Low doses of carbon monoxide protect against experimental focal brain ischemia

Neurotoxicity Research

Volumn 15, Issue 2, 2009, Pages 133-137

  Zeynalov, Emil ^a   Doré, Sylvain ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Brain edema; Gas; Heme oxygenase; Ischemic stroke; Transient cerebral ischemia

Indexed keywords

CARBON MONOXIDE; CARBOXYHEMOGLOBIN; HEME OXYGENASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN BLOOD FLOW; BRAIN CORTEX; BRAIN EDEMA; BRAIN INFARCTION SIZE; BRAIN INJURY; BRAIN ISCHEMIA; BRAIN WATER; CEREBROVASCULAR ACCIDENT; CONTROLLED STUDY; DOSE RESPONSE; DRUG EXPOSURE; DRUG MECHANISM; HEMISPHERE; HEMOGLOBIN BLOOD LEVEL; LOW DRUG DOSE; MALE; MOUSE; NEUROLOGIC EXAMINATION; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; PUTAMEN; REPERFUSION; SURVIVAL TIME;

ANALYSIS OF VARIANCE; ANIMALS; BRAIN EDEMA; CARBON MONOXIDE; CARBOXYHEMOGLOBIN; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; INFARCTION, MIDDLE CEREBRAL ARTERY; MALE; MICE; MICE, INBRED C57BL; NEUROPROTECTIVE AGENTS; REPERFUSION INJURY; TIME FACTORS;

MUS;

EID: 70349730056     PISSN: 10298428     EISSN: None     Source Type: Journal    
DOI: 10.1007/s12640-009-9014-4     Document Type: Article

References (15)

1. Benignus VA, Kafer ER, Muller KE, Case MW (1987) Absence of symptoms with carboxyhemoglobin levels of 16-23%. Neurotoxicol Teratol 9:345-348
2. Brunssen SH, Morgan DL, Parham FM, Harry GJ (2003) Carbon monoxide neurotoxicity: Transient inhibition of avoidance response and delayed microglia reaction in the absence of neuronal death. Toxicology 194:51-63
3. Chen YH, Tsai HL, Chiang MT, Chau LY (2006) Carbon monoxide-induced early thrombolysis contributes to heme oxygenase-1-mediated inhibition of neointimal growth after vascular injury in hypercholesterolemic mice. J Biomed Sci 13:721-730
4. Chu K, Jung KH, Kim HJ, Jeong SW, Kang DW, Roh JK (2004) Diffusion-weighted MRI and 99mTc-HMPAO SPECT in delayed relapsing type of carbon monoxide poisoning: Evidence of delayed cytotoxic edema. Eur Neurol 51:98-103
5. Doré S, Sampei K, Goto S, Alkayed NJ, Guastella D, Blackshaw S, Gallagher M, Traystman RJ, Hurn PD, Koehler RC, Snyder SH (1999) Heme oxygenase-2 is neuroprotective in cerebral ischemia. Mol Med 5:656-663
6. Durante W, Johnson FK, Johnson RA (2006) Role of carbon monoxide in cardiovascular function. J Cell Mol Med 10:672-686
7. Koehler RC, Traystman RJ (2002) Cerebrovascular effects of carbon monoxide. Antioxid Redox Signal 4:279-290
8. Koneru P, Leffler CW (2004) Role of cGMP in carbon monoxide-induced cerebral vasodilation in piglets. Am J Physiol Heart Circ Physiol 286:H304-H309
9. Leffler CW, Parfenova H, Jaggar JH, Wang R (2006) Carbon monoxide and hydrogen sulfide: Gaseous messengers in cerebrovascular circulation. J Appl Physiol 100:1065-1076
10. Nakao A, Kimizuka K, Stolz DB, Neto JS, Kaizu T, Choi AM, Uchiyama T, Zuckerbraun BS, Nalesnik MA, Otterbein LE, Murase N (2003) Carbon monoxide inhalation protects rat intestinal grafts from ischemia/ reperfusion injury. Am J Pathol 163:1587-1598
11. Otterbein LE (2002) Carbon monoxide: Innovative anti-inflammatory properties of an age-old gas molecule. Antioxid Redox Signal 4:309-319
12. Shah ZA, Namiranian K, Klaus J, Kibler K, Dore S (2006) Use of an optimized transient occlusion of the middle cerebral artery protocol for the mouse stroke model. J Stroke Cerebrovasc Dis 15:133-138
13. Thom SR, Ischiropoulos H (1997) Mechanism of oxidative stress from low levels of carbon monoxide. Res Rep Health Eff Inst 80:1-19
14. Uemura K, Harada K, Sadamitsu D, Tsuruta R, Takahashi M, Aki T, Yasuhara M, Maekawa T, Yoshida K (2001) Apoptotic and necrotic brain lesions in a fatal case of carbon monoxide poisoning. Forensic Sci Int 116:213-219
15. Weaver LK, Hopkins RO, Chan KJ, Churchill S, Elliott CG, Clemmer TP, Orme JF Jr, Thomas FO, Morris AH (2002) Hyperbaric oxygen for acute carbon monoxide poisoning. N Engl J Med 347:1057-1067