenesis of osteoarthritis through the modulation of chondrocyte gene expressions
    • Fujita, N., Matsushita, T., Ishida, K., Kubo, S., Matsumoto, T., Takayama, K., Kurosaka, M., and Kuroda, R. (2011). Potential involvement of SIRT1 in the pathogenesis of osteoarthritis through the modulation of chondrocyte gene expressions. J. Orthop. Res. 29, 511-515.
    • (2011) J. Orthop. Res , vol.29 , pp. 511-515
    • Fujita, N.1    Matsushita, T.2    Ishida, K.3    Kubo, S.4    Matsumoto, T.5    Takayama, K.6    Kurosaka, M.7    Kuroda, R.8
  • 25
    • 78650715737 scopus 로고    scopus 로고
    • Histone acetylation influences the activity of Sox9-related transcriptional complex
    • Furumatsu, T., and Asahara, H. (2010). Histone acetylation influences the activity of Sox9-related transcriptional complex. Acta Med. Okayama 64, 351-357.
    • (2010) Acta Med. Okayama , vol.64 , pp. 351-357
    • Furumatsu, T.1    Asahara, H.2
  • 27
    • 85027953113 scopus 로고    scopus 로고
    • Increased apoptotic chondrocytes in articular cartilage from adult heterozygous SirT1 mice
    • Gabay, O., Oppenhiemer, H., Meir, H., Zaal, K., Sanchez, C., and Dvir-Ginzberg, M. (2012). Increased apoptotic chondrocytes in articular cartilage from adult heterozygous SirT1 mice. Ann. Rheum. Dis. 71, 613-616.
    • (2012) Ann. Rheum. Dis , vol.71 , pp. 613-616
    • Gabay, O.1    Oppenhiemer, H.2    Meir, H.3    Zaal, K.4    Sanchez, C.5    Dvir-Ginzberg, M.6
  • 29
    • 77951717549 scopus 로고    scopus 로고
    • SirT1 enhances survival of human osteoarthritic chondrocytes by repressing protein tyrosine phosphatase 1B and activating the insulin-like growth factor receptor pathway
    • Gagarina, V., Gabay, O., Dvir-Ginzberg, M., Lee, E.J., Brady, J.K., Quon, M.J., and Hall, D.J. (2010). SirT1 enhances survival of human osteoarthritic chondrocytes by repressing protein tyrosine phosphatase 1B and activating the insulin-like growth factor receptor pathway. Arthritis Rheum. 62, 1383-1392.
    • (2010) Arthritis Rheum , vol.62 , pp. 1383-1392
    • Gagarina, V.1    Gabay, O.2    Dvir-Ginzberg, M.3    Lee, E.J.4    Brady, J.K.5    Quon, M.J.6    Hall, D.J.7
  • 30
    • 43949131087 scopus 로고    scopus 로고
    • Crucial role of visfatin/pre-B cell colony-enhancing factor in matrix degradation and prostaglandin E2 synthesis in chondrocytes: Possible influence on osteoarthritis
    • Gosset, M., Berenbaum, F., Salvat, C., Sautet, A., Pigenet, A., Tahiri, K., and Jacques, C. (2008). Crucial role of visfatin/pre-B cell colony-enhancing factor in matrix degradation and prostaglandin E2 synthesis in chondrocytes: possible influence on osteoarthritis. Arthritis Rheum. 58, 1399-1409.
    • (2008) Arthritis Rheum , vol.58 , pp. 1399-1409
    • Gosset, M.1    Berenbaum, F.2    Salvat, C.3    Sautet, A.4    Pigenet, A.5    Tahiri, K.6    Jacques, C.7
  • 31
    • 27244432788 scopus 로고    scopus 로고
    • The role of mechanical loading in the onset and progression of osteoarthritis
    • Griffin, T.M., and Guilak, F. (2005). The role of mechanical loading in the onset and progression of osteoarthritis. Exerc. Sport Sci. Rev. 33, 195-200.
    • (2005) Exerc. Sport Sci. Rev , vol.33 , pp. 195-200
    • Griffin, T.M.1    Guilak, F.2
  • 32
    • 70349771971 scopus 로고    scopus 로고
    • Extreme obesity due to impaired leptin signaling in mice does not cause knee osteoarthritis
    • Griffin, T.M., Huebner, J.L., Kraus, V.B., and Guilak, F. (2009). Extreme obesity due to impaired leptin signaling in mice does not cause knee osteoarthritis. Arthritis Rheum. 60, 2935-2944.
    • (2009) Arthritis Rheum , vol.60 , pp. 2935-2944
    • Griffin, T.M.1    Huebner, J.L.2    Kraus, V.B.3    Guilak, F.4
  • 33
    • 84855993582 scopus 로고    scopus 로고
    • Biomechanical factors in osteoarthritis. Best practice & research
    • Guilak, F. (2011). Biomechanical factors in osteoarthritis. Best practice & research. Clin. Rheumatol. 25, 815-823.
