Arginase inhibition increases nitric oxide production in bovine pulmonary arterial endothelial cells

American Journal of Physiology - Lung Cellular and Molecular Physiology

Volumn 287, Issue 1 31-1, 2004, Pages

  Chicoine, Louis G ^a   Paffett, Michael L ^a   Young, Tamara L ^b   Nelin, Leif D ^b,c  

^a UNIVERSITY OF NEW MEXICO HEALTH SCIENCES CENTER   (United States)

^b OHIO STATE UNIVERSITY   (United States)

^c Section of Neonatology   (United States)

Author keywords

L arginine; L valine; Lipopolysaccharide; Nitric oxide synthase; Tumor necrosis factor

Indexed keywords

ARGINASE; ARGINASE I; ARGINASE II; ISOENZYME; LIPOPOLYSACCHARIDE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; ORNITHINE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; UREA; VALINE;

AMINO ACID METABOLISM; ANIMAL CELL; ARTERY ENDOTHELIUM; ARTICLE; BINDING COMPETITION; CATTLE; CELL CULTURE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CULTURE MEDIUM; ENDOTHELIUM CELL; ENZYME INHIBITION; LUNG ARTERY; LUNG ARTERY ENDOTHELIUM CELL; NONHUMAN; PRIORITY JOURNAL; REGULATORY MECHANISM;

ANIMALS; ARGINASE; ARGININE; CATTLE; CELLS, CULTURED; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG COMBINATIONS; ENDOTHELIUM, VASCULAR; ISOENZYMES; LIPOPOLYSACCHARIDES; NITRATES; NITRIC OXIDE; NITRITES; OSMOLAR CONCENTRATION; PULMONARY ARTERY; RNA, MESSENGER; TIME FACTORS; TUMOR NECROSIS FACTOR-ALPHA; UREA; VALINE;

EID: 2942741190     PISSN: 10400605     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajplung.00194.2003     Document Type: Article

References (28)

