Chlamydia pneumoniae: Modern insights into an ancient pathogen

Trends in Microbiology

Volumn 21, Issue 3, 2013, Pages 120-128

  Roulis, Eileen ^a   Polkinghorne, Adam ^a   Timms, Peter ^a  

^a QUEENSLAND UNIVERSITY OF TECHNOLOGY   (Australia)

Author keywords

Cell biology; Chlamydia pneumoniae; Genomics; Human; Infection; Zoonosis

Indexed keywords

MEMBRANE PROTEIN; NUCLEOTIDE;

ASTHMA; BACTERIAL GROWTH; BACTERIAL METABOLISM; BACTERIAL PHENOMENA AND FUNCTIONS; BACTERIAL REPRODUCTION; BACTERIAL SURVIVAL; BACTERIAL TRANSMISSION; BACTERIAL VIRULENCE; BACTERIOPHAGE INFECTION; BRONCHITIS; CHLAMYDIA TRACHOMATIS; CHLAMYDIAL PNEUMONIA; CHLAMYDOPHILA PNEUMONIAE; CHRONIC OBSTRUCTIVE LUNG DISEASE; COMMUNITY ACQUIRED PNEUMONIA; DISEASE ASSOCIATION; EXTRACHROMOSOMAL PLASMID; GENE STRUCTURE; GENETIC REGULATION; GENETIC VARIABILITY; GENOME ANALYSIS; HOST PATHOGEN INTERACTION; HUMAN; MICROBIAL MORPHOLOGY; MOLECULAR TYPING; NONHUMAN; NUCLEOTIDE METABOLISM; PLASMID; PRIORITY JOURNAL; REVIEW; SEQUENCE ANALYSIS; SEQUENCE HOMOLOGY; STRAIN DIFFERENCE; TISSUE SPECIFICITY; TRANSCRIPTION REGULATION; TYPE III SECRETION SYSTEM; ZOONOSIS;

ANIMALS; CHLAMYDOPHILA INFECTIONS; CHLAMYDOPHILA PNEUMONIAE; EVOLUTION, MOLECULAR; GENOME, BACTERIAL; HUMANS;

ANIMALIA; CHLAMYDIA TRACHOMATIS; CHLAMYDOPHILA PNEUMONIAE;

EID: 84875267234     PISSN: 0966842X     EISSN: 18784380     Source Type: Journal    
DOI: 10.1016/j.tim.2012.10.009     Document Type: Review

References (91)