    • (2011) Clin. Rheumatol , vol.25 , pp. 815-823
    • Guilak, F.1
  • 35
    • 0028998579 scopus 로고
    • Association between metabolic factors and knee osteoarthritis in women: The Chingford Study
    • Hart, D.J., Doyle, D.V., and Spector, T.D. (1995). Association between metabolic factors and knee osteoarthritis in women: the Chingford Study. J. Rheumatol. 22, 1118-1123.
    • (1995) J. Rheumatol , vol.22 , pp. 1118-1123
    • Hart, D.J.1    Doyle, D.V.2    Spector, T.D.3
  • 36
    • 70350561846 scopus 로고    scopus 로고
    • DNA demethylation at specific CpG sites in the IL1B promoter in response to inflammatory cytokines in human articular chondrocytes
    • Hashimoto, K., Oreffo, R.O., Gibson, M.B., Goldring, M.B., and Roach, H.I. (2009). DNA demethylation at specific CpG sites in the IL1B promoter in response to inflammatory cytokines in human articular chondrocytes. Arthritis Rheum. 60, 3303-3313.
    • (2009) Arthritis Rheum , vol.60 , pp. 3303-3313
    • Hashimoto, K.1    Oreffo, R.O.2    Gibson, M.B.3    Goldring, M.B.4    Roach, H.I.5
  • 37
    • 84875999020 scopus 로고    scopus 로고
    • Regulated transcription of human matrix metalloproteinase 13 (MMP13) and interleukin-1 beta (IL1B) genes in chondrocytes depends on methylation of specific proximal promoter CpG sites
    • Hashimoto, K., Otero, M., Imagawa, K., de Andres, M.C., Coico, J.M., Roach, H.I., Oreffo, R.O., Marcu, K.B., and Goldring, M.B. (2013). Regulated transcription of human matrix metalloproteinase 13 (MMP13) and interleukin-1 beta (IL1B) genes in chondrocytes depends on methylation of specific proximal promoter CpG sites. J. Biol. Chem. 288, 10061-10072.
    • (2013) J. Biol. Chem , vol.288 , pp. 10061-10072
    • Hashimoto, K.1    Otero, M.2    Imagawa, K.3    De Andres, M.C.4    Coico, J.M.5    Roach, H.I.6    Oreffo, R.O.7    Marcu, K.B.8    Goldring, M.B.9
  • 39
    • 78650982530 scopus 로고    scopus 로고
    • The role of the cartilage matrix in osteoarthritis
    • Heinegard, D., and Saxne, T. (2011). The role of the cartilage matrix in osteoarthritis. Nat. Rev. Rheumatol. 7, 50-56.
    • (2011) Nat. Rev. Rheumatol , vol.7 , pp. 50-56
    • Heinegard, D.1    Saxne, T.2
  • 41
    • 70349670585 scopus 로고    scopus 로고
    • A novel domain in histone deacetylase 1 and 2 mediates repression of cartilage-specific genes in human chondrocytes
    • Hong, S., Derfoul, A., Pereira-Mouries, L., and Hall, D.J. (2009). A novel domain in histone deacetylase 1 and 2 mediates repression of cartilage-specific genes in human chondrocytes. FASEB J. 23, 3539-3552.
    • (2009) FASEB J , vol.23 , pp. 3539-3552
    • Hong, S.1    Derfoul, A.2    Pereira-Mouries, L.3    Hall, D.J.4
  • 42
    • 80051536994 scopus 로고    scopus 로고
    • Nicotinamide phosphoribosyltransferase is essential for interleukin-1 beta- mediated dedifferentiation of articular chondrocytes via SIRT1 and extracellular signal-regulated kinase (ErK) complex signaling
    • Hong, E.H., Yun, H.S., Kim, J., Um, H.D., Lee, K.H., Kang, C.M., Lee, S.J., Chun, J.S., and Hwang, S.G (2011). Nicotinamide phosphoribosyltransferase is essential for interleukin-1 beta- mediated dedifferentiation of articular chondrocytes via SIRT1 and extracellular signal-regulated kinase (ErK) complex signaling. J. Biol. Chem. 286, 28619-28631.
    • (2011) J. Biol. Chem , vol.286 , pp. 28619-28631
    • Hong, E.H.1    Yun, H.S.2    Kim, J.3    Um, H.D.4    Lee, K.H.5    Kang, C.M.6    Lee, S.J.7    Chun, J.S.8    Hwang, S.G.9
  • 43
    • 78650727090 scopus 로고    scopus 로고
    • Correlation of plasma and synovial fluid adiponectin with knee osteoarthritis severity
    • Honsawek, S., and Chayanupatkul, M. (2010). Correlation of plasma and synovial fluid adiponectin with knee osteoarthritis severity. Arch. Med. Res. 41, 593-598.
