L-arginine for testing endothelium-dependent vascular functions in health and disease

American Journal of Physiology - Endocrinology and Metabolism

Volumn 273, Issue 3 36-3, 1997, Pages

  Giugliano, Dario ^a,b   Marfella, Raffaele ^a   Verrazzo, Giovanni ^a   Acampora, Rita ^a   Nappo, Francesco ^a   Ziccardi, Patrizia ^a   Coppola, Ludovico ^a   D'Onofrio, Felice ^a  

^a SECOND UNIVERSITY OF NAPLES   (Italy)

^b NONE   (Italy)

Author keywords

Blood pressure; Blood viscosity; D arginine; Diabetes mellitus; Hypercholesterolemia; Hypertension; L arginine test; N(G) monomethyl L arginine; Platelet aggregation

Indexed keywords

ARGININE;

ADULT; ARTICLE; BLOOD PRESSURE; BLOOD VESSEL FUNCTION; BLOOD VISCOSITY; CELL FUNCTION; DIABETES MELLITUS; ENDOTHELIUM CELL; HUMAN; HUMAN EXPERIMENT; HYPERCHOLESTEROLEMIA; HYPERTENSION; NORMAL HUMAN; PRIORITY JOURNAL; STEM CELL; THROMBOCYTE AGGREGATION; VASOMOTOR REFLEX;

EID: 0030856744     PISSN: 01931849     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpendo.1997.273.3.e606     Document Type: Article

References (44)

