메뉴 건너뛰기




Volumn 11, Issue 1, 2008, Pages 55-61

L-Arginine therapy in cardiovascular pathologies: Beneficial or dangerous?

Author keywords

Asymmetric dimethylarginine; Endothelium; Nitric oxide; Nitric oxide synthase

Indexed keywords

ARGININE; DIMETHYLARGININASE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; PLACEBO;

EID: 37349064459     PISSN: 13631950     EISSN: 15353885     Source Type: Journal    
DOI: 10.1097/MCO.0b013e3282f2b0c3     Document Type: Review
Times cited : (73)

References (62)
  • 1
    • 0001416816 scopus 로고
    • The nutritional significance of the amino acids
    • Rose WC. The nutritional significance of the amino acids. Physiol Rev 1938; 18:109-136.
    • (1938) Physiol Rev , vol.18 , pp. 109-136
    • Rose, W.C.1
  • 2
    • 0032533159 scopus 로고    scopus 로고
    • Arginine metabolism: Nitric oxide and beyond
    • Wu G, Morris SM Jr. Arginine metabolism: nitric oxide and beyond. Biochem J 1998; 336:1-17.
    • (1998) Biochem J , vol.336 , pp. 1-17
    • Wu, G.1    Morris Jr., S.M.2
  • 3
    • 0027752805 scopus 로고
    • The L-arginine-nitric oxide pathway
    • Moncada S, Higgs A. The L-arginine-nitric oxide pathway. N Engl J Med 1993; 329:2002-2012.
    • (1993) N Engl J Med , vol.329 , pp. 2002-2012
    • Moncada, S.1    Higgs, A.2
  • 4
    • 0028332056 scopus 로고
    • Nitric oxide synthase isozymes. Characterization, purification, molecular cloning, and functions
    • Förstermann U, Closs EI, Pollock JS, et al. Nitric oxide synthase isozymes. Characterization, purification, molecular cloning, and functions. Hypertension 1994; 23:1121-1131.
    • (1994) Hypertension , vol.23 , pp. 1121-1131
    • Förstermann, U.1    Closs, E.I.2    Pollock, J.S.3
  • 5
    • 0039558662 scopus 로고    scopus 로고
    • Expressional control of the 'constitutive' isoforms of nitric oxide synthase (NOS I and NOS III)
    • Förstermann U, Boissel JP, Kleinert H. Expressional control of the 'constitutive' isoforms of nitric oxide synthase (NOS I and NOS III). FASEB J 1998; 12:773-790.
    • (1998) FASEB J , vol.12 , pp. 773-790
    • Förstermann, U.1    Boissel, J.P.2    Kleinert, H.3
  • 7
    • 0027424664 scopus 로고
    • Altered synaptic plasticity and memory formation in nitric oxide synthase inhibitor-treated rats
    • Bohme GA, Bon C, Lemaire M, et al. Altered synaptic plasticity and memory formation in nitric oxide synthase inhibitor-treated rats. Proc Natl Acad Sci U S A 1993; 90:9191-9194.
    • (1993) Proc Natl Acad Sci U S A , vol.90 , pp. 9191-9194
    • Bohme, G.A.1    Bon, C.2    Lemaire, M.3
  • 8
    • 0029074513 scopus 로고
    • Nitric oxide in the central nervous system
    • Paakkari I, Lindsberg P. Nitric oxide in the central nervous system. Ann Med 1995; 27:369-377.
    • (1995) Ann Med , vol.27 , pp. 369-377
    • Paakkari, I.1    Lindsberg, P.2
  • 9
    • 0030588667 scopus 로고    scopus 로고
    • The L-arginine-nitric oxide pathway: Role in atherosclerosis and therapeutic implications
    • Böger RH, Bode-Böger SM, Frölich JC. The L-arginine-nitric oxide pathway: role in atherosclerosis and therapeutic implications. Atherosclerosis 1996; 127:1-11.
    • (1996) Atherosclerosis , vol.127 , pp. 1-11
    • Böger, R.H.1    Bode-Böger, S.M.2    Frölich, J.C.3
  • 10
    • 0031054463 scopus 로고    scopus 로고
    • Nitric oxide synthase: Role in the genesis of vascular disease
    • Cooke JP, Dzau VJ. Nitric oxide synthase: role in the genesis of vascular disease. Annu Rev Med 1997; 48:489-509.
