Telmisartan ameliorates glutamate-induced neurotoxicity: Roles of AT 1 receptor blockade and PPARγ activation

Neuropharmacology

Volumn 79, Issue , 2014, Pages 249-261

  Wang, Juan ^a   Pang, Tao ^a,b   Hafko, Roman ^a   Benicky, Julius ^a   Sanchez Lemus, Enrique ^a   Saavedra, Juan M ^a,c  

^a NATIONAL INSTITUTE OF MENTAL HEALTH   (United States)

^b CHINA PHARMACEUTICAL UNIVERSITY   (China)

^c GEORGETOWN UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Angiotensin II AT1 Receptor Blockers; Apoptosis; Glutamate neurotoxicity; Neuroprotection; PPAR ; Telmisartan

Indexed keywords

ANGIOTENSIN 1 RECEPTOR; ANGIOTENSIN 1 RECEPTOR ANTAGONIST; ANGIOTENSIN 1A RECEPTOR; ANGIOTENSIN 2 RECEPTOR; CANDESARTAN; CASPASE 3; GLUTAMIC ACID; LOSARTAN; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PHOSPHATIDYLINOSITOL 3 KINASE; PIOGLITAZONE; PROTEIN KINASE B; TELMISARTAN; VALSARTAN; AGTR1A PROTEIN, MOUSE; BENZIMIDAZOLE DERIVATIVE; BENZOIC ACID DERIVATIVE; NEUROPROTECTIVE AGENT;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CONTROLLED STUDY; DRUG MECHANISM; DRUG POTENCY; ENZYME ACTIVATION; EXCITOTOXICITY; FEMALE; GENE EXPRESSION; GENE TRANSLOCATION; GRANULE CELL; IN VITRO STUDY; MALE; MOUSE; NERVE CELL LESION; NEUROPROTECTION; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; RAT; RECEPTOR BINDING; RECEPTOR BLOCKING; RECEPTOR UPREGULATION; SIGNAL TRANSDUCTION; ANIMAL; ANTAGONISTS AND INHIBITORS; C57BL MOUSE; CELL CULTURE; CEREBELLUM; DRUG EFFECTS; GENETICS; KNOCKOUT MOUSE; METABOLISM; NERVE CELL; PHYSIOLOGY; SPRAGUE DAWLEY RAT; TOXICITY; TRANSGENIC MOUSE;

ANGIOTENSIN II TYPE 1 RECEPTOR BLOCKERS; ANIMALS; APOPTOSIS; BENZIMIDAZOLES; BENZOATES; CELLS, CULTURED; CEREBELLUM; FEMALE; GLUTAMIC ACID; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICE, TRANSGENIC; NEURONS; NEUROPROTECTIVE AGENTS; PPAR GAMMA; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, ANGIOTENSIN, TYPE 1;

EID: 84890952731     PISSN: 00283908     EISSN: 18737064     Source Type: Journal    
DOI: 10.1016/j.neuropharm.2013.11.022     Document Type: Article

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