Disruption of Sirt1 in chondrocytes causes accelerated progression of osteoarthritis under mechanical stress and during ageing in mice

Annals of the Rheumatic Diseases

Volumn 73, Issue 7, 2014, Pages 1397-1404

  Matsuzaki, Tokio ^a   Matsushita, Takehiko ^a   Takayama, Koji ^a   Matsumoto, Tomoyuki ^a   Nishida, Kotaro ^a   Kuroda, Ryosuke ^a   Kurosaka, Masahiro ^a  

^a KOBE UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

AGGRECANASE 2; COLLAGEN TYPE 10; COLLAGENASE 3; CRE RECOMBINASE; SIRTUIN 1; TRANSCRIPTION FACTOR RELA;

AGING; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; C57BL 6 MOUSE; CARTILAGE CELL; CELL COUNT; COL2A1 GENE; CONTROLLED STUDY; CRE GENE; DISEASE ACTIVITY; DISEASE COURSE; DISEASE MODEL; ENZYME DEFICIENCY; EXPERIMENTAL STUDY; FEMALE; GENE; HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY; IN VIVO STUDY; KNOCKOUT MOUSE; MALE; MECHANICAL STRESS; MOUSE; NONHUMAN; OSTEOARTHRITIS; PATHOPHYSIOLOGY; PRIORITY JOURNAL; SCORING SYSTEM; SIRT1 GENE;

CHONDROCYTES; KNEE OSTEOARTHRITIS; OSTEOARTHRITIS;

AGING; ANIMALS; ARTHRITIS, EXPERIMENTAL; CARTILAGE, ARTICULAR; CHONDROCYTES; DISEASE MODELS, ANIMAL; DISEASE PROGRESSION; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; OSTEOARTHRITIS, KNEE; SIRTUIN 1; STRESS, MECHANICAL;

EID: 84902267233     PISSN: 00034967     EISSN: 14682060     Source Type: Journal    
DOI: 10.1136/annrheumdis-2012-202620     Document Type: Article

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