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Volumn 16, Issue 2, 2016, Pages 94-103

Benefits of L-arginine on cardiovascular system

Author keywords

Amino acid; Arginase; Cardiovascular disorders; Cardiovascular system; L Arg; NO; NOS

Indexed keywords

ACETYLCHOLINE; ADENOSINE DIPHOSPHATE; AGMATINE; ARGINASE; ARGININE; ARGININE DECARBOXYLASE; ARGININOSUCCINATE LYASE; ARGININOSUCCINATE SYNTHASE; BRADYKININ; CALMODULIN; CITRULLINE; CREATINE; CYCLIC GMP; DIMETHYLARGININASE; ENDOTHELIN 1; GLYCINE AMIDINOTRANSFERASE; GROWTH HORMONE; N(G),N(G) DIMETHYLARGININE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; ORNITHINE CARBAMOYLTRANSFERASE; OXYGEN; PHOSPHODIESTERASE V INHIBITOR; REACTIVE OXYGEN METABOLITE; TETRAHYDROBIOPTERIN; THROMBIN;

EID: 84949816844     PISSN: 13895575     EISSN: 18755607     Source Type: Journal    
DOI: 10.2174/1389557515666151016125826     Document Type: Article
Times cited : (28)

References (161)
  • 2
    • 15044353411 scopus 로고    scopus 로고
    • The role of NOS2 and NOS3 in renal protein and arginine metabolism during early endotoxemia in mice
    • Luiking, Y. C.; Hallemeesch, M. M.; Lamers, W. H.; Deutz, N. E. The role of NOS2 and NOS3 in renal protein and arginine metabolism during early endotoxemia in mice. Am. J. Physiol. Renal. Physiol., 2005, 288(4), F816-822.
    • (2005) Am. J. Physiol. Renal. Physiol. , vol.288 , Issue.4 , pp. F816-F822
    • Luiking, Y.C.1    Hallemeesch, M.M.2    Lamers, W.H.3    Deutz, N.E.4
  • 3
    • 0036864788 scopus 로고    scopus 로고
    • The metabolic basis of arginine nutrition and pharmacotherapy. Biomed
    • Flynn, N. E.; Meininger, C. J.; Haynes, T. E.; Wu, G. The metabolic basis of arginine nutrition and pharmacotherapy. Biomed. Pharmacother., 2002, 56(9), 427-438.
    • (2002) Pharmacother. , vol.56 , Issue.9 , pp. 427-438
    • Flynn, N.E.1    Meininger, C.J.2    Haynes, T.E.3    Wu, G.4
  • 4
    • 0032533159 scopus 로고    scopus 로고
    • Arginine metabolism: Nitric oxide and beyond
    • Wu, G.; Morris, S. M., Jr. Arginine metabolism: nitric oxide and beyond. Biochem. J., 1998, 336(Pt 1), 1-17.
    • (1998) Biochem. J. , vol.336 , pp. 1-17
    • Wu, G.1    Morris, S.M.2
  • 6
    • 31344464146 scopus 로고    scopus 로고
    • Arginine metabolism in vascular biology and disease
    • Morris, S. M., Jr. Arginine metabolism in vascular biology and disease. Vasc Med., 2005, 10 Suppl 1, S83-87.
    • Vasc Med., 2005, 10 Suppl , vol.1 , pp. S83-S87
    • Morris, S.M.1
  • 9
    • 0030988217 scopus 로고    scopus 로고
    • Structure-function aspects in the nitric oxide synthases
    • Stuehr, D. J. Structure-function aspects in the nitric oxide synthases. Ann. Rev. Pharmacol. Toxicol., 1997, 37, 339-359.
    • (1997) Ann. Rev. Pharmacol. Toxicol , vol.37 , pp. 339-359
    • Stuehr, D.J.1
  • 10
    • 0033020374 scopus 로고    scopus 로고
    • Dietary protein or arginine deficiency impairs constitutive and inducible nitric oxide synthesis by young rats
    • Wu, G.; Flynn, N. E.; Flynn, S. P.; Jolly, C. A.; Davis, P. K. Dietary protein or arginine deficiency impairs constitutive and inducible nitric oxide synthesis by young rats. J. Nutr., 1999, 129(7), 1347-1354.
    • (1999) J. Nutr , vol.129 , Issue.7 , pp. 1347-1354
    • Wu, G.1    Flynn, N.E.2    Flynn, S.P.3    Jolly, C.A.4    Davis, P.K.5
  • 11
    • 18044377751 scopus 로고    scopus 로고
    • L-arginine and cardiovascular system
    • Cylwik, D.; Mogielnicki, A.; Buczko, W. L-arginine and cardiovascular system. Pharmacol. Rep., 2005, 57(1), 14-22.
    • (2005) Pharmacol. Rep , vol.57 , Issue.1 , pp. 14-22
    • Cylwik, D.1    Mogielnicki, A.2    Buczko, W.3
  • 13
    • 0029933180 scopus 로고    scopus 로고
    • Treatment with L-arginine is likely to stimulate generation of nitric oxide in patients with peripheral arterial obstructive disease
    • Gryglewski, R. J.; Grodzinska, L.; Kostka-Trabka, E.; Korbut, R.; Bieroon, K.; Goszcz, A.; Slawinski, M. Treatment with L-arginine is likely to stimulate generation of nitric oxide in patients with peripheral arterial obstructive disease. Wien Klin Wochenschr. 1996, 108(4), 111-116.
    • (1996) Wien Klin Wochenschr , vol.108 , Issue.4 , pp. 111-116
    • Gryglewski, R.J.1    Grodzinska, L.2    Kostka-Trabka, E.3    Korbut, R.4    Bieroon, K.5    Goszcz, A.6    Slawinski, M.7
  • 14
  • 15
    • 0032029268 scopus 로고    scopus 로고
    • Chronic dietary supplementation with L-arginine inhibits platelet aggregation and thromboxane A2 synthesis in hypercholesterolaemic rabbits in vivo
    • Bode-Boger, S. M.; Boger, R. H.; Kienke, S.; Bohme, M.; Phivthong-ngam, L.; Tsikas, D.; Frolich, J. C. Chronic dietary supplementation with L-arginine inhibits platelet aggregation and thromboxane A2 synthesis in hypercholesterolaemic rabbits in vivo. Cardiovasc Res., 1998, 37(3), 756-764.
    • (1998) Cardiovasc Res. , vol.37 , Issue.3 , pp. 756-764
    • Bode-Boger, S.M.1    Boger, R.H.2    Kienke, S.3    Bohme, M.4    Phivthong-Ngam, L.5    Tsikas, D.6    Frolich, J.C.7
  • 16
    • 0029816959 scopus 로고    scopus 로고
    • Attenuation by prolonged nitric oxide synthase inhibition of the enhancement of fibrinolysis caused by environmental stress in the rat
    • Kawabata, A.; Hata, T. Attenuation by prolonged nitric oxide synthase inhibition of the enhancement of fibrinolysis caused by environmental stress in the rat. Br. J. Pharmacol., 1996, 119(2), 346-350.
    • (1996) Br. J. Pharmacol. , vol.119 , Issue.2 , pp. 346-350
    • Kawabata, A.1    Hata, T.2
  • 17
    • 0027967616 scopus 로고
    • L-arginine attenuates platelet reactivity in hypercholesterolemic rabbits
    • Tsao, P. S.; Theilmeier, G.; Singer, A. H.; Leung, L. L.; Cooke, J. P. L-arginine attenuates platelet reactivity in hypercholesterolemic rabbits. Arterioscler Thromb., 1994, 14(10), 1529-1533.
    • (1994) Arterioscler Thromb. , vol.14 , Issue.10 , pp. 1529-1533
    • Tsao, P.S.1    Theilmeier, G.2    Singer, A.H.3    Leung, L.L.4    Cooke, J.P.5
  • 19
    • 3142762125 scopus 로고    scopus 로고
    • McGraw-Hill Education
    • McKee, T. Biochemistry, McGraw-Hill Education: 1998.
    • (1998) Biochemistry
    • McKee, T.1
  • 23
    • 0022630695 scopus 로고
    • Arginine needs, physiological state and usual diets. A reevaluation
    • Visek, W. J. Arginine needs, physiological state and usual diets. A reevaluation. J. Nutr., 1986, 116(1), 36-46.
    • (1986) J. Nutr. , vol.116 , Issue.1 , pp. 36-46
    • Visek, W.J.1
  • 24
    • 0031296497 scopus 로고    scopus 로고
    • Wound healing in sepsis and trauma
    • Thornton, F. J.; Schaffer, M. R.; Barbul, A. Wound healing in sepsis and trauma. Shock, 1997, 8(6), 391-401.
    • (1997) Shock , vol.8 , Issue.6 , pp. 391-401
    • Thornton, F.J.1    Schaffer, M.R.2    Barbul, A.3
  • 25
    • 38049021468 scopus 로고    scopus 로고
    • Variation in Larginine intake follow demographics and lifestyle factors that may impact cardiovascular disease risk
    • King, D. E.; Mainous, A. G., III; Geesey, M. E. Variation in Larginine intake follow demographics and lifestyle factors that may impact cardiovascular disease risk. Nutr. Res., 2008, 28(1), 21-24.
