Toxicological mechanisms of nanosized titanium dioxide-induced spleen injury in mice after repeated peroral application

Journal of Agricultural and Food Chemistry

Volumn 61, Issue 23, 2013, Pages 5590-5599

  Sang, Xuezi ^a   Li, Bing ^a   Ze, Yuguan ^a   Hong, Jie ^a   Ze, Xiao ^a   Gui, Suxin ^a   Sun, Qingqing ^a   Liu, Huiting ^a   Zhao, Xiaoyang ^a   Sheng, Lei ^a   Liu, Dong ^a   Yu, Xiaohong ^a   Wang, Ling ^a   Hong, Fashui ^a,b,c  

^a MEDICAL COLLEGE OF SOOCHOW UNIVERSITY   (China)

^b SOOCHOW UNIVERSITY   (China)

^c Ministry of Science and Technology and Jiangsu Province   (China)

Author keywords

cyclic adenosine monophosphate response element; cyclooxygenase 2; MAPKs PI3 K Akt signaling pathways; nanosized titanium dioxide; spleen damage

Indexed keywords

CYCLIC ADENOSINE; CYCLOOXYGENASE 2; NANO-SIZED TITANIUM DIOXIDE; SIGNALING PATHWAYS; SPLEEN DAMAGE;

MAMMALS; OXIDES; SIGNALING; TRANSCRIPTION FACTORS;

TITANIUM DIOXIDE;

CYCLOOXYGENASE 2; NANOPARTICLE; PROSTAGLANDIN E2; PROTEIN KINASE B; REACTIVE OXYGEN METABOLITE; TITANIUM; TITANIUM DIOXIDE;

ANIMAL; ARTICLE; DRUG EFFECT; FEMALE; INJURY; METABOLISM; MOUSE; OXIDATIVE STRESS; SIGNAL TRANSDUCTION; SPLEEN;

ANIMALS; CYCLOOXYGENASE 2; DINOPROSTONE; FEMALE; MICE; NANOPARTICLES; OXIDATIVE STRESS; PROTO-ONCOGENE PROTEINS C-AKT; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; SPLEEN; TITANIUM;

MUS;

EID: 84879020530     PISSN: 00218561     EISSN: 15205118     Source Type: Journal    
DOI: 10.1021/jf3035989     Document Type: Article

References (42)

