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Volumn 89, Issue 12, 2015, Pages 2207-2217

Toxicology of nanosized titanium dioxide: an update

Author keywords

Cytotoxicity; Genotoxicity; Nanosized titanium dioxide; Organs and systems; Oxidative stress

Indexed keywords

CASPASE 3; TITANIUM DIOXIDE NANOPARTICLE; METAL NANOPARTICLE; TITANIUM; TITANIUM DIOXIDE;

EID: 84949322537     PISSN: 03405761     EISSN: 14320738     Source Type: Journal    
DOI: 10.1007/s00204-015-1594-6     Document Type: Review
Times cited : (110)

References (75)
  • 2
    • 84949315235 scopus 로고    scopus 로고
    • 2) nanoparticles induced apoptosis of splenocytes in adult male albino rat and the protective role of Milk thistle seeds extract
    • 2) nanoparticles induced apoptosis of splenocytes in adult male albino rat and the protective role of Milk thistle seeds extract. Int J 2:732–746
    • (2014) Int J , vol.2 , pp. 732-746
    • Aziz, H.O.A.1    Awaad, A.2
  • 3
    • 84876832827 scopus 로고    scopus 로고
    • 2 after direct intracerebral exposure in mice. In: Journal of physics: conference series, vol 1. IOP Publishing
    • 2 after direct intracerebral exposure in mice. In: Journal of physics: conference series, vol 1. IOP Publishing, p 012027
    • (2013) p 012027
    • Balvay, A.1    Thieriet, N.2    Lakhdar, L.3    Bencsik, A.4
  • 4
    • 82355180994 scopus 로고    scopus 로고
    • Preosteoblasts and fibroblasts respond differently to anatase titanium dioxide nanoparticles: a cytotoxicity and inflammation study
    • COI: 1:CAS:528:DC%2BC3MXhsFegs73F
    • Bernier M-C, El Kirat K, Besse M, Morandat S, Vayssade M (2012) Preosteoblasts and fibroblasts respond differently to anatase titanium dioxide nanoparticles: a cytotoxicity and inflammation study. Colloids Surf B 90:68–74
    • (2012) Colloids Surf B , vol.90 , pp. 68-74
    • Bernier, M.-C.1    El Kirat, K.2    Besse, M.3    Morandat, S.4    Vayssade, M.5
  • 5
    • 84861671086 scopus 로고    scopus 로고
    • NanoTIO2 (UV-Titan) does not induce ESTR mutations in the germline of prenatally exposed female mice
    • COI: 1:CAS:528:DC%2BC38XhvVSiu7zE, PID: 22656316
    • Boisen A, Shipley T, Jackson P, Hougaard KS, Wallin H, Yauk CL, Vogel U (2012) NanoTIO2 (UV-Titan) does not induce ESTR mutations in the germline of prenatally exposed female mice. Part Fibre Toxicol 9:19
    • (2012) Part Fibre Toxicol , vol.9 , pp. 19
    • Boisen, A.1    Shipley, T.2    Jackson, P.3    Hougaard, K.S.4    Wallin, H.5    Yauk, C.L.6    Vogel, U.7
  • 6
    • 34547486889 scopus 로고    scopus 로고
    • Titanium dioxide nanomaterials: synthesis, properties, modifications, and applications
    • COI: 1:CAS:528:DC%2BD2sXmslyrurc%3D, PID: 17590053
    • Chen X, Mao SS (2007) Titanium dioxide nanomaterials: synthesis, properties, modifications, and applications. Chem Rev 107:2891–2959
    • (2007) Chem Rev , vol.107 , pp. 2891-2959
    • Chen, X.1    Mao, S.S.2
  • 7
    • 84924911880 scopus 로고    scopus 로고
    • Molecular mechanism of DNA damage induced by titanium dioxide nanoparticles in toll-like receptor 3 or 4 expressing human hepatocarcinoma cell lines
    • El-Said KS, Ali EM, Kanehira K, Taniguchi A (2014) Molecular mechanism of DNA damage induced by titanium dioxide nanoparticles in toll-like receptor 3 or 4 expressing human hepatocarcinoma cell lines. J Nanobiotechnol 12:48
    • (2014) J Nanobiotechnol , vol.12 , pp. 48
    • El-Said, K.S.1    Ali, E.M.2    Kanehira, K.3    Taniguchi, A.4
  • 8
    • 0037926875 scopus 로고    scopus 로고
    • Nanotechnology and medicine
    • COI: 1:CAS:528:DC%2BD3sXkvFegsLs%3D, PID: 12831370
    • Emerich DF, Thanos CG (2003) Nanotechnology and medicine. Expert Opin Biol Ther 3:655–663
    • (2003) Expert Opin Biol Ther , vol.3 , pp. 655-663
    • Emerich, D.F.1    Thanos, C.G.2
  • 9
    • 41849120840 scopus 로고    scopus 로고