    • (2008) Nutr. Res. , vol.28 , Issue.1 , pp. 21-24
    • King, D.E.1    Mainous, A.G.2    Geesey, M.E.3
  • 26
    • 37149048470 scopus 로고    scopus 로고
    • Dietary supplementation with watermelon pomace juice enhances arginine availability and ameliorates the metabolic syndrome in Zucker diabetic fatty rats
    • Wu, G.; Collins, J.K.; Perkins-Veazie, P.; Siddiq, M.; Dolan, K.D.; Kelly, K.A.; Heaps, C.L.; Meininger, C.J. Dietary supplementation with watermelon pomace juice enhances arginine availability and ameliorates the metabolic syndrome in Zucker diabetic fatty rats. J. Nutr., 2007, 137(12), 2680-2685.
    • (2007) J. Nutr. , vol.137 , Issue.12 , pp. 2680-2685
    • Wu, G.1    Collins, J.K.2    Perkins-Veazie, P.3    Siddiq, M.4    Dolan, K.D.5    Kelly, K.A.6    Heaps, C.L.7    Meininger, C.J.8
  • 27
    • 43249129399 scopus 로고    scopus 로고
    • Rice protein concentrate partially replaces dried whey in the diet for early-weaned piglets and improves their growth performance
    • Ping, H. Z.; Long, Y. Y.; Lin, H. R.; Jun, L. T.; Qing, H. R.; Lan, L. Y.; Xin, W.; Qiang, L. Z.; Ce, W. W.; Hua, X.; Wu, G. Y.; Xi, T. L. Rice protein concentrate partially replaces dried whey in the diet for early-weaned piglets and improves their growth performance. J. Sci. Food Agric., 2008, 88(7), 1187-1193.
    • (2008) J. Sci. Food Agric. , vol.88 , Issue.7 , pp. 1187-1193
    • Ping, H.Z.1    Long, Y.Y.2    Lin, H.R.3    Jun, L.T.4    Qing, H.R.5    Lan, L.Y.6    Xin, W.7    Qiang, L.Z.8    Ce, W.W.9    Hua, X.10    Wu, G.Y.11    Xi, T.L.12
  • 28
    • 0015547712 scopus 로고
    • Relative importance of kidney and liver in synthesis of arginine by the rat
    • Featherston, W. R.; Rogers, Q. R.; Freedland, R. A. Relative importance of kidney and liver in synthesis of arginine by the rat. Am. J. Physiol., 1973, 224(1), 127-129.
    • (1973) Am. J. Physiol. , vol.224 , Issue.1 , pp. 127-129
    • Featherston, W.R.1    Rogers, Q.R.2    Freedland, R.A.3
  • 29
    • 14444272504 scopus 로고    scopus 로고
    • Intestinal mucosal amino acid catabolism
    • Wu, G. Intestinal mucosal amino acid catabolism. J. Nutr., 1998, 128(8), 1249-1252.
    • (1998) J. Nutr. , vol.128 , Issue.8 , pp. 1249-1252
    • Wu, G.1
  • 30
    • 0018373246 scopus 로고
    • Creatine: Biosynthesis, regulation, and function
    • Walker, J. B. Creatine: biosynthesis, regulation, and function. Adv. Enzymol. Relat. Areas Mol. Biol., 1979, 50, 177-242.
    • (1979) Adv. Enzymol. Relat. Areas Mol. Biol. , vol.50 , pp. 177-242
    • Walker, J.B.1
  • 31
    • 0035008935 scopus 로고    scopus 로고
    • Clinical pharmacology of the dietary supplement creatine monohydrate. Pharmacol
    • Persky, A. M.; Brazeau, G. A. Clinical pharmacology of the dietary supplement creatine monohydrate. Pharmacol. Rev., 2001, 53(2), 161-176.
    • (2001) Rev. , vol.53 , Issue.2 , pp. 161-176
    • Persky, A.M.1    Brazeau, G.A.2
  • 32
    • 0033935979 scopus 로고    scopus 로고
    • Creatine and creatinine metabolism
    • Wyss, M.; Kaddurah-Daouk, R. Creatine and creatinine metabolism. Physiol. Rev., 2000, 80(3), 1107-1213.
    • (2000) Physiol. Rev , vol.80 , Issue.3 , pp. 1107-1213
    • Wyss, M.1    Kaddurah-Daouk, R.2
  • 35
    • 4344610098 scopus 로고    scopus 로고
    • Plasma guanidino compounds are altered by oral creatine supplementation in healthy humans
    • Derave, W.; Marescau, B.; Vanden Eede, E.; Eijnde, B. O.; De Deyn, P. P.; Hespel, P. Plasma guanidino compounds are altered by oral creatine supplementation in healthy humans. J. Appl. Physiol., 2004, 97(3), 852-857.
    • (2004) J. Appl. Physiol. , vol.97 , Issue.3 , pp. 852-857
    • Derave, W.1    Marescau, B.2    Vanden Eede, E.3    Eijnde, B.O.4    De Deyn, P.P.5    Hespel, P.6
  • 36
    • 0030812153 scopus 로고    scopus 로고
    • Synthesis of citrulline and arginine from proline in enterocytes of postnatal pigs
    • Wu, G. Synthesis of citrulline and arginine from proline in enterocytes of postnatal pigs. Am. J. Physiol., 1997, 272(6 Pt 1), G1382-1390.
    • (1997) Am. J. Physiol , vol.272 , Issue.6 , pp. G1382-G1390
    • Wu, G.1
  • 37
    • 33845533614 scopus 로고    scopus 로고
    • Altered L-arginine/nitric oxide synthase/nitric oxide pathway in the vascular adventitia of rats with sepsis
    • Jia, Y. X.; Pan, C. S.; Yang, J. H.; Liu, X. H.; Yuan, W. J.; Zhao, J.; Tang, C. S.; Qi, Y. F. Altered L-arginine/nitric oxide synthase/nitric oxide pathway in the vascular adventitia of rats with sepsis. Clin Exp Pharmacol Physiol., 2006, 33(12), 1202-1208.
    • (2006) Clin Exp Pharmacol Physiol. , vol.33 , Issue.12 , pp. 1202-1208
    • Jia, Y.X.1    Pan, C.S.2    Yang, J.H.3    Liu, X.H.4    Yuan, W.J.5    Zhao, J.6    Tang, C.S.7    Qi, Y.F.8
  • 39
    • 2942741190 scopus 로고    scopus 로고
    • Arginase inhibition increases nitric oxide production in bovine pulmonary arterial endothelial cells
    • Chicoine, L. G.; Paffett, M. L.; Young, T. L.; Nelin, L. D. Arginase inhibition increases nitric oxide production in bovine pulmonary arterial endothelial cells. Am. J. Physiol. Lung Cell Mol. Physiol., 2004, 287(1), L60-68.
    • (2004) Am. J. Physiol. Lung Cell Mol. Physiol. , vol.287 , Issue.1 , pp. L60-L68
    • Chicoine, L.G.1    Paffett, M.L.2    Young, T.L.3    Nelin, L.D.4
  • 40
    • 4744365177 scopus 로고    scopus 로고
    • Ischemia-reperfusion selectively impairs nitric oxidemediated dilation in coronary arterioles: Counteracting role of arginase
    • Hein, T. W.; Zhang, C.; Wang, W.; Chang, C. I.; Thengchaisri, N.; Kuo, L. Ischemia-reperfusion selectively impairs nitric oxidemediated dilation in coronary arterioles: counteracting role of arginase. FASEB J., 2003, 17(15), 2328-2330.
    • (2003) FASEB J. , vol.17 , Issue.15 , pp. 2328-2330
    • Hein, T.W.1    Zhang, C.2    Wang, W.3    Chang, C.I.4    Thengchaisri, N.5    Kuo, L.6
  • 42
    • 0035347173 scopus 로고    scopus 로고
    • Constitutive expression of arginase in microvascular endothelial cells counteracts nitric oxide-mediated vasodilatory function
    • Zhang, C.; Hein, T. W.; Wang, W.; Chang, C. I.; Kuo, L. Constitutive expression of arginase in microvascular endothelial cells counteracts nitric oxide-mediated vasodilatory function. FASEB J., 2001, 15(7), 1264-1266.
    • (2001) FASEB J. , vol.15 , Issue.7 , pp. 1264-1266
    • Zhang, C.1    Hein, T.W.2    Wang, W.3    Chang, C.I.4    Kuo, L.5
  • 43
    • 9644282852 scopus 로고    scopus 로고
    • Upregulation of vascular arginase in hypertension decreases nitric oxide-mediated dilation of coronary arterioles
    • Zhang, C.; Hein, T. W.; Wang, W.; Miller, M. W.; Fossum, T. W.; McDonald, M. M.; Humphrey, J. D.; Kuo, L. Upregulation of vascular arginase in hypertension decreases nitric oxide-mediated dilation of coronary arterioles. Hypertension, 2004, 44(6), 935-943.
    • (2004) Hypertension , vol.44 , Issue.6 , pp. 935-943
    • Zhang, C.1    Hein, T.W.2    Wang, W.3    Miller, M.W.4    Fossum, T.W.5    McDonald, M.M.6    Humphrey, J.D.7    Kuo, L.8
  • 45
    • 34249730961 scopus 로고    scopus 로고
    • Regulation of the inducible nitric oxide synthase and sodium pump in type 1 diabetes
    • Zakula, Z.; Koricanac, G.; Putnikovic, B.; Markovic, L.; Isenovic, E. R. Regulation of the inducible nitric oxide synthase and sodium pump in type 1 diabetes. Med. Hypotheses, 2007, 69(2), 302-306.
    • (2007) Med. Hypotheses , vol.69 , Issue.2 , pp. 302-306
    • Zakula, Z.1    Koricanac, G.2    Putnikovic, B.3    Markovic, L.4    Isenovic, E.R.5
  • 46
    • 84883607506 scopus 로고    scopus 로고
    • Arginase: The emerging therapeutic target for vascular oxidative stress and inflammation
    • Yang, Z.; Ming, X. F. Arginase: the emerging therapeutic target for vascular oxidative stress and inflammation. Front Immunol., 2013, 4, 149.
