Totarol prevents neuronal injury in vitro and ameliorates brain ischemic stroke: Potential roles of Akt activation and HO-1 induction

Toxicology and Applied Pharmacology

Volumn 289, Issue 2, 2015, Pages 142-154

  Gao, Yuanxue ^a   Xu, Xiaojun ^a   Chang, Sai ^a   Wang, Yunjie ^a   Xu, Yazhou ^a   Ran, Siqi ^a   Huang, Zhangjian ^a   Li, Ping ^a   Li, Jia ^b   Zhang, Luyong ^a   Saavedra, Juan M ^c   Liao, Hong ^a   Pang, Tao ^a,c  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

^b SHANGHAI INSTITUTE OF MATERIA MEDICA   (China)

^c GEORGETOWN UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Akt; HO 1; Neuroprotection; Stroke; Totarol

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; GLUTATHIONE; GLYCOGEN SYNTHASE KINASE 3BETA; HEME OXYGENASE 1; LACTATE DEHYDROGENASE; NATURAL PRODUCT; NEUROPROTECTIVE AGENT; NORPHENAZONE; PROTEIN KINASE B; PROTOPORPHYRIN ZINC; SUPEROXIDE DISMUTASE; TOTAROL; TRANSCRIPTION FACTOR NRF2; UNCLASSIFIED DRUG; AMINO ACID RECEPTOR STIMULATING AGENT; ANTIOXIDANT; DITERPENE; GLUCOSE; GLUTAMIC ACID; GLYCOGEN SYNTHASE KINASE 3; GLYCOGEN SYNTHASE KINASE 3 BETA; HEME OXYGENASE; HMOX1 PROTEIN, RAT; NFE2L2 PROTEIN, RAT;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; BRAIN CORTEX; BRAIN INFARCTION SIZE; BRAIN ISCHEMIA; BRAIN NERVE CELL; CEREBELLUM GRANULAR LAYER; CONTROLLED STUDY; DRUG MECHANISM; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INDUCTION; ENZYME PHOSPHORYLATION; EXCITOTOXICITY; IN VITRO STUDY; MALE; MIDDLE CEREBRAL ARTERY OCCLUSION; NERVE CELL LESION; NEUROLOGIC DISEASE; NEUROPROTECTION; NEUROTOXICITY; NEWBORN; NONHUMAN; OXIDATIVE STRESS; PROTEIN DEPHOSPHORYLATION; PROTEIN EXPRESSION; RAT; REPERFUSION; ANIMAL; BIOSYNTHESIS; BRAIN; CELL CULTURE; CELL DEATH; CELL HYPOXIA; DEFICIENCY; DISEASE MODEL; DOSE RESPONSE; DRUG EFFECTS; ENZYMOLOGY; INFARCTION, MIDDLE CEREBRAL ARTERY; METABOLISM; NERVE CELL; PATHOLOGY; PHOSPHORYLATION; SIGNAL TRANSDUCTION; SPRAGUE DAWLEY RAT; TIME FACTOR;

ANIMALS; ANTIOXIDANTS; BRAIN; CELL DEATH; CELL HYPOXIA; CELLS, CULTURED; DISEASE MODELS, ANIMAL; DITERPENES; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME ACTIVATION; ENZYME INDUCTION; EXCITATORY AMINO ACID AGONISTS; GLUCOSE; GLUTAMIC ACID; GLUTATHIONE; GLYCOGEN SYNTHASE KINASE 3; HEME OXYGENASE (DECYCLIZING); INFARCTION, MIDDLE CEREBRAL ARTERY; MALE; NEURONS; NEUROPROTECTIVE AGENTS; NF-E2-RELATED FACTOR 2; OXIDATIVE STRESS; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; RATS, SPRAGUE-DAWLEY; SIGNAL TRANSDUCTION; SUPEROXIDE DISMUTASE; TIME FACTORS;

EID: 84949185429     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2015.10.001     Document Type: Article

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