    • Tissue distribution and toxicity of intravenously administered titanium dioxide nanoparticles in rats
    • COI: 1:CAS:528:DC%2BD1cXktVegs78%3D, PID: 18000654
    • Fabian E, Landsiedel R, Ma-Hock L, Wiench K, Wohlleben W, Van Ravenzwaay B (2008) Tissue distribution and toxicity of intravenously administered titanium dioxide nanoparticles in rats. Arch Toxicol 82:151–157
    • (2008) Arch Toxicol , vol.82 , pp. 151-157
    • Fabian, E.1    Landsiedel, R.2    Ma-Hock, L.3    Wiench, K.4    Wohlleben, W.5    Van Ravenzwaay, B.6
  • 10
    • 84892619273 scopus 로고    scopus 로고
    • 2 toward human keratinocyte cells by iron doping
    • 2 toward human keratinocyte cells by iron doping. J Nanopart Res 16:1–17
    • (2014) J Nanopart Res , vol.16 , pp. 1-17
    • Ghiazza, M.1
  • 11
    • 84880964950 scopus 로고    scopus 로고
    • 2) nanoparticles on human erythrocyte and lymphocyte cells in vitro
    • COI: 1:CAS:528:DC%2BC3sXmsVeitr8%3D, PID: 23616399
    • 2) nanoparticles on human erythrocyte and lymphocyte cells in vitro. J Appl Toxicol 33:1097–1110
    • (2013) J Appl Toxicol , vol.33 , pp. 1097-1110
    • Ghosh, M.1    Chakraborty, A.2    Mukherjee, A.3
  • 12
    • 80054111428 scopus 로고    scopus 로고
    • Molecular mechanism of kidney injury of mice caused by exposure to titanium dioxide nanoparticles
    • COI: 1:CAS:528:DC%2BC3MXhtlWltr7L, PID: 21907489
    • Gui S et al (2011) Molecular mechanism of kidney injury of mice caused by exposure to titanium dioxide nanoparticles. J Hazard Mater 195:365–370
    • (2011) J Hazard Mater , vol.195 , pp. 365-370
    • Gui, S.1
  • 13
    • 84884489334 scopus 로고    scopus 로고
    • 2 nanoparticles
    • COI: 1:CAS:528:DC%2BC3sXhtlWrurfE, PID: 23968166
    • 2 nanoparticles. J Agric Food Chem 61:8959–8968
    • (2013) J Agric Food Chem , vol.61 , pp. 8959-8968
    • Gui, S.1
  • 14
    • 84867232136 scopus 로고    scopus 로고
    • In vitro toxicity of multi-walled carbon nanotubes in C6 rat glioma cells
    • COI: 1:CAS:528:DC%2BC38XhsFSrtrjK, PID: 22728153
    • Han Y, Xu J, Li Z, Ren G, Yang Z (2012) In vitro toxicity of multi-walled carbon nanotubes in C6 rat glioma cells. Neurotoxicology 33:1128–1134
    • (2012) Neurotoxicology , vol.33 , pp. 1128-1134
    • Han, Y.1    Xu, J.2    Li, Z.3    Ren, G.4    Yang, Z.5
  • 15
    • 84904438983 scopus 로고    scopus 로고
    • 2 NP-Induced hepatic inflammation
    • COI: 1:CAS:528:DC%2BC2cXhtVGks7jL, PID: 24971501
    • 2 NP-Induced hepatic inflammation. J Agric Food Chem 62:6871–6878
    • (2014) J Agric Food Chem , vol.62 , pp. 6871-6878
    • Hong, J.1
  • 16
    • 84925456785 scopus 로고    scopus 로고
    • 2 catalyzed oxidations of caffeine and isocaffeine and their cytotoxicity and genotoxicity towards ovarian cancer cells
    • COI: 1:CAS:528:DC%2BC2MXjsFegsLc%3D
    • 2 catalyzed oxidations of caffeine and isocaffeine and their cytotoxicity and genotoxicity towards ovarian cancer cells. BioNanoScience 4:27–36
    • (2014) BioNanoScience , vol.4 , pp. 27-36
    • Huang, X.1
  • 17
    • 84876976486 scopus 로고    scopus 로고
    • Pulmonary instillation of low doses of titanium dioxide nanoparticles in mice leads to particle retention and gene expression changes in the absence of inflammation
    • COI: 1:CAS:528:DC%2BC3sXnsVyqs7s%3D, PID: 23557971
    • Husain M et al (2013) Pulmonary instillation of low doses of titanium dioxide nanoparticles in mice leads to particle retention and gene expression changes in the absence of inflammation. Toxicol Appl Pharmacol 269:250–262
    • (2013) Toxicol Appl Pharmacol , vol.269 , pp. 250-262
    • Husain, M.1
  • 18
    • 84942861839 scopus 로고    scopus 로고
    • Husain M et al (2015) Intratracheally instilled titanium dioxide nanoparticles translocate to heart and liver and activate complement cascade in the heart of C57BL/6 mice. Nanotoxicology 1–10.