    • (2010) Arch. Med. Res , vol.41 , pp. 593-598
    • Honsawek, S.1    Chayanupatkul, M.2
  • 44
    • 84893782724 scopus 로고    scopus 로고
    • Homeostatic mechanisms in articular cartilage and role of inflammation in osteoarthritis
    • Houard, X., Goldring, M.B., and Berenbaum, F. (2013). Homeostatic mechanisms in articular cartilage and role of inflammation in osteoarthritis. Curr. Rheumatol. Rep. 15, 375.
    • (2013) Curr. Rheumatol. Rep , vol.15 , pp. 375
    • Houard, X.1    Goldring, M.B.2    Berenbaum, F.3
  • 45
    • 34447131517 scopus 로고    scopus 로고
    • Regulation of type II collagen expression by histone deacetylase in articular chondrocytes
    • Huh, Y.H., Ryu, J.H., and Chun, J.S. (2007). Regulation of type II collagen expression by histone deacetylase in articular chondrocytes. J. Biol. Chem. 282, 17123-17131.
    • (2007) J. Biol. Chem , vol.282 , pp. 17123-17131
    • Huh, Y.H.1    Ryu, J.H.2    Chun, J.S.3
  • 46
    • 36549024994 scopus 로고    scopus 로고
    • Epigenetic regulation of leptin affects MMP-13 expression in osteoarthritic chondrocytes: Possible molecular target for osteoarthritis therapeutic intervention
    • Iliopoulos, D., Malizos, K.N., and Tsezou, A. (2007). Epigenetic regulation of leptin affects MMP-13 expression in osteoarthritic chondrocytes: possible molecular target for osteoarthritis therapeutic intervention. Ann. Rheumatic Dis. 66, 1616-1621.
    • (2007) Ann. Rheumatic Dis , vol.66 , pp. 1616-1621
    • Iliopoulos, D.1    Malizos, K.N.2    Tsezou, A.3
  • 47
    • 84924253904 scopus 로고    scopus 로고
    • Association of reduced type IX collagen gene expression in human osteoarthritic chondrocytes with epigenetic silencing by DNA hypermethylation
    • Imagawa, K., de Andres, M.C., Hashimoto, K., Itoi, E., Otero, M., Roach, H.I., Goldring, M.B., and Oreffo, R.O. (2014). Association of reduced type IX collagen gene expression in human osteoarthritic chondrocytes with epigenetic silencing by DNA hypermethylation. Arthritis Rheumatol. 66, 3040-3051.
    • (2014) Arthritis Rheumatol , vol.66 , pp. 3040-3051
    • Imagawa, K.1    De Andres, M.C.2    Hashimoto, K.3    Itoi, E.4    Otero, M.5    Roach, H.I.6    Goldring, M.B.7    Oreffo, R.O.8
  • 49
    • 84855454389 scopus 로고    scopus 로고
    • Lysine acetylation in obesity, diabetes and metabolic disease
    • Iyer, A., Fairlie, D.P., and Brown, L. (2012). Lysine acetylation in obesity, diabetes and metabolic disease. Immunol. Cell Biol. 90, 39-46.
    • (2012) Immunol. Cell Biol , vol.90 , pp. 39-46
    • Iyer, A.1    Fairlie, D.P.2    Brown, L.3
  • 50
    • 20944433514 scopus 로고    scopus 로고
    • Vulnerability to ROS-induced cell death in ageing articular cartilage: The role of antioxidant enzyme activity
    • Jallali, N., Ridha, H., Thrasivoulou, C., Underwood, C., Butler, P.E., and Cowen, T. (2005). Vulnerability to ROS-induced cell death in ageing articular cartilage: the role of antioxidant enzyme activity. Osteoarthritis Cartilage 13, 614-622.
    • (2005) Osteoarthritis Cartilage , vol.13 , pp. 614-622
    • Jallali, N.1    Ridha, H.2    Thrasivoulou, C.3    Underwood, C.4    Butler, P.E.5    Cowen, T.6
  • 51
    • 84875755814 scopus 로고    scopus 로고
    • Influence of metabolism on epigenetics and disease
    • Kaelin, W.G., Jr., and McKnight, S.L. (2013). Influence of metabolism on epigenetics and disease. Cell 153, 56-69.
    • (2013) Cell , vol.153 , pp. 56-69
    • Kaelin, W.G.1    McKnight, S.L.2
  • 53
    • 84876738726 scopus 로고    scopus 로고
    • Changes in the epigenetic status of the SOX-9 promoter in human osteoarthritic cartilage
    • Kim, K.I., Park, Y.S., and Im, G.I. (2013). Changes in the epigenetic status of the SOX-9 promoter in human osteoarthritic cartilage. J. Bone Miner. Res. 28, 1050-1060.
    • (2013) J. Bone Miner. Res , vol.28 , pp. 1050-1060
    • Kim, K.I.1    Park, Y.S.2    Im, G.I.3
  • 54
    • 84894114401 scopus 로고    scopus 로고
    • Regulation of the catabolic cascade in osteoarthritis by the zinc-ZIP8-MTF1 axis
    • Kim, J.H., Jeon, J., Shin, M., Won, Y, Lee, M., Kwak, J.S., Lee, G., Rhee, J., Ryu, J.H., Chun, C.H., et al. (2014). Regulation of the catabolic cascade in osteoarthritis by the zinc-ZIP8-MTF1 axis. Cell 156, 730-743.