1. Horn M., et al. Illuminating the evolutionary history of Chlamydiae. Science 2004, 304:728-730.
2. Hogan R.J., et al. Chlamydial persistence: beyond the biphasic paradigm. Infect. Immun. 2004, 72:1843-1855.
3. World Health Organisation Department of HIV/AIDS. Chlamydia 2001, World Health Organisation. http://www.who.int/docstore/hiv/GRSTI/003.htm.
4. Grayston J.T. Background and current knowledge of Chlamydia pneumoniae and atherosclerosis. J. Infect. Dis. 2000, 181:S402-S410.
5. Saikku P., et al. An epidemic of mild pneumonia due to an unusual strain of Chlamydia psittaci. J. Infect. Dis. 1985, 151:832-839.
6. Grayston J.T., et al. Chlamydia pneumoniae SP-Nov for Chlamydia SP strain TWAR. Int. J. Syst. Bacteriol. 1989, 39:88-90.
7. Teh B., et al. Doxycycline vs. macrolides in combination therapy for treatment of community-acquired pneumonia. Clin. Microbiol. Infect. 2012, 18:E71-E73.
8. Hahn D.L., et al. Chlamydia pneumoniae-specific IgE is prevalent in asthma and is associated with disease severity. PLoS ONE 2012, 7:e35945.
9. Zaitsu M. The development of asthma in wheezing infants with Chlamydia pneumoniae infection. J. Asthma 2007, 44:565-568.
10. Hahn D.L., et al. Chlamydia pneumoniae as a respiratory pathogen. Front. Biosci. 2002, 7:E66-E76.
11. Kurz H., et al. Role of Chlamydophila pneumoniae in children hospitalized for community-acquired pneumonia in Vienna, Austria. Pediatr. Pulmonol. 2009, 44:873-876.
12. Hasan Z.N. Association of Chlamydia pneumoniae serology and ischemic stroke. South. Med. J. 2011, 104:319-321.
13. Deniset J.F., et al. Chlamydophila pneumoniae infection leads to smooth muscle cell proliferation and thickening in the coronary artery without contributions from a host immune response. Am. J. Pathol. 2010, 176:1028-1037.
14. Dreses-Werringloer U., et al. Initial characterization of Chlamydophila (Chlamydia) pneumoniae cultured from the late-onset Alzheimer brain. Int. J. Med. Microbiol. 2009, 299:187-201.
15. Carter J.D., Hudson A.P. The evolving story of Chlamydia-induced reactive arthritis. Curr. Opin. Rheumatol. 2010, 22:424-430.
16. Zhan P., et al. Chlamydia pneumoniae infection and lung cancer risk: a meta-analysis. Eur. J. Cancer 2011, 47:742-747.
17. Wang C.M., et al. Acute Chlamydia pneumoniae reinfection accelerates the development of insulin resistance and diabetes in obese C57BL/6 Mice. J. Infect. Dis. 2009, 200:279-287.
18. Sutherland E.R., et al. A trial of clarithromycin for the treatment of suboptimally controlled asthma. J. Allergy Clin. Immunol. 2010, 126:747-753.
19. Deniset J.F., Pierce G.N. Possibilities for therapeutic interventions in disrupting Chlamydophila pneumoniae involvement in atherosclerosis. Fundam. Clin. Pharmacol. 2010, 24:607-617.
20. Cannon C.P., et al. Antibiotic treatment of Chlamydia pneumoniae after acute coronary syndrome. N. Engl. J. Med. 2005, 352:1646-1654.
21. Benitez A.J., et al. Comparison of real-time PCR and a microimmunofluorescence serological assay for detection of Chlamydophila pneumoniae infection in an outbreak investigation. J. Clin. Microbiol. 2012, 50:151-153.
22. Oktem I.M.A., et al. PCR and serology were effective for identifying Chlamydophila pneumoniae in a lower respiratory infection outbreak among military recruits. Jpn. J. Infect. Dis. 2007, 60:97-101.
23. Sevketbeyoglu H., et al. Outbreak of Chlamydia pneumoniae infection in a military unit: the distribution of lobar and segmental infiltration. Nobel Med. 2012, 8:26-31.
24. Cockram F.A., Jackson A.R.B. Isolation of a Chlamydia from cases of keratoconjunctivitis in Koalas. Aust. Vet. J. 1974, 50:82-83.
25. Girjes A.A., et al. Two distinct forms of Chlamydia psittaci associated with disease and infertility in Phascolarctos cinereus (Koala). Infect. Immun. 1988, 56:1897-1900.
26. Girjes A.A., et al. Remarkable sequence relatedness in the DNA encoding the Major Outer Membrane Protein of Chlamydia psittaci (Koala Type-I) and Chlamydia pneumoniae. Gene 1994, 138:139-142.
27. Bodetti T.J., et al. Molecular evidence to support the expansion of the hostrange of Chlamydophila pneumoniae to include reptiles as well as humans, horses, koalas and amphibians. Syst. Appl. Microbiol. 2002, 25:146-152.
28. Collingro A., et al. Unity in variety- the pan-genome of the Chlamydiae. Mol. Biol. Evol. 2011, 28:3253-3270.
29. Read T.D., et al. Genome sequences of Chlamydia trachomatis MoPn and Chlamydia pneumoniae AR39. Nucleic Acids Res. 2000, 28:1397-1406.
30. Kalman S., et al. Comparative genomes of Chlamydia pneumoniae and C. trachomatis. Nat. Genet. 1999, 21:385-389.
31. Shirai M., et al. Comparison of whole genome sequences of Chlamydia pneumoniae J138 from Japan and CWL029 from USA. Nucleic Acids Res. 2000, 28:2311-2314.
