Gardenamide A attenuated cell apoptosis induced by serum deprivation insult via the ERK1/2 and PI3K/AKT signaling pathways

Neuroscience

Volumn 286, Issue , 2015, Pages 242-250

  Wang, R ^a   Yang, J ^b   Peng, L ^b   Zhao, J ^b   Mu, N ^c   Huang, J ^e   Lazarovici, P ^f   Chen, H ^b,d   Zheng, W ^a  

^a SUN YAT SEN UNIVERSITY   (China)

^b JINAN UNIVERSITY   (China)

^c Guangzhou Brain Hospital   (China)

^d Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drug Research   (China)

^e Family Planning Service Center of Dongguan   (China)

^f HEBREW UNIVERSITY OF JERUSALEM   (Israel)

Author keywords

Akt; Cell apoptosis; ERK1 2; Gardenamide A; ROS; Serum deprivation

Indexed keywords

CASPASE 3; GARDENAMIDE A; GENIPIN; MITOGEN ACTIVATED PROTEIN KINASE 1; PROTEIN KINASE B; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG; IRIDOID; NEUROPROTECTIVE AGENT; PHOSPHATIDYLINOSITOL 3 KINASE;

ANIMAL CELL; ANIMAL EXPERIMENT; APOPTOSIS; ARTICLE; CELL SURVIVAL; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFICACY; DRUG MECHANISM; MITOCHONDRIAL MEMBRANE POTENTIAL; NEUROPROTECTION; NONHUMAN; PHARMACOLOGICAL BLOCKING; PHEOCHROMOCYTOMA CELL; PROTEIN CLEAVAGE; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; RAT; ANIMAL; CELL CULTURE; DRUG EFFECTS; METABOLISM; NERVE CELL; PC12 CELL LINE; PHOSPHORYLATION; RETINA GANGLION CELL; SIGNAL TRANSDUCTION; SYNTHESIS;

ANIMALS; APOPTOSIS; CELL SURVIVAL; CELLS, CULTURED; IRIDOIDS; MAP KINASE SIGNALING SYSTEM; NEURONS; NEUROPROTECTIVE AGENTS; PC12 CELLS; PHOSPHATIDYLINOSITOL 3-KINASES; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; RATS; RETINAL GANGLION CELLS; SIGNAL TRANSDUCTION;

EID: 84918767986     PISSN: 03064522     EISSN: 18737544     Source Type: Journal    
DOI: 10.1016/j.neuroscience.2014.11.056     Document Type: Article

References (29)