    • (2014) Cell , vol.156 , pp. 730-743
    • Kim, J.H.1    Jeon, J.2    Shin, M.3    Won, Y.4    Lee, M.5    Kwak, J.S.6    Lee, G.7    Rhee, J.8    Ryu, J.H.9    Chun, C.H.10
  • 57
    • 70450245346 scopus 로고    scopus 로고
    • Positive association between increased popliteal artery vessel wall thickness and generalized osteoarthritis: Is OA also part of the metabolic syndrome?
    • Kornaat, P.R., Sharma, R., van der Geest, R.J., Lamb, H.J., Kloppenburg, M., Hellio le Graverand, M.P., Bloem, J.L., and Watt, I. (2009). Positive association between increased popliteal artery vessel wall thickness and generalized osteoarthritis: is OA also part of the metabolic syndrome? Skeletal Radiol. 38, 1147-1151.
    • (2009) Skeletal Radiol , vol.38 , pp. 1147-1151
    • Kornaat, P.R.1    Sharma, R.2    Van Der Geest, R.J.3    Lamb, H.J.4    Kloppenburg, M.5    Hellio Le Graverand, M.P.6    Bloem, J.L.7    Watt, I.8
  • 58
    • 81055126964 scopus 로고    scopus 로고
    • Adiponectin associates with markers of cartilage degradation in osteoarthritis and induces production of proinflammatory and catabolic factors through mitogen-activated protein kinase pathways
    • Koskinen, A., Juslin, S., Nieminen, R., Moilanen, T., Vuolteenaho, K., and Moilanen, E. (2011). Adiponectin associates with markers of cartilage degradation in osteoarthritis and induces production of proinflammatory and catabolic factors through mitogen-activated protein kinase pathways. Arthritis Res. Ther. 13, R184.
    • (2011) Arthritis Res. Ther , vol.13 , pp. 184
    • Koskinen, A.1    Juslin, S.2    Nieminen, R.3    Moilanen, T.4    Vuolteenaho, K.5    Moilanen, E.6
  • 59
    • 33847076849 scopus 로고    scopus 로고
    • Chromatin modifications and their function
    • Kouzarides, T. (2007). Chromatin modifications and their function. Cell 128, 693-705.
    • (2007) Cell , vol.128 , pp. 693-705
    • Kouzarides, T.1
  • 60
    • 70450255129 scopus 로고    scopus 로고
    • Correlation of synovial fluid leptin concentrations with the severity of osteoarthritis
    • Ku, J.H., Lee, C.K., Joo, B.S., An, B.M., Choi, S.H., Wang, T.H., and Cho, H.L. (2009). Correlation of synovial fluid leptin concentrations with the severity of osteoarthritis. Clin. Rheumatol. 28, 1431-1435.
    • (2009) Clin. Rheumatol , vol.28 , pp. 1431-1435
    • Ku, J.H.1    Lee, C.K.2    Joo, B.S.3    An, B.M.4    Choi, S.H.5    Wang, T.H.6    Cho, H.L.7
  • 61
    • 49149103250 scopus 로고    scopus 로고
    • A new player in cartilage homeostasis: Adiponectin induces nitric oxide synthase type II and pro-inflammatory cytokines in chondrocytes
    • Lago, R., Gomez, R., Otero, M., Lago, F., Gallego, R., Dieguez, C., Gomez-Reino, J.J., and Gualillo, O. (2008). A new player in cartilage homeostasis: adiponectin induces nitric oxide synthase type II and pro-inflammatory cytokines in chondrocytes. Osteoarthritis Cartilage 16, 1101-1109.
    • (2008) Osteoarthritis Cartilage , vol.16 , pp. 1101-1109
    • Lago, R.1    Gomez, R.2    Otero, M.3    Lago, F.4    Gallego, R.5    Dieguez, C.6    Gomez-Reino, J.J.7    Gualillo, O.8
  • 63
    • 0032189223 scopus 로고    scopus 로고
    • A new long form of Sox5 (L-Sox5), Sox6 and Sox9 are coexpressed in chondrogenesis and cooperatively activate the type II collagen gene
    • Lefebvre, V., Li, P., and de Crombrugghe, B. (1998). A new long form of Sox5 (L-Sox5), Sox6 and Sox9 are coexpressed in chondrogenesis and cooperatively activate the type II collagen gene. EMBO J. 17, 5718-5733.
    • (1998) EMBO J , vol.17 , pp. 5718-5733
    • Lefebvre, V.1    Li, P.2    De Crombrugghe, B.3
  • 64
    • 73249133400 scopus 로고    scopus 로고
    • Epigenetics: A molecular link between environmental factors and type 2 diabetes
    • Ling, C., and Groop, L. (2009). Epigenetics: a molecular link between environmental factors and type 2 diabetes. Diabetes 58, 2718-2725.
