Extracellular nicotinamide phosphoribosyltransferase (NAMPT/visfatin) inhibits insulin-like growth factor-1 signaling and proteoglycan synthesis in human articular chondrocytes

Arthritis Research and Therapy

Volumn 14, Issue 1, 2012, Pages

  Yammani, Raghunatha R ^a   Loeser, Richard F ^a  

^a WAKE FOREST SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; EXTRACELLULAR NICOTINAMIDE PHOSPHORIBOSYLTRAN; INSULIN RECEPTOR SUBSTRATE 1; MITOGEN ACTIVATED PROTEIN KINASE; NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE; PROTEIN KINASE B; SOMATOMEDIN C; SULFUR 35; UNCLASSIFIED DRUG; 1,3 BUTADIENE DERIVATIVE; ADIPOCYTOKINE; COLLAGEN TYPE 2; ENZYME INHIBITOR; INSULIN RECEPTOR SUBSTRATE; NITRILE; PROTEOGLYCAN;

ARTICLE; CARTILAGE CELL; CELL LYSATE; CELL STIMULATION; CONTROLLED STUDY; HUMAN; HUMAN CELL; IMMUNOBLOTTING; INHIBITION KINETICS; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PROTEOGLYCAN SYNTHESIS; SIGNAL TRANSDUCTION; ARTICULAR CARTILAGE; BIOSYNTHESIS; CELL CULTURE; CYTOLOGY; DRUG ANTAGONISM; DRUG EFFECT; GENE EXPRESSION; GENETICS; METABOLISM; PHOSPHORYLATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ADIPOKINES; BUTADIENES; CARTILAGE, ARTICULAR; CELLS, CULTURED; CHONDROCYTES; COLLAGEN TYPE II; ENZYME INHIBITORS; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; GENE EXPRESSION; HUMANS; IMMUNOBLOTTING; INSULIN RECEPTOR SUBSTRATE PROTEINS; INSULIN-LIKE GROWTH FACTOR I; MAP KINASE SIGNALING SYSTEM; NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE; NITRILES; PHOSPHORYLATION; PROTEOGLYCANS; PROTO-ONCOGENE PROTEINS C-AKT; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION;

EID: 84856291934     PISSN: 14786354     EISSN: 14786362     Source Type: Journal    
DOI: 10.1186/ar3705     Document Type: Article

References (32)

