The metabolic basis of arginine nutrition and pharmacotherapy

Biomedicine and Pharmacotherapy

Volumn 56, Issue 9, 2002, Pages 427-438

  Flynn, Nick ^a   Meininger, C J ^b   Haynes, T E ^c   Wu, G ^b,c  

^a ANGELO STATE UNIVERSITY   (United States)

^b TEXAS A M COLLEGE OF MEDICINE   (United States)

^c TEXAS A AND M UNIVERSITY   (United States)

Author keywords

Amino acids; Disease; Metabolism; Nitric oxide

Indexed keywords

AGMATINE; AMINO ACID; ARGININE; ARGININE DECARBOXYLASE; ARGININE DERIVATIVE; CITRULLINE; CREATINE; DIMETHYLARGININE; GLUTAMATE ACETYLTRANSFERASE; GLUTAMIC ACID; GLUTAMINE; GUANIDINOACETIC ACID; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITROGEN; ORNITHINE; POLYAMINE; PROLINE; PYRROLINE 5 CARBOXYLATE REDUCTASE; UNCLASSIFIED DRUG; UREA;

AMINO ACID SYNTHESIS; ANGIOGENESIS; BIOAVAILABILITY; BRAIN FUNCTION; CARCINOGENESIS; CARDIOVASCULAR FUNCTION; CATABOLISM; CLINICAL TRIAL; DIARRHEA; DIETARY INTAKE; DIGESTIVE FUNCTION; DRUG SAFETY; ENDOTHELIUM; GASTROINTESTINAL DISEASE; GENE EXPRESSION; HORMONE RELEASE; HUMAN; HYPERAMMONEMIA; HYPERCHOLESTEROLEMIA; IMMUNE RESPONSE; INTESTINE CELL; KIDNEY FUNCTION; LUNG FUNCTION; MAMMAL; METABOLIC REGULATION; MUSCLE FUNCTION; NAUSEA; NITROGEN BALANCE; NONHUMAN; NUTRITION; PARENTERAL NUTRITION; PRECURSOR; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN SYNTHESIS; REGULATORY MECHANISM; REPRODUCTION; REVIEW; SIGNAL TRANSDUCTION; WOUND HEALING; ANIMAL; DRUG THERAPY; METABOLISM; PHYSIOLOGY;

ANIMALS; ARGININE; DRUG THERAPY; HUMANS; NUTRITION PHYSIOLOGY;

EID: 0036864788     PISSN: 07533322     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0753-3322(02)00273-1     Document Type: Article

References (88)