    • (1997) Annu Rev Med , vol.48 , pp. 489-509
    • Cooke, J.P.1    Dzau, V.J.2
  • 11
    • 19444374004 scopus 로고    scopus 로고
    • The pivotal role of nitric oxide for vascular health
    • Cooke JP. The pivotal role of nitric oxide for vascular health. Can J Cardiol 2004; 20 (Suppl B):7B-15B.
    • (2004) Can J Cardiol , vol.20 , Issue.SUPPL. B
    • Cooke, J.P.1
  • 12
    • 33746424427 scopus 로고    scopus 로고
    • Nitric oxide, caveolae, and vascular pathology
    • Li XA, Everson W, Smart EJ. Nitric oxide, caveolae, and vascular pathology. Cardiovasc Toxicol 2006; 6:1-13.
    • (2006) Cardiovasc Toxicol , vol.6 , pp. 1-13
    • Li, X.A.1    Everson, W.2    Smart, E.J.3
  • 13
    • 33750445289 scopus 로고    scopus 로고
    • Nitric oxide and atherosclerosis: An update
    • This review summarizes currently available experimental data on the pathophysiological role of NO in atherosclerosis
    • Napoli C, De Nigris F, Williams-Ignarro S, et al. Nitric oxide and atherosclerosis: an update. Nitric Oxide 2006; 15:265-279. This review summarizes currently available experimental data on the pathophysiological role of NO in atherosclerosis.
    • (2006) Nitric Oxide , vol.15 , pp. 265-279
    • Napoli, C.1    De Nigris, F.2    Williams-Ignarro, S.3
  • 14
    • 0002696532 scopus 로고    scopus 로고
    • The discovery of nitric oxide as a key mediator in septic shock
    • Kilbourn R. The discovery of nitric oxide as a key mediator in septic shock. Sepsis 1998; 1:85-91.
    • (1998) Sepsis , vol.1 , pp. 85-91
    • Kilbourn, R.1
  • 15
    • 0022016803 scopus 로고
    • Protein digestion and amino acid and peptide absorption
    • Silk DB, Grimble GK, Rees RG. Protein digestion and amino acid and peptide absorption. Proc Nutr Soc 1985; 44:63-72.
    • (1985) Proc Nutr Soc , vol.44 , pp. 63-72
    • Silk, D.B.1    Grimble, G.K.2    Rees, R.G.3
  • 17
    • 0018643202 scopus 로고
    • Effect of aging on free amino acids and electrolytes in leg skeletal muscle
    • Möller P, Bergström J, Eriksson S, et al. Effect of aging on free amino acids and electrolytes in leg skeletal muscle. Clin Sci 1979; 56:427-432.
    • (1979) Clin Sci , vol.56 , pp. 427-432
    • Möller, P.1    Bergström, J.2    Eriksson, S.3
  • 18
    • 0020680049 scopus 로고
    • Electrolytes and free amino acids in leg skeletal muscle of young and elderly women
    • Möller P, Alvestrand A, Bergström J, et al. Electrolytes and free amino acids in leg skeletal muscle of young and elderly women. Gerontology 1983; 29:1-8.
    • (1983) Gerontology , vol.29 , pp. 1-8
    • Möller, P.1    Alvestrand, A.2    Bergström, J.3
  • 20
    • 0034698038 scopus 로고    scopus 로고
    • LDL Cholesterol upregulates synthesis of asymmetric dimethylarginine (ADMA) in human endothelial cells. Involvement of S-adenosylmethionine-dependent methyltransferases
    • Böger RH, Sydow K, Borlak J, et al. LDL Cholesterol upregulates synthesis of asymmetric dimethylarginine (ADMA) in human endothelial cells. Involvement of S-adenosylmethionine-dependent methyltransferases. Circ Res 2000; 87:99-105.