    • (2009) Diabetes , vol.58 , pp. 2718-2725
    • Ling, C.1    Groop, L.2
  • 66
    • 84871226206 scopus 로고    scopus 로고
    • Aging processes and the development of osteoarthritis
    • Loeser, R.F. (2013). Aging processes and the development of osteoarthritis. Curr. Opin. Rheumatol. 25, 108-113.
    • (2013) Curr. Opin. Rheumatol , vol.25 , pp. 108-113
    • Loeser, R.F.1
  • 67
    • 28544442661 scopus 로고    scopus 로고
    • Contribution of psychosocial and mechanical variables to physical performance measures in knee osteoarthritis
    • Maly, M.R., Costigan, P.A., and Olney, S.J. (2005). Contribution of psychosocial and mechanical variables to physical performance measures in knee osteoarthritis. Phys. Ther. 85, 1318-1328.
    • (2005) Phys. Ther , vol.85 , pp. 1318-1328
    • Maly, M.R.1    Costigan, P.A.2    Olney, S.J.3
  • 69
    • 84902267233 scopus 로고    scopus 로고
    • Disruption of Sirt1 in chondrocytes causes accelerated progression of osteoarthritis under mechanical stress and during ageing in mice
    • Matsuzaki, T., Matsushita, T., Takayama, K., Matsumoto, T., Nishida, K., Kuroda, R., and Kurosaka, M. (2014). Disruption of Sirt1 in chondrocytes causes accelerated progression of osteoarthritis under mechanical stress and during ageing in mice. Ann. Rheumatic Dis. 73, 1397-1404.
    • (2014) Ann. Rheumatic Dis , vol.73 , pp. 1397-1404
    • Matsuzaki, T.1    Matsushita, T.2    Takayama, K.3    Matsumoto, T.4    Nishida, K.5    Kuroda, R.6    Kurosaka, M.7
  • 70
    • 78650208106 scopus 로고    scopus 로고
    • Metabolism strikes back: Metabolic flux regulates cell signaling
    • Metallo, C.M., and Vander Heiden, M.G (2010). Metabolism strikes back: metabolic flux regulates cell signaling. Genes Dev. 24, 2717-2722.
    • (2010) Genes Dev , vol.24 , pp. 2717-2722
    • Metallo, C.M.1    Vander Heiden, M.G.2
  • 72
    • 25444467426 scopus 로고    scopus 로고
    • Secondary gait changes in patients with medial compartment knee osteoarthritis: Increased load at the ankle, knee, and hip during walking
    • Mundermann, A., Dyrby, C.O., and Andriacchi, T.P. (2005). Secondary gait changes in patients with medial compartment knee osteoarthritis: increased load at the ankle, knee, and hip during walking. Arthritis Rheum. 52, 2835-2844.
    • (2005) Arthritis Rheum , vol.52 , pp. 2835-2844
    • Mundermann, A.1    Dyrby, C.O.2    Andriacchi, T.P.3
  • 74
    • 44549083450 scopus 로고    scopus 로고
    • Trichostatin A, a histone deacetylase inhibitor, suppresses synovial inflammation and subsequent cartilage destruction in a collagen antibody-induced arthritis mouse model
    • Nasu, Y, Nishida, K., Miyazawa, S., Komiyama, T., Kadota, Y, Abe, N., Yoshida, A., Hirohata, S., Ohtsuka, A., and Ozaki, T. (2008). Trichostatin A, a histone deacetylase inhibitor, suppresses synovial inflammation and subsequent cartilage destruction in a collagen antibody-induced arthritis mouse model. Osteoarthritis Cartilage 16, 723-732.
    • (2008) Osteoarthritis Cartilage , vol.16 , pp. 723-732
    • Nasu, Y.1    Nishida, K.2    Miyazawa, S.3    Komiyama, T.4    Kadota, Y.5    Abe, N.6    Yoshida, A.7    Hirohata, S.8    Ohtsuka, A.9    Ozaki, T.10
  • 76
    • 0032964421 scopus 로고    scopus 로고
    • Body weight, body mass index, and incident symptomatic osteoarthritis of the hand, hip, and knee
    • Oliveria, S.A., Felson, D.T., Cirillo, P.A., Reed, J.I., and Walker, A.M. (1999). Body weight, body mass index, and incident symptomatic osteoarthritis of the hand, hip, and knee. Epidemiology 10, 161-166.
    • (1999) Epidemiology , vol.10 , pp. 161-166
    • Oliveria, S.A.1    Felson, D.T.2    Cirillo, P.A.3    Reed, J.I.4    Walker, A.M.5
  • 80
    • 30344486078 scopus 로고    scopus 로고
    • Signalling pathway involved in nitric oxide synthase type II activation in chondrocytes: Synergistic effect of leptin with interleukin-1
    • Otero, M., Lago, R., Lago, F., Reino, J.J., and Gualillo, O. (2005). Signalling pathway involved in nitric oxide synthase type II activation in chondrocytes: synergistic effect of leptin with interleukin-1. Arthritis Res. Ther. 7, R581-591.