1. Palmer R.M.J., Ashton D., Moncada S. Vascular endothelial cells synthesize nitric oxide from L-arginine. Nature. 333:1988;664-666.
2. Ignarro L.J., Cirino G., Casini A., Napoli C. Nitric oxide as a signaling molecule in the vascular system: an overview. J Cardiovasc Pharmacol. 34:1999;879-886.
3. Wu G., Meininger C.J., Knabe D.A., Bazer F.W., Rhoads J.M. Arginine nutrition in development, health and disease. Curr Opin Clin Nutr Metab Care. 3:2000;59-66.
4. Wu G., Meininger C.J. Arginine nutrition and cardiovascular function. J Nutr. 130:2000;2626-2629.
5. Cooke J.P., Mont-Reynaud R., Tsao P.S., Maxwell A.J. Nitric oxide and vascular disease. Ignarro L.J. Nitric oxide: biology and pathology. 2000;759-783 Academic Press, New York.
6. Wu G., Morris Jr S.M. Arginine metabolism: nitric oxide and beyond. Biochem J. 336:1998;1-17.
7. Morris Jr S.M. Regulation of enzymes of the urea cycle and arginine metabolism. Annu Rev Nutr. 22:2002;87-105.
8. Crenn P., Coudray-Lucas C., Thuillier F., Cynober L., Messing B. Postabsorptive plasma citrulline concentration is a marker of absorptive enterocyte mass and intestinal failure in humans. Gastroenterol. 119:2000;1496-1505.
9. Pappas P.A., Saudubray J.M., Tzakis A.G., Rabier D., Carreno M.R., Gomez-Marin O., et al. Serum citrulline as a marker of acute cellular rejection for intestinal transplantation. Transplant Proc. 34:2002;915-917.
10. Wu G., Becker R.M., Bose C.L., Rhoads J.M. Serum amino acid concentrations in preterm infants. J Pediatr. 139:2001;334-337.
11. Flynn N.E., Knabe D.A., Wu G. Postnatal changes of plasma amino acids in suckling pigs. J Anim Sci. 78:2000;2369-2375.
12. Wakabayashi Y. The glutamate crossway. Cynober L.A. Amino acid metabolism and therapy in health and nutritional disease. 1995;89-98 CRC Press, New York.
13. Flynn N.E., Wu G. An important role for endogenous synthesis of arginine in maintaining arginine homeostasis in neonatal pigs. Am J Physiol. 271:1996;R1149-1155.
14. Wu G. Synthesis of citrulline and arginine from proline in enterocytes of postnatal pigs. Am J Physiol. 272:1997;G1382-1390.
15. Closs E.I., Mann G.E. Membrane transport of arginine and cationic amino acid analogs. Ignarro L.J. Nitric oxide: biology and pathology. 2000;225-241 Academic Press, New York.
16. Ochoa J.B., Bernard A.C., Mistry S.K., Morris S.M., Figert P.L., Maley M.E., et al. Trauma increases extrahepatic arginase activity. Surgery. 127:2000;419-426.
17. Kamoun P., Aral B., Saudubray J.M. A new inherited metabolic disease: pyrroline-5-carboxylate deficiency. Bull Acad Natl Med (Paris). 182:1998;131-139.
18. Baumgartner M.R., Hu C.A.A., Almashanu S., Steel G., Obie C., Aral B., et al. Hyperammonemia with reduced ornithine, citrulline, arginine and proline: a new inborn error caused by a mutation in the gene encoding Δpyrroline-5-carboxylate synthase. Hum Mol Genet. 9:2000;2853-2858.
19. Brunton J.A., Bertolo R.F.P., Pencharz P.B., Ball R.O. Proline ameliorates arginine deficiency during enteral but not parenteral feeding in neonatal pigs. Am J Physiol. 277:1999;E223-231.
20. Morris J.G. Nutritional and metabolic responses to arginine deficiency in carnivores. J Nutr. 115:1985;524-531.
21. Ignarro L.J., Buga G.M., Wei L.H., Bauer P.M., Wu G., del Soldato P. Role of the arginine-nitric oxide pathway in the regulation of vascular smooth muscle cell proliferation. Proc Natl Acad Sci USA. 98:2001;4202-4208.
22. Wei L.H., Wu G., Morris Jr S.M., Ignarro L.J. Elevated arginase I expression in rat aortic smooth muscle cells increases cell proliferation. Proc Natl Acad Sci USA. 98:2001;9260-9264.