    • (2000) Circ Res , vol.87 , pp. 99-105
    • Böger, R.H.1    Sydow, K.2    Borlak, J.3
  • 21
    • 0023814833 scopus 로고
    • Arginine is a physiological precursor of endothelium-derived nitric oxide
    • Schmidt HH, Nau H, Wittfoht W, et al. Arginine is a physiological precursor of endothelium-derived nitric oxide. Eur J Pharmacol 1988; 154:213-216.
    • (1988) Eur J Pharmacol , vol.154 , pp. 213-216
    • Schmidt, H.H.1    Nau, H.2    Wittfoht, W.3
  • 22
    • 0027396811 scopus 로고
    • Splanchnic metabolism of dietary arginine in relation to nitric oxide synthesis in normal adult man
    • Castillo L, de Rojas T, Chapman TE, et al. Splanchnic metabolism of dietary arginine in relation to nitric oxide synthesis in normal adult man. Proc Natl Acad Sci U S A 1993; 90:193-197.
    • (1993) Proc Natl Acad Sci U S A , vol.90 , pp. 193-197
    • Castillo, L.1    de Rojas, T.2    Chapman, T.E.3
  • 24
    • 0014214491 scopus 로고
    • Plasma growth hormone after arginine injection
    • Merimee TJ, Rabinovitz D, Riggs L, et al. Plasma growth hormone after arginine injection. N Engl J Med 1967; 276:434-439.
    • (1967) N Engl J Med , vol.276 , pp. 434-439
    • Merimee, T.J.1    Rabinovitz, D.2    Riggs, L.3
  • 25
    • 0028106498 scopus 로고    scopus 로고
    • Bode-Böger SM, Böger RH, Creutzig A, et al. L-Arginine infusion decreases peripheral arterial resistance and inhibits platelet aggregation in healthy volunteers. Clin Sci 1994; 87:303-310.
    • Bode-Böger SM, Böger RH, Creutzig A, et al. L-Arginine infusion decreases peripheral arterial resistance and inhibits platelet aggregation in healthy volunteers. Clin Sci 1994; 87:303-310.
  • 26
    • 0030027672 scopus 로고    scopus 로고
    • Bode-Böger SM, Böger RH, Alfke H, et al. L-Arginine induces NO-dependent vasodilation in patients with critical limb ischemia - a randomized, controlled study. Circulation 1996; 93:85-90.
    • Bode-Böger SM, Böger RH, Alfke H, et al. L-Arginine induces NO-dependent vasodilation in patients with critical limb ischemia - a randomized, controlled study. Circulation 1996; 93:85-90.
  • 27
    • 0031731634 scopus 로고    scopus 로고
    • Pharmacokinetic-pharmacodynamic relationship of the effects of intravenous and oral L-arginine on nitric oxide formation and peripheral haemodynamics in healthy human subjects
    • Bode-Böger SM, Böger RH, Galland A, et al. Pharmacokinetic-pharmacodynamic relationship of the effects of intravenous and oral L-arginine on nitric oxide formation and peripheral haemodynamics in healthy human subjects. Br J Clin Pharmacol 1998; 46:489-497.
    • (1998) Br J Clin Pharmacol , vol.46 , pp. 489-497
    • Bode-Böger, S.M.1    Böger, R.H.2    Galland, A.3
  • 28
    • 0029775876 scopus 로고    scopus 로고
    • Differential systemic and pulmonary haemodynamic effects of L-arginine in patients with coronary heart disease and primary pulmonary hypertension
    • Böger RH, Bode-Böger SM, Heinzel D, et al. Differential systemic and pulmonary haemodynamic effects of L-arginine in patients with coronary heart disease and primary pulmonary hypertension. Int J Clin Pharmacol Ther 1996; 34:323-328.
    • (1996) Int J Clin Pharmacol Ther , vol.34 , pp. 323-328
    • Böger, R.H.1    Bode-Böger, S.M.2    Heinzel, D.3
  • 29
    • 0032602366 scopus 로고    scopus 로고
    • Bode-Böger SM, Böger RH, Löffler M, et al. L-arginine stimulates NO-dependent vasodilation in humans - effect of somatostatin pretreatment. J Invest Med 1999; 47:43-50.
    • Bode-Böger SM, Böger RH, Löffler M, et al. L-arginine stimulates NO-dependent vasodilation in humans - effect of somatostatin pretreatment. J Invest Med 1999; 47:43-50.
