Synonymous variants in HTRA1 implicated in AMD susceptibility impair its capacity to regulate TGF-βsignaling

Human Molecular Genetics

Volumn 24, Issue 22, 2015, Pages 6361-6373

  Friedrich, Ulrike ^a   Datta, Shyamtanu ^a   Schubert, Thomas ^a,b   Plössl, Karolina ^a   Schneider, Magdalena ^a   Grassmann, Felix ^a   Fuchshofer, Rudolf ^a   Tiefenbach, Klaus Jürgen ^a   Längst, Gernot ^a   Weber, Bernhard H F ^a  

^a UNIVERSITY OF REGENSBURG   (Germany)

^b 2BIND GMBH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

DODECYL SULFATE SODIUM; HIGH TEMPERATURE REQUIREMENT A1 ENZYME; SERINE PROTEINASE; TRANSFORMING GROWTH FACTOR BETA1; TRYPSIN; UNCLASSIFIED DRUG; HTRA1 PROTEIN, HUMAN; MESSENGER RNA; PLASMINOGEN ACTIVATOR INHIBITOR 1; SERPINE1 PROTEIN, HUMAN;

AGE RELATED MACULAR DEGENERATION; ANALYSIS; ARTICLE; CELL CULTURE; CONTROLLED STUDY; DEGENERATIVE DISEASE; DISEASE PREDISPOSITION; DOWN REGULATION; GENETIC RISK; GENOTYPE; HUMAN; HUMAN CELL; IN VITRO STUDY; MICROGLIA; NONHUMAN; PATHOGENESIS; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN DEGRADATION; PROTEIN INTERACTION; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; PROTEIN UNFOLDING; QUALITY CONTROL; SIGNAL TRANSDUCTION; TEMPERATURE; VISUAL IMPAIRMENT; WESTERN BLOTTING; ENZYMOLOGY; EXON; GENETIC PREDISPOSITION; GENETICS; HEK293 CELL LINE; MACULAR DEGENERATION; METABOLISM; PROMOTER REGION; RISK FACTOR; SILENT MUTATION; SINGLE NUCLEOTIDE POLYMORPHISM;

DOWN-REGULATION; EXONS; GENETIC PREDISPOSITION TO DISEASE; HEK293 CELLS; HUMANS; MACULAR DEGENERATION; PLASMINOGEN ACTIVATOR INHIBITOR 1; POLYMORPHISM, SINGLE NUCLEOTIDE; PROMOTER REGIONS, GENETIC; RISK FACTORS; RNA, MESSENGER; SERINE ENDOPEPTIDASES; SIGNAL TRANSDUCTION; SILENT MUTATION; TRANSFORMING GROWTH FACTOR BETA1;

EID: 84949035607     PISSN: 09646906     EISSN: 14602083     Source Type: Journal    
DOI: 10.1093/hmg/ddv346     Document Type: Article

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