Association of reduced type IX collagen gene expression in human osteoarthritic chondrocytes with epigenetic silencing by DNA hypermethylation

Arthritis and Rheumatology

Volumn 66, Issue 11, 2014, Pages 3040-3051

  Imagawa, Kei ^a,c   De Andrés, María C ^b   Hashimoto, Ko ^c   Itoi, Eiji ^b   Otero, Miguel ^c   Roach, Helmtrud I ^d   Goldring, Mary B ^c   Oreffo, Richard O C ^b  

^a UNIVERSITY OF SOUTHAMPTON   (United Kingdom)

^b TOHOKU UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^c WEILL CORNELL MEDICAL COLLEGE   (United States)

^d NONE

Author keywords

[No Author keywords available]

Indexed keywords

COLLAGEN TYPE 2; COLLAGEN TYPE 2 A1; COLLAGEN TYPE 9; COLLAGEN TYPE 9 A1; DECITABINE; HYPOXIA INDUCIBLE FACTOR 1ALPHA; HYPOXIA INDUCIBLE FACTOR 2ALPHA; MESSENGER RNA; TRANSCRIPTION FACTOR SOX9; UNCLASSIFIED DRUG; COL2A1 PROTEIN, HUMAN; COL9A1 PROTEIN, HUMAN; HIF1A PROTEIN, HUMAN; SOX9 PROTEIN, HUMAN;

AGED; ARTICLE; ARTICULAR CARTILAGE; CARTILAGE CELL; CHROMATIN IMMUNOPRECIPITATION; CLINICAL ARTICLE; CONTROLLED STUDY; CPG ISLAND; DNA EXTRACTION; DNA METHYLATION; DOWN REGULATION; ENHANCER REGION; EPIGENETICS; EXPRESSION VECTOR; FEMALE; FEMUR NECK FRACTURE; GENE EXPRESSION REGULATION; GENE MUTATION; GENE SILENCING; GENETIC ASSOCIATION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; MALE; OSTEOARTHRITIS; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN BINDING; PYROSEQUENCING; QUANTITATIVE ANALYSIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA EXTRACTION; TRANSCRIPTION INITIATION SITE; BLOOD; CASE CONTROL STUDY; CELL CULTURE; EPIGENETIC REPRESSION; GENETICS; METABOLISM; MOLECULAR GENETICS; NUCLEOTIDE SEQUENCE; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; VERY ELDERLY;

AGED; AGED, 80 AND OVER; BASE SEQUENCE; CASE-CONTROL STUDIES; CELLS, CULTURED; CHONDROCYTES; COLLAGEN TYPE II; COLLAGEN TYPE IX; CPG ISLANDS; DNA METHYLATION; DOWN-REGULATION; EPIGENETIC REPRESSION; FEMALE; GENE EXPRESSION REGULATION; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; IN VITRO TECHNIQUES; MALE; MOLECULAR SEQUENCE DATA; OSTEOARTHRITIS; PROMOTER REGIONS, GENETIC; SOX9 TRANSCRIPTION FACTOR;

EID: 84924253904     PISSN: 23265191     EISSN: 23265205     Source Type: Journal    
DOI: 10.1002/art.38774     Document Type: Article

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