  • 30
    • 0030867403 scopus 로고    scopus 로고
    • The vascular effects of L-arginine in humans
    • Giugliano D, Marfella R, Verazzo G, et al. The vascular effects of L-arginine in humans. J Clin Invest 1997; 99:433-438.
    • (1997) J Clin Invest , vol.99 , pp. 433-438
    • Giugliano, D.1    Marfella, R.2    Verazzo, G.3
  • 31
    • 0027256181 scopus 로고
    • Effect of local intra-arterial asymmetric dimethylarginine (ADMA) on the forearm arteriolar bed of healthy volunteers
    • Calver A, Collier J, Leone A, et al. Effect of local intra-arterial asymmetric dimethylarginine (ADMA) on the forearm arteriolar bed of healthy volunteers. J Hum Hypertens 1993; 7:193-194.
    • (1993) J Hum Hypertens , vol.7 , pp. 193-194
    • Calver, A.1    Collier, J.2    Leone, A.3
  • 32
    • 0141607693 scopus 로고    scopus 로고
    • Oral L-arginine improves endothelial function in healthy individuals older than 70 years
    • Bode-Böger SM, Muke J, Surdacki A, et al. Oral L-arginine improves endothelial function in healthy individuals older than 70 years. Vasc Med 2003; 8:77-81.
    • (2003) Vasc Med , vol.8 , pp. 77-81
    • Bode-Böger, S.M.1    Muke, J.2    Surdacki, A.3
  • 33
    • 0026531080 scopus 로고
    • Reduced plasma L-arginine in hypercholesterolaemia
    • Jeserich M, Münzel T, Just H, Drexler H. Reduced plasma L-arginine in hypercholesterolaemia. Lancet 1992; 339:561.
    • (1992) Lancet , vol.339 , pp. 561
    • Jeserich, M.1    Münzel, T.2    Just, H.3    Drexler, H.4
  • 34
    • 4744355192 scopus 로고    scopus 로고
    • Enzymes of arginine metabolism
    • Morris SM Jr. Enzymes of arginine metabolism. J Nutr 2004; 134:2743S-2747S.
    • (2004) J Nutr , vol.134
    • Morris Jr., S.M.1
  • 35
    • 3242678848 scopus 로고    scopus 로고
    • Arginase pathway in human endothelial cells in pathophysiological conditions
    • Bachetti T, Comini L, Francolini G, et al. Arginase pathway in human endothelial cells in pathophysiological conditions. J Mol Cell Cardiol 2004; 37:515-523.
    • (2004) J Mol Cell Cardiol , vol.37 , pp. 515-523
    • Bachetti, T.1    Comini, L.2    Francolini, G.3
  • 36
    • 0142023863 scopus 로고    scopus 로고
    • Arginase reciprocally regulates nitric oxide synthase activity and contributes to endothelial dysfunction in aging blood vessels
    • Berkowitz DE, White R, Li D, et al. Arginase reciprocally regulates nitric oxide synthase activity and contributes to endothelial dysfunction in aging blood vessels. Circulation 2003; 108:2000-2006.
    • (2003) Circulation , vol.108 , pp. 2000-2006
    • Berkowitz, D.E.1    White, R.2    Li, D.3
  • 37
    • 9444220218 scopus 로고    scopus 로고
    • Increased arginase II and decreased NO synthesis in endothelial cells of patients with pulmonary arterial hypertension
    • Xu W, Kaneko FT, Zheng S, et al. Increased arginase II and decreased NO synthesis in endothelial cells of patients with pulmonary arterial hypertension. FASEB J 2004; 18:1746-1748.
    • (2004) FASEB J , vol.18 , pp. 1746-1748
    • Xu, W.1    Kaneko, F.T.2    Zheng, S.3
  • 38
    • 9644282852 scopus 로고    scopus 로고
    • Upregulation of vascular arginase in hypertension decreases nitric oxide-mediated dilation of coronary arterioles
    • Zhang C, Hein TW, Wang W, et al. Upregulation of vascular arginase in hypertension decreases nitric oxide-mediated dilation of coronary arterioles. Hypertension 2004; 44:935-943.