1. Angus, J. A., and M. J. Lew. Interpretation of the acetylcholine test of endothelial cell dysfunction in hypertension. J. Hypertens. 10: S179-S186, 1992.
2. Bacchus, R. A., and D. R. London. The measurement of L-arginine in plasma. Clin. Chim. Acta 33: 479-482, 1971.
3. Bode-Böger, S. M., R. H. Böger, H. Alfke, D. Heinzel, D. Tsikas, A. Creutzig, K. Alexander, and J. C. Frölich. L-Arginine induces nitric oxide-dependent vasodilation in patients with critical limb ischemia. A randomized, controlled study. Circulation 93: 85-90, 1996.
4. Bode-Böger, S. M., R. H. Böger, A. Creutzig, D. Tsikas, E.-M. Gutzhi, K. Alexander, and J. C. Frölich. L-Arginine infusion decreases peripheral arterial resistance and inhibits platelet aggregation in healthy subjects. Clin. Sci. (Colch.) 87: 303-310, 1994.
5. Born, A. V. Aggregation of blood platelets by adenosinediphosphate and its reversal. Nature 94: 927-929, 1962.
6. Bucala, R., K. J. Tracey, and A. Cerami. Advanced glycosylation products quench nitric oxide and mediate defective endothelium-dependent vasodilation in experimental diabetes. J. Clin. Invest. 87: 432-438, 1991.
7. Calver, A., J. Collier, and P. Vallance. Dilator actions of arginine in human peripheral vasculature. Clin. Sci. (Colch.) 81: 695-700, 1991.
8. Celermajer, D. S., K. E. Sorensen, V. M. Gooch, D. J. Spiegelhalter, O. I. Miller, I. D. Sullivan, J. K. Lloyd, and J. E. Deanfield. Non-invasive detection of endothelial dysfunction in children and adults at risk of atherosclerosis. Lancet 340: 1111-1115, 1992.
9. Cockcroft, J. R., P. J. Chowienczyk, N. Benjamin, and J. M. Ritter. Preserved endothelium-dependent vasodilatation in patients with essential hypertension. N. Engl. J. Med. 330: 1036-1040, 1994.
10. Cooke, J. P., and P. S. Tsao. Cytoprotective effects of nitric oxide. Circulation 88: 2451-2454, 1993.
11. Creager, M. C., J. P. Cooke, M. E. Mendelsohn, S. G. Gallagher, S. M. Coleman, J. Loscalzo, and D. J. Dzau. Impaired vasodilation of forearm resistance vessels in hypercholesterolemic humans. J. Clin. Invest. 86: 228-234, 1990.
12. Creager, M. C., S. J. Gallagher, X. J. Girerd, S. M. Coleman, V. J. Dzau, and J. P. Cooke. L-Arginine improves endothelium-dependent vasodilation in hypercholesterolemic humans. J. Clin. Invest. 90: 1248-1253, 1992.
13. Giugliano, D., A. Ceriello, and G. Paolisso. Diabetes mellitus, hypertension and cardiovascular disease: which role for oxidative stress? Metabolism 44: 363-368, 1995.
14. Giugliano, D., A. Ceriello, and G. Paolisso. Oxidative stress and diabetic vascular complications. Diabetes Care 19: 257-267, 1996.
15. Giugliano, D., R. Marfella, G. Verrazzo, R. Acampora, C. Donzella, A. Quatraro, L. Coppola, and F. D'Onofrio. Abnormal rheologic effects of glyceryl trinitrate in patients with non-insulin-dependent diabetes mellitus and reversal by antioxidants. Ann. Intern. Med. 123: 338-343, 1995.
16. Handln, R. I. Platelets and coronary heart disease. N. Engl. J. Med. 334: 1126-1128, 1996.
17. Hogg, R. V., and A. T. Craig. Introduction to Mathematical Statistics. (4th ed.). New York: Macmillan, 1978.
18. Imaizumi, T., Y. Hirooka, H. Masaki, S. Harada, M. Momohara, T. Tagawa, and A. Takeshita. Effects of L-arginine on forearm vessels and responses to acetylcholine. Hypertension 20: 511-517, 1992.
19. Kanno, K., Y. Hirata, T. Emori, K. Ohta, S. Eguchi, T. Imai, and F. Marumo. L-Arginine infusion induces hypotension and diuresis natriuresis with concomitant increased urinary excretion of nitrite/nitrate and cyclic GMP in humans. Clin. Exp. Pharmacol. Physiol. 19: 619-625, 1992.
20. Kharitonov, S. A., G. Lubec, B. Lubec, M. Hjelm, and P. J. Barnes. L-Arginine increases exhaled nitric oxide in normal human subjects. Clin. Sci. (Colch.) 88: 135-139, 1995.
21. Koenig, W., M. Sund, A. J. Lowe, K. L. Resch, H. Tunstall-Pedoe, U. Keil, and E. Ernst. Geographical variations in plasma viscosity and relation to coronary heart rates. Lancet 344: 711-714, 1994.
22. Koga, T., Y. Takata, K. Kobayashi, S. Takishita, Y. Yamashita, and M. Fujishima. Age and hypertension promote endothelium-dependent contractions to acetylcholine in the aorta of the rat. Hypertension 14: 542-548, 1989.
23. Levine, G. N., J. F. Keaney, and J. A. Vita. Medical progress: cholesterol reduction in cardiovascular disease - clinical benefits and possible mechanisms. N. Engl. J. Med. 332: 512-521, 1995.