23. Li H., Meininger C.J., Hawker J.R. Jr, Haynes T.E., Kepka-Lenhart D., Mistry S.K., et al. Regulatory role of arginase I and II in nitric oxide, polyamine, and proline syntheses in endothelial cells. Am J Physiol. 280:2001;E75-E82.
24. Li H., Meininger C.J., Hawker J.R. Jr, Kelly K.A., Morris S.M. Jr, Wu G. Activities of arginase I and II are limiting for endothelial cell proliferation. Am J Physiol. 282:2002;R64-R69.
25. Kepka-Lenhart D., Mistry S.K., Wu G., Morris S.M. Jr. Arginase I: a limiting factor for nitric oxide and polyamine synthesis by activated macrophages? Am J Physiol. 279:2000;R2237-R2242.
26. Gotoh T., Mori M. Arginase II downregulates nitric oxide (NO) production and prevents NO-mediated apoptosis in murine macrophage-derived RAW 264.7 cells. J Cell Biol. 144:1999;427-434.
27. Wyss M., Kaddurah-Daouk R. Creatine and creatinine metabolism. Physiol Rev. 80:2000;1107-1113.
28. de Jonge W.J., Marescau B., D'Hooge R., de Deyn P.P., Hallemeesch M.M., Deutz N.E.P., et al. Overexpression of arginase alters circulating and tissue amino acids and guanidino compounds and affects neuromotor behavior in mice. J Nutr. 131:2001;2732-2740.
29. Alderton W.K., Cooper C.E., Knowles R.G. Nitric oxide synthases: structure, function and inhibition. Biochem J. 357:2001;593-615.
30. Wu G., Meininger C.J. Regulation of nitric oxide synthesis by dietary factors. Annu Rev Nutr. 22:2002;61-86.
31. Mistry S.K., Burwell T.J., Chambers R.M., Rudolph-Owen L., Spaltmann F., Cook W.J., et al. Cloning of human agmatinase. An alternate path for polyamine synthesis induced in liver by hepatitis B virus. Am J Physiol. 282:2002;G375-381.
32. McBride A.E., Silver P.A. State of the arg:protein methylation at arginine comes of age. Cell. 106:2001;5-8.
33. Qi C., Chang J., Zhu Y., Yeldandi A.V., Rao S.M., Zhu Y.J. Identification of protein arginine methyltransferase 2 as a coactivator for estrogen receptor α J Biol Chem. 277:2002;28624-28630.
34. Leiper J.M., Maria J.S., Chubb A., MacAllister R.J., Charles I.G., Whitley G.S.J., et al. Identification of two human dimethylarginine dimethylaminohydrolases with distinct tissue distributions and homology with microbial arginine deaminases. Biochem J. 343:1999;209-214.
35. G-dimethylarginine dimethylaminohydrolase, from rat kidney. J Biol Chem. 264:1989;10205-10209.
36. Vallance P. The asymmetrical dimethylarginine/dimethylarginine dimethylaminohydrolase pathway in the regulation of nitric oxide generation. Clin Sci. 100:2001;159-160.
37. Barbul A. The use of arginine in clinical practice. Cynober L.A. Amino acid metabolism and therapy in health and nutritional disease. 1995;361-372 CRC Press, New York.
38. Ciechanover A., Schwartz A.L. The ubiquitin-mediated pathway: mechanisms of recognition of the proteolytic substrate and involvement in the degradation of native cellular proteins. FASEB J. 8:1994;182-191.
39. Rodriguez P.C., Zea A.H., Culotta K.S., Zabaleta J., Ochoa J.B., Ochoa A.C. Regulation of T cell receptor CD3ξ chain expression by L-arginine. J Biol Chem. 277:2002;21123-21129.
40. Fang Y.Z., Yang S., Wu G. Free radicals, antioxidants, and nutrition. Nutrition. 18:2002;872-879.
41. Battegay E.J. Angiogenesis: mechanistic insights, neovascular diseases, and therapeutic prospects. J Mol M. 73:1995;333-346.
42. Cook H.T., Cattell V. Role of nitric oxide in immune-mediated diseases. Clin Sci. 91:1996;375-384.
43. ω-hydroxy-L-arginine induced apoptosis in MDA-MB-468 cells: antagonistic effects of L-ornithine. J Biol Chem. in press.
44. Igarashi K., Kashiwagi K. Polyamines: mysterious modulators of cellular functions. Biochem Biophys Res Commun. 271:2000;559-564.
