Cathepsin B overexpression due to acid sphingomyelinase ablation promotes liver fibrosis in Niemann-Pick disease

Journal of Biological Chemistry

Volumn 287, Issue 2, 2012, Pages 1178-1188

  Moles, Anna ^a,b   Tarrats, Núria ^a,b   Fernández Checa, José C ^a,b,c,d   Marí, Montserrat ^a,b,d  

^a INSTITUT D INVESTIGACIONS BIOMÈDIQUES AUGUST PI I SUNYER IDIBAPS   (Spain)

^b INST D INVESTIGACIONS B   (Spain)

^c UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^d HOSPITAL CLÍNIC   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

ACID SPHINGOMYELINASE; BASAL LEVELS; CATHEPSIN B; CHRONIC TREATMENT; FUNCTIONAL RELATIONSHIP; HEPATIC STELLATE CELLS; IN-VITRO; IN-VIVO; LIVER DISEASE; LIVER FIBROSIS; MICE MODELS; NEURODEGENERATION; OVER-EXPRESSION; PHARMACOLOGICAL INHIBITION; PROTEOLYTIC PROCESSING; SMOOTH MUSCLE ACTINS; WILD TYPES;

CELL CULTURE; MAMMALS; NEURODEGENERATIVE DISEASES; PATIENT TREATMENT; PRODUCT DEVELOPMENT; PROTEINS;

ABLATION;

ALPHA SMOOTH MUSCLE ACTIN; CARBON TETRACHLORIDE; CATHEPSIN B; CATHEPSIN D; PROCOLLAGEN; PROCOLLAGEN ALPHA 1; SPHINGOMYELIN PHOSPHODIESTERASE; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL ACTIVATION; CELL PROLIFERATION; CONTROLLED STUDY; DISEASE ACTIVITY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME LOCALIZATION; ENZYME REGULATION; IN VITRO STUDY; IN VIVO STUDY; LIVER FIBROSIS; MALE; MOUSE; NIEMANN PICK DISEASE; NONHUMAN; NUCLEOTIDE SEQUENCE; PATHOGENESIS; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PROCESSING; PROTEIN TARGETING; STELLATE CELL; WILD TYPE;

ANIMALS; BIOLOGICAL MARKERS; CARBON TETRACHLORIDE; CARBON TETRACHLORIDE POISONING; CATHEPSIN B; CATHEPSIN D; CELL PROLIFERATION; DISEASE MODELS, ANIMAL; HUMANS; LIVER CIRRHOSIS; MICE; MICE, KNOCKOUT; NIEMANN-PICK DISEASES; SPHINGOMYELIN PHOSPHODIESTERASE;

MUS;

EID: 84855503594     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.272393     Document Type: Article

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