Subtoxic oxidative stress induces senescence in retinal pigment epithelial cells via TGF-β release

Investigative Ophthalmology and Visual Science

Volumn 50, Issue 2, 2009, Pages 926-935

  Yu, Alice L ^a   Fuchshofer, Rudolf ^b   Kook, Daniel ^a   Kampik, Anselm ^a   Bloemendal, Hans ^c   Welge Lüssen, Ulrich ^a,d  

^a UNIVERSITY OF MUNICH   (Germany)

^b UNIVERSITY OF REGENSBURG   (Germany)

^c RADBOUD UNIVERSITY NIJMEGEN   (Netherlands)

^d UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

BETA GALACTOSIDASE; CLUSTERIN; CONNECTIVE TISSUE GROWTH FACTOR; FIBRONECTIN; HYDROGEN PEROXIDE; MESSENGER RNA; NEUTRALIZING ANTIBODY; PROTEIN P16; PROTEIN P21; REACTIVE OXYGEN METABOLITE; RETINOBLASTOMA PROTEIN; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA RECEPTOR; TRANSFORMING GROWTH FACTOR BETA1; TRANSFORMING GROWTH FACTOR BETA2; TRANSFORMING GROWTH FACTOR BETA3; TRANSGELIN; ACTIN BINDING PROTEIN; MUSCLE PROTEIN;

ADULT; ARTICLE; CELL AGING; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVITY; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; LIPID PEROXIDATION; OXIDATIVE STRESS; PIGMENT EPITHELIUM; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; BIOSYNTHESIS; CELL CULTURE; CYTOLOGY; DRUG EFFECT; GENETICS; METABOLISM; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

ADULT; BETA-GALACTOSIDASE; BLOTTING, WESTERN; CELL AGING; CELLS, CULTURED; CLUSTERIN; CONNECTIVE TISSUE GROWTH FACTOR; FIBRONECTINS; HUMANS; HYDROGEN PEROXIDE; LIPID PEROXIDATION; MICROFILAMENT PROTEINS; MUSCLE PROTEINS; OXIDATIVE STRESS; REACTIVE OXYGEN SPECIES; RETINAL PIGMENT EPITHELIUM; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SIGNAL TRANSDUCTION; TRANSFORMING GROWTH FACTOR BETA1; TRANSFORMING GROWTH FACTOR BETA2;

EID: 59449099708     PISSN: 01460404     EISSN: 15525783     Source Type: Journal    
DOI: 10.1167/iovs.07-1003     Document Type: Article

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