    • Husain M et al (2015) Intratracheally instilled titanium dioxide nanoparticles translocate to heart and liver and activate complement cascade in the heart of C57BL/6 mice. Nanotoxicology 1–10. doi:10.3109/17435390.2014.996192
  • 19
    • 33747131513 scopus 로고    scopus 로고
    • Cobalt in hard-metals and cobalt sulfate, gallium arsenide, indium phosphide and vanadium pentoxide, vol 86
    • IARC (2006) Cobalt in hard-metals and cobalt sulfate, gallium arsenide, indium phosphide and vanadium pentoxide, vol 86. IARC Scientific Publication
    • (2006) IARC Scientific Publication
  • 20
    • 84860005709 scopus 로고    scopus 로고
    • Oxidative stress-induced cytotoxic and genotoxic effects of nano-sized titanium dioxide particles in human HaCaT keratinocytes
    • COI: 1:CAS:528:DC%2BC38XltVeit78%3D, PID: 22449567
    • Jaeger A, Weiss DG, Jonas L, Kriehuber R (2012) Oxidative stress-induced cytotoxic and genotoxic effects of nano-sized titanium dioxide particles in human HaCaT keratinocytes. Toxicology 296:27–36. doi:10.1016/j.tox.2012.02.016
    • (2012) Toxicology , vol.296 , pp. 27-36
    • Jaeger, A.1    Weiss, D.G.2    Jonas, L.3    Kriehuber, R.4
  • 22
    • 84896711604 scopus 로고    scopus 로고
    • 2 exposure on testosterone synthesis and spermatogenesis in mice
    • COI: 1:CAS:528:DC%2BC3sXhslymu7bJ, PID: 24241477
    • 2 exposure on testosterone synthesis and spermatogenesis in mice. Arch Toxicol 88:781–788
    • (2014) Arch Toxicol , vol.88 , pp. 781-788
    • Jia, F.1    Sun, Z.2    Yan, X.3    Zhou, B.4    Wang, J.5
  • 23
  • 24
    • 45849128316 scopus 로고    scopus 로고
    • Titanium dioxide nanoparticles trigger p53-mediated damage response in peripheral blood lymphocytes
    • COI: 1:CAS:528:DC%2BD1cXotVynsrs%3D, PID: 18418868
    • Kang SJ, Kim BM, Lee YJ, Chung HW (2008) Titanium dioxide nanoparticles trigger p53-mediated damage response in peripheral blood lymphocytes. Environ Mol Mutagen 49:399–405
    • (2008) Environ Mol Mutagen , vol.49 , pp. 399-405
    • Kang, S.J.1    Kim, B.M.2    Lee, Y.J.3    Chung, H.W.4
  • 26
    • 83355166280 scopus 로고    scopus 로고
    • Induction of ROS, mitochondrial damage and autophagy in lung epithelial cancer cells by iron oxide nanoparticles
    • COI: 1:CAS:528:DC%2BC3MXhsF2lt7%2FI, PID: 22098780
    • Khan MI, Mohammad A, Patil G, Naqvi S, Chauhan L, Ahmad I (2012) Induction of ROS, mitochondrial damage and autophagy in lung epithelial cancer cells by iron oxide nanoparticles. Biomaterials 33:1477–1488
    • (2012) Biomaterials , vol.33 , pp. 1477-1488
    • Khan, M.I.1    Mohammad, A.2    Patil, G.3    Naqvi, S.4    Chauhan, L.5    Ahmad, I.6
  • 28
    • 79959576956 scopus 로고    scopus 로고
    • 2 caused minor airflow limitation in the murine airways
    • PID: 21259060
    • 2 caused minor airflow limitation in the murine airways. Arch Toxicol 85:827–839
    • (2011) Arch Toxicol , vol.85 , pp. 827-839
    • Leppänen, M.1
  • 30
    • 71849101617 scopus 로고    scopus 로고
    • Oxidative stress and apoptosis induced by nanosized titanium dioxide in PC12 cells
    • COI: 1:CAS:528:DC%2BD1MXhsFyntb7N, PID: 19922763
    • Liu S, Xu L, Zhang T, Ren G, Yang Z (2010) Oxidative stress and apoptosis induced by nanosized titanium dioxide in PC12 cells. Toxicology 267:172–177
