HtrA1 Inhibits mineral deposition by osteoblasts: Requirement for the protease and PDZ domains

Journal of Biological Chemistry

Volumn 283, Issue 9, 2008, Pages 5929-5938

  Hadfield, Kristen D ^a,b   Rock, Claire Farrington ^a   Inkson, Colette A ^a   Dallas, Sarah L ^c   Sudre, Laure ^a   Wallis, Gillian A ^a   Boot Handford, Raymond P ^a   Canfield, Ann E ^a,b  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

^b UNIVERSITY OF MANCHESTER   (United Kingdom)

^c UNIVERSITY OF MISSOURI KANSAS CITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; BIOMINERALIZATION; BONE; CELL CULTURE; COLLAGEN; DIFFERENTIATION (CALCULUS); GENE EXPRESSION; MINERALS; MOLECULAR INTERACTIONS; NUCLEIC ACIDS; OSTEOBLASTS; PROTEINS; RNA; SILICA; SILICATE MINERALS;

COLLAGEN TYPE I; DECORIN; DO-MAINS; FUNCTIONAL ROLES; INHIBITORY EFFECTS; MATRIX PROTEINS; MINERAL DEPOSITIONS; MULTIDOMAIN PROTEINS; OSTEOBLAST DIFFERENTIATIONS; OSTEOBLAST MINERALIZATIONS; OVEREXPRESSION; PDZ DOMAINS; SERINE PROTEASE ACTIVITIES; SHORT INTERFERING RNAS; SKELETAL DEVELOPMENTS; TYPE I COLLAGENS;

MINERALOGY;

BONE MORPHOGENETIC PROTEIN 2; COLLAGEN TYPE 1; DECORIN; FIBRONECTIN; HIGH TEMPERATURE REQUIREMENT PROTEIN A1; OSTEOCALCIN; SERINE PROTEINASE; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR RUNX2; UNCLASSIFIED DRUG; BONE MORPHOGENETIC PROTEIN; HTRA1 PROTEIN, HUMAN; RECOMBINANT PROTEIN; SCLEROPROTEIN; TRANSFORMING GROWTH FACTOR BETA;

ARTICLE; BONE MINERALIZATION; CALCIFICATION; CELL DIFFERENTIATION; COLLAGEN DEGRADATION; CONTROLLED STUDY; ENZYME ACTIVITY; EXTRACELLULAR MATRIX; HUMAN; HUMAN CELL; NORTHERN BLOTTING; NUCLEOTIDE SEQUENCE; OSTEOBLAST; PDZ DOMAIN; POLYACRYLAMIDE GEL ELECTROPHORESIS; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; WESTERN BLOTTING; CELL LINE; CYTOLOGY; DOWN REGULATION; ENZYME SPECIFICITY; GENETICS; METABOLISM; PHYSIOLOGY; PROTEIN TERTIARY STRUCTURE; SECRETION; SIGNAL TRANSDUCTION;

BONE MORPHOGENETIC PROTEINS; CALCIFICATION, PHYSIOLOGIC; CELL DIFFERENTIATION; CELL LINE; CORE BINDING FACTOR ALPHA 1 SUBUNIT; DOWN-REGULATION; EXTRACELLULAR MATRIX PROTEINS; HUMANS; OSTEOBLASTS; PROTEIN STRUCTURE, TERTIARY; RECOMBINANT PROTEINS; RNA, SMALL INTERFERING; SERINE ENDOPEPTIDASES; SIGNAL TRANSDUCTION; SUBSTRATE SPECIFICITY; TRANSFORMING GROWTH FACTOR BETA;

EID: 41949118339     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M709299200     Document Type: Article

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