Sphingomyelin depletion in cultured cells blocks proteolysis of sterol regulatory element binding proteins at site 1

Proceedings of the National Academy of Sciences of the United States of America

Volumn 94, Issue 21, 1997, Pages 11179-11183

  Scheek, Sigrid ^a   Brown, Michael S ^a   Goldstein, Joseph L ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

Cholesterol biosynthesis; Cholesteryl ester formation; Endoplasmic reticulum; Neutral sphingomyelinase; Transcription

Indexed keywords

SPHINGOMYELIN; SPHINGOMYELIN PHOSPHODIESTERASE;

ANIMAL CELL; ARTICLE; CHOLESTEROL SYNTHESIS; ENDOPLASMIC RETICULUM; ESTERIFICATION; GENETIC TRANSCRIPTION; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; CELL MEMBRANE; CELL NUCLEUS; CHO CELLS; CLONE CELLS; CRICETINAE; DNA-BINDING PROTEINS; DRUG RESISTANCE; HYDROXYMETHYLGLUTARYL-COA SYNTHASE; LEUCINE ZIPPERS; MAMMALS; RNA, MESSENGER; SERINE; SPHINGOMYELIN PHOSPHODIESTERASE; SPHINGOMYELINS; STEROL REGULATORY ELEMENT BINDING PROTEIN 2; STEROLS; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC;

EID: 0030771982     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.94.21.11179     Document Type: Article

References (26)

1. Brown, D. A. & Rose, J. K. (1992) Cell 68, 533-544.
2. Smart, E. J., Ying, Y.-S., Conrad, P. A. & Anderson, R. G. W. (1994) J. Cell Biol. 127, 1185-1197.
3. Murata, M., Peränen, J., Schreiner, R., Wieland, F., Kurzchalia, T. & Simons, K. (1995) Proc. Natl. Acad. Sci. USA 92, 10339-10343.
4. Schuchman, E. H. & Desnick, R. J. (1995) in The Metabolic and Molecular Basis of Inherited Disease, eds. Scriver, C. R., Beaudet, A. L., Sly, W. S. & Valle, D. (McGraw-Hill, New York), pp. 2601-2624.
5. Gatt, S. & Bierman, E. L. (1980) J. Biol. Chem. 255, 3371-3376.
6. Slotte, J. P. & Bierman, E. L. (1988) Biochem. J. 250, 653-658.
7. Stein, O., Ben-Naim, M., Dabach, Y., Hollander, G. & Stein, Y. (1992) Biochim. Biophys. Acta 1126, 291-297.
8. Lange, Y. & Steck, T. L. (1997) J. Biol. Chem. 272, 13103-13108.
9. Gupta, A. K. & Rudney, H. (1991) J. Lipid Res. 32, 125-136.
10. Slotte, J. P., Harmala, A.-S., Jansson, C. & Porn, M. I. (1990) Biochim. Biophvs. Acta 1030, 251-257.
11. Brown, M. S. & Goldstein. J. L. (1997) Cell 89, 331-340.
12. Lopez, J. M., Bennett, M. K., Sanchez, H. B., Rosenfeld, J. M. & Osborne, T. F. (1996) Proc. Natl. Acad. Sci. USA 93, 1049-1053.
13. Kim, J. B. & Spiegelman, B. M. (1996) Genes Dev. 10, 1096-1107.
14. Hua, X., Nohturfft, A., Goldstein, J. L. & Brown, M. S. (1996) Cell 87, 415-426.
15. Nohturfft, A., Hua, X., Brown, M. S. & Goldstein, J. L. (1996) Proc. Natl. Acad. Sci. USA 93, 13709-13714.
16. Goldstein, J. L., Basu, S. K. & Brown, M. S. (1983) Methods Enzymol. 98, 241-260.
17. Metherall, J. E., Goldstein, J. L., Luskey, K. L. & Brown, M. S. (1989) J. Biol. Chem. 264, 15634-15641.
18. Chang, T.-Y. & Limanek, J. S. (1980) J. Biol. Chem. 255, 7787-7795.
19. Hua, X., Sakai, J., Ho, Y. K., Goldstein. J. L. & Brown, M. S. (1995) J. Biol. Chem. 270, 29422-29427.
20. Hua, X., Sakai, J., Brown, M. S. & Goldstein, J. L. (1996) J. Biol. Chem. 271, 10379-10384.
21. Bollag, D. M. & Edelstein, S. J. (1991) Protein Methods (Wiley-Liss, New York), p. 100.
22. Yang, J., Brown, M. S., Ho, Y. K. & Goldstein, J. L. (1995) J. Biol. Chem. 270, 12152-12161.
23. Gil, G., Goldstein, J. L., Slaughter, C. A. & Brown, M. S. (1986) J. Biol. Chem. 261, 3710-3716.
24. Ross, A. C., Go, K. J., Heider, J. G. & Rothblat, G. H. (1984) J. Biol. Chem. 259, 815-819.
25. Metherall, J. E., Ridgway, N. D., Dawson, P. A., Goldstein, J. L. & Brown, M. S. (1991) J. Biol. Chem. 266, 12734-12740.
26. Wang, X., Sato, R., Brown, M. S., Hua, X. & Goldstein, J. L. (1994) Cell 77, 53-62.