32. Myers G.S.A., et al. Evidence that human Chlamydia pneumoniae was zoonotically acquired. J. Bacteriol. 2009, 191:7225-7233.
33. Mitchell C.M., et al. Comparison of koala LPCoLN and human strains of Chlamydia pneumoniae highlights extended genetic diversity in the species. BMC Genomics 2010, 11:442.
34. Mojica S., et al. Genome Sequence of the obligate intracellular animal pathogen Chlamydia pecorum E58. J. Bacteriol. 2011, 193:3690.
35. Fehlner-Gardiner C., et al. Molecular basis defining human Chlamydia trachomatis tissue tropism - a possible role for tryptophan synthase. J. Biol. Chem. 2002, 277:26893-26903.
36. Bellmann-Weiler R., et al. Divergent modulation of Chlamydia pneumoniae infection cycle in human monocytic and endothelial cells by iron, tryptophan availability and interferon gamma. Immunobiology 2010, 215:842-848.
37. Abromaitis S., et al. Chlamydia pneumoniae encodes a functional aromatic amino acid hydroxylase. FEMS Immunol. Med. Microbiol. 2009, 55:196-205.
38. Everson J.S., et al. Host range of chlamydiaphages phi CPAR39 and Chp3. J. Bacteriol. 2003, 185:6490-6492.
39. Rupp J., et al. Prevalence, genetic conservation and transmissibility of the Chlamydia pneumoniae bacteriophage (phi Cpn1). FEMS Microbiol. Lett. 2007, 273:45-49.
40. Bavoil P., et al. Role of disulphide bonding in outer-membrane structure and permeability in Chlamydia trachomatis. Infect. Immun. 1984, 44:479-485.
41. Shirai M., et al. Comparison of outer membrane protein genes omp and pmp in the whole genome sequences of Chlamydia pneumoniae isolates from Japan and the United States. J. Infect. Dis. 2000, 181:S524-S527.
42. Cochrane M., et al. Multiple genotypes of Chlamydia pneumoniae identified in human carotid plaque. Microbiology 2005, 151:2285-2290.
43. Henderson I.R., Lam A.C. Polymorphic proteins of Chlamydia spp. - autotransporters beyond the Proteobacteria. Trends Microbiol. 2001, 9:573-578.
44. Harley R., et al. Molecular characterisation of 12 Chlamydophila felis polymorphic membrane protein genes. Vet. Microbiol. 2007, 124:230-238.
45. Tanzer R.J., et al. Identification of polymorphic outer membrane proteins of Chlamydia psittaci 6BC. Infect. Immun. 2001, 69:2428-2434.
46. Wehrl W., et al. From the inside out - processing of the chlamydial autotransporter PmpD and its role in bacterial adhesion and activation of human host cells. Mol. Microbiol. 2004, 51:319-334.
47. Voigt A., et al. The Chlamydia psittaci genome: a comparative analysis of intracellular pathogens. PLoS ONE 2012, 7:e35097.
48. Gophna U., et al. Bacterial type III secretion systems are ancient and evolved by multiple horizontal-transfer events. Gene 2003, 312:151-163.
49. Troisfontaines P., Cornelis G.R. Type III secretion: more systems than you think. Physiology 2005, 20:326-339.
50. Beeckman D.S.A., Vanrompay D.C.G. Bacterial secretion systems with an emphasis on the chlamydial type III secretion system. Curr. Issues Mol. Biol. 2010, 12:17-41.
51. Lutter E.I., et al. Evolution and conservation of predicted inclusion membrane proteins in Chlamydiae. Comp. Funct. Genomics 2012, 2012:362104.
52. Saka H.A., Valdivia R.H. Acquisition of nutrients by Chlamydiae: unique challenges of living in an intracellular compartment. Curr. Opin. Microbiol. 2010, 13:4-10.
53. Gieffers J., et al. Genotypic differences in the Chlamydia pneumoniae tyrP locus related to vascular tropism and pathogenicity. J. Infect. Dis. 2003, 188:1085-1093.
54. Mitchell C.M., et al. Chlamydia pneumoniae is genetically diverse in animals and appears to have crossed the host barrier to humans on (at least) two occasions. PLoS Pathog. 2010, 6:e1000903.
55. Wolf K., et al. Ultrastructural analysis of developmental events in Chlamydia pneumoniae-infected cells. Infect. Immun. 2000, 68:2379-2385.
56. Mitchell C.M., et al. In vitro characterisation of koala Chlamydia pneumoniae: morphology, inclusion development and doubling time. Vet. Microbiol. 2009, 136:91-99.
57. Miyairi I., et al. Different growth rates of Chlamydia trachomatis biovars reflect pathotype. J. Infect. Dis. 2006, 194:350-357.
58. Hoestgaard-Jensen K., et al. Influence of the Chlamydia pneumoniae AR39 bacteriophage phi CPAR39 on chlamydial inclusion morphology. FEMS Immunol. Med. Microbiol. 2011, 62:148-156.
59. Hybiske K., Stephens R. Mechanisms of host cell exit by the intracellular bacterium Chlamydia. Proc. Natl. Acad. Sci. U.S.A. 2007, 104:11430-11435.
60. Karunakaran K., et al. Evolutionary conservation of infection-induced cell death inhibition among Chlamydiales. PLoS ONE 2011, 6:e22528.
61. Sharma M., Rudel T. Apoptosis resistance in Chlamydia-infected cells: a fate worse than death?. FEMS Immunol. Med. Microbiol. 2009, 55:154-161.