24. Linder, L., W. Kiowski, F. R. Bühler, and T. F. Lüscher. Indirect evidence for release of endothelium-derived relaxing factor in human forearm circulation in vivo: blunted response in essential hypertension. Circulation 81: 1762-1778, 1990.
25. Lüscher, T. F. The endothelium and cardiovascular disease - a complex relation. N. Engl. J. Med. 330: 1081-1083, 1994.
26. Lüscher, T. F., and P. M. Vanhoutte. The Endothelium: Modulator of Cardiovascular Function. Boca Raton, FL: CRC, 1990.
27. MacAllister, R. J., A. L. Calver, J. Collier, C. M. B. Edwards, B. Herreros, S. S. Nussey, and P. Vallance. Vascular and hormonal responses to arginine: provision of substrate for nitric oxide or non-specific effect? Clin. Sci. (Colch.) 89: 183-190, 1995.
28. Mayhan, W. G., F. M. Faraci, G. L. Baumbach, and D. D. Heistad. Effects of aging on responses of cerebral arterioles. Am. J. Physiol. 258 (Heart Circ. Physiol. 27): H1138-H1143, 1990.
29. McMillan, D. E. The microcirculation: changes in diabetes mellitus. Mayo Clin. Proc. 63: 517-520, 1988.
30. Mehta, S., D. J. Stewart, S. Hussain, and R. D. Levy. L-Arginine produces systemic vasodilation and increases nitric oxide excretion in expired gas in humans (Abstract). Circulation 90: I-138, 1994.
31. Mimran, A., J. Ribstein, and G. DuCailar. Contrasting effect of antihypertensive treatment on the renal response to L-arginine. Hypertension 26: 937-946, 1995.
32. Moncada, S., and A. Higgs. The L-arginine-nitric oxide pathway. N. Engl. J. Med. 329: 2002-2012, 1993.
33. Mülsch, A., P. Mordvintcev, E. Bassenge, F. Jung, B. Clement, and R. Busse. In vivo spin trapping of glyceryl trinitrate-derived nitric oxide in rabbit blood vessel and organs. Circulation 92: 1876-1882, 1995.
34. Nitemberg, A., P. Valensi, R. Sachs, M. Dali, E. Aptecar, and J.-R. Attali. Impairment of coronary vascular reserve and Ach-induced coronary vasodilation in diabetic patients with angiographically normal coronary arteries and normal left ventricular systolic function. Diabetes 42: 1017-1025, 1993.
35. Panza, J. A., P. R. Casino, D. M. Badar, and A. A. Quyyumi. Effect of increased availability of endothelium-derived nitric oxide precursor on endothelium-dependent vascular relaxation in normal subjects and in patients with essential hypertension. Circulation 87: 1475-1481, 1993.
36. Panza, J. A., A. A. Quyyumi, J. E. Brush, Jr., and S. E. Epstein. Abnormal endothelium-dependent vascular relaxation in patients with essential hypertension. N. Engl. J. Med. 323: 22-27, 1990.
37. Parati, G., R. Casadei, A. Groppelli, M. Di Rienzo, and G. Mancia. Comparison of finger and intra-arterial blood pressure monitoring at rest and during laboratory testing. Hypertension 13: 647-655, 1989.
38. Rees, D. D., R. M. J. Palmer, R. Schulz, H. F. Hodson, and S. Moncada. Characterization of three inhibitors of endothelium nitric oxide synthase in vitro and in vivo. Br. J. Pharmacol. 101: 746-752, 1990.
39. Saenz de Tejada, I., I. Goldstein, K. Azadzoi, R. J. Krane, and R. A. Cohen. Impaired neurogenic and endothelium-mediated relaxation in penile smooth muscle from diabetic men with impotence. N. Engl. J. Med. 320: 1025-1030, 1989.
40. Seiler, C., O. M. Hess, M. Buechi, T. M. Suter, and H. P. Krayenbuehl. Influence of serum cholesterol and other coronary risk factors on vasomotion of angiographically normal coronary arteries. Circulation 88: 2139-2148, 1993.
41. Smulders, R. A., C. D. A. Stehouwer, C. G. Olthof, G. J. van Kamp, T. Teerlink, P. M. J. M. de Vries, and A. J. M. Donker. Plasma endothelin levels and vascular effects of intravenous L-arginine infusion in subjects with uncomplicated insulin-dependent diabetes mellitus. Clin. Sci. (Colch.) 87: 37-43, 1994.
42. Taddei, S., A. Virdis, P. Mattei, L. Ghiadoni, A. Gennari, C. B. Fasolo, I. Sudano, and A. Salvetti. Aging and endothelial function in normotensive subjects and patients with essential hypertension. Circulation 91: 1981-1987, 1995.
43. Vita, J. A., C. B. Treasure, E. G. Nabel, J. M. McLenacham, R. D. Fish, A. C. Yeung, V. I. Vekshtein, A. P. Seluyn, and P. Ganz. Coronary vasomotor response to acetylcholine relates to risk factors for coronary artery disease. Circulation 81: 491-497, 1990.
44. World Health Organization. Diabetes mellitus: report of a WHO study group. World Health Organ. Monogr. Ser. 727: 9-17, 1985.