Oral L-arginine improves endothelium-dependent dilatation and reduces monocyte adhesion to endothelial cells in young men with coronary artery disease

Atherosclerosis

Volumn 129, Issue 2, 1997, Pages 261-269

  Adams, Mark R ^a   McCredie, Robyn ^b   Jessup, Wendy ^b   Robinson, Jacqui ^b   Sullivan, David ^a   Celermajer, David S ^a,b  

^a ROYAL PRINCE ALFRED HOSPITAL   (Australia)

^b HEART RESEARCH INSTITUTE   (Australia)

Author keywords

atherosclerosis; leukocytes; nitric oxide

Indexed keywords

ARGININE; PLACEBO;

ADULT; ARTERY DILATATION; ARTICLE; ATHEROSCLEROSIS; BLOOD PRESSURE; BRACHIAL ARTERY; CELL ADHESION; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CORONARY ARTERY DISEASE; CROSSOVER PROCEDURE; DOUBLE BLIND PROCEDURE; ENDOTHELIUM CELL; HEART RATE; HUMAN; HYPERCHOLESTEROLEMIA; LIPID BLOOD LEVEL; MALE; MONOCYTE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL;

ADMINISTRATION, ORAL; ADULT; ARGININE; BLOOD PROTEINS; BRACHIAL ARTERY; CELL ADHESION; CELLS, CULTURED; CORONARY ARTERIOSCLEROSIS; CROSS-OVER STUDIES; DOUBLE-BLIND METHOD; ENDOTHELIUM, VASCULAR; HEMODYNAMIC PROCESSES; HUMANS; LIPIDS; MALE; MONOCYTES; NITRIC OXIDE; PROSPECTIVE STUDIES; UMBILICAL VEINS; VASODILATION;

EID: 0031002483     PISSN: 00219150     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0021-9150(96)06044-3     Document Type: Article

References (49)