    • (2005) Arthritis Res. Ther , vol.7 , pp. 581-591
    • Otero, M.1    Lago, R.2    Lago, F.3    Reino, J.J.4    Gualillo, O.5
  • 82
    • 14144251836 scopus 로고    scopus 로고
    • DNA methylation is not likely to be responsible for aggrecan down regulation in aged or osteoarthritic cartilage
    • Poschl, E., Fidler, A., Schmidt, B., Kallipolitou, A., Schmid, E., and Aigner, T. (2005). DNA methylation is not likely to be responsible for aggrecan down regulation in aged or osteoarthritic cartilage. Ann. Rheumatic Dis. 64, 477-480.
    • (2005) Ann. Rheumatic Dis , vol.64 , pp. 477-480
    • Poschl, E.1    Fidler, A.2    Schmidt, B.3    Kallipolitou, A.4    Schmid, E.5    Aigner, T.6
  • 83
    • 0142247187 scopus 로고    scopus 로고
    • Mammalian DNA (Cytosine- 5) methyltransferases and their expression
    • Pradhan, S., and Esteve, P.-O. (2003). Mammalian DNA (cytosine- 5) methyltransferases and their expression. Clin. Immunol. 109, 6-16.
    • (2003) Clin. Immunol , vol.109 , pp. 6-16
    • Pradhan, S.1    Esteve, P.-O.2
  • 84
    • 73949108742 scopus 로고    scopus 로고
    • Increased prevalence of metabolic syndrome in individuals with osteoarthritis: An analysis of NHANES III data
    • Puenpatom, R.A., and Victor, T.W. (2009). Increased prevalence of metabolic syndrome in individuals with osteoarthritis: an analysis of NHANES III data. Postgrad. Med. 121, 9-20.
    • (2009) Postgrad. Med , vol.121 , pp. 9-20
    • Puenpatom, R.A.1    Victor, T.W.2
  • 85
    • 0032168678 scopus 로고    scopus 로고
    • CpG methylation, chromatin structure and gene silencing-a three-way connection
    • Razin, A. (1998). CpG methylation, chromatin structure and gene silencing-a three-way connection. EMBO J. 17, 4905-4908.
    • (1998) EMBO J , vol.17 , pp. 4905-4908
    • Razin, A.1
  • 86
    • 80051693596 scopus 로고    scopus 로고
    • Expression of the osteoarthritis-associated gene GDF5 is modulated epigenetically by DNA methylation
    • Reynard, L.N., Bui, C., Canty-Laird, E.G, Young, D.A., and Loughlin, J. (2011). Expression of the osteoarthritis-associated gene GDF5 is modulated epigenetically by DNA methylation. Hum. Mol. Genet. 20, 3450-3460.
    • (2011) Hum. Mol. Genet , vol.20 , pp. 3450-3460
    • Reynard, L.N.1    Bui, C.2    Canty-Laird, E.G.3    Young, D.A.4    Loughlin, J.5
  • 87
    • 26844518429 scopus 로고    scopus 로고
    • Association between the abnormal expression of matrix-degrading enzymes by human osteoarthritic chondrocytes and demethylation of specific CpG sites in the promoter regions
    • Roach, H.I., Yamada, N., Cheung, K.S., Tilley, S., Clarke, N.M., Oreffo, R.O., Kokubun, S., and Bronner, F. (2005). Association between the abnormal expression of matrix-degrading enzymes by human osteoarthritic chondrocytes and demethylation of specific CpG sites in the promoter regions. Arthritis Rheum. 52, 3110-3124.
    • (2005) Arthritis Rheum , vol.52 , pp. 3110-3124
    • Roach, H.I.1    Yamada, N.2    Cheung, K.S.3    Tilley, S.4    Clarke, N.M.5    Oreffo, R.O.6    Kokubun, S.7    Bronner, F.8
  • 88
    • 79960647136 scopus 로고    scopus 로고
    • Nfat1 regulates adult articular chondrocyte function through its age-dependent expression mediated by epigenetic histone methylation
    • Rodova, M., Lu, Q., Li, Y, Woodbury, B.G, Crist, J.D., Gardner, A. M., Yost, J.G, Zhong, X.B., Anderson, H.C., and Wang, J. (2010). Nfat1 regulates adult articular chondrocyte function through its age-dependent expression mediated by epigenetic histone methylation. J. Bone Miner. Res. 26, 1974-1986.