    • (2004) Hypertension , vol.44 , pp. 935-943
    • Zhang, C.1    Hein, T.W.2    Wang, W.3
  • 39
  • 40
    • 0842347848 scopus 로고    scopus 로고
    • The emerging role of asymmetric dimethylarginine as a novel cardiovascular risk factor
    • Böger RH. The emerging role of asymmetric dimethylarginine as a novel cardiovascular risk factor. Cardiovasc Res 2003; 59:824-833.
    • (2003) Cardiovasc Res , vol.59 , pp. 824-833
    • Böger, R.H.1
  • 41
    • 33645501775 scopus 로고    scopus 로고
    • Böger RH. Asymmetric dimethylarginine (ADMA): a novel risk marker in cardiovascular medicine and beyond. Ann Med 2006; 38:126-136. This review gives an overview of the biochemistry, physiology and clinical data on ADMA, and its role as a cardiovascular risk marker.
    • Böger RH. Asymmetric dimethylarginine (ADMA): a novel risk marker in cardiovascular medicine and beyond. Ann Med 2006; 38:126-136. This review gives an overview of the biochemistry, physiology and clinical data on ADMA, and its role as a cardiovascular risk marker.
  • 42
    • 15444379908 scopus 로고    scopus 로고
    • Böger RH, Ron ES. L-Arginine improves vascular function by overcoming deleterious effects of ADMA, a novel cardiovascular risk factor. Altern Med Rev 2005; 10:14-23.
    • Böger RH, Ron ES. L-Arginine improves vascular function by overcoming deleterious effects of ADMA, a novel cardiovascular risk factor. Altern Med Rev 2005; 10:14-23.
  • 43
    • 0026338964 scopus 로고
    • Correction of endothelial dysfunction in coronary microcirculation of hypercholesterolaemic patients by L-arginine
    • Drexler H, Zeiher AM, Meinzer K, Just H. Correction of endothelial dysfunction in coronary microcirculation of hypercholesterolaemic patients by L-arginine. Lancet 1991; 338:1546-1550.
    • (1991) Lancet , vol.338 , pp. 1546-1550
    • Drexler, H.1    Zeiher, A.M.2    Meinzer, K.3    Just, H.4
  • 44
    • 0343306727 scopus 로고    scopus 로고
    • Effect of supplemental oral L-arginine on exercise capacity in patients with stable angina pectoris
    • Ceremuzynski L, Chamiec T, Herbaczynska-Cedro K. Effect of supplemental oral L-arginine on exercise capacity in patients with stable angina pectoris. Am J Cardiol 1997; 80:331-333.
    • (1997) Am J Cardiol , vol.80 , pp. 331-333
    • Ceremuzynski, L.1    Chamiec, T.2    Herbaczynska-Cedro, K.3
  • 45
    • 0034664895 scopus 로고    scopus 로고
    • Effects of oral L-arginine supplementation on exercise-induced QT dispersion and exercise tolerance in stable angina pectoris
    • Bednarz B, Wolk R, Chamiec T, et al. Effects of oral L-arginine supplementation on exercise-induced QT dispersion and exercise tolerance in stable angina pectoris. Int J Cardiol 2000; 75:205-210.
    • (2000) Int J Cardiol , vol.75 , pp. 205-210
    • Bednarz, B.1    Wolk, R.2    Chamiec, T.3
  • 46
    • 0029993977 scopus 로고    scopus 로고
    • Randomized, double-blind, placebo-controlled study of supplemental oral L-arginine in patients with heart failure
    • Rector TS, Bank AJ, Mullen KA, et al. Randomized, double-blind, placebo-controlled study of supplemental oral L-arginine in patients with heart failure. Circulation 1996; 93:2135-2141.
    • (1996) Circulation , vol.93 , pp. 2135-2141
    • Rector, T.S.1    Bank, A.J.2    Mullen, K.A.3
  • 47
    • 2342559944 scopus 로고    scopus 로고
    • Bednarz B, Jaxa-Chamiec T, Gebalska J, et al. L-Arginine supplementation prolongs exercise capacity in congestive heart failure. Kardiol Pol 2004;60:348-353.
