4-Ketopinoresinol, a novel naturally occurring ARE activator, induces the Nrf2/HO-1 axis and protects against oxidative stress-induced cell injury via activation of PI3K/AKT signaling

Free Radical Biology and Medicine

Volumn 52, Issue 6, 2012, Pages 1054-1066

  Chen, Huang Hui ^a   Chen, Yu Tsen ^a   Huang, Yen Wen ^a   Tsai, Hui Ju ^a   Kuo, Ching Chuan ^a,b  

^a NATIONAL HEALTH RESEARCH INSTITUTES   (Taiwan)

^b NATIONAL CHENG KUNG UNIVERSITY   (Taiwan)

Author keywords

4 Ketopinoresinol; ARE activator; Free radicals; HO 1; Nrf2; PI3K AKT

Indexed keywords

4 KETOPINORESINOL; HEME OXYGENASE 1; PHOSPHATIDYLINOSITOL 3 KINASE; PINORESINOL; PROTEIN KINASE B; TERT BUTYLHYDROQUINONE; TRANSCRIPTION FACTOR NRF2; UNCLASSIFIED DRUG;

ANTIOXIDANT RESPONSIVE ELEMENT; ARTICLE; CELL DAMAGE; CELL PROTECTION; COIX; CONTROLLED STUDY; DNA DAMAGE; DRUG EFFECT; DRUG MECHANISM; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; ENZYME REGULATION; GENE CONTROL; GENE EXPRESSION; NUCLEOTIDE SEQUENCE; OXIDATIVE STRESS; PRIORITY JOURNAL; RNA INTERFERENCE; SIGNAL TRANSDUCTION;

ANTIOXIDANTS; CELL DEATH; CELL LINE, TUMOR; COIX; CYTOPROTECTION; DNA DAMAGE; FURANS; HEME OXYGENASE-1; HUMANS; HYDROQUINONES; LIGNANS; NF-E2-RELATED FACTOR 2; OXIDATIVE STRESS; PHOSPHATIDYLINOSITOL 3-KINASES; PROTO-ONCOGENE PROTEINS C-AKT; RESPONSE ELEMENTS; SIGNAL TRANSDUCTION; UP-REGULATION;

COIX LACRYMA-JOBI;

EID: 84862798490     PISSN: 08915849     EISSN: 18734596     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2011.12.012     Document Type: Article

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