1. Ross R. The pathogenesis of atherosclerosis; a perspective for the 1990s. Nature 1993;362:801-809.
2. Healy B. Endothelial cell dysfunction: an emerging endocrinopathy linked to coronary disease. J Am Coll Cardiol 1990;16:357-358.
3. Celermajer DS, Sorensen KE, Gooch VM, et al. Non-invasive detection of endothelial dysfunction in children and adults at risk of atherosclerosis. Lancet 1992;340:1111-1115.
4. Creager MA, Gallagher SH, Girerd XJ, Coleman S, Dzau VJ, Cooke JP. Impaired vasodilation of forearm resistance vessels in hypercholesterolemic humans. J Clin Invest 1990;86:228-234.
5. Vita JA, Treasure CB, Ganz P, Cox DA, Fish RD, Selwyn AP. Control of shear stress in the epicardial coronary arteries of humans: impairment by atherosclerosis. J Am Coll Cardiol 1989;14:1193-1199.
6. Ludmer PL, Selwyn AP, Shook TL, et al. Paradoxical vasoconstriction induced by acetylcholine in atherosclerotic coronary arteries. N Engl J Med 1986;315:1046-1051.
7. Andrews HE, Bruckdorfer KR, Dunn RC, Jacobs M. Low density lipoproteins inhibit endothelium-dependent relaxation in rabbit aorta. Nature 1987;327:237-239.
8. Verbeuren TJ, Jordaens FH, Zonnekeyn LL, VanHove CE, Coene MC, Herman AG. Effect of hypercholesterolemia on vascular reactivity in the rabbit. Circ Res 1988;58:552-564.
9. Zeiher AM, Drexler H, Wollschlager H, Just H. Modulation of coronary vasomotor tone in humans. Progressive endothelial dysfunction with different early stages of coronary atherosclerosis. Circulation 1991;83:391-401.
10. Lefer AM, Ma XI. Decreased basal nitric oxide release in hypercholesterolemia increases neutrophil adherence to rabbit coronary artery endothelium. Arterioscler Thromb 1993;13:771-776.
11. Cohen RA, Zitnay KM, Haudenschild CC, Cunningham LD. Loss of selective endothelial cell vasoactive functions caused by hypercholesterolemia in pig coronary arteries. Circ Res 1988;63:903-910.
12. Cooke JP, Tsao PS. Is NO an endogenous antiatherogenic molecule? Arterioscler Thromb 1994;14:653-655.
13. Palmer RMJ, Ferridge AG, Moncada S. Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor. Nature 1987;327:524-526.
14. Cooke JP, Singer AH, Tsao P, Zera P, Rowan RA, Billingham ME. Antiatherogenic effects of L-arginine in the hypercholesterolemic rabbit. J Clin Invest 1992;90:1168-1172.
15. Böger RH, Bode-Böger SM, Mügge A, et al. Supplementation of hypercholesterolemic rabbits with L-arginine reduces the vascular release of superoxide anions and restores NO production. Atherosclerosis 1995;117:273-284.
16. Tsao PS, Theilmeier G, Singer AH, Leung LK, Cooke JP. L-Arginine attenuates platelet reactivity in hypercholesterolemic rabbits. Arterioscler Thromb 1994; 14:1529-1533.
17. Tsao PS, McEvoy LM, Drexler H, Butcher EC, Cooke JP. Enhanced endothelial adhesiveness in hypercholesterolemia is attenuated by L-arginine. Circulation 1994;89:2176-2182.
18. Adams MR, Forsyth CJ, Jessup W, Robinson J, Celermajer DS. Oral L-arginine inhibits platelet aggregation but does not enhance endothelium-dependent dilation in healthy young adults. J Am Coll Cardiol 1995;26:1054-1061.
19. Clarkson P, Adams MR, Powe AJ, et al. Oral L-arginine improves endothelium-dependent dilation in hypercholesterolemic young adults. J Clin Invest 1996;97:1989-1994.
20. Adams MR, Robinson J, Sorensen KE, Deanfield JE, Celermajer DS. Normal ranges for brachial artery flow-mediated dilatation: a non-invasive ultrasound test of arterial endothelial function. J Vasc Invest 1996;2:146-150.
21. Friedwald WT, Levy RI, Fredrickson DS. Estimation of the concentration of low density lipoprotein cholesterol in plasma without the use of the preparative ultracentrifuge. Clin Chem 1972;18:499-502.
22. Stamler JS, Jaraki O, Osborne J et al. Nitric oxide circulates in mammalian plasma primarily as an S-nitroso adduct of serum albumin. Proc Natl Acad Sci USA 1992;89:7674-7677.
23. Wennmalm A, Benthin G, Edlund A et al. Metabolism and excretion of nitric oxide in humans. Circ Res 1993;73:1121-1127.
24. Saville B. A scheme for the colorimetric determination of microgram amounts of thiols. Analyst 1958;83:670-672.
25. Joannides R, Haefeli WE, Linder L, et al. Nitric oxide is responsible for flow-dependent dilation of human peripheral conduit arteries in vivo. Circulation 1995;91:1314-1319.
