Antioxidant Vitamin C Improves Endothelial Dysfunction in Chronic Smokers

Circulation

Volumn 94, Issue 1, 1996, Pages 6-9

  Heitzer, Thomas ^a   Just, Hanjörg ^a   Münzel, Thomas ^a,b  

^a UNIVERSITY OF FREIBURG   (Germany)

^b UNIVERSITY MEDICAL CENTER HAMBURG EPPENDORF   (Germany)

Author keywords

Antioxidants; Endothelium; Free radicals; Smoking

Indexed keywords

ACETYLCHOLINE; ANTIOXIDANT; ASCORBIC ACID; NITROPRUSSIDE SODIUM;

ARTICLE; BLOOD FLOW; CLINICAL TRIAL; DRUG EFFECT; FOREARM; HUMAN; INTRAARTERIAL DRUG ADMINISTRATION; MIDDLE AGED; PATHOPHYSIOLOGY; REFERENCE VALUE; SMOKING; TIME; VASCULAR ENDOTHELIUM; VASCULARIZATION;

ACETYLCHOLINE; ANTIOXIDANTS; ASCORBIC ACID; ENDOTHELIUM, VASCULAR; FOREARM; HUMANS; INJECTIONS, INTRA-ARTERIAL; MIDDLE AGED; NITROPRUSSIDE; REFERENCE VALUES; REGIONAL BLOOD FLOW; SMOKING; TIME FACTORS;

EID: 0030187648     PISSN: 00097322     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.CIR.94.1.6     Document Type: Article

References (24)

1. Sackett DL, Gibson RW, Bross IDJ, Pickren JW. Relation between aortic atherosclerosis and the use of cigarettes and alcohol: an autopsy study. N Engl J Med. 1968;279:1413-1420.
2. Church DF, Pryor WA. Free radical chemistry of cigarette smoke and its toxicological implications. Environ Health Perspect. 1985; 64:111-126.
3. Heitzer T, Ylä-Herttuala S, Luoma J, Kurz S, Münzel T, Just H, Olschewski M, Drexler H. Cigarette smoking potentiates endothelial dysfunction of forearm resistance vessels in patients with hypercholesterolemia: role of oxidized LDL. Circulation. 1996;93:1347-1353.
4. Zeiher AM, Schächinger V, Minners J. Long-term cigarette smoking impairs endothelium-dependent coronary arterial vasodilator function. Circulation. 1995;92:1094-1100.
5. Cohen R. The role of nitric oxide and other endothelium-derived vasoactive substances in vascular disease. Prog Cardiovasc Dis. 1995;38:105-128.
6. Morrow JD, Frei B, Longmire AW, Gaziano JM, Lynch SM, Shyr Y, Strauss WE, Oates JA, Roberts LJ. Increase in circulating products of lipid peroxidation (F2-isoprostanes) in smokers. N Engl J Med. 1995;332:1198-1203.
7. Murohara T, Kugiyama K, Ohgushi M, Sugiyama S, Yasue H. Cigarette smoke extract contracts isolated porcine coronary arteries by superoxide anion-mediated degradation of EDRF. Am J Physiol. 1994;266:H874-H880.
8. Frei B. Reactive oxygen species and antioxidant vitamins: mechanisms of action. Am J Med. 1994;97:5S-13S.
9. Frei B, Forte TM, Ames BN, Cross CE. Gas phase oxidants of cigarette smoke induce lipid peroxidation and changes in lipoprotein properties in human blood plasma: protective effects of ascorbic acid. Biochem J. 1991;277:133-138.
10. Schectman G, Byrd JC, Gruchow HW. The influence of smoking on vitamin C status in adults. Am J Public Health. 1989;79:158-162.
11. Frei B, England L, Ames BN. Ascorbate is an outstanding antioxidant in human blood plasma. Proc Natl Acad Sci U S A. 1989;86: 6377-6381.
12. Ting HH, Timimi FK, Boles KS, Creager SJ, Ganz P, Creager MA. Vitamin C improves endothelium-dependent vasodilation in patients with non-insulin-dependent diabetes mellitus. J Clin Invest. 1996; 97:22-28.
13. Radi R, Beckman JW, Bush KM, Freeman BA. Peroxynitrite induced membrane lipid peroxidation: the cytotoxic potential of superoxide and nitric oxide. Arch Biochem Biophys. 1991;288:481-487.
14. White CR, Brock TA, Chang LY, Crapo J, Briscoe P, Ku D, Bradley WA, Gianturco SH, Gore J, Freeman BA, Tarpey MM. Superoxide and peroxynitrite in atherosclerosis. Proc Natl Acad Sci U S A. 1994;91:1044-1048.
15. Reznick AZ, Cross CE, Hu ML, Suzuki YJ, Khwaja S, Safadi A, Motchnik PA, Packer L, Halliwell B. Modification of plasma proteins by cigarette smoke as measured by protein carbonyl formation. Biochem J. 1992;286:607-611.
16. Lehr HA, Kress E, Menger MD, Friedl HP, Hübner C, Arfors KE, Messmer K. Cigarette smoke elicits leukocyte adhesion to endothelium in hamsters: inhibition by Cu/Zn SOD. Free Radic Biol Med. 1993;14:573-581.
17. Blache D. Involvement of hydrogen and lipid peroxides in acute tobacco smoking-induced platelet hyperactivity. Am J Physiol. 1995;268:H679-H685.
18. Galle J, Mülsch A, Busse R, Bassenge E. Effects of native and oxidized low-density lipoproteins on formation and inactivation of endothelium-derived relaxing factor. Arterioscler Thromb. 1991; 11:198-203.
19. Galle J, Bengen J, Schollmeyer P, Wanner C. Impairment of endothelium-dependent dilation in rabbit renal arteries by oxidized lipoprotein(a): role of oxygen-derived radicals. Circulation. 1995; 92:1582-1589.
20. Duthie GG, Wahle KJ. Smoking, antioxidants, essential fatty acids and coronary heart disease. Biochem Soc Trans. 1990;18:1051-1054.
21. Lehr HA, Frei B, Arfors KE. Vitamin C prevents cigarette smoke-induced leukocyte aggregation and adhesion to the endothelium in vivo. Proc Natl Acad Sci U S A. 1994;91:7688-7692.
22. Retsky KL, Freeman MW, Frei B. Ascorbic acid oxidation product(s) protect human low density lipoprotein against atherogenic modification. J Biol Chem. 1993;268:1304-1309.
23. Bisby RH, Ahmed S, Cundall RB. Repair of amino acid radicals by vitamin E analogue. Biochem Biophys Res Commun. 1984;119:245-250.
24. 2 radicals: a pulse radiolysis and stopped-flow photolysis study. J Phys Chem. 1983;87:1809-1812. File paper.