    • (2013) Front Immunol. , vol.4 , pp. 149
    • Yang, Z.1    Ming, X.F.2
  • 47
    • 33645780634 scopus 로고    scopus 로고
    • Endothelial nitric oxide synthase in vascular disease: From marvel to menace
    • Forstermann, U.; Munzel, T. Endothelial nitric oxide synthase in vascular disease: from marvel to menace. Circulation, 2006, 113(13), 1708-1714.
    • (2006) Circulation , vol.113 , Issue.13 , pp. 1708-1714
    • Forstermann, U.1    Munzel, T.2
  • 49
    • 0033752910 scopus 로고    scopus 로고
    • Tetrahydrobiopterin improves endothelium-dependent vasodilation by increasing nitric oxide activity in patients with Type II diabetes mellitus
    • Heitzer, T.; Krohn, K.; Albers, S.; Meinertz, T. Tetrahydrobiopterin improves endothelium-dependent vasodilation by increasing nitric oxide activity in patients with Type II diabetes mellitus. Diabetologia, 2000, 43(11), 1435-1438.
    • (2000) Diabetologia , vol.43 , Issue.11 , pp. 1435-1438
    • Heitzer, T.1    Krohn, K.2    Albers, S.3    Meinertz, T.4
  • 50
    • 0036100972 scopus 로고    scopus 로고
    • Tetrahydrobiopterin enhances forearm vascular response to acetylcholine in both normotensive and hypertensive individuals
    • Higashi, Y.; Sasaki, S.; Nakagawa, K.; Fukuda, Y.; Matsuura, H.; Oshima, T.; Chayama, K. Tetrahydrobiopterin enhances forearm vascular response to acetylcholine in both normotensive and hypertensive individuals. Am. J. Hypertens, 2002, 15(4 Pt 1), 326-332.
    • (2002) Am. J. Hypertens , vol.15 , Issue.4 , pp. 326-332
    • Higashi, Y.1    Sasaki, S.2    Nakagawa, K.3    Fukuda, Y.4    Matsuura, H.5    Oshima, T.6    Chayama, K.7
  • 51
    • 80052758036 scopus 로고    scopus 로고
    • M. ENOS activation and NO function: Structural motifs responsible for the posttranslational control of endothelial nitric oxide synthase activity
    • Rafikov, R.; Fonseca, F. V.; Kumar, S.; Pardo, D.; Darragh, C.; Elms, S.; Fulton, D.; Black, S. M. eNOS activation and NO function: structural motifs responsible for the posttranslational control of endothelial nitric oxide synthase activity. J. Endocrinol., 2011, 210(3), 271-284.
    • (2011) J. Endocrinol. , vol.210 , Issue.3 , pp. 271-284
    • Rafikov, R.1    Fonseca, F.V.2    Kumar, S.3    Pardo, D.4    Darragh, C.5    Elms, S.6    Fulton, D.7    Black, S.8
  • 52
    • 0028846979 scopus 로고
    • Impaired arginine metabolism and NO synthesis in coronary endothelial cells of the spontaneously diabetic BB rat
    • Wu, G.; Meininger, C. J. Impaired arginine metabolism and NO synthesis in coronary endothelial cells of the spontaneously diabetic BB rat. Am. J. Physiol., 1995, 269(4 Pt 2), H1312-1318.
    • (1995) Am. J. Physiol , vol.269 , Issue.4 , pp. H1312-H1318
    • Wu, G.1    Meininger, C.J.2
  • 55
    • 0027265470 scopus 로고
    • Cardiac weight in hypertension induced by nitric oxide synthase blockade
    • Arnal, J. F.; el Amrani, A. I.; Chatellier, G.; Menard, J.; Michel, J. B. Cardiac weight in hypertension induced by nitric oxide synthase blockade. Hypertension, 1993, 22(3), 380-387.
    • (1993) Hypertension , vol.22 , Issue.3 , pp. 380-387
    • Arnal, J.F.1    El Amrani, A.I.2    Chatellier, G.3    Menard, J.4    Michel, J.B.5
  • 57
    • 0032617299 scopus 로고    scopus 로고
    • Interleukin-1beta regulation of inducible nitric oxide synthase and cyclooxygenase-2 involves the p42/44 and p38 MAPK signaling pathways in cardiac myocytes
    • LaPointe, M. C.; Isenovic, E. Interleukin-1beta regulation of inducible nitric oxide synthase and cyclooxygenase-2 involves the p42/44 and p38 MAPK signaling pathways in cardiac myocytes. Hypertension, 1999, 33(1 Pt 2), 276-282.
    • (1999) Hypertension , vol.33 , Issue.1 , pp. 276-282
    • Lapointe, M.C.1    Isenovic, E.2
  • 58
    • 84949915854 scopus 로고    scopus 로고
    • Regulation of Cardiac Nitric Oxide Synthase in Acute Type I Diabetes: Modulation of LArginine Availability and Arginase Activity
    • Stojiljkovic, M.; Zakula Z; Koricanac, G.; Milosavljevic, T.; Tepavcevic, S.; Sudar, E.; Isenovic, E. R. Regulation of Cardiac Nitric Oxide Synthase in Acute Type I Diabetes: Modulation of LArginine Availability and Arginase Activity 2012, p. 1-9.
    • (2012) , pp. 1-9
    • Stojiljkovic, M.1    Zakula, Z.2    Koricanac, G.3    Milosavljevic, T.4    Tepavcevic, S.5    Sudar, E.6    Isenovic, E.R.7
  • 61
    • 0032910873 scopus 로고    scopus 로고
    • Nitric oxide. I. Physiological chemistry of nitric oxide and its metabolites: Implications in inflammation
    • Grisham, M. B.; Jourd'Heuil, D.; Wink, D. A. Nitric oxide. I. Physiological chemistry of nitric oxide and its metabolites: implications in inflammation. Am. J. Physiol., 1999, 276(2 Pt 1), G315-321.
    • (1999) Am. J. Physiol. , vol.276 , Issue.2 , pp. G315-G321
    • Grisham, M.B.1    Jourd'heuil, D.2    Wink, D.A.3
  • 62
    • 0030694038 scopus 로고    scopus 로고
    • Biosynthesis and action of nitric oxide in mammalian cells
    • Mayer, B.; Hemmens, B. Biosynthesis and action of nitric oxide in mammalian cells. Trends Biochem. Sci., 1997, 22(12), 477-481.
    • (1997) Trends Biochem. Sci. , vol.22 , Issue.12 , pp. 477-481
    • Mayer, B.1    Hemmens, B.2
  • 63
    • 77954812252 scopus 로고    scopus 로고
    • Calcium-activated potassium channels-a therapeutic target for modulating nitric oxide in cardiovascular disease? Expert Opin Ther
    • Dalsgaard, T.; Kroigaard, C.; Simonsen, U. Calcium-activated potassium channels-a therapeutic target for modulating nitric oxide in cardiovascular disease? Expert Opin Ther. Targets, 2010, 14(8), 825-837.
    • (2010) Targets , vol.14 , Issue.8 , pp. 825-837
    • Dalsgaard, T.1    Kroigaard, C.2    Simonsen, U.3
  • 64
    • 0023912670 scopus 로고
    • Vascular endothelial cells synthesize nitric oxide from L-arginine
    • Palmer, R. M.; Ashton, D. S.; Moncada, S. Vascular endothelial cells synthesize nitric oxide from L-arginine. Nature, 1988, 333(6174), 664-666.
    • (1988) Nature , vol.333 , Issue.6174 , pp. 664-666
    • Palmer, R.M.1    Ashton, D.S.2    Moncada, S.3
  • 65
    • 79952014698 scopus 로고    scopus 로고
    • Three decades of endothelium research: From the detection of nitric oxide to the everyday implementation of endothelial function measurements in cardiovascular diseases
    • Flammer, A. J.; Luscher, T. F. Three decades of endothelium research: from the detection of nitric oxide to the everyday implementation of endothelial function measurements in cardiovascular diseases. Swiss Med. Wkly, 2010, 140, w13122.
    • (2010) Swiss Med. Wkly , pp. 140
    • Flammer, A.J.1    Luscher, T.F.2
  • 66
    • 34247282009 scopus 로고    scopus 로고
    • Nitric oxide-independent stimulation of soluble guanylate cyclase with BAY 41-2272 in cardiovascular disease
    • Boerrigter, G.; Burnett, J. C., Jr. Nitric oxide-independent stimulation of soluble guanylate cyclase with BAY 41-2272 in cardiovascular disease. Cardiovasc Drug Rev., 2007, 25(1), 30-45.
    • (2007) Cardiovasc Drug Rev. , vol.25 , Issue.1 , pp. 30-45
    • Boerrigter, G.1    Burnett, J.C.2
  • 67
    • 0029116612 scopus 로고
    • Peroxynitrite-induced accumulation of cyclic GMP in endothelial cells and stimulation of purified soluble guanylyl cyclase. Dependence on glutathione and possible role of S-nitrosation
    • Mayer, B.; Schrammel, A.; Klatt, P.; Koesling, D.; Schmidt, K. Peroxynitrite-induced accumulation of cyclic GMP in endothelial cells and stimulation of purified soluble guanylyl cyclase. Dependence on glutathione and possible role of S-nitrosation. J. Biol. Chem., 1995, 270(29), 17355-17360.