    • (2010) Toxicology , vol.267 , pp. 172-177
    • Liu, S.1    Xu, L.2    Zhang, T.3    Ren, G.4    Yang, Z.5
  • 31
    • 84868499831 scopus 로고    scopus 로고
    • Titanium dioxide nanoparticles inhibit proliferation and induce morphological changes and apoptosis in glial cells
    • PID: 23044362
    • Márquez-Ramírez SG, Delgado-Buenrostro NL, Chirino YI, Iglesias GG, López-Marure R (2012) Titanium dioxide nanoparticles inhibit proliferation and induce morphological changes and apoptosis in glial cells. Toxicology 302:146–156
    • (2012) Toxicology , vol.302 , pp. 146-156
    • Márquez-Ramírez, S.G.1    Delgado-Buenrostro, N.L.2    Chirino, Y.I.3    Iglesias, G.G.4    López-Marure, R.5
  • 32
    • 84863719795 scopus 로고    scopus 로고
    • 2-induced apoptosis by oxidative stress-mediated DNA damage and activation of p53 in human embryonic kidney cells
    • COI: 1:CAS:528:DC%2BC38XotVOgu78%3D, PID: 22614867
    • 2-induced apoptosis by oxidative stress-mediated DNA damage and activation of p53 in human embryonic kidney cells. Appl Biochem Biotechnol 167:791–808
    • (2012) Appl Biochem Biotechnol , vol.167 , pp. 791-808
    • Meena, R.1    Rani, M.2    Pal, R.3    Rajamani, P.4
  • 33
    • 84921022915 scopus 로고    scopus 로고
    • Cytotoxic and genotoxic effects of titanium dioxide nanoparticles in testicular cells of male Wistar rat
    • PID: 25344432
    • Meena R, Kajal K, Paulraj R (2014) Cytotoxic and genotoxic effects of titanium dioxide nanoparticles in testicular cells of male Wistar rat. Appl Biochem Biotechnol 175(2):825–840
    • (2014) Appl Biochem Biotechnol , vol.175 , Issue.2 , pp. 825-840
    • Meena, R.1    Kajal, K.2    Paulraj, R.3
  • 34
    • 84921415463 scopus 로고    scopus 로고
    • 2) nanoparticles in induction of apoptosis and inflammatory response in brain
    • COI: 1:CAS:528:DC%2BC2MXhtFKktr8%3D
    • 2) nanoparticles in induction of apoptosis and inflammatory response in brain. J Nanopart Res 17:1–14
    • (2015) J Nanopart Res , vol.17 , pp. 1-14
    • Meena, R.1    Kumar, S.2    Paulraj, R.3
  • 35
    • 31944451232 scopus 로고    scopus 로고
    • Toxic potential of materials at the nanolevel
    • COI: 1:CAS:528:DC%2BD28XptVyrsg%3D%3D, PID: 16456071
    • Nel A, Xia T, Mädler L, Li N (2006) Toxic potential of materials at the nanolevel. Science 311:622–627
    • (2006) Science , vol.311 , pp. 622-627
    • Nel, A.1    Xia, T.2    Mädler, L.3    Li, N.4
  • 36
    • 20644449754 scopus 로고    scopus 로고
    • Nanotoxicology: an emerging discipline evolving from studies of ultrafine particles
    • PID: 16002369
    • Oberdörster G, Oberdörster E, Oberdörster J (2005) Nanotoxicology: an emerging discipline evolving from studies of ultrafine particles. Environ Health Perspect 113(7):823–839
    • (2005) Environ Health Perspect , vol.113 , Issue.7 , pp. 823-839
    • Oberdörster, G.1    Oberdörster, E.2    Oberdörster, J.3
  • 37
    • 82655174047 scopus 로고    scopus 로고
    • 2 nanoparticles to induce skin irritation, phototoxicity, and sensitization
    • COI: 1:CAS:528:DC%2BC3MXhsVKmt7%2FI, PID: 21664450
    • 2 nanoparticles to induce skin irritation, phototoxicity, and sensitization. Toxicol In Vitro 25:1863–1869. doi:10.1016/j.tiv.2011.05.022
    • (2011) Toxicol In Vitro , vol.25 , pp. 1863-1869