1. Powell, J. J.; Faria, N.; Thomas, McKay, E.; Pele, L. C. Origin and fate of dietary nanoparticles and microparticles in the gastrointestinal tract J. Autoimmun. 2010, 34, 226-233
2. Weir, A.; Westerhoff, P.; Fabricius, L.; Hristovski, K.; von Goetz, N. Titanium dioxide nanoparticles in food and personal care products Environ. Sci. Technol. 2012, 46, 2242-2250
3. Fayaz, A. M.; Balaji, K.; Girilal, M.; Kalaichelvan, P. T.; Venkatesan, R. Mycobased synthesis of silver nanoparticles and their incorporation into sodium alginate films for vegetable and fruit preservation J. Agric. Food Chem. 2009, 57, 6246-6252
4. 2 nanoparticles and assessment of their differential toxicity in four hdible plant species J. Agric. Food Chem. 2010, 58, 3689-3693
5. Goutailler, G.; Guillard, C.; Faure, R.; Païssé, O. Degradation pathway of dicyclanil in water in the presence of titanium dioxide. Comparison with photolysis J. Agric. Food Chem. 2002, 50, 5115-5120 (Pubitemid 34925099)
6. Gimeno, O.; Rivas, F. J.; Beltrán, F. J.; Carbajo, M. Photocatalytic ozonation of winery wastewaters J. Agric. Food Chem. 2007, 55, 9944-9950 (Pubitemid 350305180)
7. Chen, J. Y.; Dong, X.; Zhao, J.; Tang, G. P. In vivo acute toxicity of titanium dioxide nanoparticles to mice after intraperitoneal injection J. Appl. Toxicol. 2009, 29, 330-337
8. 2 Biol. Trace Elem. Res. 2011, 140, 186-197
9. Li, N.; Duan, Y. M.; Hong, M. M.; Zheng, L.; Fei, M.; Zhao, X. Y.; Wang, Y.; Cui, Y. L.; Liu, H. T.; Cai, J. W.; Gong, S. J.; Wang, H.; Hong, F. S. Spleen injury and apoptotic pathway in mice caused by titanium dioxide nanoparticules Toxicol. Lett. 2010, 195, 161-168
10. Sang, X. Z.; Zheng, L.; Sun, Q. Q.; Li, N.; Cui, Y. L.; Hu, R. P.; Gao, G. D.; Cheng, Z.; Cheng, J.; Gui, S. X.; Liu, H. T.; Zhang, Z. L.; Hong, F. S. The chronic spleen injury of mice following long-period exposure to titanium dioxide nanoparticles J. Biomed. Mater. Res. A 2012, 100A, 894-902
11. Kuwano, T.; Nakao, S.; Yamamoto, H.; Tsuneyoshi, M.; Yamamoto, T.; Kuwano, M.; Ono, M. Cyclooxygenase 2 is a key enzyme for inflammatory cytokine-induced angiogenesis FASEB J. 2004, 18, 300-310 (Pubitemid 38186249)
12. Fukunaga, K.; Kohli, P.; Bonnans, C.; Fredenburgh, L. E.; Levy, B. D. Cyclooxygenase 2 plays a pivotal role in the resolution of acute lung injury J. Immunol. 2005, 174, 5033-5039
13. Harris, S. G.; Padilla, J.; Koumas, L.; Ray, D.; Phipps, R. P. Prostaglandins as modulators of immunity Trends Immunol. 2002, 23, 144-150 (Pubitemid 34178297)
14. Tilley, S. L.; Coffman, T. M.; Koller, B. H. Mixed messages: modulation of inflammation and immune responses by prostaglandins and thromboxanes J. Clin. Invest. 2001, 108, 15-23 (Pubitemid 32634916)
15. Goetzl, E. J.; An, S.; Smith, W. L. Specificity of expression and effects of eicosanoid mediators in normal physiology and human diseases FASEB J. 1995, 9, 1051-1058
16. Phipps, R. P.; Stein, S. H.; Roper, R. L. A new view of prostaglandin E regulation of the immune response Immunol. Today 1991, 12, 349-352
17. Inoue, H.; Nanayama, T.; Hara, S.; Yokoyama, C.; Tanabe, T. The cyclic AMP response element plays an essential role in the expression of the human prostaglandin-endoperoxide synthase 2 gene in differentiated U937 monocytic cells FEBS Lett. 1994, 350, 51-54 (Pubitemid 24261395)
18. Inoue, H.; Yokoyama, C.; Hara, S.; Tone, Y.; Tanabe, T. Transcriptional regulation of human prostaglandin-endoperoxide synthase-2 gene by lipopolysaccharide and phorbol ester in vascular endothelial cells. Involvement of both nuclear factor for interleukin-6 expression site and cAMP response element J. Biol. Chem. 1995, 270, 24965-24971
19. Kosaka, T.; Miyata, A.; Ihara, H.; Hara, S.; Sugimoto, T.; Takeda, O.; Takahashi, E.; Tanabe, T. Characterization of the human gene (PTGS2) encoding prostaglandin-endoperoxide synthase 2 Eur. J. Biochem. 1994, 221, 889-897 (Pubitemid 24146188)
20. Mestre, J. R.; Subbaramaiah, K.; Sacks, P. G.; Schantz, S. P.; Tanabe, T.; Inoue, H.; Dannenberg, A. J. Retinoids suppress phorbol ester-mediated induction of cyclooxygenase-2 Cancer Res. 1997, 57, 1081-1085 (Pubitemid 27138605)
21. Subbaramaiah, K.; Cole, P. A.; Dannenberg, A. J. Retinoids and carnosol suppress cyclooxygenase-2 transcription by CREB-binding protein/p300-dependent and -independent mechanisms Cancer Res. 2002, 62, 2522-2530 (Pubitemid 34462729)