    • (1995) J. Biol. Chem. , vol.270 , Issue.29 , pp. 17355-17360
    • Mayer, B.1    Schrammel, A.2    Klatt, P.3    Koesling, D.4    Schmidt, K.5
  • 68
    • 46349086870 scopus 로고    scopus 로고
    • Vascular system: Role of nitric oxide in cardiovascular diseases
    • Bian, K.; Doursout, M. F.; Murad, F. Vascular system: role of nitric oxide in cardiovascular diseases. J. Clin. Hypertens (Greenwich), 2008, 10(4), 304-310.
    • (2008) J. Clin. Hypertens (Greenwich) , vol.10 , Issue.4 , pp. 304-310
    • Bian, K.1    Doursout, M.F.2    Murad, F.3
  • 69
    • 0031435306 scopus 로고    scopus 로고
    • Soluble guanylate cyclase: The forgotten sibling. Trends Pharmacol
    • Hobbs, A. J. Soluble guanylate cyclase: the forgotten sibling. Trends Pharmacol. Sci., 1997, 18(12), 484-491.
    • (1997) Sci. , vol.18 , Issue.12 , pp. 484-491
    • Hobbs, A.J.1
  • 70
    • 13844269298 scopus 로고    scopus 로고
    • The role of nitric oxide in cardiovascular diseases. Mol
    • Naseem, K. M. The role of nitric oxide in cardiovascular diseases. Mol. Aspects Med., 2005, 26(1-2), 33-65.
    • (2005) Aspects Med. , vol.26 , Issue.1-2 , pp. 33-65
    • Naseem, K.M.1
  • 71
    • 69949111623 scopus 로고    scopus 로고
    • Nitric oxide and pathogenic mechanisms involved in the development of vascular diseases
    • Napoli, C.; Ignarro, L. J. Nitric oxide and pathogenic mechanisms involved in the development of vascular diseases. Arch. Pharm. Res., 2009, 32(8), 1103-1108.
    • (2009) Arch. Pharm. Res , vol.32 , Issue.8 , pp. 1103-1108
    • Napoli, C.1    Ignarro, L.J.2
  • 72
    • 33846636038 scopus 로고    scopus 로고
    • Nitric oxide, cardiovascular disease and physical exercise
    • Zago, A. S.; Zanesco, A. Nitric oxide, cardiovascular disease and physical exercise. Arq. Bras. Cardiol., 2006, 87(6), e264-270.
    • (2006) Arq. Bras. Cardiol , vol.87 , Issue.6 , pp. e264-e270
    • Zago, A.S.1    Zanesco, A.2
  • 73
    • 33846968842 scopus 로고    scopus 로고
    • Nitric oxide-dependent endothelial function and cardiovascular disease
    • Desjardins, F.; Balligand, J. L. Nitric oxide-dependent endothelial function and cardiovascular disease. Acta Clin. Belg., 2006, 61(6), 326-334.
    • (2006) Acta Clin. Belg , vol.61 , Issue.6 , pp. 326-334
    • Desjardins, F.1    Balligand, J.L.2
  • 74
    • 0030033842 scopus 로고    scopus 로고
    • Nitric oxide reversibly inhibits the migration of cultured vascular smooth muscle cells
    • Sarkar, R.; Meinberg, E. G.; Stanley, J. C.; Gordon, D.; Webb, R. C. Nitric oxide reversibly inhibits the migration of cultured vascular smooth muscle cells. Circ. Res., 1996, 78(2), 225-230.
    • (1996) Circ. Res , vol.78 , Issue.2 , pp. 225-230
    • Sarkar, R.1    Meinberg, E.G.2    Stanley, J.C.3    Gordon, D.4    Webb, R.C.5
  • 75
    • 0031812583 scopus 로고    scopus 로고
    • Does nitric oxide regulate smooth muscle cell proliferation? A critical appraisal
    • Sarkar, R.; Webb, R. C. Does nitric oxide regulate smooth muscle cell proliferation? A critical appraisal. J. Vasc. Res., 1998, 35(3), 135-142.
    • (1998) J. Vasc. Res. , vol.35 , Issue.3 , pp. 135-142
    • Sarkar, R.1    Webb, R.C.2
  • 76
    • 84949915855 scopus 로고
    • The Endothelium, Taylor & Francis
    • Luscher, T. F.; Vanhoutte, P. M. The Endothelium, Taylor & Francis: 1990.
    • (1990)
    • Luscher, T.F.1    Vanhoutte, P.M.2
  • 77
    • 0026560972 scopus 로고
    • L-arginine transport is increased in macrophages generating nitric oxide
    • Bogle, R. G.; Baydoun, A. R.; Pearson, J. D.; Moncada, S.; Mann, G. E. L-arginine transport is increased in macrophages generating nitric oxide. Biochem. J., 1992, 284(Pt 1), 15-18.
    • (1992) Biochem. J. , vol.284 , Issue.1 , pp. 15-18
    • Bogle, R.G.1    Baydoun, A.R.2    Pearson, J.D.3    Moncada, S.4    Mann, G.E.5
  • 78
    • 0029805172 scopus 로고    scopus 로고
    • Nitric oxide, superoxide, and peroxynitrite: The good, the bad, and ugly
    • Beckman, J. S.; Koppenol, W. H. Nitric oxide, superoxide, and peroxynitrite: the good, the bad, and ugly. Am. J. Physiol., 1996, 271(5 Pt 1), C1424-1437.
    • (1996) Am. J. Physiol. , vol.271 , Issue.5 , pp. C1424-C1437
    • Beckman, J.S.1    Koppenol, W.H.2
  • 79
    • 77955282773 scopus 로고    scopus 로고
    • Nitric oxide and oxidative stress in vascular disease
    • Forstermann, U. Nitric oxide and oxidative stress in vascular disease. Pflugers Arch., 2010, 459(6), 923-939.
    • (2010) Pflugers Arch. , vol.459 , Issue.6 , pp. 923-939
    • Forstermann, U.1
  • 80
    • 77951642455 scopus 로고    scopus 로고
    • The Role of Asymmetric Dimethylarginine (ADMA) in Endothelial Dysfunction and Cardiovascular Disease
    • Sibal, L.; Agarwal, S. C.; Home, P. D.; Boger, R. H. The Role of Asymmetric Dimethylarginine (ADMA) in Endothelial Dysfunction and Cardiovascular Disease. Curr. Cardiol. Rev., 2010, 6(2), 82-90.
    • (2010) Curr. Cardiol. Rev. , vol.6 , Issue.2 , pp. 82-90
    • Sibal, L.1    Agarwal, S.C.2    Home, P.D.3    Boger, R.H.4
  • 81
    • 0031452440 scopus 로고    scopus 로고
    • A caveolar complex between the cationic amino acid transporter 1 and endothelial nitric-oxide synthase may explain the "arginine paradox"
    • McDonald, K. K.; Zharikov, S.; Block, E. R.; Kilberg, M. S. A caveolar complex between the cationic amino acid transporter 1 and endothelial nitric-oxide synthase may explain the "arginine paradox". J. Biol. Chem., 1997, 272(50), 31213-31216.
    • (1997) J. Biol. Chem. , vol.272 , Issue.50 , pp. 31213-31216
    • McDonald, K.K.1    Zharikov, S.2    Block, E.R.3    Kilberg, M.S.4
  • 82
    • 34249706763 scopus 로고    scopus 로고
    • The L-arginine paradox: Importance of the L-arginine/asymmetrical dimethylarginine ratio
    • Bode-Boger, S. M.; Scalera, F.; Ignarro, L. J. The L-arginine paradox: Importance of the L-arginine/asymmetrical dimethylarginine ratio. Pharmacol. Ther., 2007, 114(3), 295-306.
    • (2007) Pharmacol. Ther , vol.114 , Issue.3 , pp. 295-306
    • Bode-Boger, S.M.1    Scalera, F.2    Ignarro, L.J.3
  • 83
    • 0025011716 scopus 로고
    • Characterization of three inhibitors of endothelial nitric oxide synthase in vitro and in vivo
    • Rees, D. D.; Palmer, R. M.; Schulz, R.; Hodson, H. F.; Moncada, S. Characterization of three inhibitors of endothelial nitric oxide synthase in vitro and in vivo. Br. J. Pharmacol., 1990, 101(3), 746-752.
    • (1990) Br. J. Pharmacol. , vol.101 , Issue.3 , pp. 746-752
    • Rees, D.D.1    Palmer, R.M.2    Schulz, R.3    Hodson, H.F.4    Moncada, S.5
  • 85
    • 0031557659 scopus 로고    scopus 로고
    • Koyama, A. A novel nonenzymatic pathway for the generation of nitric oxide by the reaction of hydrogen peroxide and D-or L-arginine
    • Nagase, S.; Takemura, K.; Ueda, A.; Hirayama, A.; Aoyagi, K.; Kondoh, M.; Koyama, A. A novel nonenzymatic pathway for the generation of nitric oxide by the reaction of hydrogen peroxide and D-or L-arginine. Biochem. Biophys. Res. Commun., 1997, 233(1), 150-153.
    • (1997) Biochem. Biophys. Res. Commun , vol.233 , Issue.1 , pp. 150-153
    • Nagase, S.1    Takemura, K.2    Ueda, A.3    Hirayama, A.4    Aoyagi, K.5    Kondoh, M.6
  • 86
    • 0034708366 scopus 로고    scopus 로고
    • Pharmacological concentrations of arginine influence human whole blood viscosity independent of nitric oxide synthase activity in vitro
    • Walter, R.; Mark, M.; Reinhart, W. H. Pharmacological concentrations of arginine influence human whole blood viscosity independent of nitric oxide synthase activity in vitro. Biochem. Biophys. Res. Commun., 2000, 269(3), 687-691.