    • Park, Y.H.1
  • 39
    • 84907876485 scopus 로고    scopus 로고
    • 2 nanoparticles: comparison by crystalline phase
    • COI: 1:CAS:528:DC%2BC2cXoslCktLY%3D, PID: 24891253
    • 2 nanoparticles: comparison by crystalline phase. J Appl Toxicol 34:1265–1270
    • (2014) J Appl Toxicol , vol.34 , pp. 1265-1270
    • Park, E.J.1
  • 41
    • 84872403099 scopus 로고    scopus 로고
    • Differential mouse pulmonary dose-and time course-responses to titanium dioxide nanospheres and nanobelts
    • PID: 22956629
    • Porter DW et al (2012) Differential mouse pulmonary dose-and time course-responses to titanium dioxide nanospheres and nanobelts. Toxicol Sci. doi:10.1093/toxsci/kfs261
    • (2012) Toxicol Sci
    • Porter, D.W.1
  • 42
    • 84898058889 scopus 로고    scopus 로고
    • Cellular interactions and biological responses to titanium dioxide nanoparticles in HepG2 and BEAS-2B cells: role of cell culture media
    • COI: 1:CAS:528:DC%2BC2cXptFGisw%3D%3D, PID: 24446152
    • Prasad RY et al (2014) Cellular interactions and biological responses to titanium dioxide nanoparticles in HepG2 and BEAS-2B cells: role of cell culture media. Environ Mol Mutagen 55:336–342
    • (2014) Environ Mol Mutagen , vol.55 , pp. 336-342
    • Prasad, R.Y.1
  • 43
    • 84879020530 scopus 로고    scopus 로고
    • Toxicological mechanisms of nanosized titanium dioxide-induced spleen injury in mice after repeated peroral application
    • COI: 1:CAS:528:DC%2BC3sXmsFeltr4%3D, PID: 23621103
    • Sang X et al (2013) Toxicological mechanisms of nanosized titanium dioxide-induced spleen injury in mice after repeated peroral application. J Agric Food Chem 61:5590–5599
    • (2013) J Agric Food Chem , vol.61 , pp. 5590-5599
    • Sang, X.1
  • 44
    • 77951130018 scopus 로고    scopus 로고
    • Human safety review of “nano” titanium dioxide and zinc oxide
    • COI: 1:CAS:528:DC%2BC3cXktVClurk%3D, PID: 20354643
    • Schilling K et al (2010) Human safety review of “nano” titanium dioxide and zinc oxide. Photochem Photobiol Sci 9:495–509
    • (2010) Photochem Photobiol Sci , vol.9 , pp. 495-509
    • Schilling, K.1
  • 45
    • 84906785229 scopus 로고    scopus 로고
    • Revision of the opinion on titanium dioxide, nano form
    • Scientific Committee on Consumer Safety (SCCS) (2013) Revision of the opinion on titanium dioxide, nano form. doi:10.2772/70108
    • (2013) doi:10.2772/70108
  • 46
    • 84923061549 scopus 로고    scopus 로고
    • 2 nanoparticle‐induced neuronal apoptosis in rat primary cultured hippocampal neurons
    • PID: 25045142
    • 2 nanoparticle‐induced neuronal apoptosis in rat primary cultured hippocampal neurons. J Biomed Mater Res A 103(3):1141–1149
    • (2014) J Biomed Mater Res A , vol.103 , Issue.3 , pp. 1141-1149
    • Sheng, L.1
  • 47
    • 78650519473 scopus 로고    scopus 로고
    • ROS-mediated genotoxicity induced by titanium dioxide nanoparticles in human epidermal cells
    • COI: 1:CAS:528:DC%2BC3cXhs1agsLbN, PID: 21092754
    • Shukla RK, Sharma V, Pandey AK, Singh S, Sultana S, Dhawan A (2011) ROS-mediated genotoxicity induced by titanium dioxide nanoparticles in human epidermal cells. Toxicol In Vitro 25:231–241. doi:10.1016/j.tiv.2010.11.008
    • (2011) Toxicol In Vitro , vol.25 , pp. 231-241
