Neuroprotection of early and short-time applying berberine in the acute phase of cerebral ischemia: Up-regulated pAkt, pGSK and pCREB, down-regulated NF-κB expression, ameliorated BBB permeability

Brain Research

Volumn 1459, Issue , 2012, Pages 61-70

  Zhang, Xiangjian ^a,b,c   Zhang, Xiaolin ^a   Wang, Chaohui ^a   Li, Yanhua ^a   Dong, Lipeng ^a   Cui, Lili ^a   Wang, Lina ^a   Liu, Zongjie ^a   Qiao, Huimin ^a   Zhu, Chunhua ^a   Xing, Yinxue ^a   Cao, Xiaoyun ^a   Ji, Ye ^a   Zhao, Kang ^a  

^a HEBEI MEDICAL UNIVERSITY   (China)

^b Hebei Institute of Cardio Cerebral Vascular Diseases   (China)

^c Hebei Key Laboratory for Neurology   (China)

Author keywords

Akt GSK; Berberine; CREB; Middle cerebral artery occlusion; Neuroprotection; NF B

Indexed keywords

BERBERINE; CLAUDIN 5; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN BINDING PROTEIN; GLYCOGEN SYNTHASE KINASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PHOSPHOGLYCOGEN SYNTHASE KINASE 3 BETA; PROTEIN KINASE B; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BLOOD BRAIN BARRIER; BRAIN CORTEX; BRAIN INFARCTION SIZE; BRAIN ISCHEMIA; BRAIN WATER; CONTROLLED STUDY; DOWN REGULATION; DRUG STRUCTURE; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; MALE; MEMBRANE PERMEABILITY; MIDDLE CEREBRAL ARTERY OCCLUSION; NEUROLOGIC DISEASE; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; UPREGULATION; WESTERN BLOTTING;

ANIMALS; BERBERINE; BLOOD-BRAIN BARRIER; BRAIN EDEMA; CEREBRAL INFARCTION; CREB-BINDING PROTEIN; DISEASE MODELS, ANIMAL; DRUG ADMINISTRATION SCHEDULE; GENE EXPRESSION REGULATION; GLYCOGEN SYNTHASE KINASE 3; INFARCTION, MIDDLE CEREBRAL ARTERY; MALE; NERVOUS SYSTEM DISEASES; NEUROPROTECTIVE AGENTS; NF-KAPPA B; ONCOGENE PROTEIN V-AKT; PERMEABILITY; RATS; RATS, SPRAGUE-DAWLEY; TIME FACTORS;

RATTUS;

EID: 84861228539     PISSN: 00068993     EISSN: 18726240     Source Type: Journal    
DOI: 10.1016/j.brainres.2012.03.065     Document Type: Article

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