    • (2000) Biochem. Biophys. Res. Commun , vol.269 , Issue.3 , pp. 687-691
    • Walter, R.1    Mark, M.2    Reinhart, W.H.3
  • 88
    • 0030959249 scopus 로고    scopus 로고
    • Argininosuccinate synthetase overexpression in vascular smooth muscle cells potentiates immunostimulantinduced NO production
    • Xie, L.; Gross, S. S. Argininosuccinate synthetase overexpression in vascular smooth muscle cells potentiates immunostimulantinduced NO production. J. Biol. Chem., 1997, 272(26), 16624-16630.
    • (1997) J. Biol. Chem. , vol.272 , Issue.26 , pp. 16624-16630
    • Xie, L.1    Gross, S.S.2
  • 89
    • 0027434655 scopus 로고
    • Dependence of endotoxininduced vascular hyporeactivity on extracellular L-arginine
    • Schott, C. A.; Gray, G. A.; Stoclet, J. C. Dependence of endotoxininduced vascular hyporeactivity on extracellular L-arginine. Br. J. Pharmacol., 1993, 108(1), 38-43.
    • (1993) Br. J. Pharmacol. , vol.108 , Issue.1 , pp. 38-43
    • Schott, C.A.1    Gray, G.A.2    Stoclet, J.C.3
  • 90
    • 0033986606 scopus 로고    scopus 로고
    • Substrate supply for nitric-oxide synthase in macrophages and endothelial cells: Role of cationic amino acid transporters. Mol
    • Closs, E. I.; Scheld, J. S.; Sharafi, M.; Forstermann, U. Substrate supply for nitric-oxide synthase in macrophages and endothelial cells: role of cationic amino acid transporters. Mol. Pharmacol., 2000, 57(1), 68-74.
    • (2000) Pharmacol. , vol.57 , Issue.1 , pp. 68-74
    • Closs, E.I.1    Scheld, J.S.2    Sharafi, M.3    Forstermann, U.4
  • 91
    • 0035844305 scopus 로고    scopus 로고
    • Sustained nitric oxide production in macrophages requires the arginine transporter CAT2
    • Nicholson, B.; Manner, C. K.; Kleeman, J.; MacLeod, C. L. Sustained nitric oxide production in macrophages requires the arginine transporter CAT2. J. Biol. Chem., 2001, 276(19), 15881-15885.
    • (2001) J. Biol. Chem. , vol.276 , Issue.19 , pp. 15881-15885
    • Nicholson, B.1    Manner, C.K.2    Kleeman, J.3    MacLeod, C.L.4
  • 92
    • 34548491443 scopus 로고    scopus 로고
    • L-arginine availability regulates inducible nitric oxide synthase-dependent host defense against Helicobacter pylori. Infect
    • Chaturvedi, R.; Asim, M.; Lewis, N. D.; Algood, H. M.; Cover, T. L.; Kim, P. Y.; Wilson, K. T. L-arginine availability regulates inducible nitric oxide synthase-dependent host defense against Helicobacter pylori. Infect. Immun., 2007, 75(9), 4305-4315.
    • (2007) Immun. , vol.75 , Issue.9 , pp. 4305-4315
    • Chaturvedi, R.1    Asim, M.2    Lewis, N.D.3    Algood, H.M.4    Cover, T.L.5    Kim, P.Y.6    Wilson, K.T.7
  • 93
    • 1942501159 scopus 로고    scopus 로고
    • Asymmetrical methylarginine (ADMA) as a cardiovascular risk factor: Epidemiological and prospective data
    • Boger, R. H. [Asymmetrical methylarginine (ADMA) as a cardiovascular risk factor: epidemiological and prospective data]. Dtsch. Med. Wochenschr., 2004, 129(15), 820-824.
    • (2004) Dtsch. Med. Wochenschr , vol.129 , Issue.15 , pp. 820-824
    • Boger, R.H.1
  • 94
    • 0033537633 scopus 로고    scopus 로고
    • Endogenous nitric oxide synthase inhibitor: A novel marker of atherosclerosis
    • Miyazaki, H.; Matsuoka, H.; Cooke, J. P.; Usui, M.; Ueda, S.; Okuda, S.; Imaizumi, T. Endogenous nitric oxide synthase inhibitor: a novel marker of atherosclerosis. Circulation, 1999, 99(9), 1141-1146.
    • (1999) Circulation , vol.99 , Issue.9 , pp. 1141-1146
    • Miyazaki, H.1    Matsuoka, H.2    Cooke, J.P.3    Usui, M.4    Ueda, S.5    Okuda, S.6    Imaizumi, T.7
  • 95
    • 0026548912 scopus 로고
    • Accumulation of an endogenous inhibitor of nitric oxide synthesis in chronic renal failure
    • Vallance, P.; Leone, A.; Calver, A.; Collier, J.; Moncada, S. Accumulation of an endogenous inhibitor of nitric oxide synthesis in chronic renal failure. Lancet., 1992, 339(8793), 572-575.
    • (1992) Lancet. , vol.339 , Issue.8793 , pp. 572-575
    • Vallance, P.1    Leone, A.2    Calver, A.3    Collier, J.4    Moncada, S.5
  • 96
    • 15444379908 scopus 로고    scopus 로고
    • L-Arginine improves vascular function by overcoming deleterious effects of ADMA, a novel cardiovascular risk factor. Altern. Med
    • Boger, R. H.; Ron, E. S. L-Arginine improves vascular function by overcoming deleterious effects of ADMA, a novel cardiovascular risk factor. Altern. Med. Rev., 2005, 10(1), 14-23.
    • (2005) Rev. , vol.10 , Issue.1 , pp. 14-23
    • Boger, R.H.1    Ron, E.S.2
  • 97
    • 34249817585 scopus 로고    scopus 로고
    • The pharmacodynamics of L-arginine
    • Boger, R. H. The pharmacodynamics of L-arginine. J. Nutr., 2007, 137(6 Suppl 2), 1650S-1655S.
    • (2007) J. Nutr. , vol.137 , Issue.6 , pp. 1650S-1655S
    • Boger, R.H.1
  • 98
    • 0025018196 scopus 로고
    • The metabolism of L-arginine and its significance for the biosynthesis of endothelium-derived relaxing factor: Cultured endothelial cells recycle L-citrulline to L-arginine
    • Hecker, M.; Sessa, W. C.; Harris, H. J.; Anggard, E. E.; Vane, J. R. The metabolism of L-arginine and its significance for the biosynthesis of endothelium-derived relaxing factor: cultured endothelial cells recycle L-citrulline to L-arginine. Proc. Natl. Acad. Sci. U.S.A., 1990, 87(21), 8612-8616.
    • (1990) Proc. Natl. Acad. Sci. U.S.A. , vol.87 , Issue.21 , pp. 8612-8616
    • Hecker, M.1    Sessa, W.C.2    Harris, H.J.3    Anggard, E.E.4    Vane, J.R.5
  • 99
    • 0025114688 scopus 로고
    • The metabolism of L-arginine and its significance for the biosynthesis of endothelium-derived relaxing factor: L-glutamine inhibits the generation of L-arginine by cultured endothelial cells
    • Sessa, W. C.; Hecker, M.; Mitchell, J. A.; Vane, J. R. The metabolism of L-arginine and its significance for the biosynthesis of endothelium-derived relaxing factor: L-glutamine inhibits the generation of L-arginine by cultured endothelial cells. Proc. Natl. Acad. Sci. U.S.A., 1990, 87(21), 8607-8611.
    • (1990) Proc. Natl. Acad. Sci. U.S.A. , vol.87 , Issue.21 , pp. 8607-8611
    • Sessa, W.C.1    Hecker, M.2    Mitchell, J.A.3    Vane, J.R.4
  • 100
    • 0029070801 scopus 로고
    • Interactions between L-arginine and L-glutamine change endothelial NO production. An effect independent of NO synthase substrate availability
    • Arnal, J. F.; Munzel, T.; Venema, R. C.; James, N. L.; Bai, C. L.; Mitch, W. E.; Harrison, D. G. Interactions between L-arginine and L-glutamine change endothelial NO production. An effect independent of NO synthase substrate availability. J. Clin. Invest., 1995, 95(6), 2565-2572.
    • (1995) J. Clin. Invest , vol.95 , Issue.6 , pp. 2565-2572
    • Arnal, J.F.1    Munzel, T.2    Venema, R.C.3    James, N.L.4    Bai, C.L.5    Mitch, W.E.6    Harrison, D.G.7
  • 102
    • 0026561920 scopus 로고
    • Insulin secretion from pancreatic B cells caused by L-argininederived nitrogen oxides
    • Schmidt, H. H.; Warner, T. D.; Ishii, K.; Sheng, H.; Murad, F. Insulin secretion from pancreatic B cells caused by L-argininederived nitrogen oxides. Science, 1992, 255(5045), 721-723.
    • (1992) Science , vol.255 , Issue.5045 , pp. 721-723
    • Schmidt, H.H.1    Warner, T.D.2    Ishii, K.3    Sheng, H.4    Murad, F.5
  • 103
    • 0032602366 scopus 로고    scopus 로고
    • L-arginine stimulates NO-dependent vasodilation in healthy humans--effect of somatostatin pretreatment
    • Bode-Boger, S. M.; Boger, R. H.; Loffler, M.; Tsikas, D.; Brabant, G.; Frolich, J. C. L-arginine stimulates NO-dependent vasodilation in healthy humans--effect of somatostatin pretreatment. J. Investig Med., 1999, 47(1), 43-50.