    • Shukla, R.K.1    Sharma, V.2    Pandey, A.K.3    Singh, S.4    Sultana, S.5    Dhawan, A.6
  • 48
    • 84872123775 scopus 로고    scopus 로고
    • TiO2 nanoparticles induce oxidative DNA damage and apoptosis in human liver cells
    • COI: 1:CAS:528:DC%2BC3sXntVKktQ%3D%3D, PID: 22047016
    • Shukla RK, Kumar A, Gurbani D, Pandey AK, Singh S, Dhawan A (2013) TiO2 nanoparticles induce oxidative DNA damage and apoptosis in human liver cells. Nanotoxicology 7:48–60
    • (2013) Nanotoxicology , vol.7 , pp. 48-60
    • Shukla, R.K.1    Kumar, A.2    Gurbani, D.3    Pandey, A.K.4    Singh, S.5    Dhawan, A.6
  • 49
    • 84872311835 scopus 로고    scopus 로고
    • Srivastava R et al (2012) Nano-titanium dioxide induces genotoxicity and apoptosis in human lung cancer cell line, A549
    • Srivastava R et al (2012) Nano-titanium dioxide induces genotoxicity and apoptosis in human lung cancer cell line, A549. Hum Exp Toxicol. doi:10.1177/0960327112462725
    • (2012) Hum Exp Toxicol
    • Srivastava, R.1
  • 51
    • 84876424732 scopus 로고    scopus 로고
    • Mitochondrial injury induced by nanosized titanium dioxide in A549 cells and rats
    • COI: 1:CAS:528:DC%2BC3sXnsFSqsLc%3D, PID: 23598258
    • Tang Y, Wang F, Jin C, Liang H, Zhong X, Yang Y (2013) Mitochondrial injury induced by nanosized titanium dioxide in A549 cells and rats. Environ Toxicol Pharmacol 36:66–72
    • (2013) Environ Toxicol Pharmacol , vol.36 , pp. 66-72
    • Tang, Y.1    Wang, F.2    Jin, C.3    Liang, H.4    Zhong, X.5    Yang, Y.6
  • 52
    • 84900851916 scopus 로고    scopus 로고
    • Nano-hydroxyapatite and nano-titanium dioxide exhibit different subcellular distribution and apoptotic profile in human oral epithelium
    • COI: 1:CAS:528:DC%2BC2cXmtlSlsr8%3D, PID: 24734929
    • Tay CY, Fang W, Setyawati MI, Chia SL, Tan KS, Hong CH, Leong DT (2014) Nano-hydroxyapatite and nano-titanium dioxide exhibit different subcellular distribution and apoptotic profile in human oral epithelium. ACS Appl Mater Interfaces 6:6248–6256. doi:10.1021/am501266a
    • (2014) ACS Appl Mater Interfaces , vol.6 , pp. 6248-6256
    • Tay, C.Y.1    Fang, W.2    Setyawati, M.I.3    Chia, S.L.4    Tan, K.S.5    Hong, C.H.6    Leong, D.T.7
  • 53
    • 81055140644 scopus 로고    scopus 로고
    • 2 on human lung cell lines A549 and H1299: particle size distribution effects
    • COI: 1:CAS:528:DC%2BC3MXhtVSiurfF
    • 2 on human lung cell lines A549 and H1299: particle size distribution effects. J Nanopart Res 13:3801–3813
    • (2011) J Nanopart Res , vol.13 , pp. 3801-3813
    • Tedja, R.1    Marquis, C.2    Lim, M.3    Amal, R.4
  • 55
    • 84856079653 scopus 로고    scopus 로고
    • Titanium dioxide particles phosphorylate histone H2AX independent of ROS production
    • COI: 1:CAS:528:DC%2BC38XhtFGisbw%3D
    • Toyooka T, Amano T, Ibuki Y (2012) Titanium dioxide particles phosphorylate histone H2AX independent of ROS production. Mutat Res Genet Toxicol Environ Mutagen 742:84–91
    • (2012) Mutat Res Genet Toxicol Environ Mutagen , vol.742 , pp. 84-91
    • Toyooka, T.1    Amano, T.2    Ibuki, Y.3
  • 56
    • 84875895164 scopus 로고    scopus 로고
    • 2 nanoparticles, a common component of sunscreens and cosmetics, on human keratinocytes
    • COI: 1:CAS:528:DC%2BC3sXhtVyku7%2FK, PID: 23519118