1. Cooper C, Snow S, McAlindon TE, Kellingray S, Stuart B, Coggon D, Dieppe PA. Risk factors for the incidence and progression of radiographic knee osteoarthritis. Arthritis Rheum 2000, 43:995-1000. 10.1002/1529-0131(200005)43:5<995::AID-ANR6>3.0.CO;2-1, 10817551.
2. Hart DJ, Spector TD. The relationship of obesity, fat distribution and osteoarthritis in women in the general population: the Chingford Study. J Rheumatol 1993, 20:331-335.
3. Presle N, Pottie P, Dumond H, Guillaume C, Lapicque F, Pallu S, Mainard D, Netter P, Terlain B. Differential distribution of adipokines between serum and synovial fluid in patients with osteoarthritis. Contribution of joint tissues to their articular production. Osteoarthritis Cartilage 2006, 14:690-695. 10.1016/j.joca.2006.01.009, 16527497.
4. Simopoulou T, Malizos KN, Iliopoulos D, Stefanou N, Papatheodorou L, Ioannou M, Tsezou A. Differential expression of leptin and leptin's receptor isoform (Ob-Rb) mRNA between advanced and minimally affected osteoarthritic cartilage; effect on cartilage metabolism. Osteoarthritis Cartilage 2007, 15:872-883. 10.1016/j.joca.2007.01.018, 17350295.
5. Lago R, Gomez R, Otero M, Lago F, Gallego R, Dieguez C, Gomez-Reino JJ, Gualillo O. A new player in cartilage homeostasis: adiponectin induces nitric oxide synthase type II and pro-inflammatory cytokines in chondrocytes. Osteoarthritis Cartilage 2008, 16:1101-1109. 10.1016/j.joca.2007.12.008, 18261936.
6. Lee JH, Ort T, Ma K, Picha K, Carton J, Marsters PA, Lohmander LS, Baribaud F, Song XY, Blake S. Resistin is elevated following traumatic joint injury and causes matrix degradation and release of inflammatory cytokines from articular cartilage in vitro. Osteoarthritis Cartilage 2009, 17:613-620. 10.1016/j.joca.2008.08.007, 19095472.
7. Chen WP, Bao JP, Feng J, Hu PF, Shi ZL, Wu LD. Increased serum concentrations of visfatin and its production by different joint tissues in patients with osteoarthritis. Clin Chem Lab Med 2010, 48:1141-1145. 10.1515/CCLM.2010.230, 20482384.
8. Duan Y, Hao D, Li M, Wu Z, Li D, Yang X, Qiu G. Increased synovial fluid visfatin is positively linked to cartilage degradation biomarkers in osteoarthritis. Rheumatol Int 2011,
9. Revollo JR, Grimm AA, Imai S. The NAD biosynthesis pathway mediated by nicotinamide phosphoribosyltransferase regulates Sir2 activity in mammalian cells. J Biol Chem 2004, 279:50754-50763. 10.1074/jbc.M408388200, 15381699.
10. Kitani T, Okuno S, Fujisawa H. Growth phase-dependent changes in the subcellular localization of pre-B-cell colony-enhancing factor. FEBS Lett 2003, 544:74-78. 10.1016/S0014-5793(03)00476-9, 12782293.
11. Samal B, Sun Y, Stearns G, Xie C, Suggs S, McNiece I. Cloning and characterization of the cDNA encoding a novel human pre-B-cell colony-enhancing factor. Mol Cell Biol 1994, 14:1431-1437. 358498, 8289818.
12. Revollo JR, Körner A, Mills KF, Satoh A, Wang T, Garten A, Dasgupta B, Sasaki Y, Wolberger C, Townsend RR, Milbrandt J, Kiess W, Imai S. Nampt/PBEF/visfatin regulates insulin secretion in beta cells as a systemic NAD biosynthetic enzyme. Cell Metab 2007, 6:363-375. 10.1016/j.cmet.2007.09.003, 2098698, 17983582.
13. Garten A, Petzold S, Körner A, Imai S, Kiess W. NAMPT: linking NAD biology, metabolism and cancer. Trends Endocrinol Metab 2009, 20:130-138. 10.1016/j.tem.2008.10.004, 2738422, 19109034.
14. Fukuhara A, Matsuda M, Nishizawa M, Segawa K, Tanaka M, Kishimoto K, Matsuki Y, Murakami M, Ichisaka T, Murakami H, Watanabe E, Takagi T, Akiyoshi M, Ohtsubo T, Kihara S, Yamashita S, Makishima M, Funahashi T, Yamanaka S, Hiramatsu R, Matsuzawa Y, Shimomura I. Visfatin: a protein secreted by visceral fat that mimics the effects of insulin. Science 2005, 307:426-430. 10.1126/science.1097243, 15604363.
15. Alghasham AA, Barakat YA. Serum visfatin and its relation to insulin resistance and inflammation in type 2 diabetic patients with and without macroangiopathy. Saudi Med J 2008, 29:185-192.
16. Berndt J, Klöting N, Kralisch S, Kovacs P, Fasshauer M, Schön MR, Stumvoll M, Blüher M. Plasma visfatin concentrations and fat depot-specific mRNA expression in humans. Diabetes 2005, 54:2911-2916. 10.2337/diabetes.54.10.2911, 16186392.
