Mechanisms of TiO2 nanoparticle-induced neuronal apoptosis in rat primary cultured hippocampal neurons

Journal of Biomedical Materials Research - Part A

Volumn 103, Issue 3, 2015, Pages 1141-1149

  Sheng, Lei ^a   Ze, Yuguan ^a   Wang, Ling ^a   Yu, Xiaohong ^a   Hong, Jie ^a   Zhao, Xiaoyang ^a   Ze, Xiao ^a   Liu, Dong ^a   Xu, Bingqing ^a   Zhu, Yunting ^a   Long, Yi ^a   Lin, Anan ^a   Zhang, Chi ^a   Zhao, Yue ^a   Hong, Fashui ^a  

^a SOOCHOW UNIVERSITY   (China)

Author keywords

Calcium overload; Endoplasmic reticulum mediated signal pathway; Mitochondria mediated signal pathway; Primary cultured hippocampal neurons; Titanium dioxide nanoparticles

Indexed keywords

CALCIUM; CELL DEATH; CELL MEMBRANES; CELL SIGNALING; NANOPARTICLES; OXIDES; PROTEINS; TITANIUM; TITANIUM DIOXIDE;

ANTIOXIDANT CAPACITY; CALCIUM OVERLOAD; DOSE-DEPENDENT MANNER; ENDOPLASMIC RETICULUM; HIPPOCAMPAL NEURONS; LACTATE DEHYDROGENASE; SIGNAL PATHWAYS; TITANIUM DIOXIDE NANOPARTICLES;

NEURONS;

CASPASE 12; CASPASE 3; CCAAT ENHANCER BINDING PROTEIN; CYTOCHROME C; GLUCOSE REGULATED PROTEIN 78; LACTATE DEHYDROGENASE; PROTEIN BAX; PROTEIN BCL 2; TITANIUM DIOXIDE NANOPARTICLE; APOPTOSIS REGULATORY PROTEIN; NANOPARTICLE; TITANIUM; TITANIUM DIOXIDE;

ANIMAL CELL; ANTIOXIDANT ACTIVITY; APOPTOSIS; ARTICLE; CALCIUM HOMEOSTASIS; CELL ULTRASTRUCTURE; CELL VIABILITY; CONTROLLED STUDY; DOSE RESPONSE; DOWN REGULATION; ENDOPLASMIC RETICULUM; ENZYME ACTIVITY; FETUS; HIPPOCAMPAL NEURONAL CULTURE; HYDRODYNAMICS; MITOCHONDRIAL MEMBRANE POTENTIAL; NERVE CELL NECROSIS; NONHUMAN; OXIDATIVE STRESS; PARTICLE SIZE; PROTEIN EXPRESSION; RAT; SIGNAL TRANSDUCTION; ANIMAL; BIOSYNTHESIS; CELL CULTURE; CELL SURVIVAL; CHEMISTRY; DRUG EFFECTS; HIPPOCAMPUS; METABOLISM; NERVE CELL; PATHOLOGY; SPRAGUE DAWLEY RAT;

ANIMALS; APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; CELL SURVIVAL; CELLS, CULTURED; HIPPOCAMPUS; MEMBRANE POTENTIAL, MITOCHONDRIAL; NANOPARTICLES; NEURONS; RATS; RATS, SPRAGUE-DAWLEY; SIGNAL TRANSDUCTION; TITANIUM;

EID: 84923061549     PISSN: 15493296     EISSN: 15524965     Source Type: Journal    
DOI: 10.1002/jbm.a.35263     Document Type: Article

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