    • Bednarz B, Jaxa-Chamiec T, Gebalska J, et al. L-Arginine supplementation prolongs exercise capacity in congestive heart failure. Kardiol Pol 2004;60:348-353.
  • 48
    • 0034625152 scopus 로고    scopus 로고
    • Oral L-arginine in patients with coronary artery disease on medical management
    • Blum A, Hathaway L, Mincemoyer R, et al. Oral L-arginine in patients with coronary artery disease on medical management. Circulation 2000; 101:2160-2164.
    • (2000) Circulation , vol.101 , pp. 2160-2164
    • Blum, A.1    Hathaway, L.2    Mincemoyer, R.3
  • 49
    • 0034889663 scopus 로고    scopus 로고
    • Endothelium-dependent vasodilation is independent of the plasma L-arginine/ADMA ratio in men with stable angina: Lack of effect of oral L-arginine on endothelial function, oxidative stress and exercise performance
    • Walker HA, McGing E, Fisher I, et al. Endothelium-dependent vasodilation is independent of the plasma L-arginine/ADMA ratio in men with stable angina: lack of effect of oral L-arginine on endothelial function, oxidative stress and exercise performance. J Am Coll Cardiol 2001; 38:499-505.
    • (2001) J Am Coll Cardiol , vol.38 , pp. 499-505
    • Walker, H.A.1    McGing, E.2    Fisher, I.3
  • 50
    • 17944398405 scopus 로고    scopus 로고
    • Dudek D, Legutko J, Heba G, et al. L-Arginine supplementation does not inhibit neointimal formation after coronary stenting in human beings: an intravascular ultrasound study. Am Heart J 2004; 147:e12.
    • Dudek D, Legutko J, Heba G, et al. L-Arginine supplementation does not inhibit neointimal formation after coronary stenting in human beings: an intravascular ultrasound study. Am Heart J 2004; 147:e12.
  • 51
    • 20444423645 scopus 로고    scopus 로고
    • Efficacy and safety of oral L-arginine in acute myocardial infarction. Results of the multicenter, randomized, double-blind, placebo-controlled ARAMI pilot trial
    • Bednarz B, Jaxa-Chamiec T, Maciejewski P, et al. Efficacy and safety of oral L-arginine in acute myocardial infarction. Results of the multicenter, randomized, double-blind, placebo-controlled ARAMI pilot trial. Kardiol Pol 2005; 62:421-427.
    • (2005) Kardiol Pol , vol.62 , pp. 421-427
    • Bednarz, B.1    Jaxa-Chamiec, T.2    Maciejewski, P.3
  • 52
    • 85136433139 scopus 로고    scopus 로고
    • Schulman SP, Becker LC, Kass DA, et al. L-Arginine therapy in acute myocardial infarction: the Vascular Interaction With Age in Myocardial Infarction (VINTAGE MI) randomized clinical trial. JAMA 2006; 295:58-64. This paper reports the data from a large, placebo-controlled clinical trial on the effects of L-arginine supplementation in patients after myocardial infarction. The study was terminated early due to safety concerns.
    • Schulman SP, Becker LC, Kass DA, et al. L-Arginine therapy in acute myocardial infarction: the Vascular Interaction With Age in Myocardial Infarction (VINTAGE MI) randomized clinical trial. JAMA 2006; 295:58-64. This paper reports the data from a large, placebo-controlled clinical trial on the effects of L-arginine supplementation in patients after myocardial infarction. The study was terminated early due to safety concerns.
  • 53
    • 33750575381 scopus 로고    scopus 로고
    • Endothelial function is associated with pulse pressure, pulse wave velocity, and augmentation index in healthy humans
    • McEniery CM, Wallace S, Mackenzie IS, et al. Endothelial function is associated with pulse pressure, pulse wave velocity, and augmentation index in healthy humans. Hypertension 2006; 48:602-608.
    • (2006) Hypertension , vol.48 , pp. 602-608
    • McEniery, C.M.1    Wallace, S.2    Mackenzie, I.S.3
  • 54
    • 33646457071 scopus 로고    scopus 로고
    • Arginine therapy for acute myocardial infarction [letter]
    • Abumrad NN, Barbul A. Arginine therapy for acute myocardial infarction [letter]. JAMA 2006; 295:2138-2139.