17. Gallí M, Van Gool F, Rongvaux A, Andris F, Leo O. The nicotinamide phosphoribosyltransferase: a molecular link between metabolism, inflammation, and cancer. Cancer Res 2010, 70:8-11. 10.1158/0008-5472.CAN-09-2465, 20028851.
18. Jones JI, Clemmons DR. Insulin-like growth factors and their binding proteins: biological actions. Endocr Rev 1995, 16:3-34.
19. Loeser RF. Growth factor regulation of chondrocyte integrins. Differential effects of insulin-like growth factor 1 and transforming growth factor beta on alpha 1 beta 1 integrin expression and chondrocyte adhesion to type VI collagen. Arthritis Rheum 1997, 40:270-276. 10.1002/art.1780400211, 9041938.
20. Loeser RF, Shanker G, Carlson CS, Gardin JF, Shelton BJ, Sonntag WE. Reduction in the chondrocyte response to insulin-like growth factor 1 in aging and osteoarthritis: studies in a non-human primate model of naturally occurring disease. Arthritis Rheum 2000, 43:2110-2120. 10.1002/1529-0131(200009)43:9<2110::AID-ANR23>3.0.CO;2-U, 11014363.
21. Muehleman C, Bareither D, Huch K, Cole AA, Kuettner KE. Prevalence of degenerative morphological changes in the joints of the lower extremity. Osteoarthritis Cartilage 1997, 5:23-37. 10.1016/S1063-4584(97)80029-5, 9010876.
22. Henrotin YE, Deberg MA, Crielaard JM, Piccardi N, Msika P, Sanchez C. Avocado/soybean unsaponifiables prevent the inhibitory effect of osteoarthritic/subchondral osteoblasts on aggrecan and type II collagen synthesis by chondrocytes. J Rheumatol 2006, 33:1668-1678.
23. Starkman BG, Cravero JD, Delcarlo M, Loeser RF. IGF-I stimulation of proteoglycan synthesis by chondrocytes requires activation of the PI 3-kinase pathway but not ERK MAPK. Biochem J 2005, 389:723-729. 10.1042/BJ20041636, 1180722, 15801908.
24. Yin W, Park JI, Loeser RF. Oxidative stress inhibits insulin-like growth factor-I induction of chondrocyte proteoglycan synthesis through differential regulation of phosphatidylinositol 3-kinase-Akt and MEK-ERK MAPK signaling pathways. J Biol Chem 2009, 284:31972-31981. 10.1074/jbc.M109.056838, 2797269, 19762915.
25. Hu PF, Bao JP, Wu LD. The emerging role of adipokines in osteoarthritis: a narrative review. Mol Biol Rep 2011, 38:873-878. 10.1007/s11033-010-0179-y, 20480243.
26. Aguirre V, Werner ED, Giraud J, Lee YH, Shoelson SE, White MF. Phosphorylation of Ser307 in insulin receptor substrate-1 blocks interactions with the insulin receptor and inhibits insulin action. J Biol Chem 2002, 277:1531-1537. 10.1074/jbc.M101521200, 11606564.
27. Liu YF, Herschkovitz A, Boura-Halfon S, Ronen D, Paz K, Leroith D, Zick Y. Serine phosphorylation proximal to its phosphotyrosine binding domain inhibits insulin receptor substrate 1 function and promotes insulin resistance. Mol Cell Biol 2004, 24:9668-9681. 10.1128/MCB.24.21.9668-9681.2004, 522236, 15485932.
28. Gosset M, Berenbaum F, Salvat C, Sautet A, Pigenet A, Tahiri K, Jacques C. Crucial role of visfatin/pre-B cell colony-enhancing factor in matrix degradation and prostaglandin E2 synthesis in chondrocytes: possible influence on osteoarthritis. Arthritis Rheum 2008, 58:1399-1409. 10.1002/art.23431, 18438860.
29. Lovren F, Pan Y, Shukla PC, Quan A, Teoh H, Szmitko PE, Peterson MD, Gupta M, Al-Omran M, Verma S. Visfatin activates eNOS via Akt and MAP kinases and improves endothelial cell function and angiogenesis in vitro and in vivo: translational implications for atherosclerosis. Am J Physiol Endocrinol Metab 2009, 296:E1440-E1449. 10.1152/ajpendo.90780.2008, 19351806.
30. Fan Z, Söder S, Oehler S, Fundel K, Aigner T. Activation of interleukin-1 signaling cascades in normal and osteoarthritic articular cartilage. Am J Pathol 2007, 171:938-946. 10.2353/ajpath.2007.061083, 1959501, 17640966.
31. Boileau C, Martel-Pelletier J, Brunet J, Schrier D, Flory C, Boily M, Pelletier JP. PD-0200347, an α2δ ligand of the voltage gated calcium channel, inhibits in vivo activation of the Erk1/2 pathway in osteoarthritic chondrocytes: a PKCα dependent effect. Ann Rheum Dis 2006, 65:573-580. 10.1136/ard.2005.041855, 1798126, 16249226.
32. Gual P, Le Marchand-Brustel Y, Tanti JF. Positive and negative regulation of insulin signaling through IRS-1 phosphorylation. Biochimie 2005, 87:99-109. 10.1016/j.biochi.2004.10.019, 15733744.