45. Visek W.J. Arginine needs, physiological state and usual diets. A reevaluation. J Nutr. 116:1986;36-46.
46. Wang T., Steel G., Milam A.H., Valle D. Correction of ornithine accumulation prevents retinal degeneration in a mouse model of gyrate of the choroid and retina. Proc Natl Acad Sci USA. 97:2000;1224-1229.
47. Phang J.M. The regulatory functions of proline and pyrroline-5-carboxylic acid. Curr Top Cell Regul. 25:1985;91-132.
48. Stead L.M., Au K.P., Jacobs R.L., Brosnan M.E., Brosnan J.T. Methylation demand and homocysteine metabolism: effects of dietary provision of creatine and guanidinoacetate. Am J Physiol. 281:2001;E1095-1100.
49. Stockler S., Isbrandt D., Hanefeld F., Schmidt B., von Figura K. Guanidinoacetate methyltransferase deficiency: the first inborn error of creatine metabolism in man. Am J Hum Genet. 58:1996;914-922.
50. de Jonge W.J., Hallemeesch M.M., Kwikkers K.L., Ruijter J.M., de Gier-de Vries C., van Roon M.A., et al. Overexpression of arginase I in enterocytes of transgenic mice elicits a selective arginine deficiency and affects skin, muscle, and lymphoid development. Am J Clin Nutr. 76:2002;128-140.
51. Li G., Regunathan S., Barrow C.J., Eshraghi J., Cooper R., Reids D.J. Agmatine: an endogenous clonidine-displacing substance in the brain. Science. 263:1994;966-969.
52. Brosnan J.T. Glutamate, at the interface between amino acid and carbohydrate metabolism. J Nutr. 130:2000;988S-990S.
53. Richman P.G., Meister A. Regulation of γ-glutamylcysteine synthetase by nonallosteric feedback inhibition by glutathione. J Biol Chem. 250:1974;1422-1426.
54. Wu G. Intestinal mucosal amino acid catabolism. J Nutr. 128:1998;1249-1252.
55. Young V.R., Ajami A.M. Glutamine: the emperor or his clothes. J Nutr. 131:2001;2449S-2459S.
56. Wu G., Haynes T.E., Li H., Yan W., Meininger C.J. Glutamine metabolism to glucosamine is necessary for glutamine inhibition of endothelial nitric oxide synthesis. Biochem J. 353:2001;245-252.
57. Wu G., Thompson J.R. The effect of glutamine on protein turnover in chick skeletal muscle in vitro. Biochem J. 265:1990;593-598.
58. Cardounel A.J., Zweier J.L. Endogenous methyl-arginines regulate neuronal nitric oxide synthase and prevent excitotoxic injur. J Biol Chem. 277:2002;33995-34002.
59. Wu G., Ott T.L., Knabe D.A., Bazer F.W. Amino acid composition of the fetal pig. J Nutr. 129:1999;1031-1038.
60. Pau M.Y., Milner J.A. Arginine deficiency during gestation and lactation in the rat. J Nutr. 111:1981;184-193.
61. Rose W.C. The amino acid requirements of adult man. Nutr Abstr Rev. 27:1957;631-647.
62. Holt L.E. Jr, Albanese A.A. Observations on amino acid deficiencies in man. Trans Assoc Am Physicians. 58:1944;143-156.
63. Greenberg S.S., Lancaster J.R., Xie J., Sarphie T.G., Zhao X., Hua L., et al. Effects of NO synthase inhibitors, arginine-deficient diet, and amiloride in pregnant rats. Am J Physiol. 273:1997;R1031-R1045.
64. Vosatka R.J., Hassoun P.M., Harvey-Wilkes K.B. Dietary L-arginine prevents fetal growth restriction in rats. Am J Obstet Gynecol. 178:1998;242-246.
65. Yu Y.M., Ryan C.M., Castillo L., Lu X.M., Beaumier L., Tompkins R.G., et al. Arginine and ornithine kinetics in severely burned patients: increased rate of arginine disposal. Am J Physiol. 280:2001;E509-517.
66. Snyderman S.E., Boyer A., Holt L.E. Jr. The arginine requirement of the infant. AMA J Dis Child. 97:1959;192-195.
67. Heird W.C., Nicholson J.F., Driscoll J.M., Schullinger J.N., Winters R.W. Hyperammonemia resulting from intravenous alimentation using a mixture of synthetic L-amino acids: a preliminary report. J Pediatr. 81:1972;162-165.
