High sphingomyelin levels induce lysosomal damage and autophagy dysfunction in Niemann Pick disease type A

Cell Death and Differentiation

Volumn 21, Issue 6, 2014, Pages 864-875

  Gabande Rodriguez E ^a   Boya, P ^b   Labrador, V ^a   Dotti, C G ^a   Ledesma, M D ^a  

^a CENTRO DE BIOLOGÍA MOLECULAR SEVERO OCHOA   (Spain)

^b CENTRO DE INVESTIGACIONES BIOLÓGICAS   (Spain)

Author keywords

autophagy; Cathepsin B; lysosomal membrane permeabilization; Niemann Pick type A; sphingomyelin

Indexed keywords

CATHEPSIN B; LIPID; SPHINGOMYELIN; SPHINGOMYELIN PHOSPHODIESTERASE; ACID SPHINGOMYELINASE-1;

ANIMAL TISSUE; ARTICLE; ASM GENE; AUTOPHAGOSOME; AUTOPHAGY; CONTROLLED STUDY; CYTOSOL; FIBROBLAST; GENE; GENE MUTATION; HUMAN; HUMAN CELL; KNOCKOUT MOUSE; LYSOSOME; LYSOSOME MEMBRANE; MEMBRANE PERMEABILITY; MOUSE; NERVE DEGENERATION; NIEMANN PICK DISEASE; NONHUMAN; PRIORITY JOURNAL; ANIMAL; GENETICS; METABOLISM; NIEMANN-PICK DISEASE, TYPE A; PATHOLOGY;

MUS;

ANIMALS; AUTOPHAGY; CATHEPSIN B; HUMANS; LYSOSOMES; MICE; NIEMANN-PICK DISEASE, TYPE A; SPHINGOMYELIN PHOSPHODIESTERASE; SPHINGOMYELINS;

EID: 84899957348     PISSN: 13509047     EISSN: 14765403     Source Type: Journal    
DOI: 10.1038/cdd.2014.4     Document Type: Article

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