    • (1999) J. Investig Med. , vol.47 , Issue.1 , pp. 43-50
    • Bode-Boger, S.M.1    Boger, R.H.2    Loffler, M.3    Tsikas, D.4    Brabant, G.5    Frolich, J.C.6
  • 105
    • 0030454148 scopus 로고    scopus 로고
    • Nitric oxide may mediate the hemodynamic effects of recombinant growth hormone in patients with acquired growth hormone deficiency. A double-blind, placebo-controlled study
    • Boger, R. H.; Skamira, C.; Bode-Boger, S. M.; Brabant, G.; von zur Muhlen, A.; Frolich, J. C. Nitric oxide may mediate the hemodynamic effects of recombinant growth hormone in patients with acquired growth hormone deficiency. A double-blind, placebo-controlled study. J. Clin. Invest., 1996, 98(12), 2706-2713.
    • (1996) J. Clin. Invest. , vol.98 , Issue.12 , pp. 2706-2713
    • Boger, R.H.1    Skamira, C.2    Bode-Boger, S.M.3    Brabant, G.4    Von Zur Muhlen, A.5    Frolich, J.C.6
  • 107
    • 0027256181 scopus 로고
    • Effect of local intra-arterial asymmetric dimethylarginine (ADMA) on the forearm arteriolar bed of healthy volunteers
    • Calver, A.; Collier, J.; Leone, A.; Moncada, S.; Vallance, P. Effect of local intra-arterial asymmetric dimethylarginine (ADMA) on the forearm arteriolar bed of healthy volunteers. J. Hum. Hypertensm, 1993, 7(2), 193-194.
    • (1993) J. Hum. Hypertensm , vol.7 , Issue.2 , pp. 193-194
    • Calver, A.1    Collier, J.2    Leone, A.3    Moncada, S.4    Vallance, P.5
  • 108
    • 0033744268 scopus 로고    scopus 로고
    • Arginine nutrition and cardiovascular function
    • Wu, G.; Meininger, C. J. Arginine nutrition and cardiovascular function. J Nutr. 2000, 130(11), 2626-2629.
    • (2000) J Nutr , vol.130 , Issue.11 , pp. 2626-2629
    • Wu, G.1    Meininger, C.J.2
  • 109
    • 0033014013 scopus 로고    scopus 로고
    • Effect of L-arginine infusion on systemic and renal hemodynamics in hypertensive patients
    • Higashi, Y.; Oshima, T.; Ozono, R.; Matsuura, H.; Kambe, M.; Kajiyama, G. Effect of L-arginine infusion on systemic and renal hemodynamics in hypertensive patients. Am. J. Hypertens, 1999, 12(1 Pt 1), 8-15.
    • (1999) Am. J. Hypertens , vol.12 , Issue.1 , pp. 8-15
    • Higashi, Y.1    Oshima, T.2    Ozono, R.3    Matsuura, H.4    Kambe, M.5    Kajiyama, G.6
  • 110
    • 0033922798 scopus 로고    scopus 로고
    • Endothelial dysfunction in hypercholesterolemia is reversed by a nutritional product designed to enhance nitric oxide activity. Cardiovasc
    • Maxwell, A. J.; Anderson, B.; Zapien, M. P.; Cooke, J. P. Endothelial dysfunction in hypercholesterolemia is reversed by a nutritional product designed to enhance nitric oxide activity. Cardiovasc. Drugs Ther., 2000, 14(3), 309-316.
    • (2000) Drugs Ther. , vol.14 , Issue.3 , pp. 309-316
    • Maxwell, A.J.1    Anderson, B.2    Zapien, M.P.3    Cooke, J.P.4
  • 111
    • 0034464238 scopus 로고    scopus 로고
    • Postabsorptive plasma citrulline concentration is a marker of absorptive enterocyte mass and intestinal failure in humans
    • Crenn, P.; Coudray-Lucas, C.; Thuillier, F.; Cynober, L.; Messing, B. Postabsorptive plasma citrulline concentration is a marker of absorptive enterocyte mass and intestinal failure in humans. Gastroenterology, 2000, 119(6), 1496-1505.
    • (2000) Gastroenterology , vol.119 , Issue.6 , pp. 1496-1505
    • Crenn, P.1    Coudray-Lucas, C.2    Thuillier, F.3    Cynober, L.4    Messing, B.5
  • 112
    • 12244252221 scopus 로고    scopus 로고
    • Plasma urea-cycle-related amino acids, ammonium levels, and urinary orotic acid excretion in short-bowel patients managed with an oral diet
    • Pita, A. M.; Wakabayashi, Y.; Fernandez-Bustos, M. A.; Virgili, N.; Riudor, E.; Soler, J.; Farriol, M. Plasma urea-cycle-related amino acids, ammonium levels, and urinary orotic acid excretion in short-bowel patients managed with an oral diet. Clin. Nutr., 2003, 22(1), 93-98.
    • (2003) Clin. Nutr. , vol.22 , Issue.1 , pp. 93-98
    • Pita, A.M.1    Wakabayashi, Y.2    Fernandez-Bustos, M.A.3    Virgili, N.4    Riudor, E.5    Soler, J.6    Farriol, M.7
  • 113
    • 0033192865 scopus 로고    scopus 로고
    • Long-term outcome of short bowel syndrome in adult and pediatric patients
    • Wasa, M.; Takagi, Y.; Sando, K.; Harada, T.; Okada, A. Long-term outcome of short bowel syndrome in adult and pediatric patients. JPEN J. Parenter Enteral. Nutr., 1999, 23(5 Suppl), S110-112.
    • (1999) JPEN J. Parenter Enteral. Nutr. , vol.23 , Issue.5 , pp. S110-S112
    • Wasa, M.1    Takagi, Y.2    Sando, K.3    Harada, T.4    Okada, A.5
  • 114
    • 0020856682 scopus 로고
    • Dietary protein and atherosclerosis
    • Kritchevsky, D. Dietary protein and atherosclerosis. Atherosclerosis, 1983, 49(2), 209-210.
    • (1983) Atherosclerosis , vol.49 , Issue.2 , pp. 209-210
    • Kritchevsky, D.1
  • 115
    • 0032185604 scopus 로고    scopus 로고
    • Is atherosclerosis an arginine deficiency disease
    • Cooke, J. P. Is atherosclerosis an arginine deficiency disease? J. Investig Med., 1998, 46(8), 377-380.
    • (1998) J. Investig Med. , vol.46 , Issue.8 , pp. 377-380
    • Cooke, J.P.1
  • 116
    • 0031023733 scopus 로고    scopus 로고
    • L-arginine prevents xanthoma development and inhibits atherosclerosis in LDL receptor knockout mice
    • Aji, W.; Ravalli, S.; Szabolcs, M.; Jiang, X. C.; Sciacca, R. R.; Michler, R. E.; Cannon, P. J. L-arginine prevents xanthoma development and inhibits atherosclerosis in LDL receptor knockout mice. Circulation, 1997, 95(2), 430-437.
    • (1997) Circulation , vol.95 , Issue.2 , pp. 430-437
    • Aji, W.1    Ravalli, S.2    Szabolcs, M.3    Jiang, X.C.4    Sciacca, R.R.5    Michler, R.E.6    Cannon, P.J.7
  • 117
  • 118
    • 0031821197 scopus 로고    scopus 로고
    • Dietary L-arginine decreases myointimal cell proliferation and vascular monocyte accumulation in cholesterolfed rabbits
    • Boger, R. H.; Bode-Boger, S. M.; Kienke, S.; Stan, A. C.; Nafe, R.; Frolich, J. C. Dietary L-arginine decreases myointimal cell proliferation and vascular monocyte accumulation in cholesterolfed rabbits. Atherosclerosis, 1998, 136(1), 67-77.
    • (1998) Atherosclerosis , vol.136 , Issue.1 , pp. 67-77
    • Boger, R.H.1    Bode-Boger, S.M.2    Kienke, S.3    Stan, A.C.4    Nafe, R.5    Frolich, J.C.6
  • 119
    • 0035679872 scopus 로고    scopus 로고
    • Isolated systolic hypertension in elderly WKY is reversed with L-arginine and ACE inhibition
    • Susic, D.; Varagic, J.; Frohlich, E. D. Isolated systolic hypertension in elderly WKY is reversed with L-arginine and ACE inhibition. Hypertension, 2001, 38(6), 1422-1426.
    • (2001) Hypertension , vol.38 , Issue.6 , pp. 1422-1426
    • Susic, D.1    Varagic, J.2    Frohlich, E.D.3
  • 120
    • 0032954522 scopus 로고    scopus 로고
    • Prolonged L-arginine on cardiovascular mass and myocardial hemodynamics and collagen in aged spontaneously hypertensive rats and normal rats
    • Susic, D.; Francischetti, A.; Frohlich, E. D. Prolonged L-arginine on cardiovascular mass and myocardial hemodynamics and collagen in aged spontaneously hypertensive rats and normal rats. Hypertension, 1999, 33(1 Pt 2), 451-455.
    • (1999) Hypertension , vol.33 , Issue.1 , pp. 451-455
    • Susic, D.1    Francischetti, A.2    Frohlich, E.D.3
  • 121
    • 0035079471 scopus 로고    scopus 로고
    • Lariviere, R. Supplementation with a low dose of L-arginine reduces blood pressure and endothelin-1 production in hypertensive uraemic rats. Nephrol. Dial
    • Dumont, Y.; D'Amours, M.; Lebel, M.; Lariviere, R. Supplementation with a low dose of L-arginine reduces blood pressure and endothelin-1 production in hypertensive uraemic rats. Nephrol. Dial. Transplant., 2001, 16(4), 746-754.