68. Zamora S.A., Amin H.J., Mcmillan D.D., Kubes P., Fick G.H., Butzner J.D., et al. Plasma L-arginine concentrations in premature infants with necrotizing enterocolitis. J Pediatr. 131:1997;226-232.
69. Becker R.M., Wu G., Galanko J.A., Chen W., Maynor A.R., Bose C.L., et al. Reduced serum amino acid concentrations in infants with necrotizing enterocolitis. J Pediatr. 137:2000;785-793.
70. Zamora S.A., Amin H.J., Mcmillan D.D., Fick G.H., Butzner J.D., Parsons H.G., et al. Plasma L-arginine concentrations, oxygenation index, and systemic blood pressure in premature infants. Crit Care M. 26:1998;1271-1276.
71. Amin H.J., Zamora S.A., McMillan D.D., Fick G.H., Butzner J.D., Parsons H.G., et al. Arginine supplementation prevents necrotizing enterocolitis in the premature infant. J Pediatr. 140:2002;425-431.
72. McCaffrey M.J., Bose C.L., Reiter P.D., Stiles A.D. Effect of L-arginine infusion on infant with persistent pulmonary hypertension of the newborn. Biol Neonate. 67:1995;240-243.
73. Jones M.E. Pyrimidine nucleotide biosynthesis in animals: genes, enzymes, and regulation of UMP biosynthesis. Annu Rev Biochem. 49:1980;253-279.
74. Milner J.A., Visek W.J. Orotic aciduria and arginine deficiency. Nature. 245:1973;211-213.
75. Enwonwu C.O., Xu X.X., Turner E. Nitrogen metabolism in sickle cell anemia - free amino acids in plasma and urine. Am J Med Sci. 300:1990;366-371.
76. Castillo L., Chapman T.E., Yu Y.M., Ajami A., Burke J.F., Young V.R. Dietary arginine uptake by the splanchnic region in adult humans. Am J Physiol. 265:1993;E532-539.
77. Tangphao O., Chalon S., Moreno H., Hoffman B.B., Blaschke T.F. Pharmacokinetics of L-arginine during chronic administration to patients with hypercholesterolaemia. Clin Sci. 96:1999;199-207.
78. Beaumier L., Castillo L., Ajami A.M., Young V.R. Urea cycle intermediate kinetics and nitrate excretion at normal and "therapeutic" intake of arginine in humans. Am J Physiol. 269:1995;E884-896.
79. Creager M.A., Gallagher S.J., Girerd X.J., Coleman S.M., Dzau V.J., Cooke J.P. L-Arginine improves endothelium-dependent vasodilation in hypercholesterolemic humans. J Clin Invest. 90:1992;1248-1253.
80. Morris C.R., Kuypers F.A., Larkin S., Sweeters N., Simon J., Vichinsky E.P., et al. Arginine therapy: a novel strategy to induce nitric oxide production in sickle cell disease. Br J Haematol. 111:2000;498-500.
81. Mendez J.D., Balderas F. Regulation of hyperglycemia and dyslipidemia by exogenous L-arginine in diabetic rats. Biochimie. 83:2001;453-458.
82. Durante W. Regulation of L-arginine transport and metabolism in vascular smooth muscle cells. Cell Biochem Biophys. 35:2001;19-34.
83. Shi O., Morris S.M., Zoghbi H., Porter C.W., O'Brien W.E. Generation of a mouse model for arginase II deficiency by targeted disruption of the arginase II gene. Mol Cell Biol. 21:2001;811-813.
84. Iyer R.K., Yoo R.K., Kern R.M., Rozengurt N., Tsoa R., O'Brien W.E., et al. Mouse model for human arginase deficiency. Mol Cell Biol. 22:2002;4491-4498.
85. Caldovic L., Morizono H., Yu X.L., Thmpson M., Shi D.S., Gallegos R., et al. Identification, cloning and expression of the mouse N-acetylglutamate synthase gene. Biochem J. 364:2002;825-831.
86. Wu G., Bazer F.W., Tuo W., Flynn S.P. Unusual abundance of arginine and ornithine in porcine allantoic fluid. Biol Reprod. 54:1996;1261-1265.
87. Wu G., Pond W.G., Ott T., Bazer F.W. Maternal dietary protein deficiency decreases amino acid concentrations in fetal plasma and allantoic fluid of pigs. J Nutr. 128:1998;894-902.
88. Kwon H., Wu G., Bazer F.W., Spencer T.E. Developmental changes of amino acids in ovine uterine and fetal fluids during pregnancy. Biol Reprod. 66:(Suppl. 1):2002;186-187.