Lysosomal Instability and Cathepsin B Release during Acetaminophen Hepatotoxicity

Basic and Clinical Pharmacology and Toxicology

Volumn 111, Issue 6, 2012, Pages 417-425

  Woolbright, Benjamin L ^a   Ramachandran, Anup ^a   Mcgill, Mitchell R ^a   Yan, Hui min ^a   Bajt, Mary Lynn ^a   Sharpe, Matthew R ^a   Lemasters, John J ^b   Jaeschke, Hartmut ^a  

^a UNIVERSITY OF KANSAS SCHOOL OF MEDICINE   (United States)

^b MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE AMINOTRANSFERASE; CATHEPSIN B; CATHEPSIN B INHIBITOR; DIMETHYL SULFOXIDE; PARACETAMOL;

ADULT; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; C57BL 6 MOUSE; CONTROLLED STUDY; CYTOPLASM; DRUG OVERDOSE; ENZYME ACTIVITY; ENZYME RELEASE; HISTOPATHOLOGY; HUMAN; IN VITRO STUDY; IN VIVO STUDY; LIVER CELL; LIVER MICROSOME; LIVER NECROSIS; LIVER TOXICITY; LYSOSOME; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL;

ACETAMINOPHEN; ADULT; ANIMALS; CATHEPSIN B; CYSTEINE PROTEINASE INHIBITORS; DIPEPTIDES; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG-INDUCED LIVER INJURY; HEPATOCYTES; HUMANS; KETONES; LIVER; LYSOSOMES; MALE; MICE; MICE, INBRED C57BL; MIDDLE AGED; PROSPECTIVE STUDIES;

MUS;

EID: 84869154208     PISSN: 17427835     EISSN: 17427843     Source Type: Journal    
DOI: 10.1111/j.1742-7843.2012.00931.x     Document Type: Article

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