Molecular mechanism of DNA damage induced by titanium dioxide nanoparticles in toll-like receptor 3 or 4 expressing human hepatocarcinoma cell lines

Journal of Nanobiotechnology

Volumn 12, Issue 1, 2014, Pages

  El Said, Karim Samy ^a,c   Ali, Ehab Mostafa ^c   Kanehira, Koki ^d   Taniguchi, Akiyoshi ^a,b  

^a NATIONAL INSTITUTE FOR MATERIALS SCIENCE   (Japan)

^b WASEDA UNIVERSITY   (Japan)

^c Tanta University   (Egypt)

^d TOTO LTD   (Japan)

Author keywords

Apoptosis; DNA damage; ROS; TiO2 NPs; TLRs

Indexed keywords

CELL CULTURE; CELL DEATH; CELLS; CYTOLOGY; DNA; GENE EXPRESSION; GENES; INTERFERONS; NANOPARTICLES; OXIDES; PEPTIDES; TITANIUM;

DNA DAMAGES; DNA DOUBLE STRAND BREAKS; GLUTATHIONE PEROXIDASE; REACTIVE OXYGEN SPECIES; ROS; TIO; TITANIUM DIOXIDE NANOPARTICLES; TLRS;

TITANIUM DIOXIDE;

APYRIMIDINIC EXONUCLEASE 1; ATM PROTEIN; CASPASE 3; GLUTATHIONE; GLUTATHIONE PEROXIDASE; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 45A; HYDROGEN PEROXIDE; INOSITOL HEXAKISPHOSPHATE KINASE 3; MESSENGER RNA; METHYL CPG BINDING PROTEIN 4; REACTIVE OXYGEN METABOLITE; STRUCTURAL MAINTENANCE OF CHROMOSOME 1A; TITANIUM DIOXIDE NANOPARTICLE; TOLL LIKE RECEPTOR 3; TOLL LIKE RECEPTOR 4; UNCLASSIFIED DRUG; NANOPARTICLE; TITANIUM; TITANIUM DIOXIDE; TLR3 PROTEIN, HUMAN; TLR4 PROTEIN, HUMAN;

APOPTOSIS; ARTICLE; CELL CYCLE ARREST; CONTROLLED STUDY; DNA DAMAGE; DNA REPAIR; DOUBLE STRANDED DNA BREAK; ENZYME ACTIVATION; GENE OVEREXPRESSION; GENETIC TRANSFECTION; HEPG2 CELL LINE; LIVER CELL CARCINOMA; OXIDATIVE STRESS; REAL TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; UPREGULATION; CHEMISTRY; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETICS; HEP-G2 CELL LINE; HUMAN; METABOLISM;

DNA DAMAGE; GENE EXPRESSION REGULATION; GLUTATHIONE; GLUTATHIONE PEROXIDASE; HEP G2 CELLS; HUMANS; HYDROGEN PEROXIDE; NANOPARTICLES; OXIDATIVE STRESS; REACTIVE OXYGEN SPECIES; REAL-TIME POLYMERASE CHAIN REACTION; TITANIUM; TOLL-LIKE RECEPTOR 3; TOLL-LIKE RECEPTOR 4;

EID: 84924911880     PISSN: None     EISSN: 14773155     Source Type: Journal    
DOI: 10.1186/s12951-014-0048-2     Document Type: Article

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