26. Lieberman EH, Knab ST, Creager MA. Nitric oxide mediates the vasodilator response to flow in humans (abstract). Circulation 1994;90(suppl I):138.
27. Anderson TJ, Uehata A, Gerhard MD, et al. Close relationship of endothelial function in the human coronary and peripheral circulations. J Am Coll Cardiol 1995;26:1235-1241.
28. Sorensen KE, Celermajer DS, Speigenhalter DJ, et al. Non-invasive measurement of endothelium-dependent arterial responses in man: accuracy and reproducibility. Br Heart J 1995;74:247-53.
29. Minter AJ, Dawes J, Chesterman CN. Effects of heparin and endothelial growth supplement on hemostatic functions of vascular endothelium. Thromb Haemostas 1992;67:718-723.
30. Garner B, Dean RT, Jessup W. Human macrophage-mediated oxidation of low-density lipoprotein is delayed and independent of superoxide production. Biochem J 1994;301:421-428.
31. Creager MA, Gallagher SJ, Girerd XJ, Coleman SM, Dzau VJ, Cooke JP. L-Arginine improves endothelium-dependent vasodilation in hypercholesterolemic humans. J Clin Invest 1992;90:1248-1253.
32. Otsuji S, Nakajima O, Waku S, et al. Attenuation of acetylcholine-induced vasoconstriction by L-arginine is related to the progression of atherosclerosis. Am Heart J 1995;129:1094-1100.
33. Drexler H, Zeiher AM, Meisner K, Just H. Correction of endothelial dysfunction in coronary microcirculation of hypercholesteremic patients by L-arginine. Lancet 1991;338:1546-1550.
34. Endeman G, Pronzcuck A, Friedman G, Lindsey S, Alderson L, Hayes KC. Monocyte adherence to endothelial cells in vitro is increased by β-VLDL. Am J Pathol 1989;126:1-6.
35. Berliner JA, Territo MC, Sevanian A, et al. Minimally modified low density lipoprotein stimulates monocyte endothelial interactions. J Clin Invest 1990;85:1260-1266.
36. Kalra VK, Ying Y, Deemer K, Natarajan R, Nadler JL, Coates TD. Mechanism of cigarette smoke condensate-induced adhesion of human monocytes to cultured endothelial cells. J Cell Physiol 1994;160:154-162.
37. Kubes P, Suzuki M, Granger DN. Nitric oxide: an endogenous modulator of leukocyte adhesion. Proc Natl Acad Sci 1991;88:4651-4655.
38. Weber C, Erl W, Weber K, Weber PC. Increased adhesiveness of isolated monocytes to endothelium is prevented by vitamin C intake in smokers. Circulation 1996;93:1488-1492.
39. Reckelhoff JF, Kellum JA, Blanchard EJ, Bacon EE, Wesley AJ, Kruckeberg WC. Changes in nitric oxide precursor, L-arginine, and metabolites, nitrate and nitrite, with aging. Life Sci 1994;55:1895-1902.
40. Drexler H, Fischell TA, Pinto FJ et al. Effect of L-arginine on coronary endothelial function in cardiac transplant recipients. Circulation 1994;89:1615-1623.
41. Celermajer DS, Dollery C, Burch M, Deanfield JE. Role of endothelium in the maintenance of low pulmonary vascular tone in normal children. Circulation 1994;89:2041-2044.
42. Arnal JF, Munzel T, Venema RC, et al. Interactions between L-arginine and L-glutamine change endothelial NO production. J Clin Invest 1995;95:2565-2572.
43. Chen LY, Mehta P, Mehta JL. Oxidized LDL decreases L-arginine uptake and nitric oxide synthase protein expression in human platelets. Circulation 1996;93:1740-1746.
44. Philis-Tsimikas A, Witztum JL. L-Arginine may inhibit atherosclerosis through inhibition of LDL oxidation (abstract). Circulation 1995;92(suppl I):422.
45. Engelman DT, Watanabe M, Maulik N, et al. L-Arginine reduces endothelial inflammation and myocardial stunning during ischemia/reperfusion. Ann Thorac Surg 1995;60:1275-1281.
46. De Caterina R, Libby P, Peng H-B, et al. Nitric oxide decreases cytokine-induced endothelial activation. J Clin Invest 1995;96:60-68.
47. Adams MR, Jessup W, Hailstones D, Celermajer DS. L-Arginine reduces human monocyte adhesion to vascular endothelium and endothelial expression of cell adhesion molecules. Circulation 1997 (in press).
48. Celermajer DS, Sorensen KE, Spiegelhalter DJ, Georgakopoulos D, Robinson J, Deanfield JE. Aging is associated with endothelial dysfunction in healthy men years before the age-related decline in women. J Am Coll Cardiol 1994;24:471-476.
49. O'Brien KD, Allen MD, McDonald TO, et al. Vascular cell adhesion molecule-1 is expressed in human coronary atherosclerotic plaques. Implications for the mode of progression of advanced coronary atherosclerosis. J Clin Invest 1993;92:945-951.