    • (2010) J. Bone Miner. Res , vol.26 , pp. 1974-1986
    • Rodova, M.1    Lu, Q.2    Li, Y.3    Woodbury, B.G.4    Crist, J.D.5    Gardner, A.M.6    Yost, J.G.7    Zhong, X.B.8    Erson, H.C.9    Wang, J.10
  • 89
    • 59149096239 scopus 로고    scopus 로고
    • Mitochondrial dysregulation of osteoarthritic human articular chondrocytes analyzed by proteomics a decrease in mitochondrial superoxide dismutase points to a redox imbalance
    • Ruiz-Romero, C., Calamia, V., Mateos, J.s., Carreira, V., Martinez- Gomariz, M., Fernandez, M.F., and Blanco, F.J. (2009). Mitochondrial dysregulation of osteoarthritic human articular chondrocytes analyzed by proteomics a decrease in mitochondrial superoxide dismutase points to a redox imbalance. Mol. Cell. Proteomics 8, 172-189.
    • (2009) Mol. Cell. Proteomics , vol.8 , pp. 172-189
    • Ruiz-Romero, C.1    Calamia, V.2    Mateos, J.S.3    Carreira, V.4    Martinez- Gomariz, M.5    Fernandez, M.F.6    Blanco, F.J.7
  • 90
    • 77953208836 scopus 로고    scopus 로고
    • Transcriptional regulation of endochondral ossification by HIF-2alpha during skeletal growth and osteoarthritis development
    • Saito, T., Fukai, A., Mabuchi, A., Ikeda, T., Yano, F., Ohba, S., Nishida, N., Akune, T., Yoshimura, N., Nakagawa, T., et al. (2010). Transcriptional regulation of endochondral ossification by HIF-2alpha during skeletal growth and osteoarthritis development. Nat. Med. 16, 678-686.
    • (2010) Nat. Med , vol.16 , pp. 678-686
    • Saito, T.1    Fukai, A.2    Mabuchi, A.3    Ikeda, T.4    Yano, F.5    Ohba, S.6    Nishida, N.7    Akune, T.8    Yoshimura, N.9    Nakagawa, T.10
  • 91
    • 0035499204 scopus 로고    scopus 로고
    • Hypoxia in cartilage: HIF-1 alpha is essential for chondrocyte growth arrest and survival
    • Schipani, E., Ryan, H.E., Didrickson, S., Kobayashi, T., Knight, M., and Johnson, R.S. (2001). Hypoxia in cartilage: HIF-1 alpha is essential for chondrocyte growth arrest and survival. Genes Dev. 15, 2865-2876.
    • (2001) Genes Dev , vol.15 , pp. 2865-2876
    • Schipani, E.1    Ryan, H.E.2    Didrickson, S.3    Kobayashi, T.4    Knight, M.5    Johnson, R.S.6
  • 92
    • 38649123072 scopus 로고    scopus 로고
    • Conserved metabolic regulatory functions of sirtuins
    • Schwer, B., and Verdin, E. (2008). Conserved metabolic regulatory functions of sirtuins. Cell Metab. 7, 104-112.
    • (2008) Cell Metab , vol.7 , pp. 104-112
    • Schwer, B.1    Verdin, E.2
  • 93
    • 61549140408 scopus 로고    scopus 로고
    • DNA methylation is not responsible for p21WAF1/CIP1 down-regulation in osteoarthritic chondrocytes
    • Sesselmann, S., Soder, S., Voigt, R., Haag, J., Grogan, S., and Aigner, T. (2009). DNA methylation is not responsible for p21WAF1/CIP1 down-regulation in osteoarthritic chondrocytes. Osteoarthritis Cartilage 17, 507-512.
    • (2009) Osteoarthritis Cartilage , vol.17 , pp. 507-512
    • Sesselmann, S.1    Soder, S.2    Voigt, R.3    Haag, J.4    Grogan, S.5    Aigner, T.6
  • 94
    • 0034051227 scopus 로고    scopus 로고
    • Acetylation of histones and transcription-related factors
    • Sterner, D.E., and Berger, S.L. (2000). Acetylation of histones and transcription-related factors. Microbiol. Mol. Biol. Rev. 64, 435-459.
    • (2000) Microbiol. Mol. Biol. Rev , vol.64 , pp. 435-459
    • Sterner, D.E.1    Berger, S.L.2
  • 95
    • 64749111074 scopus 로고    scopus 로고
    • Role of Jhdm2a in regulating metabolic gene expression and obesity resistance
    • Tateishi, K., Okada, Y, Kallin, E.M., and Zhang, Y. (2009). Role of Jhdm2a in regulating metabolic gene expression and obesity resistance. Nature 458, 757-761.
    • (2009) Nature , vol.458 , pp. 757-761
    • Tateishi, K.1    Okada, Y.2    Kallin, E.M.3    Zhang, Y.4
  • 96
    • 82755197933 scopus 로고    scopus 로고
    • Proteases involved in cartilage matrix degradation in osteoarthritis
    • Troeberg, L., and Nagase, H. (2012). Proteases involved in cartilage matrix degradation in osteoarthritis. Biochim. Biophys. Acta 1824, 133-145.