    • (2001) Transplant. , vol.16 , Issue.4 , pp. 746-754
    • Dumont, Y.1    D'amours, M.2    Lebel, M.3
  • 122
    • 67349172140 scopus 로고    scopus 로고
    • L-arginine supplementation reduces cardiac noradrenergic neurotransmission in spontaneously hypertensive rats
    • Lee, C. W.; Li, D.; Channon, K. M.; Paterson, D. J. L-arginine supplementation reduces cardiac noradrenergic neurotransmission in spontaneously hypertensive rats. J. Mol. Cell Cardiol., 2009, 47(1), 149-155.
    • (2009) J. Mol. Cell Cardiol. , vol.47 , Issue.1 , pp. 149-155
    • Lee, C.W.1    Li, D.2    Channon, K.M.3    Paterson, D.J.4
  • 123
    • 0026029655 scopus 로고
    • Urinary excretion of endothelin-1 in normal subjects and patients with renal disease
    • Ohta, K.; Hirata, Y.; Shichiri, M.; Kanno, K.; Emori, T.; Tomita, K.; Marumo, F. Urinary excretion of endothelin-1 in normal subjects and patients with renal disease. Kidney Int., 1991, 39(2), 307-311.
    • (1991) Kidney Int. , vol.39 , Issue.2 , pp. 307-311
    • Ohta, K.1    Hirata, Y.2    Shichiri, M.3    Kanno, K.4    Emori, T.5    Tomita, K.6    Marumo, F.7
  • 124
    • 0025100874 scopus 로고
    • Release of endothelin from the porcine aorta. Inhibition by endothelium-derived nitric oxide
    • Boulanger, C.; Luscher, T. F. Release of endothelin from the porcine aorta. Inhibition by endothelium-derived nitric oxide. J. Clin. Invest., 1990, 85(2), 587-590.
    • (1990) J. Clin. Invest. , vol.85 , Issue.2 , pp. 587-590
    • Boulanger, C.1    Luscher, T.F.2
  • 127
    • 0031002483 scopus 로고    scopus 로고
    • Oral L-arginine improves endotheliumdependent dilatation and reduces monocyte adhesion to endothelial cells in young men with coronary artery disease
    • Adams, M. R.; McCredie, R.; Jessup, W.; Robinson, J.; Sullivan, D.; Celermajer, D. S. Oral L-arginine improves endotheliumdependent dilatation and reduces monocyte adhesion to endothelial cells in young men with coronary artery disease. Atherosclerosis, 1997, 129(2), 261-269.
    • (1997) Atherosclerosis , vol.129 , Issue.2 , pp. 261-269
    • Adams, M.R.1    McCredie, R.2    Jessup, W.3    Robinson, J.4    Sullivan, D.5    Celermajer, D.S.6
  • 131
    • 0141607693 scopus 로고    scopus 로고
    • Oral L-arginine improves endothelial function in healthy individuals older than 70 years
    • Bode-Boger, S. M.; Muke, J.; Surdacki, A.; Brabant, G.; Boger, R. H.; Frolich, J. C. Oral L-arginine improves endothelial function in healthy individuals older than 70 years. Vasc. Med., 2003, 8(2), 77-81.
    • (2003) Vasc. Med , vol.8 , Issue.2 , pp. 77-81
    • Bode-Boger, S.M.1    Muke, J.2    Surdacki, A.3    Brabant, G.4    Boger, R.H.5    Frolich, J.C.6
  • 132
    • 77954296378 scopus 로고    scopus 로고
    • Evaluation of the antihypertensive effect of L-arginine supplementation in patients with mild hypertension assessed with ambulatory blood pressure monitoring
    • Ast, J.; Jablecka, A.; Bogdanski, P.; Smolarek, I.; Krauss, H.; Chmara, E. Evaluation of the antihypertensive effect of L-arginine supplementation in patients with mild hypertension assessed with ambulatory blood pressure monitoring. Med. Sci. Monit., 2010, 16(5), 266-271.
    • (2010) Med. Sci. Monit , vol.16 , Issue.5 , pp. 266-271
    • Ast, J.1    Jablecka, A.2    Bogdanski, P.3    Smolarek, I.4    Krauss, H.5    Chmara, E.6
  • 133
    • 84878976899 scopus 로고    scopus 로고
    • Supplementation with L-arginine favorably influences plasminogen activator inhibitor type 1 concentration in obese patients. A randomized, double blind trial
    • Bogdanski, P.; Szulinska, M.; Suliburska, J.; Pupek-Musialik, D.; Jablecka, A.; Witmanowski, H. Supplementation with L-arginine favorably influences plasminogen activator inhibitor type 1 concentration in obese patients. A randomized, double blind trial. J. Endocrinol. Invest., 2013, 36(4), 221-226.
    • (2013) J. Endocrinol. Invest. , vol.36 , Issue.4 , pp. 221-226
    • Bogdanski, P.1    Szulinska, M.2    Suliburska, J.3    Pupek-Musialik, D.4    Jablecka, A.5    Witmanowski, H.6
  • 134
    • 37349064459 scopus 로고    scopus 로고
    • L-Arginine therapy in cardiovascular pathologies: Beneficial or dangerous
    • Boger, R. H. L-Arginine therapy in cardiovascular pathologies: beneficial or dangerous? Curr. Opin Clin. Nutr. Metab. Care, 2008, 11(1), 55-61.
    • (2008) Curr. Opin Clin. Nutr. Metab. Care , vol.11 , Issue.1 , pp. 55-61
    • Boger, R.H.1
  • 135
    • 0032474451 scopus 로고    scopus 로고
    • Long-term L-arginine supplementation improves small-vessel coronary endothelial function in humans
    • Lerman, A.; Burnett, J. C., Jr.; Higano, S. T.; McKinley, L. J.; Holmes, D. R., Jr. Long-term L-arginine supplementation improves small-vessel coronary endothelial function in humans. Circulation, 1998, 97(21), 2123-2128.
    • (1998) Circulation , vol.97 , Issue.21 , pp. 2123-2128
    • Lerman, A.1    Burnett, J.C.2    Higano, S.T.3    McKinley, L.J.4    Holmes, D.R.5
  • 137
    • 34447334222 scopus 로고    scopus 로고
    • L-arginine supplementation in peripheral arterial disease: No benefit and possible harm
    • Wilson, A. M.; Harada, R.; Nair, N.; Balasubramanian, N.; Cooke, J. P. L-arginine supplementation in peripheral arterial disease: no benefit and possible harm. Circulation, 2007, 116(2), 188-195.
    • (2007) Circulation , vol.116 , Issue.2 , pp. 188-195
    • Wilson, A.M.1    Harada, R.2    Nair, N.3    Balasubramanian, N.4    Cooke, J.P.5
  • 138
    • 0037233948 scopus 로고    scopus 로고
    • Effects of chronic treatment with L-arginine on atherosclerosis in apoE knockout and apoE/inducible NO synthase double-knockout mice
    • Chen, J.; Kuhlencordt, P.; Urano, F.; Ichinose, H.; Astern, J.; Huang, P. L. Effects of chronic treatment with L-arginine on atherosclerosis in apoE knockout and apoE/inducible NO synthase double-knockout mice. Arterioscler Thromb. Vasc. Biol., 2003, 23(1), 97-103.
    • (2003) Arterioscler Thromb. Vasc. Biol. , vol.23 , Issue.1 , pp. 97-103
    • Chen, J.1    Kuhlencordt, P.2    Urano, F.3    Ichinose, H.4    Astern, J.5    Huang, P.L.6
  • 139
    • 2442484388 scopus 로고    scopus 로고
    • Critical timing of L-arginine treatment in post-ischemic myocardial apoptosis-role of NOS isoforms
    • Liang, F.; Gao, E.; Tao, L.; Liu, H.; Qu, Y.; Christopher, T. A.; Lopez, B. L.; Ma, X. L. Critical timing of L-arginine treatment in post-ischemic myocardial apoptosis-role of NOS isoforms. Cardiovasc Res., 2004, 62(3), 568-577.
    • (2004) Cardiovasc Res. , vol.62 , Issue.3 , pp. 568-577
    • Liang, F.1    Gao, E.2    Tao, L.3    Liu, H.4    Qu, Y.5    Christopher, T.A.6    Lopez, B.L.7    Ma, X.L.8
  • 141
    • 33947261256 scopus 로고    scopus 로고
    • Diverse effects of L-arginine on cardiac function of rats subjected to myocardial ischemia and reperfusion in vivo
    • Wang, X.; Liang, F.; Jiao, X.; Liu, L.; Bai, X.; Li, M.; Zhi, J.; Liu, H. Diverse effects of L-arginine on cardiac function of rats subjected to myocardial ischemia and reperfusion in vivo. Acta Biochim Biophys Sin (Shanghai), 2007, 39(3), 201-207.
    • (2007) Acta Biochim Biophys Sin (Shanghai) , vol.39 , Issue.3 , pp. 201-207
    • Wang, X.1    Liang, F.2    Jiao, X.3    Liu, L.4    Bai, X.5    Li, M.6    Zhi, J.7    Liu, H.8
  • 143
    • 84940893043 scopus 로고    scopus 로고
    • Strategies to increase nitric oxide signalling in cardiovascular disease. Nat
    • Lundberg, J. O.; Gladwin, M. T.; Weitzberg, E. Strategies to increase nitric oxide signalling in cardiovascular disease. Nat. Rev. Drug Discov., 2015, 14(9), 623-41.
