Discovery of a potential anti-ischemic stroke agent: 3-pentylbenzo[c] thiophen-1(3H)-one

Journal of Medicinal Chemistry

Volumn 55, Issue 16, 2012, Pages 7173-7181

  Wu, Jing ^a   Ling, Lingjing ^a   Wang, Xuliang ^b   Li, Tingting ^a   Liu, Jingchao ^a   Lai, Yisheng ^a   Ji, Hui ^a   Peng, Sixun ^a   Tian, Jide ^c   Zhang, Yihua ^a  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

^b CSPC Central Institute of Pharmaceutical Research   (China)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3 BUTYLPHTHALIDE; 3 PENTYLBENZO[C]THIOPHEN 1(3H) ONE; ACETYLSALICYLIC ACID; ADENOSINE DIPHOSPHATE; ANTICOAGULANT AGENT; ARACHIDONIC ACID; FREE RADICAL; GLUTATHIONE; MALONALDEHYDE; NORPHENAZONE; OXIDOREDUCTASE; SUPEROXIDE DISMUTASE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN DAMAGE; BRAIN INFARCTION SIZE; BRAIN ISCHEMIA; BRAIN WATER; CONTROLLED STUDY; DRUG DESIGN; DRUG DOSE COMPARISON; DRUG SYNTHESIS; HISTOPATHOLOGY; MALE; NEUROPROTECTION; NONHUMAN; OCCLUSIVE CEREBROVASCULAR DISEASE; RAT; REPERFUSION INJURY; THROMBOCYTE AGGREGATION; THROMBOCYTE AGGREGATION INHIBITION; TREATMENT OUTCOME;

ANIMALS; ANTIOXIDANTS; BRAIN; BRAIN EDEMA; BRAIN INFARCTION; BRAIN ISCHEMIA; FIBRINOLYTIC AGENTS; FREE RADICAL SCAVENGERS; MALE; NEUROPROTECTIVE AGENTS; PC12 CELLS; PLATELET AGGREGATION INHIBITORS; RABBITS; RATS; RATS, SPRAGUE-DAWLEY; REPERFUSION INJURY; STEREOISOMERISM; STROKE; STRUCTURE-ACTIVITY RELATIONSHIP; THIOPHENES;

EID: 84866925084     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm300681r     Document Type: Article

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