    • (2012) Biochim. Biophys. Acta , vol.1824 , pp. 133-145
    • Troeberg, L.1    Nagase, H.2
  • 101
    • 84856291934 scopus 로고    scopus 로고
    • Extracellular nicotinamide phosphoribosyltransferase (NAMPT/visfatin) inhibits insulin-like growth factor-1 signaling and proteoglycan synthesis in human articular chondrocytes
    • Yammani, R.R., and Loeser, R.F. (2012). Extracellular nicotinamide phosphoribosyltransferase (NAMPT/visfatin) inhibits insulin-like growth factor-1 signaling and proteoglycan synthesis in human articular chondrocytes. Arthritis Res. Ther. 14, R23.
    • (2012) Arthritis Res. Ther , vol.14 , pp. 23
    • Yammani, R.R.1    Loeser, R.F.2
  • 102
    • 77953183739 scopus 로고    scopus 로고
    • Hypoxia-inducible factor-2alpha is a catabolic regulator of osteoarthritic cartilage destruction
    • Yang, S., Kim, J., Ryu, J.H., Oh, H., Chun, C.H., Kim, B.J., Min, A. H., and Chun, J.S. (2010). Hypoxia-inducible factor-2alpha is a catabolic regulator of osteoarthritic cartilage destruction. Nat. Med. 16, 687-693.
    • (2010) Nat. Med , vol.16 , pp. 687-693
    • Yang, S.1    Kim, J.2    Ryu, J.H.3    Oh, H.4    Chun, C.H.5    Kim, B.J.6    Min, A.H.7    Chun, J.S.8
  • 103
    • 84922349501 scopus 로고    scopus 로고
    • NAMPT (Visfatin), a direct target of hypoxia-inducible factor-2alpha, is an essential catabolic regulator of osteoarthritis
    • Yang, S., Ryu, J.H., Oh, H., Jeon, J., Kwak, J.S., Kim, J.H., Kim, G. A., Chun, C.H., and Chun, J.S. (2015). NAMPT (visfatin), a direct target of hypoxia-inducible factor-2alpha, is an essential catabolic regulator of osteoarthritis. Ann. Rheumatic Dis. 74, 595-602.
    • (2015) Ann. Rheumatic Dis , vol.74 , pp. 595-602
    • Yang, S.1    Ryu, J.H.2    Oh, H.3    Jeon, J.4    Kwak, J.S.5    Kim, J.H.6    Kim, G.A.7    Chun, C.H.8    Chun, J.S.9
  • 105
    • 0036203419 scopus 로고    scopus 로고
    • The phosphorylation status of nuclear NF-kappa B determines its association with CBP/p300 or HDAC-1
    • Zhong, H., May, M.J., Jimi, E., and Ghosh, S. (2002). The phosphorylation status of nuclear NF-kappa B determines its association with CBP/p300 or HDAC-1. Mol. Cell 9, 625-636.
    • (2002) Mol. Cell , vol.9 , pp. 625-636
    • Zhong, H.1    May, M.J.2    Jimi, E.3    Ghosh, S.4
  • 106
    • 84881505489 scopus 로고    scopus 로고
    • Vorinostat, a HDAC inhibitor, showed anti-osteoarthritic activities through inhibition of iNOS and MMP expression, p38 and ERK phosphorylation and blocking NF-kappaB nuclear translocation
    • Zhong, H.M., Ding, Q.H., Chen, W.P., and Luo, R.B. (2013). Vorinostat, a HDAC inhibitor, showed anti-osteoarthritic activities through inhibition of iNOS and MMP expression, p38 and ERK phosphorylation and blocking NF-kappaB nuclear translocation. Int. Immunopharmacol. 17, 329-335.
    • (2013) Int. Immunopharmacol , vol.17 , pp. 329-335
    • Zhong, H.M.1    Ding, Q.H.2    Chen, W.P.3    Luo, R.B.4
  • 107
    • 84870696930 scopus 로고    scopus 로고
    • Metabolic syndrome meets osteoarthritis
    • Zhuo, Q., Yang, W., Chen, J., and Wang, Y. (2012). Metabolic syndrome meets osteoarthritis. Nat. Rev. Rheumatol. 8, 729-737.
    • (2012) Nat. Rev. Rheumatol , vol.8 , pp. 729-737
    • Zhuo, Q.1    Yang, W.2    Chen, J.3    Wang, Y.4
  • 108
    • 51849083414 scopus 로고    scopus 로고
    • Correlation of COL10A1 induction during chondrogenesis of mesenchymal stem cells with demethylation of two CpG sites in the COL10A1 promoter
    • Zimmermann, P., Boeuf, S., Dickhut, A., Boehmer, S., Olek, S., and Richter, W. (2008). Correlation of COL10A1 induction during chondrogenesis of mesenchymal stem cells with demethylation of two CpG sites in the COL10A1 promoter. Arthritis Rheum. 58, 2743-2753.
    • (2008) Arthritis Rheum , vol.58 , pp. 2743-2753
    • Zimmermann, P.1    Boeuf, S.2    Dickhut, A.3    Boehmer, S.4    Olek, S.5    Richter, W.6


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