1. G-hydroxy-L-arginine during high-output NO production. Am J Physiol Heart Circ Physiol 271: H1988-H1998, 1996.
2. Chang IC, Liao JC, and Kuo L. Macrophage arginase promotes tumor cell growth and suppresses nitric oxide-mediated tumor cytotoxicity. Cancer Res 61: 1100-1106, 2001.
3. Chang IC, Liao JC, and Kuo L. Arginase modulates nitric oxide production in activated macrophages. Am J Physiol Heart Circ Physiol 274: H342-H348, 1998.
4. Chang IC, Zoghi B, Liao JC, and Kuo L. The involvement of tyrosine kinases, cyclic AMP/protein kinase A, and p38 mitogen-activated protein kinase in IL-13-mediated arginase I induction in macrophages: its implications in IL-13-inhibited nitric oxide production. J Immunol 165: 2134-2141, 2000.
5. Davel LE, Jasnis MA, de le Torre E, Gotoh T, Diament M, Magenta G, de Lustig ES, and Sales ME. Arginine metabolic pathways involved in the modulation of tumor-induced angiogenesis by macrophages. FEBS Lett 532: 216-220, 2002.
6. Deves R and Boyd CAR. Transporters for cationic amino acids in animal cells: Discovery, structure and function. Physiol Rev 78: 487-545, 1998.
7. Hardy TA and May JM. Coordinate regulation of L-arginine uptake and nitric oxide synthase activity in cultured endothelial cells. Free Radic Biol Med 32: 122-131, 2002.
8. Janne J, Alhonen L, and Leinonen P. Polyamines: from molecular biology to clinical applications. Ann Med 23: 241-259, 1991.
9. Ignarro LJ, Fukuto JM, Griscavage JM, Rogers NE, and Byrns RE. Oxidation of nitric oxide in aqueous solution to nitrite but not nitrate: comparison with enzymatically formed nitric oxide from L-arginine. Proc Natl Acad Sci USA 90: 8103-8107, 1993.
10. Koga T, Koshiyama Y, Gotoh T, Yonemura N, Hirata A, Tanihara H, Negi A, and Mori M. Coinduction of nitric oxide synthase and arginine metabolic enzymes in endotoxin-induced uveitis rats. Exp Eye Res 75: 659-667, 2002.
11. a. Li H, Meininger CJ, Hawker JR Jr, Haynes TE, Kepka-Lenhart D, Mistry SK, Morris SM Jr, and Wu G. Regulatory role of arginase I and II in nitric oxide, polyamine, and proline synthesis in endothelial cells. Am J Physiol Endocrinol Metab 280: E75-E82, 2001.
12. b. Li H, Meininger CJ, Kelly KA, Hawker JR, Jr, Morris SM Jr, and Wu G. Activities of arginase I and II are limiting for endothelial cell proliferation. Am J Physiol Regul Integr Comp Physiol 282: R64-R69, 2002.
13. Louis CA, Reichner JS, Henry WL, Mastrofrancesco B, Gotoh T, Mori M, and Albina JE. Distinct arginase isoforms expressed in primary and transformed macrophages: regulation by oxygen tension. Am J Physiol Regul Integr Comp Physiol 274: R775-R782, 1998.
14. Mann GE, Yudilevich DL, and Sobrevia L. Regulation of amino acid and glucose transporters in endothelial and smooth muscle cells. Physiol Rev 83: 183-252, 2003.
15. McDonald KK, Zharikov S, Block ER, and Kilberg MS. A caveolar complex between the cationic amino acid transporter 1 and endothelial nitric-oxide synthase may explain the "arginine paradox." J Biol Chem 272: 31213-31216, 1997.
16. Modolell M, Corraliza IM, Link F, Soler G, and Eichmann K. Reciprocal regulation of the nitric oxide synthase/arginase balance in mouse bone marrow-derived macrophages by TH1 and TH2 cytokines. Eur J Immunol 25: 1101-1104, 1995.
17. Morris SM, Kepka-Lenhart D, and Chen LC. Differential regulation of arginases and inducible nitric oxide synthase in murine macrophage cells. Am J Physiol Endocrinol Metab 275: E740-E747, 1998.
18. Nelin LD, Krenz GS, Chicoine LG, Dawson CA, and Schapira RM. L-arginine uptake and metabolism following in vivo silica exposure in rat lungs. Am J Respir Cell Mol Biol 26: 348-355. 2002.
19. Nelin LD, Nash HE, and Chicoine LG. Cytokine treatment increases arginine metabolism and uptake in bovine pulmonary arterial endothelial cells. Am J Physiol Lung Cell Mol Physiol 281: L1232-L1239, 2001.
20. Que LG, George SE, Gotoh T, Mori M, and Huang YCT. Effects of arginase isoforms on NO production by nNOS. Nitric Oxide 6: 1-8, 2002.
21. Que LG, Kantrow SP, Jenkinson CP, Piantadosi CA, and Huang YCT. Induction of arginase isoforms in the lung during hyperoxia. Am J Physiol Lung Cell Mol Physiol 275: L96-L102, 1998.
22. Salimuddin, Nagasaki A, Gotoh T, Isobe H, and Mori M. Regulation of the genes for arginase isoforms and related enzymes in mouse macrophages by lipopolysaccharide. Am J Physiol Endocrinol Metab 277: E110-E117, 1999.
23. Schapira RM, Wiessner JH, Morrisey JF, Almagro UA, and Nelin LD. L-arginine uptake and metabolism by lung macrophages and neutrophils following intratracheal instillation of silica in vivo. Am J Respir Cell Mol Biol 19: 308-315, 1998.
24. Schearer JD, Richards JR, Mills JD, and Caldwell MD. Differential regulation of macrophage arginine metabolism: a proposed role in wound healing. Am J Physiol Endocrinol Metab 272: E181-E190, 1997.
25. Sonoki T, Nagasaki A, Gotoh T, Takiguchi M, Takeya M, Matsuzaki H, and Mori M. Coinduction of nitric oxide synthase and arginase I in cultured rat peritoneal macrophages and rat tissues in vivo by lipopolysaccharide. J Biol Chem 272: 3689-3693, 1997.
26. Waddington SN, Tam FWK, Cook HT, and Cattell V. Arginase activity is modulated by IL-4 and HOArg in nephritic glomeruli and mesangial cells. Am J Physiol Renal Physiol 274: F473-F480, 1998.
27. Wang WW, Jenkinson CP, Giscavage JM, Kern RM, Arabolos NS, Byrns RE, Cederbaum SD, and Ignarro LJ, Co-induction of arginase and nitric oxide synthase in murine macrophages activated by lipopolysaccharide. Biochem Biophys Res Commun 210: 1009-1016, 1995.
28. Zhang C, Hein TW, Wang W, Chang CI, and Kuo L. Constitutive expression of arginase in microvascular endothelial cells counteracts nitric oxide-mediated vasodilatory function. FASEB J 15: 1264-1266, 2001.