1. Ballif B.A., Blenis J. Molecular mechanisms mediating mammalian mitogen-activated protein kinase (MAPK) kinase (MEK)-MAPK cell survival signals. Cell Growth Differ 2001, 12:397-408.
2. Charles I., Khalyfa A., Kumar D.M., Krishnamoorthy R.R., Roque R.S., Cooper N., Agarwal N. Serum deprivation induces apoptotic cell death of transformed rat retinal ganglion cells via mitochondrial signaling pathways. Invest Ophthalmol & Vis Sci 2005, 46:1330-1338.
3. Datta S.R., Dudek H., Tao X., Masters S., Fu H., Gotoh Y., Greenberg M.E. Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery. Cell 1997, 91:231-241.
4. Fan Y., Chen H., Qiao B., Luo L., Ma H., Li H., Jiang J., Niu D., Yin Z. Opposing effects of ERK and p38 MAP kinases on HeLa cell apoptosis induced by dipyrithione. Mol Cell 2007, 23:30-38.
5. Gao F., Gao E., Yue T.L., Ohlstein E.H., Lopez B.L., Christopher T.A., Ma X.L. Nitric oxide mediates the antiapoptotic effect of insulin in myocardial ischemia-reperfusion: the roles of PI3-kinase, Akt, and endothelial nitric oxide synthase phosphorylation. Circulation 2002, 105:1497-1502.
6. Hamanoue M., Sato K., Takamatsu K. Inhibition of p38 mitogen-activated protein kinase-induced apoptosis in cultured mature oligodendrocytes using SB202190 and SB203580. Neurochem Int 2007, 51:16-24.
7. Han B., Wei W., Hua F., Cao T., Dong H., Yang T., Yang Y., Pan H., Xu C. Requirement for ERK activity in sodium selenite-induced apoptosis of acute promyelocytic leukemia-derived NB4 cells. J Biochem Mol Biol 2007, 40:196-204.
8. Harris C., Maroney A.C., Johnson E.M. Identification of JNK-dependent and -independent components of cerebellar granule neuron apoptosis. J Neurochem 2002, 83:992-1001.
9. Hui L., Pei D.S., Zhang Q.G., Guan Q.H., Zhang G.Y. The neuroprotection of insulin on ischemic brain injury in rat hippocampus through negative regulation of JNK signaling pathway by PI3K/Akt activation. Brain Res 2005, 1052:1-9.
10. Koriyama Y., Ohno M., Kimura T., Kato S. Neuroprotective effects of 5-S-GAD against oxidative stress-induced apoptosis in RGC-5 cells. Brain Res 2009, 1296:187-195.
11. Leinninger G.M., Backus C., Uhler M.D., Lentz S.I., Feldman E.L. Phosphatidylinositol 3-kinase and Akt effectors mediate insulin-like growth factor-I neuroprotection in dorsal root ganglia neurons. FASEB J 2004, 18:1544-1546.
12. LeRoith D., Werner H., Beitner-Johnson D., Roberts C.T. Molecular and cellular aspects of the insulin-like growth factor I receptor. Endocr Rev 1995, 16:143-163.
13. Liu J., Yin F., Zheng X., Jing J., Hu Y. Geniposide, a novel agonist for GLP-1 receptor, prevents PC12 cells from oxidative damage via MAP kinase pathway. Neurochem Int 2007, 51:361-369.
14. Luo J., Wang R., Huang Z., Yang J., Yao X., Chen H., Zheng W. Synthesis of stable genipin derivatives and studies of their neuroprotective activity in PC12 cells. ChemMedChem 2012, 7:1661-1668.
15. Ma C.J., Nie A.F., Zhang Z.J., Zhang Z.G., Du L., Li X.Y., Ning G. Genipin stimulates glucose transport in C2C12 myotubes via an IRS-1 and calcium-dependent mechanism. J Endocrinol 2013, 216:353-362.
16. Myers M.G., Sun X.J., Cheatham B., Jachna B.R., Glasheen E.M., Backer J.M., White M.F. IRS-1 is a common element in insulin and insulin-like growth factor-I signaling to the phosphatidylinositol 3'-kinase. Endocrinol 1993, 132:1421-1430.
17. Paradies G., Petrosillo G., Paradies V., Ruggiero F.M. Mitochondrial dysfunction in brain aging: role of oxidative stress and cardiolipin. Neurochem Int 2011, 58:447-457.
18. Poon H.F., Calabrese V., Scapagnini G., Butterfield D.A. Free radicals and brain aging. Clin Geriatr Med 2004, 20:329.
19. Romashkova J.A., Makarov S.S. NF-kappaB is a target of AKT in anti-apoptotic PDGF signalling. Nature 1999, 401:86-90.
20. Rukenstein A., Rydel R.E., Greene L.A. Multiple agents rescue PC12 cells from serum-free cell death by translation- and transcription-independent mechanisms. J Neurosci 1991, 11:2552-2563.
21. Sasaoka T., Rose D.W., Jhun B.H., Saltiel A.R., Draznin B., Olefsky J.M. Evidence for a functional role of Shc proteins in mitogenic signaling induced by insulin, insulin-like growth factor-1 and epidermal growth factor. J Biol Chem 1994, 269:13689-13694.
22. Sturgill T.W. MAP kinase: it's been longer than fifteen minutes. Biochem Biophys Res Commun 2008, 371:1-4.
23. Yamazaki M., Chiba K. Genipin exhibits neurotrophic effects through a common signaling pathway in nitric oxide synthase-expressing cells. Eur J Pharmacol 2008, 581:255-261.
24. Yamazaki M., Chiba K., Mohri T., Hatanaka H. Activation of the mitogen-activated protein kinase cascade through nitric oxide synthesis as a mechanism of neuritogenic effect of genipin in PC12h cells. J Neurochem 2001, 79:45-54.
25. Yamazaki M., Chiba K., Mohri T., Hatanaka H. Cyclic GMP-dependent neurite outgrowth by genipin and nerve growth factor in PC12h cells. Eur J Pharmacol 2004, 488:35-43.
26. Yeste-Velasco M., Folch J., Pallas M., Camins A. The p38(MAPK) signaling pathway regulates neuronal apoptosis through the phosphorylation of the retinoblastoma protein. Neurochem Int 2009, 54:99-105.
27. Yoo B.K., Choi J.W., Shin C.Y., Jeon S.J., Park S.J., Cheong J.H., Han S.Y., Ryu J.R., Song M.R., Ko K.H. Activation of p38 MAPK induced peroxynitrite generation in LPS plus IFN-gamma-stimulated rat primary astrocytes via activation of iNOS and NADPH oxidase. Neurochem Int 2008, 52:1188-1197.
28. Zheng W.H., Quirion R. Glutamate acting on N-methyl-d-aspartate receptors attenuates insulin-like growth factor-1 receptor tyrosine phosphorylation and its survival signaling properties in rat hippocampal neurons. J Biol Chem 2009, 284:855-861.
29. Zheng W.H., Kar S., Quirion R. Insulin-like growth factor-1-induced phosphorylation of transcription factor FKHRL1 is mediated by phosphatidylinositol 3-kinase/Akt kinase and role of this pathway in insulin-like growth factor-1-induced survival of cultured hippocampal neurons. Mol Pharmacol 2002, 62:225-233.