Pulmonary instillation of low doses of titanium dioxide nanoparticles in mice leads to particle retention and gene expression changes in the absence of inflammation

Toxicology and Applied Pharmacology

Volumn 269, Issue 3, 2013, Pages 250-262

  Husain, Mainul ^a   Saber, Anne T ^b   Guo, Charles ^a   Jacobsen, Nicklas R ^b   Jensen, Keld A ^b   Yauk, Carole L ^a   Williams, Andrew ^b   Vogel, Ulla ^b,c   Wallin, Hakan ^b,d   Halappanavar, Sabina ^a  

^a HEALTH CANADA   (Canada)

^b NATIONAL RESEARCH CENTRE FOR THE WORKING ENVIRONMENT   (Denmark)

^c TECHNICAL UNIVERSITY OF DENMARK   (Denmark)

^d UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

Calcium homeostasis; Gene expression; Hyperspectral microscopy; Inflammation; Muscle contraction; Tissue particle retention

Indexed keywords

CXCL1 CHEMOKINE; CXCL2 CHEMOKINE; CXCL9 CHEMOKINE; GRANULOCYTE COLONY STIMULATING FACTOR; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 13; INTERLEUKIN 17; INTERLEUKIN 1BETA; INTERLEUKIN 2; INTERLEUKIN 5; INTERLEUKIN 9; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; MACROPHAGE INFLAMMATORY PROTEIN 1BETA; MONOCYTE CHEMOTACTIC PROTEIN 1 INHIBITOR; NANOPARTICLE; TITANIUM DIOXIDE; VASCULOTROPIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; DNA MICROARRAY; DOWN REGULATION; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; GENE EXPRESSION; INFLAMMATION; LUNG; LUNG TOXICITY; MOUSE; MUSCLE CONTRACTION; MUSCLE DEVELOPMENT; NEUTROPHIL; NONHUMAN; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SMOOTH MUSCLE;

ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; GENE EXPRESSION; GENE EXPRESSION PROFILING; INFLAMMATION; LUNG; METAL NANOPARTICLES; MICE; MICE, INBRED C57BL; TITANIUM;

MUS;

EID: 84876976486     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2013.03.018     Document Type: Article

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