    • 2 nanoparticles, a common component of sunscreens and cosmetics, on human keratinocytes. Cell Death Dis 4:e549. doi:10.1038/cddis.2013.76
    • (2013) Cell Death Dis , vol.4 , pp. e549
    • Tucci, P.1
  • 57
    • 84904845682 scopus 로고    scopus 로고
    • 2) to developing zebrafish embryos
    • 2) to developing zebrafish embryos. J Nanopart Res 16:1–16
    • (2014) J Nanopart Res , vol.16 , pp. 1-16
    • Vicario-Parés, U.1
  • 59
    • 67651163427 scopus 로고    scopus 로고
    • 2 nanoparticles translocation and potential toxicological effect in rats after intraarticular injection
    • COI: 1:CAS:528:DC%2BD1MXpt1Cju78%3D, PID: 19500841
    • 2 nanoparticles translocation and potential toxicological effect in rats after intraarticular injection. Biomaterials 30:4590–4600
    • (2009) Biomaterials , vol.30 , pp. 4590-4600
    • Wang, J.-X.1    Fan, Y.-B.2    Gao, Y.3    Hu, Q.-H.4    Wang, T.-C.5
  • 61
    • 79954607728 scopus 로고    scopus 로고
    • 2
    • COI: 1:CAS:528:DC%2BC3MXktVOit78%3D, PID: 20422311
    • 2. Biol Trace Elem Res 140:186–197
    • (2011) Biol Trace Elem Res , vol.140 , pp. 186-197
    • Wang, J.1
  • 62
    • 84925517674 scopus 로고    scopus 로고
    • Cytotoxicity, DNA damage, and apoptosis induced by titanium dioxide nanoparticles in human non-small cell lung cancer A549 cells
    • Wang Y, Cui H, Zhou J, Li F, Wang J, Chen M, Liu Q (2014) Cytotoxicity, DNA damage, and apoptosis induced by titanium dioxide nanoparticles in human non-small cell lung cancer A549 cells. Environ Sci Pollut Res 22(7):5519–5530
    • (2014) Environ Sci Pollut Res , vol.22 , Issue.7 , pp. 5519-5530
    • Wang, Y.1    Cui, H.2    Zhou, J.3    Li, F.4    Wang, J.5    Chen, M.6    Liu, Q.7
  • 64
    • 70350593880 scopus 로고    scopus 로고
    • 2 nanoparticles in hairless mice and porcine skin after subchronic dermal exposure
    • COI: 1:CAS:528:DC%2BD1MXhtlyru7rM, PID: 19501137
    • 2 nanoparticles in hairless mice and porcine skin after subchronic dermal exposure. Toxicol Lett 191:1–8
    • (2009) Toxicol Lett , vol.191 , pp. 1-8
    • Wu, J.1
  • 65
    • 84915770260 scopus 로고    scopus 로고
    • 2 nanoparticle-induced disruption of calcium homeostasis in human lens epithelial cells
    • COI: 1:CAS:528:DC%2BC2cXhvFWjsb7M, PID: 25059545
    • 2 nanoparticle-induced disruption of calcium homeostasis in human lens epithelial cells. Photochem Photobiol 90:1324–1331. doi:10.1111/php.12322
    • (2014) Photochem Photobiol , vol.90 , pp. 1324-1331
    • Wu, Q.1    Guo, D.2    Du, Y.3    Liu, D.4    Wang, D.5    Bi, H.6
  • 66
    • 84872357492 scopus 로고    scopus 로고
    • 2 nanoparticles influences their phototoxicity: an in vitro investigation
    • COI: 1:CAS:528:DC%2BC38XhtFOgsbrO, PID: 22885792
    • 2 nanoparticles influences their phototoxicity: an in vitro investigation. Arch Toxicol 87:99–109
    • (2013) Arch Toxicol , vol.87 , pp. 99-109
    • Xiong, S.1
  • 68
    • 84856209984 scopus 로고    scopus 로고
    • Oxidative stress and apoptosis induced by hydroxyapatite nanoparticles in C6 cells
    • PID: 22213249
    • Xu J, Xu P, Li Z, Huang J, Yang Z (2012a) Oxidative stress and apoptosis induced by hydroxyapatite nanoparticles in C6 cells. J Biomed Mater Res A 100:738–745
