Alzheimer's disease-causing proline substitutions lead to presenilin 1 aggregation and malfunction

EMBO Journal

Volumn 34, Issue 22, 2015, Pages 2820-2839

  Ben Gedalya, Tziona ^a   Moll, Lorna ^a   Bejerano Sagie, Michal ^a   Frere, Samuel ^b   Cabral, Wayne A ^c   Friedmann Morvinski, Dinorah ^b   Slutsky, Inna ^b   Burstyn Cohen, Tal ^d   Marini, Joan C ^c   Cohen, Ehud ^a  

^a HEBREW UNIVERSITY   (Israel)

^b TEL AVIV UNIVERSITY   (Israel)

^c EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT   (United States)

^d HEBREW UNIVERSITY OF JERUSALEM   (Israel)

Author keywords

Alzheimer's disease; cyclophilin B; presenilin 1; proteostasis

Indexed keywords

CHAPERONE; CYCLOPHILIN B; GAMMA SECRETASE; PRESENILIN 1; PRION PROTEIN; PROLINE; PRESENILIN 1, MOUSE;

ALZHEIMER DISEASE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN MITOCHONDRION; CHO CELL LINE; CONTROLLED STUDY; ENDOPLASMIC RETICULUM; ENZYME ACTIVITY; FEMALE; HUMAN; KNOCKOUT MOUSE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN FOLDING; AMINO ACID SUBSTITUTION; ANIMAL; BRAIN; CELL LINE; GENETICS; METABOLISM; PATHOLOGY; PROTEINOSIS;

ALZHEIMER DISEASE; AMINO ACID SUBSTITUTION; ANIMALS; BRAIN; CELL LINE; MICE; MICE, KNOCKOUT; MOLECULAR CHAPERONES; PRESENILIN-1; PROLINE; PROTEIN AGGREGATION, PATHOLOGICAL; PROTEIN FOLDING;

EID: 84949503501     PISSN: 02614189     EISSN: 14602075     Source Type: Journal    
DOI: 10.15252/embj.201592042     Document Type: Article

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