62. Wolf K., et al. A protein secreted by the respiratory pathogen Chlamydia pneumoniae impairs IL-17 signalling via interaction with human Act1. Cell. Microbiol. 2009, 11:769-779.
63. Nicholson T.L., et al. Global stage-specific gene regulation during the developmental cycle of Chlamydia trachomatis. J. Bacteriol. 2003, 185:3179-3189.
64. Maurer A.P., et al. Gene expression profiles of Chlamydophila pneumoniae during the developmental cycle and iron depletion-mediated persistence. PLoS Pathog. 2007, 3:752-769.
65. Albrecht M., et al. The transcriptional landscape of Chlamydia pneumoniae. Genome Biol. 2011, 12:R98.
66. Saka H.A., et al. Quantitative proteomics reveals metabolic and pathogenic properties of Chlamydia trachomatis developmental forms. Mol. Microbiol. 2011, 82:1185-1203.
67. Hoare A., et al. Spatial constraints within the chlamydial host cell inclusion predict interrupted development and persistence. BMC Microbiol. 2008, 8:5.
68. Miura K., et al. Genome-wide analysis of Chlamydophila pneumoniae gene expression at the late stage of infection. DNA Res. 2008, 15:83-91.
69. Schoborg R.V. Chlamydia persistence - a tool to dissect chlamydia-host interactions. Microbes Infect. 2011, 13:649-662.
70. Eickhoff M., et al. Host cell responses to Chlamydia pneumoniae in gamma interferon-induced persistence overlap those of productive infection and are linked to genes involved in apoptosis, cell cycle, and metabolism. Infect. Immun. 2007, 75:2853-2863.
71. Polkinghorne A., et al. Differential expression of chlamydial signal transduction genes in normal and interferon gamma-induced persistent Chlamydophila pneumoniae infections. Microbes Infect. 2006, 8:61-72.
72. Klos A., et al. The transcript profile of persistent Chlamydophila (Chlamydia) pneumoniae in vitro depends on the means by which persistence is induced. FEMS Microbiol. Lett. 2009, 291:120-126.
73. Timms P., et al. Differential transcriptional responses between the interferon-gamma-induction and iron-limitation models of persistence for Chlamydia pneumoniae. J. Microbiol. Immunol. Infect. 2009, 42:27-37.
74. Matsuo J., et al. Stability of Chlamydophila pneumoniae in a harsh environment without a requirement for acanthamoebae. Microbiol. Immunol. 2010, 54:63-73.
75. Smadel J.E. Atypical pneumonia and psittacosis. J. Clin. Invest. 1943, 22:57-65.
76. Puolakkainen M., et al. Chlamydial pneumonitis and its serodiagnosis in infants. J. Infect. Dis. 1984, 149:598-604.
77. Grayston J.T., et al. A new respiratory tract pathogen: Chlamydia pneumoniae strain TWAR. J. Infect. Dis. 1990, 161:618-625.
78. Falck G.ñ., et al. Prevalence of Chlamydia pneumoniae in healthy children and in children with respiratory tract infections. Pediatr. Infect. Dis. J. 1997, 16:549-554.
79. Kumar S., Hammerschlag M.R. Acute respiratory infection due to Chlamydia pneumoniae: current status of diagnostic methods. Clin. Infect. Dis. 2007, 44:568-576.
80. Coon R.G., et al. Chlamydophila pneumoniae infection among Basic Underwater Demolition/SEAL (BUD/S) Candidates, Coronado, California, July 2008. Mil. Med. 2011, 176:320-323.
81. Senn L., et al. Does respiratory infection due to Chlamydia pneumoniae still exist?. Clin. Infect. Dis. 2011, 53:847-848.
82. Edvinsson M., et al. Presence of Chlamydophila pneumoniae DNA but not mRNA in stenotic aortic heart valves. Int. J. Cardiol. 2010, 143:57-62.
83. Dabiri H., et al. Detection of Chlamydia pneumoniae in atherosclerotic plaques of patients in Tehran, Iran. Jpn. J. Infect. Dis. 2009, 62:195-197.
84. Borel N., et al. Evidence for persistent Chlamydia pneumoniae infection of human coronary atheromas. Atherosclerosis 2008, 199:154-161.
85. Watson C., Alp N.J. Role of Chlamydia pneumoniae in atherosclerosis. Clin. Sci. 2008, 114:509-531.
86. Cockram F., Jackson A. Keratoconjunctivitis of the koala, Phascolarctos cinereus, caused by Chlamydia psittaci. J. Wildl. Dis. 1981, 17:497-504.
87. Blumer C., et al. Chlamydiae in free-ranging and captive frogs in Switzerland. Vet. Pathol. 2007, 44:144-150.
88. Rattei T., et al. Genetic diversity of the obligate intracellular bacterium Chlamydophila pneumoniae by genome-wide analysis of single nucleotide polymorphisms: evidence for highly clonal population structure. BMC Genomics 2007, 8:355.
89. Albrecht M., et al. Deep sequencing-based discovery of the Chlamydia trachomatis transcriptome. Nucleic Acids Res. 2010, 38:868-877.
90. Kokab A., et al. Analysis of modulated gene expression in a model of interferon-gamma-induced persistence of Chlamydia trachomatis in HEp-2 cells. Microb. Pathog. 2010, 49:217-225.
91. Di Pietro M., et al. Analysis of gene expression in penicillin G induced persistence of Chlamydia pneumoniae. J. Biol. Regul. Homeost. Agents 2012, 26:277-284.