    • (2012) J Biomed Mater Res A , vol.100 , pp. 738-745
    • Xu, J.1    Xu, P.2    Li, Z.3    Huang, J.4    Yang, Z.5
  • 69
    • 84868488887 scopus 로고    scopus 로고
    • Nano copper induced apoptosis in podocytes via increasing oxidative stress
    • PID: 23063557
    • Xu P, Xu J, Liu S, Yang Z (2012b) Nano copper induced apoptosis in podocytes via increasing oxidative stress. J Hazard Mater 241:279–286
    • (2012) J Hazard Mater , vol.241 , pp. 279-286
    • Xu, P.1    Xu, J.2    Liu, S.3    Yang, Z.4
  • 70
    • 78650518772 scopus 로고    scopus 로고
    • Chemoprotective effect of N-acetylcysteine (NAC) on cellular oxidative damages and apoptosis induced by nano titanium dioxide under UVA irradiation
    • COI: 1:CAS:528:DC%2BC3cXhs1agsLjP, PID: 20932892
    • Xue C, Liu W, Wu J, Yang X, Xu H (2011) Chemoprotective effect of N-acetylcysteine (NAC) on cellular oxidative damages and apoptosis induced by nano titanium dioxide under UVA irradiation. Toxicol In Vitro 25:110–116. doi:10.1016/j.tiv.2010.09.014
    • (2011) Toxicol In Vitro , vol.25 , pp. 110-116
    • Xue, C.1    Liu, W.2    Wu, J.3    Yang, X.4    Xu, H.5
  • 71
    • 84864120474 scopus 로고    scopus 로고
    • Phototoxicity of nano titanium dioxides in HaCaT keratinocytes—generation of reactive oxygen species and cell damage
    • COI: 1:CAS:528:DC%2BC38XpsVyjsL8%3D, PID: 22705594
    • Yin JJ, Liu J, Ehrenshaft M, Roberts JE, Fu PP, Mason RP, Zhao B (2012) Phototoxicity of nano titanium dioxides in HaCaT keratinocytes—generation of reactive oxygen species and cell damage. Toxicol Appl Pharmacol 263:81–88. doi:10.1016/j.taap.2012.06.001
    • (2012) Toxicol Appl Pharmacol , vol.263 , pp. 81-88
    • Yin, J.J.1    Liu, J.2    Ehrenshaft, M.3    Roberts, J.E.4    Fu, P.P.5    Mason, R.P.6    Zhao, B.7
  • 72
    • 84862325223 scopus 로고    scopus 로고
    • Titanium dioxide induces apoptotic cell death through reactive oxygen species-mediated Fas upregulation and Bax activation
    • COI: 1:CAS:528:DC%2BC38Xkslams7o%3D
    • Yoo K-C et al (2012) Titanium dioxide induces apoptotic cell death through reactive oxygen species-mediated Fas upregulation and Bax activation. Int J Nanomed 7:1203
    • (2012) Int J Nanomed , vol.7 , pp. 1203
    • Yoo, K.-C.1
  • 73
    • 84929838447 scopus 로고    scopus 로고
    • 2) nanoparticles in male rats: emotional behavior and pathophysiological examination
    • 2) nanoparticles in male rats: emotional behavior and pathophysiological examination. Environ Sci Pollut Res 22(11):8728–8737
    • (2015) Environ Sci Pollut Res , vol.22 , Issue.11 , pp. 8728-8737
    • Younes, N.R.B.1
  • 74
    • 84964721884 scopus 로고    scopus 로고
    • 2 nanoparticle‐induced neurotoxicity may be involved in dysfunction of glutamate metabolism and its receptor expression in mice
    • 2 nanoparticle‐induced neurotoxicity may be involved in dysfunction of glutamate metabolism and its receptor expression in mice. Environ Toxicol. doi:10.1002/tox.22077
    • (2014) Environ Toxicol
    • Ze, X.1
  • 75
    • 84886950738 scopus 로고    scopus 로고
    • 2 nanoparticles in mouse macrophages
    • 2 nanoparticles in mouse macrophages. Toxicol Ind Health 0748233712442708
    • (2012) Toxicol Ind Health
    • Zhang, J.1


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