    • (2015) Rev. Drug Discov. , vol.14 , Issue.9 , pp. 623-641
    • Lundberg, J.O.1    Gladwin, M.T.2    Weitzberg, E.3
  • 144
    • 78651391894 scopus 로고    scopus 로고
    • Free radicals, antioxidants and functional foods: Impact on human health
    • Lobo, V.; Patil, A.; Phatak, A.; Chandra, N. Free radicals, antioxidants and functional foods: Impact on human health. Pharmacogn Rev., 2010, 4(8), 118-126.
    • (2010) Pharmacogn Rev. , vol.4 , Issue.8 , pp. 118-126
    • Lobo, V.1    Patil, A.2    Phatak, A.3    Chandra, N.4
  • 145
    • 0037231551 scopus 로고    scopus 로고
    • Adverse effects of supplemental L-arginine in atherosclerosis: Consequences of methylation stress in a complex catabolism?
    • Loscalzo, J. Adverse effects of supplemental L-arginine in atherosclerosis: consequences of methylation stress in a complex catabolism? Arterioscler Thromb Vasc. Biol., 2003, 23(1), 3-5.
    • (2003) Arterioscler Thromb Vasc. Biol , vol.23 , Issue.1 , pp. 3-5
    • Loscalzo, J.1
  • 146
    • 0021334060 scopus 로고
    • Effects of injecting excess arginine on rat pancreas
    • Mizunuma, T.; Kawamura, S.; Kishino, Y. Effects of injecting excess arginine on rat pancreas. J. Nutr., 1984, 114(3), 467-471.
    • (1984) J. Nutr. , vol.114 , Issue.3 , pp. 467-471
    • Mizunuma, T.1    Kawamura, S.2    Kishino, Y.3
  • 148
    • 84893245062 scopus 로고    scopus 로고
    • Recent advances in the investigation of pancreatic inflammation induced by large doses of basic amino acids in rodents. Lab
    • Kui, B.; Balla, Z.; Vegh, E. T.; Pallagi, P.; Venglovecz, V.; Ivanyi, B.; Takacs, T.; Hegyi, P.; Rakonczay, Z., Jr. Recent advances in the investigation of pancreatic inflammation induced by large doses of basic amino acids in rodents. Lab. Invest., 2014, 94(2), 138-149.
    • (2014) Invest. , vol.94 , Issue.2 , pp. 138-149
    • Kui, B.1    Balla, Z.2    Vegh, E.T.3    Pallagi, P.4    Venglovecz, V.5    Ivanyi, B.6    Takacs, T.7    Hegyi, P.8    Rakonczay, Z.9
  • 149
    • 0342424720 scopus 로고    scopus 로고
    • The pathogenesis of L-arginine-induced acute necrotizing pancreatitis: Inflammatory mediators and endogenous cholecystokinin
    • Czako, L.; Takacs, T.; Varga, I. S.; Hai, D. Q.; Tiszlavicz, L.; Hegyi, P.; Mandi, Y.; Matkovics, B.; Lonovics, J. The pathogenesis of L-arginine-induced acute necrotizing pancreatitis: inflammatory mediators and endogenous cholecystokinin. J. Physiol. Paris., 2000, 94(1), 43-50.
    • (2000) J. Physiol. Paris. , vol.94 , Issue.1 , pp. 43-50
    • Czako, L.1    Takacs, T.2    Varga, I.S.3    Hai, D.Q.4    Tiszlavicz, L.5    Hegyi, P.6    Mandi, Y.7    Matkovics, B.8    Lonovics, J.9
  • 150
    • 0036786168 scopus 로고    scopus 로고
    • The role of nitric oxide in edema formation in L-arginine-induced acute pancreatitis
    • Takacs, T.; Czako, L.; Morschl, E.; Laszlo, F.; Tiszlavicz, L.; Rakonczay, Z., Jr.; Lonovics, J. The role of nitric oxide in edema formation in L-arginine-induced acute pancreatitis. Pancreas, 2002, 25(3), 277-282.
    • (2002) Pancreas , vol.25 , Issue.3 , pp. 277-282
    • Takacs, T.1    Czako, L.2    Morschl, E.3    Laszlo, F.4    Tiszlavicz, L.5    Rakonczay, Z.6    Lonovics, J.7
  • 151
    • 0031851599 scopus 로고    scopus 로고
    • Involvement of oxygenderived free radicals in L-arginine-induced acute pancreatitis. Dig. Dis
    • Czako, L.; Takacs, T.; Varga, I. S.; Tiszlavicz, L.; Hai, D. Q.; Hegyi, P.; Matkovics, B.; Lonovics, J. Involvement of oxygenderived free radicals in L-arginine-induced acute pancreatitis. Dig. Dis. Sci., 1998, 43(8), 1770-1777.
    • (1998) Sci. , vol.43 , Issue.8 , pp. 1770-1777
    • Czako, L.1    Takacs, T.2    Varga, I.S.3    Tiszlavicz, L.4    Hai, D.Q.5    Hegyi, P.6    Matkovics, B.7    Lonovics, J.8
  • 152
    • 2942618205 scopus 로고    scopus 로고
    • Acute pancreatitis possibly due to arginine use: A case report. Turk
    • Saka, M.; Tuzun, A.; Ates, Y.; Bagci, S.; Karaeren, N.; Dagalp, K. Acute pancreatitis possibly due to arginine use: a case report. Turk J. Gastroenterol., 2004, 15(1), 56-58.
    • (2004) J. Gastroenterol. , vol.15 , Issue.1 , pp. 56-58
    • Saka, M.1    Tuzun, A.2    Ates, Y.3    Bagci, S.4    Karaeren, N.5    Dagalp, K.6
  • 154
    • 0141453891 scopus 로고    scopus 로고
    • Influence of peroxynitrite on energy metabolism and cardiac function in a rat ischemia-reperfusion model
    • Lee, W. H.; Gounarides, J. S.; Roos, E. S.; Wolin, M. S. Influence of peroxynitrite on energy metabolism and cardiac function in a rat ischemia-reperfusion model. Am. J. Physiol. Heart Circ. Physiol., 2003, 285(4), H1385-1395.
    • (2003) Am. J. Physiol. Heart Circ. Physiol. , vol.285 , Issue.4 , pp. H1385-H1395
    • Lee, W.H.1    Gounarides, J.S.2    Roos, E.S.3    Wolin, M.S.4
  • 156
    • 0034955224 scopus 로고    scopus 로고
    • Effects of chronic N-acetylcysteine treatment on the actions of peroxynitrite on aortic vascular reactivity in hypertensive rats
    • Cabassi, A.; Dumont, E. C.; Girouard, H.; Bouchard, J. F.; Le Jossec, M.; Lamontagne, D.; Besner, J. G.; de Champlain, J. Effects of chronic N-acetylcysteine treatment on the actions of peroxynitrite on aortic vascular reactivity in hypertensive rats. J. Hypertens, 2001, 19(7), 1233-1244.
    • (2001) J. Hypertens , vol.19 , Issue.7 , pp. 1233-1244
    • Cabassi, A.1    Dumont, E.C.2    Girouard, H.3    Bouchard, J.F.4    Le Jossec, M.5    Lamontagne, D.6    Besner, J.G.7    De Champlain, J.8
  • 157
    • 0029966226 scopus 로고    scopus 로고
    • Whole body nitric oxide synthesis in healthy men determined from [15N] arginine-to-[15N]citrulline labeling
    • Castillo, L.; Beaumier, L.; Ajami, A. M.; Young, V. R. Whole body nitric oxide synthesis in healthy men determined from [15N] arginine-to-[15N]citrulline labeling. Proc. Natl. Acad. Sci. U.S.A., 1996, 93(21), 11460-11465.
    • (1996) Proc. Natl. Acad. Sci. U.S.A , vol.93 , Issue.21 , pp. 11460-11465
    • Castillo, L.1    Beaumier, L.2    Ajami, A.M.3    Young, V.R.4
  • 158
    • 0028786948 scopus 로고
    • Urea cycle intermediate kinetics and nitrate excretion at normal and "therapeutic" intakes of arginine in humans
    • Beaumier, L.; Castillo, L.; Ajami, A. M.; Young, V. R. Urea cycle intermediate kinetics and nitrate excretion at normal and "therapeutic" intakes of arginine in humans. Am. J. Physiol., 1995, 269(5 Pt 1), E884-896.
    • (1995) Am. J. Physiol. , vol.269 , Issue.5 , pp. E884-E896
    • Beaumier, L.1    Castillo, L.2    Ajami, A.M.3    Young, V.R.4
  • 159
    • 0031915818 scopus 로고    scopus 로고
    • Arginase modulates nitric oxide production in activated macrophages
    • Chang, C. I.; Liao, J. C.; Kuo, L. Arginase modulates nitric oxide production in activated macrophages. Am. J. Physiol., 1998, 274(1 Pt 2), H342-348.
    • (1998) Am. J. Physiol. , vol.274 , Issue.1 , pp. H342-H348
    • Chang, C.I.1    Liao, J.C.2    Kuo, L.3
  • 161
    • 84949757975 scopus 로고    scopus 로고
    • Role of Erk 1/2 and Akt in the Regulation of eNOS and iNOS In Cardiovascular System. Med
    • Sudar, E.; Obradovic, M.; Zafirovic, S.; Soskic, S.; Knezevic Rajic, I.; Isenovic, E.R. Role of Erk 1/2 and Akt in the Regulation of eNOS and iNOS In Cardiovascular System. Med. Investigat., 2012, 46(3), 35-42.
    • (2012) Investigat. , vol.46 , Issue.3 , pp. 35-42
    • Sudar, E.1    Obradovic, M.2    Zafirovic, S.3    Soskic, S.4    Knezevic Rajic, I.5    Isenovic, E.R.6


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