22. Xie, W.; Fletcher, B. S.; Andersen, R. D.; Herschman, H. R. v-src induction of the TIS10/PGS2 prostaglandin synthase gene is mediated by an ATF/CRE transcription response element Mol. Cell. Biol. 1994, 14, 6531-6539
23. Thomas, B.; Berenbaum, F.; Humbert, L.; Bian, H.; Béréziat, G.; Crofford, L.; Olivier, J. L. Critical role of C/EBPδ and C/EBPβ factors in the stimulation of the cyclooxygenase-2 gene transcription by interleukin-1β in articular chondrocytes Eur. J. Biochem. 2000, 267, 6798-6809
24. Wadleigh, D. J.; Reddy, S. T.; Kopp, E.; Ghosh, S.; Herschman, H. R. Transcriptional activation of the cyclooxygenase-2 gene in endotoxin-treated RAW 264.7 macrophages J. Biol. Chem. 2000, 275, 6259-6266 (Pubitemid 30129916)
25. Hsu, T. C.; Young, M. R.; Cmarik, J.; Colburn, N. H. Activator protein 1 (AP-1) and nuclear factor kappa B (NF-κB)-dependent transcriptional events in carcinogenesis Free Radical Biol. Med. 2000, 28, 1338-1348 (Pubitemid 30621478)
26. Guan, Z.; Buckman, S. Y.; Miller, B. W.; Springer, L. D.; Morrison, A. R. Interleukin 1β-induced cyclooxygenase-2 expression requires activation of both c-Jun NH2-periodinal kinase and p38 MAPK signal pathways in rat renal mesangial cells J. Biol. Chem. 1998, 273, 28670-28676 (Pubitemid 28507552)
27. Ridley, S. H.; Dean, J. L.; Sarsfield, S. J.; Brook, M.; Clark, A. R.; Saklatvala, J. A p38MAP kinase inhibitor regulates stability of interleukin-1-induced cyclooxygenase-2 mRNA FEBS Lett. 1998, 439, 75-80 (Pubitemid 28537867)
28. Pommery, N.; Hénichart, J. P. Involvement of PI3K/Akt pathway in prostate cancer-potential strategies for developing targeted therapies Mini-Rev. Med. Chem. 2005, 5, 1125-1132 (Pubitemid 41723569)
29. Whitmarsh, A. J.; Davis, R. J. Transcription factor AP-1 regulation by mitogen-activated protein kinase signal transduction pathways J. Mol. Med. 1996, 74, 589-607 (Pubitemid 26343761)
30. Roymans, D.; Slegers, H. Phosphatidylinositol 3-kinases in tumor progression Eur. J. Biochem. 2001, 268, 487-498 (Pubitemid 32862605)
31. 3+ ions for photocatalysis Mater. Lett. 2002, 57, 794-801 (Pubitemid 35405746)
32. Hu, R. P.; Zheng, L.; Zhang, T.; Cui, Y. L.; Gao, G. D.; Cheng, Z.; Chen, J.; Tang, M.; Hong, F. S. Molecular mechanism of hippocampal apoptosis of mice following exposure to titanium dioxide nanoparticles J. Hazard Mater. 2011, 191, 32-40
33. Oliveira, C. P.; Lopasso, F. P.; Laurindo, F. R.; Leitao, R. M.; Laudanna, A. A. Protection against liver ischemia-reperfusion injury in rats by silymarin or verapamil Transplant Proc. 2001, 33, 3010-3014 (Pubitemid 32785627)
34. Nourooz-Zadeh, J.; Tajaddini-Sarmadi, J.; Wolff, S. P. Measurement of plasma hydroperoxide concentrations by the ferrous oxidation-xylenol orange assay in conjunction with triphenylphosphine Anal. Biochem. 1994, 220, 403-409
35. Ke, L. D.; Chen, Z. A reliability test of standard-based quantitative PCR: exogenous vs endogenous standards Mol. Cell Probe 2000, 14 (2) 127-135 (Pubitemid 30330661)
36. Livak, K. J.; Schmittgen, T. D. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-ΔΔC(T)) method Methods 2001, 25, 402-408 (Pubitemid 34164012)
37. Liu, W. H.; Saint, D. A. Validation of a quantitative method for real time PCR kinetics Biochem Biophys. Res. Commun. 2002, 294, 347-353 (Pubitemid 34694101)
38. Mohammed, S. I.; Coffman, K.; Glickman, N. W.; Hayek, M. G.; Waters, D. J.; Schlittler, D.; DeNicola, D. B.; Knapp, D. W. Prostaglandin E2 concentrations in naturally occurring canine cancer Prostaglandins, Leukotrienes Essent. Fatty Acids 2001, 64, 1-4 (Pubitemid 32142550)
39. Stolina, M.; Sharma, S.; Zhu, L.; Dubinett, S. M. Lung cancer cyclooxygenase-2 dependent inhibition of dendritic cell maturation and function Proc. Am. Assoc. Cancer Res. 2000, 41, 619
40. Karin, M.; Liu, Z.; Zandi, E. AP-1 function and regulation Curr. Opin. Cell Biol. 1997, 9, 240-246 (Pubitemid 27135992)
41. Glinghammar, B.; Inoue, H.; Rafter, J. J. Deoxycholic acid causes DNA damage in colonic cells with subsequent induction of caspases, COX-2 promoter activity and the transcription factors NF-κB and AP-1 Carcinogenesis 2002, 23, 839-845 (Pubitemid 34567524)
42. Niederberger, E.; Tegeder, I.; Schafer, C.; Seegel, M.; Grosch, S.; Geisslinger, G. Opposite effects of rofecoxib on nuclear factor-κB and activating protein-1 activation J. Pharmacol. Exp. Ther. 2003, 304, 1153-1160 Education Institutions