    • (2006) JAMA , vol.295 , pp. 2138-2139
    • Abumrad, N.N.1    Barbul, A.2
  • 55
    • 33745893766 scopus 로고    scopus 로고
    • Böger RH. Letter to the editor re: JAMA article on L-arginine therapy in acute myocardial infarction. Altern Med Rev 2006; 11:91-92.
    • Böger RH. Letter to the editor re: JAMA article on L-arginine therapy in acute myocardial infarction. Altern Med Rev 2006; 11:91-92.
  • 56
    • 34447334222 scopus 로고    scopus 로고
    • Wilson AM, Harada R, Nair N, et al. L-Arginine supplementation in peripheral arterial disease: no benefit and possible harm. Circulation 2007; 116:188-195. This paper reports the data of a long-term supplementation study with L-arginine vs. placebo in patients with peripheral arterial disease. L-Arginine improved vascular function and walking distance significantly less than placebo in this unselected population.
    • Wilson AM, Harada R, Nair N, et al. L-Arginine supplementation in peripheral arterial disease: no benefit and possible harm. Circulation 2007; 116:188-195. This paper reports the data of a long-term supplementation study with L-arginine vs. placebo in patients with peripheral arterial disease. L-Arginine improved vascular function and walking distance significantly less than placebo in this unselected population.
  • 57
    • 0037446868 scopus 로고    scopus 로고
    • Translational control of inducible nitric oxide synthase expression by arginine can explain the arginine paradox
    • Lee J, Ryu H, Ferrante RJ, et al. Translational control of inducible nitric oxide synthase expression by arginine can explain the arginine paradox. Proc Natl Acad Sci U S A 2003; 100:4843-4848.
    • (2003) Proc Natl Acad Sci U S A , vol.100 , pp. 4843-4848
    • Lee, J.1    Ryu, H.2    Ferrante, R.J.3
  • 58
    • 31344464146 scopus 로고    scopus 로고
    • Arginine metabolism in vascular biology and disease
    • Morris SM Jr. Arginine metabolism in vascular biology and disease. Vasc Med 2005; 10 (Suppl 1):S83-S87.
    • (2005) Vasc Med , vol.10 , Issue.SUPPL. 1
    • Morris Jr., S.M.1
  • 59
    • 31344440297 scopus 로고    scopus 로고
    • Pharmacotherapeutic interventions and their influence on ADMA levels
    • Maas R. Pharmacotherapeutic interventions and their influence on ADMA levels. Vasc Med 2005; 10 (Suppl 1):S49-S57.
    • (2005) Vasc Med , vol.10 , Issue.SUPPL. 1
    • Maas, R.1
  • 60
    • 11244354179 scopus 로고    scopus 로고
    • Determination of ADMA using a novel ELISA assay
    • Schulze F, Wesemann R, Schwedhelm E, et al. Determination of ADMA using a novel ELISA assay. Clin Chem Lab Med 2004; 42:1377-1383.
    • (2004) Clin Chem Lab Med , vol.42 , pp. 1377-1383
    • Schulze, F.1    Wesemann, R.2    Schwedhelm, E.3
  • 61
    • 26044460259 scopus 로고    scopus 로고
    • Determination of a reference value for N,N-dimethyl-L-arginine in 500 subjects
    • Schulze F, Maas R, Freese R, et al. Determination of a reference value for N,N-dimethyl-L-arginine in 500 subjects. Eur J Clin Invest 2005; 35:622-626.
    • (2005) Eur J Clin Invest , vol.35 , pp. 622-626
    • Schulze, F.1    Maas, R.2    Freese, R.3
  • 62
    • 23444448460 scopus 로고    scopus 로고
    • LC-tandem MS method for the analysis of asymmetric dimethylarginine (ADMA) in human plasma
    • Schwedhelm E, Tan-Andresen J, Maas R, et al. LC-tandem MS method for the analysis of asymmetric dimethylarginine (ADMA) in human plasma. Clin Chem 2005; 51:1268-1271.
    • (2005) Clin Chem , vol.51 , pp. 1268-1271
    • Schwedhelm, E.1    Tan-Andresen, J.2    Maas, R.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.