Lysosomal Cholesterol Accumulation Sensitizes to Acetaminophen Hepatotoxicity by Impairing Mitophagy

Scientific Reports

Volumn 5, Issue , 2015, Pages

  Baulies, Anna ^a,b,c   Ribas, Vicent ^a,b,c   Núñez, Susana ^a,b,c   Torres, Sandra ^a,b,c   Alarcón Vila, Cristina ^a,b,c   Martínez, Laura ^a,b,c   Suda, Jo ^d   Ybanez, Maria D ^d   Kaplowitz, Neil ^d   García Ruiz, Carmen ^a,b,c,d   Fernández Checa, Jose C ^a,b,c,d  

^a INST D INVESTIGACIONS B   (Spain)

^b INSTITUT D INVESTIGACIONS BIOMÈDIQUES AUGUST PI I SUNYER IDIBAPS   (Spain)

^c INSTITUTO DE SALUD CARLOS III   (Spain)

^d UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ASMASE, MOUSE; CHOLESTEROL; GLUTATHIONE; PARACETAMOL; SPHINGOMYELIN PHOSPHODIESTERASE; STRESS ACTIVATED PROTEIN KINASE;

ANIMAL; DEFICIENCY; DRUG EFFECTS; DRUG RESISTANCE; GENETICS; HUMAN; KNOCKOUT MOUSE; LIVER CELL; LIVER MITOCHONDRION; LYSOSOME; METABOLISM; MITOPHAGY; MOUSE; PATHOLOGY; PHAGOSOME; TOXIC HEPATITIS;

ACETAMINOPHEN; ANIMALS; CHEMICAL AND DRUG INDUCED LIVER INJURY; CHOLESTEROL; DRUG RESISTANCE; GLUTATHIONE; HEPATOCYTES; HUMANS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; LYSOSOMES; MICE; MICE, KNOCKOUT; MITOCHONDRIA, LIVER; MITOCHONDRIAL DEGRADATION; PHAGOSOMES; SPHINGOMYELIN PHOSPHODIESTERASE;

EID: 84949682304     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep18017     Document Type: Article

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